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Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model

Journal of Traditional Chinese Medicine 2016年第4期36卷 471-478页

作者： Tian Mengxi Liu Wenlan You Hongjie Zhao Qingzhou Ouyang Luodan gao biane Zhang Xin Che Niancong College of Traditional Chinese Medicine Capital Medical University

OBJECTIVE:To investigate the inhibitory effect of Yiguanjian decoction(YD) on DNA damage in Concanavalin A(Con A)-induced liver injury mice model and to explain the possible ***:Totally 120 male BALB/c mice were randomly divided into 6 groups,20 mice each:normal group,model group,Bifendate group,YD low dose group,YD middle dose group and YD high dose *** normal group,liver injury model induced by Con A was *** modeling,each mouse in YD group was given YD(0.4 m L/20 g per day) by intragastric administration(0.13 g YD for YD low dose group;0.26 g for YD middle dose group;0.52 g for YD high dose group).Bifendate group was given Bifendate(0.2 gnd model·kg-1 grou·d-1) by *** group ap were fed with same volume of physiological saline *** 8 weeks,the serum alanine transaminase(ALT)and aspartate transaminase(AST) were *** hematoxylin-eosin staining was used to evaluate the grade of liver inflammation and liver fibrosis *** DNA damage was detected by single cell gel electrophoresis *** protein expression of tumor necrosis factor-α(TNF-α),Bax and Mut T Homolog 1(MTH1) was detected by western blotting and enzyme linked immunosorbent *** m RNA and MTH1 m RNA were detected by Real-time Polymerase Chain Reaction(PCR).RESULTS:YD can improve the degree of liver inflammation and fibrosis in the liver of chronic hepatitis mice,the dose effect relationship is remarkable(P 0.05).YD can increase the m RNA expression

关键词： Drug-induced liver injury Liver kidney Yin deficiency DNA damage Concanavalin A Yiguanjian decoction

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