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检索条件"作者=Gao Songdan Zhang Qiuju li Hongwei li ailing Xiu Ruijuan Institute of Microcircilation,Chinese Academy of Medical Science & Peking Union Medical College,Beijing 100005,China"

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Differential Regulation of Protein Kinase C Isoforms In ROS-induced Cardiomyocyte Hypertrophy

Differential Regulation of Protein Kinase C Isoforms In ROS-...

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第十一届国际人工血液大会

作者： gao songdan zhang qiuju li hongwei li ailing xiu ruijuan institute of microcircilation,chinese academy of medical science & peking union medical college,beijing 100005,china

Objective:Protein kinase C(PKC)plays a key role in myocardial *** its isoforms are involved differentially in reactive oxygen species(ROS)-induced cardiomyocyte hypertrophy are poorly *** examined whether PKC regulates cardJomyocyte hypertrophy induced by ***:Cardiomyocytes were treated with low concentrations of HO or DDC(inhibitor of superoxide dismutase).The cardiomyocyte hypertrophy was evaluated by the determination of average cell volume and protein *** translocation of protein kinase C(PKC)isoforms, PKCα,PKCδ and PKCε from soluble to particulate fractions was determined in cardiomyocytes after treatment with HO by Western blot *** phosphorylation of PKCα,PKCδ and PKCε was also determined in cardiomyocytes after treatment with *** effects of inhibition of PKC by GF109203X on the hypertrophic response of cardiomyocytes induced by HO or DDC were studied by the determination of average cell volume and protein ***:HO at 10 or 50μmol/L increased cardiomyacyte volum and protein ***,DDC at 1 and 5μmol/L stimulated cardiomyocyte hypertrophy as measured by cell volume and the protein content per *** cardJomyocytes stimulated with 50μmol/L HO,the levels of PKCα and PKCε protein in cytosolic fractions began to decrease at 5 min,and the decrease was most significant at 10 and 30 ***,the levels of PKCa and PKCε protein in membranous fractions increased at corresponding *** was no effect of HO on the levels of PKCδ protein in cytosolic and membranous fractions of *** induced the phosphorylation of PKCα,PKCδ and PKCε protein within 5 min treatmen,and the phosphorylation reached its highest level within 5 to 10 *** inhibitor GF109203X significantly decreased the volume enlargement and protein content increase of cardiomyoctes induced by HO or ***:Reactive oxygen species(ROS)mediate the regulation of cardiomyocyte hypertyophy through different iso

关键词： ROS PKC hypertrophy cardiomyocyte

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