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带蒂大网膜经阴道拖出联合结肠经肛门拖出治疗手术后膀胱阴道直肠瘘

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中华普通外科杂志 2019年第9期34卷 791-794页

作者：程勇王刚成韩广森任莹坤李志猛李剑顾焱晖张世甲霍明科润增慈郑州大学附属肿瘤医院(河南省肿瘤医院)普外科 450008

目的介绍一种利用带蒂大网膜经阴道拖出联合结肠经肛门拖出治疗膀胱阴道直肠瘘的手术方式。方法回顾性分析2013年8月至2018年8月河南省肿瘤医院普外科收治的11例膀胱阴道直肠瘘患者的临床资料,均因女性生殖系统恶性肿瘤的手术治疗而发... 详细信息

目的介绍一种利用带蒂大网膜经阴道拖出联合结肠经肛门拖出治疗膀胱阴道直肠瘘的手术方式。方法回顾性分析2013年8月至2018年8月河南省肿瘤医院普外科收治的11例膀胱阴道直肠瘘患者的临床资料,均因女性生殖系统恶性肿瘤的手术治疗而发生。通过将带蒂大网膜经阴道拖出达到隔离、保护膀胱后壁,消除阴道残腔的目的,并联合结肠经肛门拖出的办法进行修补。结果本组11例患者均顺利完成手术,术后未再出现阴道内排尿、排便。5例患者术后复查膀胱X线造影和大肠X线造影提示直肠、阴道膀胱瘘消失。中位手术时间115 min,中位出血量260 ml。术后2例出现切口脂肪液化,1例切口感染,2例膀胱排尿功能障碍,经膀胱功能恢复锻炼后好转。4例患者术后出现肛门狭窄,经间断扩肛治愈。结论通过带蒂大网膜经阴道拖出联合结肠经肛门拖出可以消除膀胱阴道直肠瘘,并能避免肠造瘘,改善患者术后的生活质量。

关键词：膀胱阴道瘘直肠阴道瘘网膜肛管

分离式环形连续缝合行胰肠黏膜吻合在胰十二指肠切除术中的临床研究

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中华胰腺病杂志 2016年第1期16卷 19-22页

作者：王刚成韩广森刘英俊程勇任莹坤卢先枝黄平郑州大学附属肿瘤医院河南省肿瘤医院普外科郑州450008 南京医科大学第一附属医院普外科

目的探讨分离式环形连续缝合行胰肠黏膜吻合在胰十二指肠切除术中的临床应用效果。方法回顾性分析2002年3月至2014年10月郑州大学附属肿瘤医院收治的76例行根治性胰十二指肠切除术患者的临床资料。43例采用分离式环形连续缝合行胰肠黏... 详细信息

目的探讨分离式环形连续缝合行胰肠黏膜吻合在胰十二指肠切除术中的临床应用效果。方法回顾性分析2002年3月至2014年10月郑州大学附属肿瘤医院收治的76例行根治性胰十二指肠切除术患者的临床资料。43例采用分离式环形连续缝合行胰肠黏膜吻合者作为研究组，33例采用端端套入捆绑式胰肠吻合方式者作为对照组。均采用Child消化道重建方式，术后胰瘘的诊断参照国际胰瘘研究小组（ISGPF）的诊断与分级标准。分析两组患者术中吻合操作时间，胰肠吻合术后吻合口漏、吻合口出血等情况。结果两组患者年龄，性别及血红蛋白、血清白蛋白、总胆红素等实验室指标，并发糖尿病例数，手术切除范围差异均无统计学意义，具有可比性。研究组43例患者的术中胰肠吻合时间平均为11min（8—15min），术后出现I级胰肠吻合口漏4例，Ⅱ级胰肠吻合口漏1例，未发生Ⅲ级胰肠吻合口漏及胰肠吻合口出血病例。对照组有记录的5例患者的胰肠吻合时间平均为16min（12—25min），其余病例无记录，术后出现Ⅰ级胰肠吻合口漏例数不详，Ⅱ级胰肠吻合口漏4例，Ⅲ级胰肠吻合口漏2例，胰肠吻合口出血4例。结论分离式环形连续缝合行胰肠黏膜对接吻合手术的视野暴露充分、吻合时间短、术后胰肠吻合口漏及吻合口出血发生率低。

关键词：胰十二指肠切除术胰管空肠吻合术缝合技术出血胰漏

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左上腹巨大肿瘤切除术的临床策略及手术方法

中国实用医刊 2017年第12期44卷 64-67页

作者：徐勇超王刚成唐礼恭李星刘英俊程勇韩广森郑州大学附属肿瘤医院河南省肿瘤医院普外科 450008

目的探讨左上腹巨大肿瘤切除术的临床策略及切除技巧.方法回顾分析2005年5月至2014年5月62例左上腹巨大肿瘤患者的临床资料.分析患者术中中位出血量、中位手术时间、术后并发症,总结左上腹巨大肿瘤的临床特点、外科治疗策略及手术操... 详细信息

目的探讨左上腹巨大肿瘤切除术的临床策略及切除技巧.方法回顾分析2005年5月至2014年5月62例左上腹巨大肿瘤患者的临床资料.分析患者术中中位出血量、中位手术时间、术后并发症,总结左上腹巨大肿瘤的临床特点、外科治疗策略及手术操作技巧.结果本组62例患者均行左上腹肿瘤根治性联合脏器切除术,不同的手术方式的中位出血量为250~600 ml,中位手术时间110~170 min,其中57例术后恢复顺利,3例出现胰瘘,2例出现左上腹积液,2例左上腹小肠粘连肠梗阻,无死亡病例.结论掌握左上腹巨大肿瘤切除术的临床策略及手术操作技巧,能明显提高肿瘤的根治性切除率,降低手术风险.

关键词：左上腹巨大肿瘤术中出血量手术时间手术并发症

A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine

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Journal of Bionic Engineering 2022年第4期19卷 1109-1123页

作者： Peng Bai gangcheng Kong Weihua Qiao Yu Song Yixuan wang Jiawei Shi Nan Zhang Chungeng Liu Chong Chu Tixiusi Xiong Ying Zhou Cuifen Lu Lin wang Nianguo Dong Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Research Center for Tissue Engineering and Regenerative Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei UniversityWuhan 430062China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Cardiac valve replacement is an effective method to treat valvular heart *** valves used routinely in clinic still have *** our study,we explored a novel method to modify the performance of Decellularized Heart Valve(DHV)*** decellularized porcine aortic valve was prepared using sequential hydrophile and lipophile solubilization *** sericin was extracted from silk fibroin-deficient silkworm cocoon by lithium bromide ***,DHV was immersed in sericin solution to produce the sericin–DHV composite ***,we modified the DHV by making a Polydopamine(PDA)coating on the DHV first and then binding the *** physical properties and biological compatibility of our composite scaffold were assessed in vitro and in *** were successfully prepared,combined to DHV and improved its *** coating further promoted the combination of sericin on DHV and improved the physical properties of *** decay rate of our modified valve scaffold was decreased in vivo and it showed good compatibility with *** conclusion,our modification improved the physical properties and biocompatibility of the valve *** combination of PDA and sericin promoted the recellularization of decellularized valves,showing great potential to be a novel artificial valve.

关键词： Decellularized heart valve Sericin Polydopamine Biocompatibility

经会阴尾骨前辅佐性切口行骶前清创压迫止血在低位直肠吻合口漏合并感染出血中的临床应用

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中华结直肠疾病电子杂志 2016年第4期5卷 343-346页

作者：卢先枝韩广森刘英俊程勇徐勇超任莹坤王刚成郑州大学附属肿瘤医院(河南省肿瘤医院)普外科 450000

目的探讨经会阴尾骨前辅佐性切口行骶前清创并压迫止血治疗低位直肠吻合口漏合并感染出血的临床应用效果。方法回顾性分析2007年10月至2013年10月本人所收治的低位直肠吻合口漏合并感染出血患者11例，全部患者均为直肠癌低位保肛，术... 详细信息

目的探讨经会阴尾骨前辅佐性切口行骶前清创并压迫止血治疗低位直肠吻合口漏合并感染出血的临床应用效果。方法回顾性分析2007年10月至2013年10月本人所收治的低位直肠吻合口漏合并感染出血患者11例，全部患者均为直肠癌低位保肛，术后出现吻合口漏合并感染出血，给予近端肠管造瘘并局部冲洗等非手术处理后，止血效果差，最终行经会阴尾骨前辅佐性切口给予清创并压迫止血治疗。结果 11例患者均经会阴尾骨前辅佐性切口给予清创并压迫止血。中位手术时间20min，中位出血量为110ml，骶前留置棉垫压迫止血中位时间为5d。术后6~12个月，7例给予预防造口还纳，造口还纳后6个月内肛门排便每天约3~6次。2人吻合口周围局部狭窄增厚，需要排除肿瘤复发，建议延迟造口还纳时间。2人放弃造口还纳。结论经会阴尾骨前辅佐性切口行骶前压迫治疗低位直肠吻合口漏合并感染出血不仅安全有效，而且保留肛门功能，操作简单易行，可作为保守治疗止血无效的首选措施。

关键词：直肠肿瘤外科手术吻合口漏感染

Preparation,structure and stability of protein-pterostilbene nanocomplexes coated by soybean polysaccharide and maltodextrin

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Food Bioscience 2022年第5期49卷 662-669页

作者： Ling Zhu Fan Yang Dongze Li gangcheng Wu Hui Zhang School of Food Science and Technology Jiangnan UniversityWuxi214122China National Engineering Research Center for Functional Food Jiangnan UniversityChina Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province China

Pterostilbene(PTS)has received considerable attention in recent years because of its beneficial effects on health;however,its poor solubility hinders its application in the food *** study aimed to prepare and characterise three types of proteins(whey protein isolate(WPI),soybean protein isolate(SPI),and flaxseed protein isolate(FPI))conjugates of PTS,which could improve its solubility and *** results showed that the spherical particles of the protein-based nano-complexes were dissociated and *** bound to PTS mainly through hydrophobic interactions and hydrogen bonding,and PTS in proteins existed in an amorphous *** conferred PTS with better thermal stability than WPI and *** coating of FPI-PTS with soybean polysaccharide and maltodextrin yielded a more stable nanocomplex *** prepared nanocomplex powder exhibited better thermal,illumination,and storage stabilities than *** study provides guidelines for the potential application of protein-based nano-complexes in functional foods.

关键词： Proteins Pterostibene Nanocomplex structure Coating Stability

Effects of structural barriers on digestive properties of highland barley as compared with unpolished rice and oats

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Food Bioscience 2022年第6期50卷 834-841页

作者： Xiaoyu Chen Hui Zhang Ling Zhu gangcheng Wu Lilin Cheng Jinxin Li National Engineering Research Center for Functional Food Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu ProvinceSchool of Food Science and TechnologyJiangnan UniversityWuxi214122China College of Food Science and Technology Henan Agricultural UniversityZhengzhou450002HenanChina

Highland barley (HB), oats, and unpolished rice (UR) are known to inhibit starch digestion. β-Glucan and structural barriers are the main factors contributing to low digestibility;however, the hypoglycaemic mechanism of these grains is still unclear. Here, food systems in the forms of flour and chymes were constructed to understand their roles. There was little difference in starch digestibility for the flours of the various grains. We speculated that β-glucan in flours could not delay digestion, and the low viscosity of gelatinised HB flour supported this hypothesis. The digestibility of chymes was lower than flours, especially for HB chyme. After cooking, more bran structures and granular starch were still observed in the HB kernels. The digested grain structure showed that the starch hydrolysis level of UR and oats was higher than that of HB. Also, the starches in the bran encapsulated exhibited a good ability of anti-hydrolysis than those in the exposed endosperm. These results all indicate that intact physical structures effectively hindered gelatinisation and digestion. This study demonstrates that structural barriers exert a more important effect on starch bioaccessibility than β-glucan, which can provide useful guidance for glycaemia management.

关键词： β-Glucan Bran layer Cell walls Intact kernel structure Starch gelatinisation Starch digestion

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骶前囊肿规范化诊疗中国专家共识

中华肿瘤杂志 2021年第10期43卷 1034-1042页

作者：海峡两岸卫生交流协会肿瘤防治专家委员会中国医师协会结直肠肿瘤专业委员会脏器联合切除与质量控制学组王刚成苗成利尹路吴小剑王玉东汪欣冯翔刘英俊张国强王有财不详郑州大学附属肿瘤医院河南省肿瘤医院普外科 450003 北京大学国际医院腹膜肿瘤外科 102206 同济大学附属第十人民医院腹部外科疑难诊治中心中山大学附属第六医院结直肠肛门外科上海交通大学附属国际和平妇幼保健院妇科北京大学第一医院普外科上海长海医院泌尿外科郑州大学附属肿瘤医院河南省肿瘤医院普外科

骶前囊肿是位于骶尾骨与直肠之间的囊性或囊实性肿块,与骶尾骨筋膜、直肠及肛门括约肌等盆底组织关系密切,多数为良性疾病,目前,学者认为其起源与胚胎发育异常有关。骶前囊肿临床少见,具体发病率未见系统文献报道。骶前囊肿的治疗以手... 详细信息

骶前囊肿是位于骶尾骨与直肠之间的囊性或囊实性肿块,与骶尾骨筋膜、直肠及肛门括约肌等盆底组织关系密切,多数为良性疾病,目前,学者认为其起源与胚胎发育异常有关。骶前囊肿临床少见,具体发病率未见系统文献报道。骶前囊肿的治疗以手术切除为主,如果囊壁未彻底切除,则可能导致复发或骶尾部形成难以愈合的窦道,给患者造成极大的痛苦。然而,目前临床对骶前囊肿的认识不足,甚至将其与卵巢囊肿、肛周脓肿等疾病相混淆,同时对该疾病的治疗缺乏彻底切除囊壁的理念与手术技巧,常导致切除困难的骶前囊肿被姑息处理,不当的手术方式甚至可能损伤肛门括约肌或重要血管、神经等,造成肛门失禁、大出血等严重的并发症。共识总结了与骶前囊肿相关的多学科专家的意见及建议,旨在增进广大医师对骶前囊肿的认识,树立骶前囊肿治疗的正确理念,规范骶前囊肿手术方式及提高手术切除技巧。

关键词：直肠后肿物骶前囊肿盆腔骶前间隙共识

Safety and Efficacy of Biodegradable Patent Foramen Ovale Occluder in Patients with Migraine:A Clinical Trial

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Congenital Heart Disease 2023年第3期18卷 373-385页

作者： Xingbang Li Xuan Zheng Bowen Jin Yunyan Li Yongyu Shao Xiaoxian Deng Dingyang Li Shanshan Li Hongmei Zhou Jie Zhang Xianya Zhang Qunshan Shen gangcheng Zhang Congenital Heart Disease Center Wuhan Asia Heart HospitalWuhan University of Science and TechnologyWuhan430022China Structural Heart Disease Center Zhongnan HospitalWuhan UniversityWuhan430071China Department of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Background:Transcatheter closure of patent foramen ovale(PFO)has been widely accepted as a highly effective way to treat high-risk PFO-related ***,traditional non-degradable occluders made of metal alloys will permanently exist in the body,resulting in thrombosis,valve damage,hemolysis,arrhythmia,or other *** biodegradable PFO occluder developed by Shanghai Mallow Medical Instrument Co.,Ltd.,China can be fully absorbed and degrade into nontoxic ingredients,reducing postoperative ***:To study the safety and efficacy of biodegradable PFO occluders in treating ***:This single-center clinical trial collected 30 patients treated with a biodegradable PFO *** follow-up period lasted 12 months to analyze the echocardiographic characteristics and headache relief through HIT-6 ***:The immediate success rate was 100%,with no intraoperative severe occlusion-related *** contrast transcranial Doppler(cTCD)at 12 months showed that all patients’right-to-left shunts(RLS)were grade I or 0 with no serious postoperative complications,indicating the overall success rate was 100%.The biodegradable PFO occluder mostly degraded six months after the ***:PFO closure with a Mallow biodegradable occluder is safe and effective and has no severe complications.

关键词： Patent foramen ovale biodegradable occluder transcatheter closure migraine complications