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Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway

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Bioactive Materials 2023年第4期22卷 75-90页

作者： zhaojie Wang Huiyi Yang Xu Xu Hongxing Hu Yuxin Bai Jian Hai Liming Cheng Rongrong Zhu Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Department of OrthopedicsTongji Hospital Affiliated to Tongji UniversitySchool of Life Science and TechnologyTongji UniversityShanghai200065China Frontier Science Center for Stem Cell Research Tongji UniversityShanghai200065China

Chronic low back pain and dyskinesia caused by intervertebral disc degeneration(IDD)are seriously aggravated and become more prevalent with *** clinical treatments do not restore the biological structure and inherent function of the *** emergence of tissue engineering and regenerative medicine has provided new insights into the treatment of *** synthesized biocompatible layered double hydroxide(LDH)nanoparticles and optimized their ion elemental compositions to promote chondrogenic differentiation of human umbilical cord mesenchymal stem cells(hUC-MSCs).The chondrogenic differentiation of LDH-treated MSCs was validated using Alcian blue staining,qPCR,and immunofluorescence ***-pretreated hUC-MSCs were differentiated prior to transplantation into the degenerative site of a needle puncture IDD rat *** and regeneration evaluated using X-ray,magnetic resonance imaging,and tissue immunostaining 4-12 weeks after transplantation showed recovery of the disc space height and integrated tissue *** sequencing revealed significant regulatory roles of the extracellular matrix(ECM)and integrin receptors of focal adhesion signaling pathway in enhancing chondrogenic differentiation and thus prompting tissue *** construction of ion-specific LDH nanomaterials for in situ intervertebral disc regeneration through the focal adhesion signaling pathway provides theoretical basis for clinical transformation in IDD treatment.

关键词： Mesenchymal stem cells Layered double hydroxide Chondrogenic differentiation Intervertebral disc degeneration Focal adhesion signaling pathway

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动态环境下基于深度相机与IMU的动态目标剔除

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计算机与数字工程 2025年第01期53卷 90-95页

作者：王险峰刘赵杰赵通杨浩伟汪柏彤东北石油大学

目前大多数优秀的SLAM方案都是基于静态环境的，而实际环境往往是动态的，动态目标的存在对SLAM系统有着严重的危害性。为了提高动态环境中位姿估计的准确性，基于ORB-SAM2提出一种IMU旋转补偿与几何约束相结合的动态点剔除算法。在追... 详细信息

目前大多数优秀的SLAM方案都是基于静态环境的，而实际环境往往是动态的，动态目标的存在对SLAM系统有着严重的危害性。为了提高动态环境中位姿估计的准确性，基于ORB-SAM2提出一种IMU旋转补偿与几何约束相结合的动态点剔除算法。在追踪过程中，利用IMU在两帧之间预积分得到的旋转矩阵补偿上一帧，补偿后两帧图像有相同旋转分量，计算两帧对应特征点的运动向量。用IMU在两帧之间的速度向量进行区分，可以将动态特征点从环境中粗略的区分出来。为了进一步剔除环境中的动态特征点，使用对极约束进行检验，进一步过滤动态特征点。动态环境中的实验结果表明，提出的方法能够有效去除动态特征点，提高了动态环境下的定位精度。

关键词： IMU RGBD 动态环境 SLAM

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The Ophiolitic Mélanges in Strike-slip Fault Zones in West Junggar,Xinjiang,NW China

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Acta Geologica Sinica(English Edition) 2017年第S1期91卷 13-14页

作者： GUO zhaojie CHEN Shi ZHANG Yuanyuan School of Earth and Space Sciences Peking UiniversityBeijing 100871China

The West Junggar region of western China,located in the far eastern end of the Kazakhstan orocline,occupies the junction of the Siberia,Tarim and Kazakhstan blocks,which is crucial for palinspastic reconstruction of the *** principal rock assemblages in West Junggar include Paleozoic ophiolitic mélanges and a thick,undeformed Upper Devonian–Lower Carboniferous sedimentary succession as the boundary of the mélanges,both of which are intruded by sub-circular Upper Carboniferous granitoid plutons and intermediate-basic-mafic *** the basis of the sedimentary structures like cross bedding and convolute bedding and the geochronology data,the Upper Devonian–Lower Carboniferous sedimentary successions were identified as the Tailegula,Baogutu,and Xibeikulasi formations from the bottom up,which is an apparent shallowing-upwards ocean basin fill succession,from radiolarian cherts through 2000 meters of flysch to a more neritic Baogutu Formation to a fluvial Xibeikulasi *** the bottom of the Tailegula Formation there is a peperite-bearing unit:a succession of extrusive mafic rock,mainly basaltic lava,with interbeds or blocks of sedimentary rocks including carbonate,radiolarian chert,calcareous siltstone and minor fine-grained tuffaceous *** in the Tailegula are thickest and best developed as the type *** types of peperites were identified based on of the volcanic clast shapes and sediment-matrix properties in Tailegula:(1)arbonatesediment-hosted fluidal peperites,(2)sandstone-hosted fluidal peperites,(3)tuff-hosted mixed fluidal and blocky peperites and(4)carbonate-sediment-hosted blocky *** LA-ICP-MS U-Pb dating of a tuff lens enclosed by lava showed that the peperites formed in the Late Devonian(ca.364 Ma).The widespread peperitebearing succession in the Tailegula Formation is of variablethickness at different sites in West Junggar,such as the Tailegula,Baijiantan,Kalaxiuka,Saertuohai,Dagun,west of the Akebastaw granite

关键词： West langes in Strike-slip Fault Zones in West Junggar Xinjiang NW China The Ophiolitic M

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Research and Design of Monolithic Decision Circuit for Optical Communication System

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Semiconductor Photonics and Technology 1997年第4期3卷 262-268页

作者： ZHANGYaqi zhaojie ElectronicInformationEngineeringCollege TianjinUniversityTianjin300072CHN ElectronicInformationEngi

In this paper,the cause of bit-error is analyzed when data are decided in the optical receiver.A monolithic D-ff decision circuit is *** can work effectively at 622 Mb/***,a decision method of parallel processing to improve the decision speed is presented,through which the parallel circuit can work up to 1 Gb/s using the same *** the technique,higher-speed data can be decided by using lower speed device.

关键词： BER D-ff Decision Circuit Multiplexer Parallel Processing

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Modeling and Simulation of Equipment Material Inventory Control Based on System Dynamics

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Journal of Donghua University(English Edition) 2018年第3期35卷 256-260页

作者： WANG Bing CHEN zhaojie LI Hao Department of Equipment Support and Remanafaeture Academy of Armored Forces for ArmyBeijing 100072China

The paper discusses how the inventory control of army equipment material runs sytematically under the two-level maintenance system,and establishes the inventory control model based on system *** the basis of modeling and simulation,the influence of different inventory upper limit on the whole system is studied,and the optimal inventory control mechanism under the model condition is *** addition,through the simulation of two replenishment strategies(s,S) and(T,s,S),the advantages and disadvantages and feasibility of each replenishment strategy are analyzed.

关键词： inventory control system dynamics equipment material simulation

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Peperites in the Permian Tarim large igneous province in Northwest China and their constraints on the local eruption environments

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Science China Earth Sciences 2014年第10期57卷 2914-2921页

作者： ZHU Bei GUO zhaojie ZHANG ZiYa CHENG Feng Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space SciencesPeking University

Peperites are special kinds of volcaniclastic materials generated by mingling of magma and unconsolidated sediments. They directly demonstrate the contemporaneity of volcanism and sedimentation, and hence they can be used to constrain the local paleoenvironments during volcanic eruptions. We identified peperites in the lower sequence of the northwest outcrops（Inggan-Kalpin area） of Permian Tarim large igneous province（TLIP）, Northwest China. In Inggan, blocky peperites were observed at the base of lava flows generated in the second eruption phase. This kind of peperites is generated by quenching of magma in a brittle fragmentation mechanism. While in Kalpin, both the second and the fourth eruption phases preserved peperites in the base of lava flows. Not only blocky but also fluidal peperites can be observed in Kalpin. The fluidal peperites were generated in vapor films, which insulated the magmas from cold sediments and avoided direct thermal shock, and therefore kept the fluidal forms of magma. All of these peperites are hosted by submarine carbonates. In lava sequences generated in the same eruption phases but located in Kaipaizileike, ~15 km east to Inggan, terrestrial flood basalts developed while peperites are absent, implying a paleoenvironmental transition between Kaipaizileike and Inggan-Kalpin area. Gathering information from observed peperites, TLIP lava flows, and the Lower Permian sedimentary strata, we precisely constrained the spatial distribution and temporal evolution of sedimentary facies of the early stage of TLIP. As a result, two marine transgressions were identified. The first transgression occurred contemporaneous with the second eruption phase. The transition from submarine to subaerial is located between Kaipaizileike and Inggan. The second transgression occurred contemporaneous with the forth eruption phase, and the transition from submarine to subaerial occurred between Inggan and Kalpin.

关键词： peperite Tarim large igneous province Permian eruption environment flood basalt

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A review:antimicrobial properties of several medicinal plants widely used in Traditional Chinese Medicine

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Food Quality and Safety 2021年第4期5卷 307-328页

作者： Kun Chen Wei Wu Xiudan Hou Qingli Yang zhaojie Li College of Food Science and Engineering Qingdao Agricultural UniversityQingdaoChina

Introduction Due to the dramatic increase in the use of antibiotics and growing health threat of bacterial resistance to many commonly used antibiotics,many studies have been directed at developing new and effective antibacterial compounds,among which many new,natural,and effective antibacterial compounds discovered from medicinal plants have drawn great interest and raised new hope for treating the challenges of antibiotic *** review aimed to summarize the most important and widely used medicinal plants that were reported to have antibacterial activities.A general literature search from 2010 to 2020 was conducted using different databases,including Science Direct,Web of Science,and *** to the literature,three medicinal plants with outstanding antibacterial activities,Taraxacum officinale,Coptis Rhizome,and Scutellaria baicalensis,were screened and reviewed by *** extraction methods,antibacterial activities of different parts of plants or the plant-derived compounds,spectra of antibacterial activities,and toxicity were described,***,the antibacterial activities of the extracts or pure compounds as reported in the reviewed literature were mostly based on in vitro assays,and moreover,the deeper antibacterial mechanisms have not been elucidated ***,further studies are required in the fields of purification and identification of the antibacterial compounds,its mechanisms of action,and synergistic effects in combination with other antibacterial drugs,which may be helpful in the development of new antibacterial drugs.

关键词： Medicinal plant antibacterial activity pathogenic bacteria antibiotic resistance antibacterial mechanism

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基于试井法的水驱气藏水侵识别及水侵规律研究

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中外能源 2025年第1期30卷 57-64页

作者：范昭宇王琴宋兆杰张骞韩鑫周鑫中海石油(中国)有限公司海南分公司海南海口570300 中国石油大学(北京)非常规油气科学技术研究院北京102249

为尽可能避免因气井过早见水造成气藏采收率降低,采用不稳定试井法研究水侵过程气水边界的动态变化,采用数值试井法研究气藏的水侵规律。结果表明,气藏水侵后体现为能量补给,压力导数曲线末端下掉;从气区到水侵区后流体流动性变差,压力... 详细信息

为尽可能避免因气井过早见水造成气藏采收率降低,采用不稳定试井法研究水侵过程气水边界的动态变化,采用数值试井法研究气藏的水侵规律。结果表明,气藏水侵后体现为能量补给,压力导数曲线末端下掉;从气区到水侵区后流体流动性变差,压力导数曲线末端上翘。边、底水推进在气井试井曲线上的动态反映特征使压力导数曲线呈现时间差异性,水离气井越近,压力导数变化时间越早。单一方向水驱的边水响应特征是压力导数曲线上翘,环绕水驱的边水响应特征是压力导数曲线先下凹后上翘。在相同累产下,配产越高,气水边界距离越小,气水边界推进速度越快。采气速度越大,无水采气时间越短。无水采出程度随采气速度的增大先上升后下降。在相同采出程度下,采气速度越高,气水边界推进速度越快;储层渗透率越大,气水边界距离越小,气水边界推进速度越快。

关键词：不稳定试井数值试井水驱气藏水侵采出程度气水边界

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How can the Dual-atom Catalyst FeCo-NC Surpass Singleatom Catalysts Fe-NC/Co-NC in CO_(2) RR?-CO Intermediate Assisted Promotion via a Synergistic Effect

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Energy & Environmental Materials 2023年第1期6卷 300-308页

作者： Shoufu Cao Sainan Zhou Hongyu Chen Shuxian Wei Siyuan Liu Xiaojing Lin Xiaodong Chen zhaojie Wang Wenyue Guo Xiaoqing Lu School of Materials Science and Engineering China University of PetroleumQingdao Shandong 266580China College of Science China University of PetroleumQingdao Shandong 266580China

Atomically dispersed catalysts are widely adopted in CO_(2)reduction reaction(CO_(2)RR)due to maximal atomic utilization and high catalytic ***-atom catalysts(DACs),with more dispersed active sites and distinct electronic structures compared with single-atom catalysts(SACs),may exhibit diverse catalytic ***,the DAC FeCo-NC and SAC Fe-NC/Co-NC are employed as probes to explore DACs advantage in CO_(2)*** show that the moderate interaction between the dual-atom center and N coordination balances structural stability and catalytic *** is the only product on Fe-NC/Co-NC,and the high limiting potentials from−1.22 to−1.67 V inhibit further ***-NC assisted with CO intermediate exhibits low limiting potentials of−0.64 V for both CH_(3)OH and CH 4,comparable to those on Cu-based *** circumstance of applied potentials,CO_(2)RR on FeCo-NC has greater advantages in yielding CH_(3)OH and CH 4 than that on Fe-NC/Co-NC,and hydrogen evolution reaction is severely *** intrinsic essence is that dual-atom center can provide large spin-polarization and multi-electron transfer capability,rendering CO intermediates as effective electronic and geometric modifiers in CO_(2)*** work highlights FeCo-NC as a high-performance CO_(2)RR catalyst toward deep-reduction C1 products and elucidates CO intermediate assisted promotion mechanism via a dual-atom synergistic effect.

关键词： dispersed limiting rendering

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第四纪晚期拉萨河谷地地貌演化研究

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第四纪研究 2025年第1期45卷 34-48页

作者：胡锦荣王刚杨文光李文韬易子韩胡俊晨孙昭杰于弋洋成都理工大学地球与行星科学学院成都理工大学沉积地质研究院四川建筑职业技术学院乌鲁木齐锦疆矿业勘查技术服务有限公司

拉萨河位于青藏高原南部，是雅鲁藏布江的重要支流之一。以拉萨河谷地为研究地区，以谷地地貌为对象，综合野外实地观测、数字高程模型、卫星遥感影像以及谷地内前人和本研究的黄土光释光测年数据(118±11～82.7±8 ka)、前人研究阶地... 详细信息

拉萨河位于青藏高原南部，是雅鲁藏布江的重要支流之一。以拉萨河谷地为研究地区，以谷地地貌为对象，综合野外实地观测、数字高程模型、卫星遥感影像以及谷地内前人和本研究的黄土光释光测年数据(118±11～82.7±8 ka)、前人研究阶地等第四系沉积物的测年数据，提出了一种以冰川作用为主的拉萨河谷地演化模式，认为现今拉萨河谷地宽阔的形态是发育在该区的一次山谷冰川侵蚀事件的产物，在该次冰川作用下，沿谷地形成开阔的“U”型谷，清空了谷地中早先可能存在的第四系沉积物，塑造了拉萨河谷地的基础。综合拉萨河谷地内第四系沉积物的年龄数据，认为该次冰川作用发生于倒数第二次冰期。伴随本次冰川的退缩和消融，谷地内充填了巨厚的中更新世晚期的冰碛物，以及晚更新世以来的冲洪积物、风成黄土等。

关键词：拉萨河青藏高原南部倒数第二次冰期地貌演化

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