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Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang Mu-Qi Wang Jiang Deng Ning gao Mei Li Ya-Ping Li Xin zhang Xiao-Li Jia Xiong-tao liu Shuang-Suo Dang Wen-jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the pEGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with pEGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

Coherent optical frequency transfer via 972-km fiber link

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Chinese Physics B 2024年第2期33卷 277-282页

作者：邓雪张翔臧琦焦东东王丹刘杰高静许冠军董瑞芳刘涛张首刚 National Time Service Centre Chinese Academy of SciencesXi’an 710600China Key Laboratory of Time Reference and Application Chinese Academy of SciencesXi’an 710600China School of Communications and Information Engineering and School of Artificial Intelligence Xi’an University of Posts and TelecommunicationsXi’an 710121Chin

We demonstrate coherent optical frequency dissemination over a distance of 972 km by cascading two spans where the phase noise is passively compensated *** of employing a phase discriminator and a phase locking loop in the conventional active phase control scheme,the passive phase noise cancellation is realized by feeding double-trip beat-note frequency to the driver of the acoustic optical modulator at the local *** passive scheme exhibits fine robustness and reliability,making it suitable for long-distance and noisy fiber *** optical regeneration station is used in the link for signal amplification and cascaded *** phase noise cancellation and transfer instability of the 972-km link is investigated,and transfer instability of 1.1×10^(-19)at 10^(4)s is *** work provides a promising method for realizing optical frequency distribution over thousands of kilometers by using fiber links.

关键词： optical frequency transfer fiber link phase noise cancellation

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao zhang Sen Luo Hai Li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-Ling Li Yan-Hang gao Zhi-Ping Qian Feng liu Xiao-Bo Lu jun-Ping liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong Deng Liang Qiao Yan zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun zhang Yan Xiong Cong-Cong Zou jun Chen Ze-Bing Huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na gao Chun-Yan liu Wei Yuan Xue Mei Jing Li tao Li Rong-Jiong Zheng Xin-Yi Zhou jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic Liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/100)for type-B ACLF,27.0%(58/215)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure Liver cirrhosis Clinical features Prognosis

Study of the response of 10B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑Jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei Xu tao Li Ze‑Bin Lin Chang‑jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang Sun Jing‑Yu Tang Rong zhang Han‑tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li Jia‑Wen Li Xiao Li Yang Li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Li‑Kun Xie Yi‑Wei Yang Han Yi Yong‑Ji Yu Guo‑Hui zhang Lin‑Hao zhang Mo‑Han zhang Qi‑Wei zhang Xian‑Peng zhang Yu‑Liang zhang Yue zhang Zhi‑Yong zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the China Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCP Neutron response Wide-energy range neutrons

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-Qiu zhang Yue Huang Lu Li Xing Wen Fei zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing liu Da-Li zhang Xi-Lei Sun Fan zhang Gang Chen Huan-Yu Wang Sheng Yang Xiao-Jing liu Min gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke zhang Can Chen Xiong-tao Yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei zhang Yue Zhu Wei Chen Jian-Jian He Zhen zhang Jin Hou Hong-jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan zhang Chao-Yue zhang Cheng-Mo zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

改进的栖息地法求解多种产漂流性卵鱼类生态流量方法研究

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中国农村水利水电 2024年第9期 45-51,59页

作者：易燃陶江平杨志刘宏高徐薇曹俊张鹏水利部中国科学院水工程生态研究所水利部水工程生态效应与生态修复重点实验室湖北省水生态保护与修复工程技术研究中心湖北武汉430079 中国长江三峡集团有限公司长江生态环境工程研究中心湖北武汉430014 武汉大学水资源工程与调度全国重点实验室湖北武汉430072

为了解决产漂流性卵鱼类产卵场栖息地模拟的多鱼种生态流量求解不足的问题,提出一种通过鱼类产卵场栖息地模拟计算,在耦合多种产漂流性卵鱼类生态需求的基础上进行生态流量及阈值计算的求解方法,包括:①采用模糊逻辑法进行产卵场栖息地... 详细信息

为了解决产漂流性卵鱼类产卵场栖息地模拟的多鱼种生态流量求解不足的问题,提出一种通过鱼类产卵场栖息地模拟计算,在耦合多种产漂流性卵鱼类生态需求的基础上进行生态流量及阈值计算的求解方法,包括:①采用模糊逻辑法进行产卵场栖息地模拟;②改进优势度模型,并运用熵权法确定鱼种的生态流量权重,加强鱼类产卵场生态流量结果的适用性;③耦合多种鱼类产卵需求求解生态流量,并基于单、多鱼种最适生态流量求解综合生态流量阈值。方法考虑了多种鱼类产卵期间的生态流量需求,增加了鱼种对河流生态需求指示作用的可靠性,研究成果可为水库生态调度提供理论基础,为河流水资源管理提供必要参考。

关键词：栖息地法漂流性卵鱼类模糊逻辑生态流量

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Study on Transient Gap Resonance with Consideration of the Motion of Floating Body

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China Ocean Engineering 2022年第6期36卷 994-1006页

作者： gao jun-liang LYU Jing WANG Jing-hua zhang Jian liu Qian ZANG jun ZOU tao School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China Key Laboratory of Port Waterway and Sedimentation Engineering of MOTNanjing Hydraulic Research InstituteNanjing 210029China Department of Civil and Environmental Engineering the Hong Kong Polytechnic UniversityHong KongChina Centre for Infrastructure Geotechnical and Water Engineering(IGWE)Department of Architecture and Civil EngineeringUniversity of BathBA27AYU.K Shandong Provincial Key Laboratory of Ocean Engineering Qingdao 266100China

In this paper, the transient fluid resonance phenomenon inside a narrow gap between two adjacent boxes excited by the incident focused waves with various spectral peak periods and focused wave amplitudes is simulated by utilizing the open-sourced computational fluid dynamics software, Open FOAM. The weather-side box is allowed to heave freely under the action of waves, and the lee-side box keeps fixed. This paper mainly focuses on how both the spectral peak period and the focused wave amplitude affect the free-surface amplification inside the gap, the motion of the weather-side box, and the wave loads(including the vertical and the horizontal wave forces) acting on both *** comparison, another two-box system with both boxes fixed is also considered as a control group. It is found that the motion of the weather-side box significantly changes the characteristics of the transient gap resonance, and it would cause that the fluid resonant period becomes 1.4-1.6 times that of the two-box system with both boxes *** the concerned physical quantities(i.e., the free-surface amplification in the gap, the motion of the weather-side box, the wave loads) are found to closely depend on both the spectral peak period and the focused wave amplitude.

关键词： transient gap resonance focused waves free-surface amplification wave loads heave motion OpenFOAM

Detachment of esophageal carcinoma cells from extracellular matrix causes relocalization of death receptor 5 and apoptosis

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World Journal of Gastroenterology 2009年第7期15卷 836-844页

作者： Guang-Chao liu jun zhang Shi-Gui liu Rong gao zhang-Fu Long Ke tao Yuan-Fang Ma Key Laboratory of Bio-resource and Eco-environment of China Ministry of Education College of Life Sciences of Sichuan University Chengdu 610064 Sichuan Province China Henan Provincial Key Laboratory for Natural Drug and Immune Engineering Henan University Kaifeng 475004 Henan Province China Institute of Immunology Medical College Henan University Kaifeng 475004 Henan Province China

AIM： To investigate the effect of detachment of esophageal cancer cells from extracellular matrix on the localization of death receptor 5 （DR5） and apoptosis. METHODS： Anchorage-dependent EC9706 cells of esophageal squamous cell carcinoma were pretreated or not treated with brefeldin A. Detached cells were harvested by ethylenediaminetetraacetic acid digestion. Expression and localization of DR5 in these cells were determined by immunocytochemical and immunofluorescence assays, as well as flow cytometry analysis. Apoptosis of EC9706 cells was detected by flow cytometry after stained with fluorescein isothiocyanate-labeled annexin V/propidium iodide. Activation of caspase 8 was detected by Western blot analysis. RESULTS： Immunocytochemical assay indicated that DR5 was predominantly perinuclear in adherent cells but was mainly localized in cell membrane in detached cells. In addition, immunofluorescence assay also confirmed the above-mentioned results, and further demonstrated that DR5 was present in the form of coarse granules in detached cells, but in the form of fine granules in adherent cells. Cytometry analysis revealed higher levels of DR5 expression on the surfaces of brefeldin-A-untreated cells than on the surfaces of brefeldin-A-treated cells, but brefeldin A treatment did not affect the total DR5 expression levels. Moreover, nocodazole did not influence the extracelluar DR5 expression levels in EC9706 cells. Apoptosis assay revealed that detached cells were more sensitive to DR5 antibody-induced apoptosis than adherent ceils. Western blotting showed that caspase 8 was activated in temporarily detached cells 4 h earlier than in adherent cells. CONCLUSION： Progress from adhesion to detachment of EC9706 cells causes DR5 relocalization, and promotes cytoplasmic translocation of DR5 to cell surfaces via a Golgi-dependent pathway. Moreover, it might also result in DR5 aggregation to render apoptosis of detached cells.

关键词： Translocation of death receptor 5 Celldetachment Esophageal carcinoma Anoikis Apoptosis

Mathematical modeling of flow field in slab continuous casting mold considering mold powder and solidified shell with high temperature quantitative measurement

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Journal of Iron and Steel Research International 2022年第3期29卷 445-461页

作者： Yi-bo liu Jian Yang Chao Ma tao zhang Fu-bin gao Tai-quan Li jun-li Chen State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai200444China Technology Center HBIS Handan Iron and Steel Group Co.Ltd.Handan56015HebeiChina

Optimization of mathematical model of flow field in slab continuous casting mold was performed by means of industrial measurement and mathematical *** rod deflection method was used to quantitatively measure the velocities near the mold surface at high *** measurement results were compared with the simulation results of three mathematical models at different argon gas flow rates of 6,10 and 14 L min^(−1).The model 1 neglects the mold powder layer,thermal effect and solidified *** model 2 only considers the influence of mold powder *** model 3 considers the influence of mold powder layer,thermal effect and solidified shell on the flow *** all three models,the diameter of argon bubbles obeys Rosin-Rammler distribution fitted according to the experimental data of others’previous *** increasing the argon gas flow rate,the velocity of liquid steel near the mold surface *** model 1 seriously underestimates the shear stress of liquid steel near the mold surface,and its calculation results show higher velocity near the mold surface,lower turbulent kinetic energy and wider distribution of argon gas bubbles in the *** simulation results of model 2 only considering the viscous resistance of the mold powder layer to liquid steel makes the velocity near the surface lower than the measurement results *** calculated velocities near the mold surface with model 3 are in best agreement with the measured results,showing the reasonable spatial distribution range of argon bubbles in the mold and the moderate turbulent kinetic *** the present conditions,the best argon gas flow rate is 10 L min^(−1) due to the moderate velocity near the mold surface,the appropriate distribution of argon gas bubbles in the mold and the smallest fluctuation amplitude on the mold surface.

关键词： Flow field Mold powder layer Solidified shell Rosin-Rammler distribution Mathematical modeling Rod deflection method