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Non-alcoholic fatty liver disease and psoriasis: So far, so near

World Journal of Hepatology 2015年第3期7卷 315-326页

作者： giulia ganzetti Anna Campanati Annamaria Offidani Dermatologic Clinic Polytechnic University of Marche Region

Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Non-alcoholic fatty liver disease(NAFLD) is defined as an excessive accumulation of triglycerides in hepatocytes and includes a wide spectrum of liver conditions ranging from relatively benign steatosis to non-alcoholic steatohepatitis with fatty infiltration and lobular inflammation and to cirrhosis and endstage liver disease. Actually, psoriasis is considered a systemic diseases associated to comorbidities, as metabolic syndrome and NAFLD is seen the hepatic manifestation of the metabolic syndrome. The possible link between psoriasis, obesity and metabolic syndrome, which are known risk factors for NAFLD has beenrecently documented focusing in the crucial role of the adipose tissue in the development of the inflammatory background sharing by the above entities. According to recent data, patients with psoriasis show a greater prevalence of NAFLD and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than those with NAFLD and without psoriasis. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple aspects linking NAFLD and psoriasis, only apparently far diseases.

关键词： Psoriasis Non-alcoholic fatty liver disease Adipose tissue Adipocytokines Biologic therapies Nonbiologictherapies

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Psoriasis,non-alcoholic fatty liver disease,and cardiovascular disease:Three different diseases on a unique background

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World Journal of Cardiology 2016年第2期8卷 120-131页

作者： giulia ganzetti Anna Campanati Elisa Molinelli Annamaria Offidani Dermatological Unit Department of Clinical and Molecular SciencesPolytehnic Marche University

Psoriasis is a chronic inflammatory immune-mediated skin disease, frequently associated with systemic comorbidities. According to recent data, patients with psoriasis show a greater prevalence of metabolic syndrome, which confers a higher cardiovascular risk. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple epidemiological and physio-pathogenetic aspects linking non-alcoholic fatty liver disease, psoriasis, and cardiovascular disease.

关键词： Psoriasis Non-alcoholic fatty liver disease Cardiovascular risk

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When the skin meets the bowel: About a case

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Open Journal of Gastroenterology 2013年第6期3卷 303-306页

作者： ganzetti giulia Campanati Anna Di Sario Antonio Rubini Corrado Zizzi Antonio Tarantino Giuseppe Benedetti Antonio Offidani Annamaria Anatomic Pathology Institute Department of Neurosciences Polytechnic University of Marche Ancona Italy Dermatological Clinic Department of Clinical and Molecular Medicine Polytechnic Marche University Ancona Italy Gastroenterologic Clinic Department of Clinical and Molecular Medicine Polytechnic Marche University Ancona Italy

Ulcerative colitis (UC) is a chronic relapsing inflammatory disease of the colorectal region which may be complicated by extraintestinal manifestations, as cutaneous involvement. Immune dysregulation resulting in a lymphocyte mediated destructive process has been suggested as a possible pathogenetic link between gut and skin-related manifestations. The authors describe an atypical clinical aspect of lichen ruber planus in a patient affected by vitiligo, alopecia areata and ulcerative colitis.

关键词： Ulcerative Colitis Vitiligo Lichen Ruber Planus Alopecia Areata Autoimmunity

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