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Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells

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Asian Journal of Andrology 2024年第2期26卷 165-174页

作者： Hai-Wei Feng Yu Zhao Yan-Ling gao Dong-Teng Liu Li-jun Huo Key Laboratory of Agricultural Animal Genetics Breeding and ReproductionEducation Ministry of ChinaCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterThe University of Hong Kong-Shenzhen HospitalShenzhen 518053China Maternal-Fetal Medicine Institute Department of Obstetrics and GynaecologyShenzhen Baoan Women's and Children's HospitalJinan UniversityShenzhen 518100China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina

Meiosis is the process of producing haploid gametes through a series of complex chromosomal events and the coordinated action of various *** mitochondrial protease complex(ClpXP),which consists of caseinolytic mitochondrial matrix peptidase X(ClpX)and caseinolytic protease P(ClpP)and mediates the degradation of misfolded,damaged,and oxidized proteins,is essential for maintaining mitochondrial *** has been implicated in meiosis regulation,but its precise role is currently *** this study,we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X(Clpx^(cKO))mouse model to investigate the function of ClpX in *** found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the ***,it caused asynapsis of homologous chromosomes and impaired meiotic recombination,resulting in meiotic arrest in the zygotene-to-pachytene transition *** loss of ClpX compromised the double-strand break(DSB)repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolog 1(RAD51)to DSB *** dysfunction may be due to an insufficient supply of energy from the aberrant mitochondria in Clpx^(cKO) spermatocytes,as discerned by electron ***,ubiquitination signals on chromosomes and the expression of oxidative phosphorylation subunits were both significantly attenuated in Clpx^(cKO) *** together,we propose that ClpX is essential for maintaining mitochondrial protein homeostasis and ensuring homologous chromosome pairing,synapsis,and recombination in spermatocytes during meiotic prophase I.

关键词： ClpX homologous chromosome meiosis mitochondrial recombination synapsis

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Towards mixed physical node reservoir computing:light-emitting synaptic reservoir system with dual photoelectric output

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Light(Science & Applications) 2024年第9期13卷 1865-1877页

作者： Minrui Lian Changsong gao Zhenyuan Lin Liuting shan Cong Chen Yi Zou Enping Cheng Changfei Liu Tailiang Guo Wei Chen Huipeng Chen Institute of Optoelectronic Display National&Local United Engineering Lab of Flat Panel Display TechnologyFuzhou UniversityFuzhou 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350100China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore Department of Physics National University of Singapore3 Science Drive 3Singapore 117543Singapore

Memristor-based physical reservoir computing holds significant potential for efficiently processing complex spatiotemporal data,which is crucial for advancing artificial ***,owing to the single physical node mapping characteristic of traditional memristor reservoir computing,it inevitably induces high repeatability of eigenvalues to a certain extent and significantly limits the efficiency and performance of memristor-based reservoir computing for complex ***,this work firstly reports an artificial light-emitting synaptic(LES)device with dual photoelectric output for reservoir computing,and a reservoir system with mixed physical nodes is *** system effectively transforms the input signal into two eigenvalue outputs using a mixed physical node reservoir comprising distinct physical quantities,namely optical output with nonlinear optical effects and electrical output with memory *** previously reported memristor-based reservoir systems,which pursue rich reservoir states in one physical dimension,our mixed physical node reservoir system can obtain reservoir states in two physical dimensions with one input without increasing the number and types of *** recognition rate of the artificial light-emitting synaptic reservoir system can achieve 97.22%in MNIST ***,the recognition task of multichannel images can be realized through the nonlinear mapping of the photoelectric dual reservoir,resulting in a recognition accuracy of 99.25%.The mixed physical node reservoir computing proposed in this work is promising for implementing the development of photoelectric mixed neural networks and material-algorithm collaborative design.

关键词： reservoir mixed system

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An innovative classification system for ranking the biological effects of marine aromatic hydrocarbons based on fish embryotoxicity

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Acta Oceanologica Sinica 2024年第6期43卷 153-162页

作者： Ronghui Zheng Chao Fang Fukun Hong Min Zhang Fulong gao Yusheng Zhang jun Bo Key Laboratory of Marine Ecological Conservation and Restoration Third Institute of OceanographyMinistry of Natural ResourcesXiamen 361005China Observation and Research Station of Coastal Wetland Ecosystem in Beibu Gulf Ministry of Natural ResourcesBeihai 536015China

Petroleum hydrocarbon pollution is a global concern,particularly in coastal *** aromatic hydrocarbons(PAHs) are regarded as the most toxic components of petroleum *** this study,the biomonitoring and ranking effects of petroleum hydrocarbons and PAHs on the marine fish model Oryzias melastigma embryos were determined in the Jiulong River Estuary(JRE) and its adjacent waters in *** results showed that the levels of petroleum hydrocarbons from almost all sites met the primary standard for marine seawater quality,and the concentrations of the 16 priority PAHs in the surface seawater were lower compared with those in other coastal areas worldwide.A new fish expert system based on the embryotoxicity of ***(OME-FES) was developed and applied in the field to evaluate the biological effects of petroleum hydrocarbons and *** selected physiological index and molecular indicators in OME-FES were appropriate biomarkers for indicating the harmful effects of petroleum hydrocarbons and *** outcome of OME-FES revealed that the biological effect levels of the sampling sites ranged from level Ⅰ(no stress) to level Ⅲ(medium stress),which is further corroborated by the findings of nested analysis of variance(ANOVA) *** results suggest that the OME-FES is an effective tool for evaluating and ranking the biological effects of marine petroleum hydrocarbons and *** method may also be applied to evaluate other marine pollutants based on its framework.

关键词： petroleum hydrocarbons polycyclic aromatic hydrocarbons fish expert system integrated biomarker response nested one-way analysis of variance

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Application of machine learning in perovskite materials and devices:A review

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Journal of Energy Chemistry 2024年第7期94卷 254-272页

作者： Ming Chen Zhenhua Yin Zhicheng shan Xiaokai Zheng Lei Liu Zhonghua Dai jun Zhang Shengzhong(Frank)Liu Zhuo Xu School of Electric Power Civil Engineering and ArchitectureCollege of Physics and Electronics EngineeringState Key Laboratory of Quantum Optics and Quantum Optics DevicesShanxiUniversityTaiyuan030006ShanxiChina Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of EducationShanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Metal-halide hybrid perovskite materials are excellent candidates for solar cells and photoelectric *** recent years,machine learning(ML)techniques have developed rapidly in many fields and provided ideas for material discovery and *** can be applied to discover new materials quickly and effectively,with significant savings in resources and time compared with traditional experiments and density functional theory(DFT)*** this review,we present the application of ML in per-ovskites and briefly review the recent works in the field of ML-assisted perovskite ***,the advantages of perovskites in solar cells and the merits of ML applied to perovskites are ***,the workflow of ML in perovskite design and some basic ML algorithms are ***,the applications of ML in predicting various properties of perovskite materials and devices are ***,we propose some prospects for the future development of this *** rapid devel-opment of ML technology will largely promote the process of materials science,and ML will become an increasingly popular method for predicting the target properties of materials and devices.

关键词： Machine learning Perovskite Materials design Bandgap engineering Stability Crystal structure

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A non-peptide-based chymotrypsin-targeted long-wavelength emission fluorescent probe with large Stokes shift and its application in bioimaging

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Chinese Chemical Letters 2024年第10期35卷 430-436页

作者： Chuanfeng Fan Jian gao Yingkai gao Xintong Yang gaoning Li Xiaochun Wang Fei Li Jin Zhou Haifeng Yu Yi Huang Jin Chen Yingying shan Li Chen Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOEShandong Provincial Key Laboratory of Biochemical EngineeringQingdao Nucleic Acid Rapid Detection Engineering Research CenterCollege of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao266042China School of Chemistry and Life Science Anshan Normal UniversityLiaoning Key Laboratory of Development and Utilization for Natural Products Active MoleculesAnshan114007China Biomedical Analysis Center Army Medical UniversityChongqing 400038China School of Pharmacy Weifang Medical UniversityWeifang 261053China College of Chemistry Baicheng Normal UniversityBaicheng 137000China

As a hydrolase,chymotrypsin(CHT)is involved in many physiological activities,and its abnormal activity is closely related to diabetes,pancreatic fibrosis,chronic pancreatitis and pancreatic *** this work,an innovative long-wavelength emission fluorescent probe TCF-CHT was designed and synthesized for the high specificity detection of CHT,which utilized TCF-OH and a mimetic peptide substrate 4-bromobutyryl as chromogenic group and recognition group,***-CHT exhibited excellent selectivity and eye-catching sensitivity(8.91 ng/m L)towards CHT,“off-on”long-wavelength emission at 670 nm and large Stokes shift(140 nm).Furthermore,the successful fulfillment and perfect performance in imaging endogenous CHT in complex organisms(P815 cells,HepG2 cells,zebrafish and tumor-bearing mice)verified its potential as a powerful tool for the recognition of CHT in complicated biological environments.

关键词： Chymotrypsin Fluorescent probe Long-wavelength emission Large Stokes shift Bioimaging

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中国寿险公司偿付能力状况的评价

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商业研究 2007年第1期 186-191页

作者：韩俊霞高俊山北京科技大学管理学院北京100083

构建寿险企业偿付能力状况指标评价体系,对17家寿险公司的绩效进行因子分析,比较了中外寿险公司之间绩效的差距,揭示了目前中资寿险公司的偿付能力危机问题。分析表明提高偿付能力应从提高资产质量、提足责任准备金、提高投资收益率三... 详细信息

构建寿险企业偿付能力状况指标评价体系,对17家寿险公司的绩效进行因子分析,比较了中外寿险公司之间绩效的差距,揭示了目前中资寿险公司的偿付能力危机问题。分析表明提高偿付能力应从提高资产质量、提足责任准备金、提高投资收益率三个方面入手。

关键词：因子分析寿险偿付能力

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矩阵束算法的改进及应用

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哈尔滨理工大学学报 2011年第3期16卷 41-45页

作者：吴勃高俊山王姗姗哈尔滨理工大学自动化学院黑龙江哈尔滨150080

针对强电磁脉冲孔耦合瞬态响应的极点参数提取问题,将传统的矩阵束算法进行改进.传统的矩阵束算法在低信噪比时,存在计算数值不稳定,极点提取精确度不高的缺点.通过对含有噪声的瞬态响应数据进行互相关预处理,能有效提高低信噪比时极点... 详细信息

针对强电磁脉冲孔耦合瞬态响应的极点参数提取问题,将传统的矩阵束算法进行改进.传统的矩阵束算法在低信噪比时,存在计算数值不稳定,极点提取精确度不高的缺点.通过对含有噪声的瞬态响应数据进行互相关预处理,能有效提高低信噪比时极点的提取精确度.再将数据经离散化后构造Hankle矩阵,结合奇异值分解,求解其广义特征值.即可提取信号的极点参数信息.最后通过仿真分析以及对波形的重构,验证改进算法具有抗噪能力强、拟合度高的特点.

关键词：极点提取改进的矩阵束算法噪声处理

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Surface-induced Microstructure and Performance Changes in P3HT Ultrathin Films

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Chinese Journal of Polymer Science 2024年第6期42卷 805-814页

作者： Hong-Tao shan Jia-Xin He Bing-Yan Zhu Xue-Ting Cao Ying-Ying Yan Jian-jun Zhou Hong Huo Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing100875China

In this work,poly(3-hexylthiophene)(P3HT)ultrathin films(P3HT-T)were prepared by spin-coating a dilute P3HT solution(in a toluene:o-dichlorobenzene(Tol:ODCB)blend with a volume ratio of 80:20)with ultrasonication and the addition of the nucleating agent bicycle[2.2.1]heptane-2,3-dicarboxylic acid disodium salt(HPN-68L)on glass,Si wafers and indium tin oxide(ITO)*** electrical and mechanical properties of the P3HT-T ultrathin films were investigated,and it was found that the conductivity and crack onset strain(COS)were simultaneously improved in comparison with those of the corresponding pristine P3HT film(P3HT-0,without ultrasonication and nucleating agent)on the same substrate,regardless of what substrate was ***,the conductivity of P3HT-T ultrathin films on different substrates was similar(varying from 3.7 S·cm^(-1)to 4.4 S·cm^(-1)),yet the COS increased from 97%to 138%by varying the substrate from a Si wafer to *** grazing-incidence wide-angle X-ray diffraction(GIXRD),UV-visible(UV-Vis)spectroscopy and atomic force microscopy(AFM),we found that the solid order and crystallinity of the P3HT-T ultrathin film on the Si wafer are highest,followed by those on glass,and much lower on ***,the surface energy and roughness of three substrates were investigated,and it was found that the polar component of the surface energyγp plays a critical role in determining the crystalline microstructures of P3HT ultrathin films on different *** work indicates that the P3HT ultrathin film can obviously improve the stretchability and simultaneously retain similar electrical performance when a suitable substrate is *** findings offer a new direction for research on stretchable CP ultrathin films to facilitate future practical applications.

关键词： P3HT ultrathin film Substrate Crystalline microstructures Polar component of the surface energy Electrical and stretchable performances

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Design and implementation of dual-mode configurable memory architecture for CNN accelerator

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High Technology Letters 2024年第2期30卷 211-220页

作者：山蕊 LI Xiaoshuo gao Xu HUO Ziqing School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi’an 710121P.R.China

With the rapid development of deep learning algorithms,the computational complexity and functional diversity are increasing ***,the gap between high computational density and insufficient memory bandwidth under the traditional von Neumann architecture is getting *** the algorithmic characteristics of convolutional neural network(CNN),it is found that the access characteristics of convolution(CONV)and fully connected(FC)operations are very *** on this feature,a dual-mode reronfigurable distributed memory architecture for CNN accelerator is *** can be configured in Bank mode or first input first output(FIFO)mode to accommodate the access needs of different *** the same time,a programmable memory control unit is designed,which can effectively control the dual-mode configurable distributed memory architecture by using customized special accessing instructions and reduce the data accessing *** proposed architecture is verified and tested by parallel implementation of some CNN *** experimental results show that the peak bandwidth can reach 13.44 GB·s^(-1)at an operating frequency of 120 *** work can achieve 1.40,1.12,2.80 and 4.70 times the peak bandwidth compared with the existing work.

关键词： distributed memory structure neural network accelerator reconfigurable arrayprocessor configurable memory structure

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Application of a concrete thermal pile in cooling the warming permafrost under climate change

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Advances in Climate Change Research 2024年第1期15卷 170-183页

作者： Yun-Hu shanG Fu-jun NIU Guo-Yu LI Jian-Hong FANG Ze-Yong gao State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Da Xing'anling Observation and Research Station of Frozen-Ground Engineering and Environment Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesJagdaqi 165000China Qinghai Research Institute of Transportation Xining 810008China

Permafrost degradation caused by climate warming is posing a serious threat to the stability of cast-in-place pile foundations in warm permafrost *** cold energy can be effectively utilized by two-phase closed thermosyphons(TPCTs)to cool the ***,we installed TPCTs in a cast-in-place pile foundation to create a unique structure called a thermal pile,which effectively utilizes the TPCTs to regulate ground *** we conducted a case study and numerical simulation to exhibit the cooling performance,and optimize the structure of the thermal *** purpose of this study is to promote the application of thermal piles in unstable permafrost *** on the findings,the thermal pile operated for approximately 53%of the entire year and effectively reduced the deep ground temperature at a rate of at least-0.1℃per ***,it successfully raised the permafrost table that is 0.35 m shallower than the natural ground *** characteristics prove highly beneficial in mitigating the adverse effects of permafrost degradation and enhancing infrastructure *** the length of the condenser section and the diameter of the TPCT in a suitable manner can effectively enhance the cooling capability of the thermal pile and ensure the long-term mechanical stability of the pile foundation even under climate warming.

关键词： Heat transfer Cold energy Warm permafrost Two-phase closed thermosyphons Cast-in-place pile foundation

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