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Vigna radiata var. GM4 Plant Growth Enhancement and Root Colonization by a Multi-Metal-Resistant Plant Growth-Promoting Bacterium Enterobacter sp. C1D in Cr(VI)-Amended Soils

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Pedosphere 2018年第1期28卷 144-156页

作者： gangavarapu subrahmanyam Rakesh Kumar SHARMA Gattupalli Naresh KUMAR Gattupalli ARCHANA Department of Microbiology and Biotechnology Centre The Maharaja Sayajirao University of Baroda Department of Biomedical Science Nitte University Center for Science Education and Research (NUCSER) Nitte University Central Muga Eri Research and Training Institute Central Silk Board Department of Biochemistry Faculty of Science The Maharaja Sayajirao University of Baroda

Contamination of agricultural soils by heavy metals has become a major concern due to their toxic effects on plant growth,symbiosis and consequently the yields of crops. In the present study, to enhance plant growth in Cr(VI)-amended soils, novel metalresistant plant growth-promoting bacteria(PGPB) were isolated from a soil contaminated with industrial waste effluent. One of the bacterial isolates, identified as Enterobacter sp. C1 D by 16 S r RNA gene sequencing, was found to be multi-metal resistant in nature with excellent plant growth-promoting(PGP) traits. Mung bean(Vigna radiata var. GM4) inoculation with Enterobacter sp.C1 D significantly(P < 0.01) increased root and shoot length, shoot and root weight, and chlorophyll content in a range of Cr(VI)treatments. Plant tolerance towards Cr(VI) measured as effective concentration showed higher values with Enterobacter sp. C1 Dtreated plants compared to un-inoculated plants. Root colonization study was also carried out using green fluorescence protein-labeled Enterobacter sp. C1 D under a hydroponic system. Confocal laser scanning microscopy of the plant roots showed heavy bacterial loads on the surface of the plant root specifically at the root tip and the point of root hair/lateral root formation. The results of PGP traits showed that elevated indole acetic acid levels and 1-aminocyclopropane-1-carboxylate deaminase activity enabled Enterobacter sp. C1 D to enhance V. radiata growth in Cr(VI)-amended soils, whereby it significantly increased plant tolerance towards elevated Cr(VI) concentrations.

关键词：植物生长农业土壤 var Cr sp 细菌修改激光扫描显微镜

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Biodegradation of Congo Red Azo Dye by Aspergillus spp, Isolated from Dye Contaminated Soils

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Journal of Agricultural Science and Technology(A) 2014年第5期4卷 422-434页

作者： Ravuri Jaya Madhuri gangavarapu Vijaya Lakshmi Department of Applied Microbiology Sri Padmavati Mahila Visvavidyalayam Tirupati 517502 A.P. lndia

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Autocrine Production of Interleukin-6: A Mechanism of Interleukin-6 Independence in Dexamethasone-Resistant 7TD1 Murine Myeloma Cells

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Journal of Cancer Therapy 2014年第6期5卷 523-530页

作者： Kalyan J. gangavarapu Alok Bhushan James C. K. Lai Christopher K. Daniels Department of Biomedical and Pharmaceutical Sciences College of Pharmacy The ISU Biomedical Research Institute Division of Health Sciences Idaho State University Pocatello USA Department of Pharmaceutical Sciences Jefferson School of Pharmacy Thomas Jefferson University Philadelphia USA

Several factors could contribute to proliferation of multiple myeloma (MM) cells independent of interleukin-6 (IL6) in the later stages of the disease. Our previous studies established a dexamethasone-resistant 7TD1 cell line (7TD1-Dxm) and have shown that one mechanism of resistance to dexamethasone is due to inhibition of cytochrome c release. We have also observed that 7TD1-Dxm cells proliferate independently of externally-added IL6. This study therefore aimed to elucidate the mechanisms responsible for IL6-independent proliferation in 7TD1-Dxm cells. Our results indicated that 7TD1-Dxm cells produced IL6 in an autocrine fashion. We have observed that dexamethasone-resistant 7TD1 cells become dexamethasone-resistant and IL6-independent for proliferation concomitantly. This strongly suggests that production of IL6 by 7TD1-Dxm cells may play an important role in the development of dexamethasone resistance. Consequently, further investigation of the molecular mechanisms responsible for IL6 production may be helpful in delineating the mechanisms leading to dexamethasone resistance.

关键词： Multiple Myeloma Interleukin-6 7TD1 Cells Autocrine Production Dexamethasone Resistance

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Differential Regulation of Cytochrome C Release in Dexamethasone-Resistant 7TD1 Cells

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Journal of Cancer Therapy 2013年第4期4卷 835-842页

作者： Kalyan J. gangavarapu Alok Bhushan James C. K. Lai Christopher K. Daniels Department of Biomedical and Pharmaceutical Sciences College of Pharmacy Idaho State University Pocatello USA ISU Bio- medical Research Institute Idaho State University Pocatello USA

Interleukin-6 (IL6)-triggered JAK/STAT3 and PI3K/AKT signaling pathways are known to mediate cell survival, drug resistance and progression in a variety of cancer cells. Resistance to induction of apoptosis plays a critical role in the pathogenesis of numerous cancers and development of resistance to chemotherapeutic agents used in its treatment. Previous research in our laboratory employing a dexamethasone-resistant subline (7TD1-Dxm) of IL6-dependent 7TD1 cells indicated that constitutively activated STAT3 was important in control of apoptosis and targets downstream to activated STAT3 appeared to be involved in the development of resistance to dexamethasone by 7TD1 cells. We therefore investigated the hypothesis that Dxm-resistance developed by 7TD1-Dxm cells was due to resistance to induction of apoptosis mainly because of the dysregulation of the downstream targeted in JAK/STAT3 signaling pathway. Our results indicate that 7TD1-Dxm cells show resistance to Dxm-induced reduction of Bcl-2 protein and the release of cytochrome c. Thus, this study suggests that development of resistance to dexamethasone by 7TD1 cells may involve altered regulation of mitochondrial anti-apoptotic proteins.

关键词： Interleukin-6 7TD1 Cells Apoptosis Cytochrome C Dexamethasone Resistance

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