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Efficient network immunization under limited knowledge

National Science Review 2021年第1期8卷 127-134页

作者： Yangyang Liu Hillel Sanhedrai gao gao dong Louis M.Shekhtman Fan Wang Sergey V.Buldyrev Shlomo Havlin Department of Systems Science National University of Defense Technology Department of Physics Bar-Ilan University Faculty of Science Jiangsu University Network Science Institute Northeastern University Department of Physics Yeshiva University

Targeted immunization of centralized nodes in large-scale networks has attracted significant ***, in real-world scenarios, knowledge and observations of the network may be limited, thereby precluding a full assessment of the optimal nodes to immunize（or quarantine） in order to avoid epidemic spreading such as that of the current coronavirus disease（COVID-19） epidemic. Here, we study a novel immunization strategy where only n nodes are observed at a time and the most central among these n nodes is immunized. This process can globally immunize a network. We find that even for small n（≈10） there is significant improvement in the immunization（quarantine）, which is very close to the levels of immunization with full knowledge. We develop an analytical framework for our method and determine the critical percolation threshold p;and the size of the giant component P∞ for networks with arbitrary degree distributions P（k）. In the limit of n →∞ we recover prior work on targeted immunization, whereas for n = 1 we recover the known case of random immunization. Between these two extremes, we observe that, as n increases,p;increases quickly towards its optimal value under targeted immunization with complete information. In particular, we find a new general scaling relationship between |p;（∞）-p;（n）| and n as |p;（∞）-p;（n）| ～n;exp（-αn）. For scale-free（SF） networks, where P（k）～ k;, 2 < γ < 3, we find that p;has a transition from zero to nonzero when n increases from n = 1 to O（log N）(where N is the size of the network). Thus, for SF networks, having knowledge of ≈log N nodes and immunizing the most optimal among them can dramatically reduce epidemic spreading. We also demonstrate our limited knowledge immunization strategy on several real-world networks and confirm that in these real networks, p;increases significantly even for small n.

关键词： percolation complex networks network immunization critical phenomena

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou gao Qin dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-dong Qian Qiao gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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十屋断陷含油气系统及勘探潜力分析

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石油物探 2004年第2期43卷 196-201页

作者：高东中国石化新星东北分公司研究院吉林长春130062

十屋断陷位于松辽盆地东南隆起区,下部是西断东超的箕状断陷,上覆沉积为坳陷地层沉积。断陷地层的暗色泥岩是好的油气源岩,最好的储集层是坳陷层的泉头组。构造运动控制了盆地的演化、油气的生成、构造圈闭的形成、原生油气藏的破坏及... 详细信息

十屋断陷位于松辽盆地东南隆起区,下部是西断东超的箕状断陷,上覆沉积为坳陷地层沉积。断陷地层的暗色泥岩是好的油气源岩,最好的储集层是坳陷层的泉头组。构造运动控制了盆地的演化、油气的生成、构造圈闭的形成、原生油气藏的破坏及浅部次生油气藏的形成;沉积环境控制了源岩和储层的发育特征、油气分布层位及原生油气藏的形成。嫩末构造运动控制局部构造的油气分布层位及次生油气藏的形成。处于休眠期的断裂作为遮挡,形成断鼻、断块圈闭,能够聚集油气形成油气藏;活动时期的断裂能作为垂向运移通道,并在浅部形成断鼻和断块次生油气藏。

关键词：十屋断陷含油气系统油气勘探油气藏断裂沉积环境构造运动

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220kV单母线双断路器分段主接线方式研究与应用

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机电工程 2016年第10期33卷 1242-1247页

作者：高亚栋高美金陈飞楼秉吾金国胜国网浙江省电力公司经济技术研究院浙江杭州310008 浙江浙电经济技术研究院有限公司浙江杭州310014

针对双母线接线在低维护、高可靠性母线设备(GIS、DCB及GIL)应用时的适应性问题,对主变规模为3台的220 k V变电站,创新提出一种单母线双断路器分段的新型电气接线方式,使任何一段母线停电均能确保两台主变正常运行。并从可靠性、灵活性... 详细信息

针对双母线接线在低维护、高可靠性母线设备(GIS、DCB及GIL)应用时的适应性问题,对主变规模为3台的220 k V变电站,创新提出一种单母线双断路器分段的新型电气接线方式,使任何一段母线停电均能确保两台主变正常运行。并从可靠性、灵活性、经济性3个方面出发,运用故障模式和后果分析法(FMEA),将单母线双断路器分段接线与双母线接线方式进行了全方面的比较和阐述。研究结果表明,单母线双断路器分断接线方式在提升可靠性的同时,还能降低投资成本,同时兼顾日常运行和远期扩建等方面的灵活性,具有较大推广和工程应用的价值。

关键词：单母线双断路器分段接线可靠性灵活性经济性

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Convergence Analysis of a Self-Stabilizing Algorithm for Minor Component Analysis

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IEEE/CAA Journal of Automatica Sinica 2020年第6期7卷 1585-1592页

作者： Haidi dong Yingbin gao Gang Liu College of Weaponry Engineering Naval University of EngineeringWuhan 430033China the 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China Xi'an Research Institute of High Technology Xi’an 710025China

The M?ller algorithm is a self-stabilizing minor component analysis *** research document involves the study of the convergence and dynamic characteristics of the M?ller algorithm using the deterministic discrete time(DDT)*** other analysis methodologies,the DDT methodology is capable of serving the distinct time characteristic and having no constraint *** analyzing the dynamic characteristics of the weight vector,several convergence conditions are drawn,which are beneficial for its *** performing computer simulations and real applications demonstrate the correctness of the analysis’s conclusions.

关键词： Convergence analysis deterministic discrete time(DDT) dynamic characteristic Moller algorithm

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Recent Progress of Layered Perovskite Solar Cells Incorporating Aromatic Spacers

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Nano-Micro Letters 2023年第10期15卷 163-181页

作者： Yuping gao Xiyue dong Yongsheng Liu The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071People’s Republic of China Renewable Energy Conversion and Storage Center(RECAST) Nankai UniversityTianjin 300071People’s Republic of China

Layered two dimensional(2D) or quasi-2D perovskites are emerging photovoltaic materials due to their superior environment and structure stability in comparison with their 3D counterparts. The typical 2D perovskites can be obtained by cutting 3D perovskites along orientation by incorporation of bulky organic spacers, which play a key role in the performance of 2D perovskite solar cells(PSCs). Compared with aliphatic spacers, aromatic spacers with high dielectric constant have the potential to decrease the dielectric and quantum confinement effect of 2D perovskites, promote efficient charge transport and reduce the exciton binding energy, all of which are beneficial for the photovoltaic performance of 2D PSCs. In this review, we aim to provide useful guidelines for the design of aromatic spacers for 2D perovskites. We systematically reviewed the recent progress of aromatic spacers used in 2D PSCs. Finally, we propose the possible design strategies for aromatic spacers that may lead to more efficient and stable 2D PSCs.

关键词： Layered perovskite solar cells Aromatic spacers Quantum and dielectric confinement effects Charge transport Efficiency and stability

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Coupling analysis-based false monitoring information identification of production system in process industry

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Science China(Technological Sciences) 2017年第6期60卷 807-817页

作者： gao ZhiYong WANG RongXi JIANG HongQuan gao JianMin dong RongGuang State Key Laboratory for Manufacturing Systems Engineering Xi 'an Jiaotong University Xi 'an 710049 China

False monitoring information is a major problem in process production system and several ineffective methods have been proposed to identify false monitoring information in the production system. In this paper, a new method is proposed to identify false monitoring information based on system coupling analysis and collision detection from the perspective of data analysis. Coupling multifractal features are extracted to reflect the changes in coupling relationship by utilizing the multifractal detrended cross-correlation analysis (MF-DXA). Each monitoring variable in process production system has more than one coupled variable, which can be regarded as multi-source. To achieve low redundancy in features and uniform description of coupling relationship, the feature level information fusion is studied based on modified Mahalanobis Taguchi system (MTS). False alarms are identified when the coupling relationships among the coupled monitoring variables collide. Analysis results of coupled R?ssler and Henon datasets indicate the feasibility of this method for selecting the effective coupling feature and uniform description of coupling relationship. The compressor system case of Coal Chemical Ltd. Group is studied and false monitoring information is identified.

关键词： false monitoring information coupling analysis MF-DXA MTS process industry

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Cell fate determination and lineage plasticity in prostate cancer

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Asian Journal of Andrology 2023年第2期25卷 149-151,F0002页

作者： dong gao State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Prostate cancer(PCa)initiation,progression,and therapy resistance involve genetic and epigenetic alterations that l e ad to ab err ant cel l line age specification and plasticity.1–3 The vast majority of primary pros... 详细信息

关键词： alterations cancer plasticity

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淡紫青霉ACCC31890对纤细薯蓣皂苷的生物转化

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中国药师 2017年第6期20卷 988-993页

作者：高冉冉郜昭慧董欣然胡宏秀乔月孙迪安中国医学科学院北京协和医学院药用植物研究所北京100193

目的:研究淡紫青霉菌对纤细薯蓣皂苷的生物转化,分离鉴定转化产物并进行药理活性探讨。方法:使用硅胶柱色谱和半制备液相色谱分离转化产物,依据质谱(MS)、核磁共振(NMR)波谱分析进行结构鉴定,并对产物进行了体外抗炎活性的研究。结果:... 详细信息

目的:研究淡紫青霉菌对纤细薯蓣皂苷的生物转化,分离鉴定转化产物并进行药理活性探讨。方法:使用硅胶柱色谱和半制备液相色谱分离转化产物,依据质谱(MS)、核磁共振(NMR)波谱分析进行结构鉴定,并对产物进行了体外抗炎活性的研究。结果:从转化粗提物中分离得到三个依次脱糖基产物,分别为5R-spirost-5-ene-3-ol-O-β-D-Glucopyranoside-(1→3)-β-D-Glucopyranosyl(1),延龄草苷(2)和薯蓣皂苷元(3),转化率分别为1%,1%,45%;体外抗炎活性研究表明三种转化产物对LPS刺激巨噬细胞分泌NO,IL-6和MCP-1具有不同程度的抑制作用,其抗炎活性随着糖链的逐步水解有所增加,以终产物薯蓣皂苷元的抗炎活性最强。结论:淡紫青霉菌转化纤细薯蓣皂苷得到薯蓣皂苷元的产率较高,糖基的数量对甾体皂苷类化合物抗炎活性有着一定的影响。

关键词：淡紫青霉ACCC31890 纤细薯蓣皂苷生物转化抗炎活性

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