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Intrinsic lithiophilic carbon host derived from bacterial cellulose nanofiber for dendrite-free and long-life lithium metal anode

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Nano Research 2024年第5期17卷 4203-4210页

作者： gangyi Xiong Jiayu Yu Yalan Xing Puheng yang Shichao Zhang School of Materials Science and Engineering Beihang UniversityBeijing 100191China School of Physics Science and Nuclear Energy Engineering Beihang UniversityBeijing 100191China

Although lithium metal is considered a promising anode for advanced Li-S and Li-air batteries,the uncontrolled dendrite growth and infinite volume change impede its practical application.Herein,we report an ideal framework composed of carbonized bacterial cellulose(CBC)nanofibers,which shows intrinsic lithiophilicity to molten lithium without any lithiophilic surface modification.The wetting behavior of molten lithium can be significantly improved because its surface functional groups provide thermodynamical driving force,and the high surface roughness derived from nanocracks leads to rapid infusion in kinetics.The hybrid anode exhibits long cycle life up to 2000 h and excellent deep stripping-platting capacity up to 20 mAh·cm^(-2).When the anode is assembled with LiFePO_(4) cathode,the full cell delivers a good cycling stability up to 700 cycles.This is attributed to the intrinsic lithiophilic scaffold,which can not only lower the nucleation barrier of Li and provide uniform nucleation sites for stable Li stripping/plating,but also offer interspace to accommodate volume fluctuation of lithium during long cycling.This work provides a new manner to achieve a series of intrinsic lithiophilic carbon skeletons based on the large family of biomass materials and organic materials.

关键词： intrinsic lithiophilicity lithium metal anode bacterial cellulose lithium dendrite long cycling life

Autophagic dysfunction of β cell dysfunction in type 2 diabetes,a double-edged sword

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Genes & Diseases 2021年第4期8卷 438-447页

作者： Ding Yao yang gangyi Wu QiNan Endocrinology and Nephrology Department Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing400030PR China Endocrinology Department The Second Affiliated Hospital of the Chongqing Medical UniversityChongqing400010PR China

Diabetes is an age-related disease,most of which is type 2 diabetes,and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes.Recent studies have revealed that autophagy plays an important role in maintaining the structure and func-tion of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress.In this review,we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus,which is the so-called double-edged sword,analysed its possible mechanism,and identifed possible research hot spots.

关键词： Apoptosis Autophagic dysfunction Insulin resistance Islet beta cell dysfunction Type 2 diabetes mellitus

Effect of Huangshukuihua(Flos Abelmoschi Manihot) on diabetic nephropathy:a Meta-analysis

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Journal of Traditional Chinese Medicine 2015年第1期35卷 15-20页

作者： Sun Qin yang gangyi Zhang Min Zhang Min Chen Shu Chen Pin Department of Gerontology Sichuan Provincial People's Hospital Chengdu 610072 China Department of Endocrinology The Second Affiliated Hospital Chongqing Medical University Chongqing400010 China

OBJECTIVE: To assess the efficacy of Huangshukuihua(Flos Abelmoschi Manihot) on diabetic nephropathy(DN).METHODS: Articles were retrieved from Pub Med,EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure Database, Chinese Evidence-Based Medicine Database, and Wanfang Database. Two reviewers independently reviewed the article. Only randomized controlled trials were included and 27 were identified involving 2239 patients(1143 in the treatment group and 1096 in the control group).RESULTS: Huangshukuihua(Flos Abelmoschi Manihot) had a significant effect on renal function by improving blood urea nitrogen and serum creatinine,reducing urine protein(24-h urine protein, and urinary albumin excretion rate), and improving serum albumin level, compared with the control group.CONCLUSION: Our findings suggest that, although the bioactive ingredients and mechanism underlying renal protection are unknown, the role of Huangshukuihua(Flos Abelmoschi Manihot) in the treatment of DN deserves further investigation.

关键词：糖尿病肾病金银花 Meta分析国家知识基础设施医学文献数据库随机对照试验生物活性成分治疗作用

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A data-driven method for feature assessment of historical settlements: A case study of Northeast Hubei, China

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Frontiers of Architectural Research 2024年第2期13卷 387-405页

作者： gangyi Tan Zhanxiang Chen Jiangkun Zhu Kai Wang School of Architecture&Urban Planning Huazhong University of Science and TechnologyWuhan 430074China Hubei Engineering and Technology Research Center of Urbanization Wuhan 430074China Hubei Rural Construction Center Wuhan 430074China HUST Built Heritage Research Center Wuhan 430074China

Formulating criteria for the assessment system of historic settlements is challenging due to complex geographical conditions and evaluator knowledge limitations, leading to subjective bias in the assessment process. To address this issue, this study proposes a data-driven method for assessing the features of historical settlements to carry out scientific and refined assessment and result analysis. Focusing on Northeast Hubei as the study area, this paper selects 3 historical settlements for validation and analysis. The results of the study show that (1) the data-driven method expands the methodological chain of assessing historical settlement features, and improves the assessment efficiency and scientificity of the assessment results by applying it to the new assessment process;(2) Through comparing the assessment results of the validation cases and data samples, the study establishes a comprehensive quantitative ranking of the assessment of historical settlement features and identifies the main influencing factors, thus enhancing the precision of result analysis;(3) By comparing the resulting assessment framework with the current assessment system, this study confirms the advantages of the proposed framework in identifying nuanced features and aligning with geographical conditions, thereby verifying the effectiveness of the data-driven method.

关键词： Historical settlement Feature assessment Data-driven method Northeast Hubei

CILP-2 is a novel secreted protein and associated with insulin resistance

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Journal of Molecular Cell Biology 2019年第12期11卷 1083-1094页

作者： Tong Wu Qin Zhang Shaobo Wu Wenjing Hu Tingting Zhou Ke Li Dongfang Liu Harvest FGu Hongting Zheng Zhiming Zhu Ling Li and gangyi yang Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing Clinical Research Center for GeriatricsChongqingChina Key Laboratory of Diagnostic Medicine(Ministry of Education)and Department of Clinical Biochemistry College of Laboratory MedicineChongqing Medical UniversityChongqingChina Center for Pathophysiology School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjingChina Department of Endocrinology Xinqiao HospitalThird Military Medical UniversityChongqingChina Department of Hypertension and Endocrinology Daping HospitalThird Military Medical UniversityChongqing Institute of HypertensionChongqingChina

Genetic association studies have implicated that cartilage intermediate layer protein 2 (CILP-2) confers the risk susceptibility for type 2 diabetes (T2DM). However, it is still unknown whether CILP-2 is involved in the regulation of glucose homeostasis and insulin resistance (IR). In the current study, we initially observed that CILP-2 as a secreted protein was detected in both conditioned medium and lysates of cells transfected with an overexpressed vector. We then found that circulating CILP-2 levels had a progressive increase from normal to impaired glucose tolerance (a pre-diabetic status) and then to diabetes, which was correlated positively with waist-to-hip ratio, triglyceride, fasting blood glucose, 2-h blood glucose after glucose overload, HbA1c, fasting insulin, 2-h plasma insulin after glucose overload, and homeostasis model assessment of insulin resistance but negatively with HDL-C. CILP-2 expression was increased in the liver and muscle but decreased in adipose tissues of obese mice or T2DM patients. Furthermore, we demonstrated that CILP-2 circulating levels were affected by OGTT and Exenatide. CILP-2 overexpression resulted in impaired glucose tolerance and hepatic IR in vivo and increased PEPCK expression whereas suppressed phosphorylation of insulin receptor and Akt kinase in vitro. Based on these findings, we have identified a direct interaction between CILP-2 and PEPCK and suggested that CILP-2 plays an important role in the regulation of hepatic glucose production.

关键词： CILP-2 secreted protein insulin resistance type 2 diabetes

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血糖监测技术研究进展

重庆医科大学学报 2022年第6期47卷 688-692页

作者：谭兴容王毅杨刚毅重庆市第九人民医院内分泌科重庆400700 重庆医科大学附属第二医院内分泌科重庆400016

糖尿病是一种以慢性高血糖为特征、严重威胁人类健康的慢性代谢性疾病。良好的血糖控制是预防糖尿病并发症的关键。血糖监测是指导血糖达标的重要手段,也是评价血糖控制状况的公认方法。血糖监测内容涵盖点血糖、糖化白蛋白、糖化血红... 详细信息

糖尿病是一种以慢性高血糖为特征、严重威胁人类健康的慢性代谢性疾病。良好的血糖控制是预防糖尿病并发症的关键。血糖监测是指导血糖达标的重要手段,也是评价血糖控制状况的公认方法。血糖监测内容涵盖点血糖、糖化白蛋白、糖化血红蛋白、1,5-无水葡萄糖醇及持续血糖监测等技术。近年来,大数据、人工智能、无创监测等新技术也不断融入血糖管理,以期为临床选择血糖监测方法提供更加科学可靠的依据。

关键词：糖尿病血糖监测技术持续血糖监测糖化血红蛋白 1,5-无水葡萄糖醇

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Selective nano-buckling improves the performance of graphene logic transistors

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National Science Review 2024年第2期11卷 95-96页

作者： Tong yang Ming yang Department of Applied Physics The Hong Kong Polytechnic University Research Centre for Nanoscience and Nanotechnology The Hong Kong Polytechnic University

The massive integration of silicon-based transistors into modern electronic devices greatly increases power consumption and heat generation/dissipation[1]. In this concern, transistors based on atomically-thin graphene that exhibit high electric and thermoelectric conductivities with negligible contact resistance,

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Deep Insight of Design,Mechanism,and Cancer Theranostic Strategy of Nanozymes

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Nano-Micro Letters 2024年第2期16卷 165-217页

作者： Lu yang Shuming Dong Shili Gai Dan yang He Ding Lili Feng Guixin yang Ziaur Rehman Piaoping yang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001People’s Republic of China Yantai Research Institute Harbin Engineering UniversityYantai 264000People’s Republic of China Key Laboratory of Green Chemical Engineering and Technology of Heilongjiang Province College of Material Science and Chemical EngineeringHarbin University of Science and TechnologyHarbin 150040People’s Republic of China Department of Chemistry Quaid-i-Azam UniversityIslamabad 45320Pakistan

Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale production.Recently,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects.Thus,various nanozymes have been developed and used for tumor therapy.In this review,more than 270 research articles are discussed systematically to present progress in the past five years.First,the discovery and development of nanozymes are summarized.Second,classification and catalytic mechanism of nanozymes are discussed.Third,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical design.Then,synergistic theranostic strategy of nanozymes are introduced.Finally,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.

关键词： Nanozymes Classification Prediction and design Catalytic mechanism Tumor theranostics

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Fresh-Keeping Decision and Coordination of Fresh Agricultural Product Supply Chain Considering Carbon Cap-and-Trade under Different Dominance

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Journal of Systems Science and Systems Engineering 2024年第1期33卷 30-51页

作者： yang yang Guanxin Yao China Institute for Agricultural Equipment Industrial Development Jiangsu UniversityZhenjiang212013China Jiangsu Modern Logistics Research Base Yangzhou UniversityYangzhou225009China

In the context of low carbon,this paper discussed the impact of the carbon cap-and-trade policy on the fresh-keeping decision-making of two-echelon fresh agricultural product supply chains under different dominance,and designed cost-sharing contracts to coordinate the supply chain of fresh agricultural products dominated by suppliers and retailers respectively.The results showed that:dominance has no effect on the fresh-keeping decision and total revenue of fresh agricultural product supply chain,but it affects the internal income distribution,and dominance does not always bring more benefits;the implementation of carbon cap-and-trade reduces the fresh-keeping decision-making of fresh agricultural products supply chain and reduces the free-rider income of followers;the role of higher carbon trading price is twofold,which not only brings about the speculation of leading enterprises,but also promotes the application of low-carbon technologies;consumers’high preference for freshness,low-cost and high-efficiency low-carbon technology are all conducive to improving the fresh-keeping efforts and benefits of the supply chain;cost-sharing contracts can coordinate the supply chain of fresh agricultural products.

关键词： Dominant power carbon cap-and-trade policy fresh agricultural product supply chain fresh-keeping decision-making