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Safety of Curcuma aromatica oil gelatin microspheres administered via hepatic artery

World Journal of Gastroenterology 2004年第18期10卷 2637-2642页

作者： Shi-GuiDeng Zhi-FengWu Wei-YingLi Zhi-gangyang GangChang Fan-ZheMeng Li-LiMo SecondAffiliatedHospitalofGuangzhouUniversityofTraditionalChineseMedicine Guangzhou510120GuangdongProvinceChina

AIM: To evaluate the safety of Curcurna aromatica oil gelatin microspheres (CAO-GMS) infused via hepatic artery against primary liver ***: The safety of CAO-GMS was evaluated in view of its acute toxicity in rats, long-term toxicity in Beagle dogs and general pharmacology in rats and mongrel ***: The 50% lethal dose (LDs0) of CAO-GMS infused via the hepatic artery was 17.19 mg/kg, and the serum biochemical indices of dying rats after the administration changed markedly while those of survived rats did *** pathological examination of the tissues from the dead rats indicated improper embolism. Similar edema and small necrotic foci in the hepatic Iobule were found in the hepatic tissue of rats receiving 10 and 5 mg/kg CAO-GMS and GMS 60 d after the last administration, while not in the rats of the blank control group, indicating that microspheres infused via the hepatic artery may induce irreversible liver damage dose-dependently. General pharmacological study showed that the activities (posture and gait), respiration frequency, blood pressure or heart rate of the dogs were not affected by CAO-GMS, nor were salivation, tremor or pupil changes of the rats observed or their balancing ability compromised, suggesting CAO-GMS infused via the hepatic artery did not significantly affect the nervous, respiratory and cardiovascular ***: CAO-GMS embolization administered via the hepatic artery is safe but undesired embolization induced by vascular variation should be given due attention in its clinical application. Individualized embolization dosage and super-selective catheterization technique are recommended to avoid undesired embolism and reduce complications.

关键词：保险装置郁金油微球体凝胶肝动脉肝癌肿瘤

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Clinical evidence of growth hormone for patients undergoing abdominal surgery: Meta-analysis of randomized controlled trials

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World Journal of Gastroenterology 2005年第25期11卷 3925-3930页

作者： YongZhou Xiao-TingWu gangyang WenZhuang Mao-LingWei DepartmentofGeneralSurgery WestChinaHospitalSichuanUniversityChengdu610041SichuanProvinceChina ChineseEvidence-BasedMedicine/CochraneCenter Chengdu610041SichuanProvinceChina

AIM: To assess the effectiveness and safety of perioperative growth hormone (GH) in patients undergoing abdominal ***: We searched the following electronic databases: MEDLINE, EMBASE, the Cochrane Controlled Trials Register, Chinese Bio-medicine Database. The search was undertaken in February 2003. No language restrictions were applied. Randomized controlled trials (RCT) comparing GH with placebo in patients undergoing abdominal surgery were extracted and *** quality was evaluated using the Jadad ***: Eighteen trials involving 646 patients were included. The combined results showed that GH had a positive effect on improving postoperative nitrogen balance (standardized mean difference [SMD] = 3.37, 95%CI [2.46, 4.27], P＜0.00001), and decreasing the length of hospital stay (weighted mean difference [WMD] = -2.07,95%CI [-3.03, -1.11], P = 0.00002), and reducing the duration of postoperative fatigue syndrome (SMD = -1.83,95%CI [-2.37, -1.30], P＜0.00001), but it could increase blood glucose levels (WMD = 0.91, 95%CI [0.56, 1.25],P＜0.00001).CONCLUSION: GH for patients undergoing abdominal surgery is effective and safe, if blood glucose can be controlled well. Further trials are required with a sufficient size to account for clinical heterogeneity and to measure other important outcomes such as infection, morbidity,mortality, fluid retention, immunomodulatory effects, and tumor recurrence.

关键词： Perioperative growth hormone Abdominal surgery

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Geochronologic constraints on magmatic intrusions and mineralization of the Zhunuo porphyry copper deposit in Gangdese,Tibet

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Chinese Science Bulletin 2007年第22期52卷 3139-3147页

作者： ZHENG YouYe ZHANG gangyang XU RongKe GAO ShunBao PANG YingChun CAO Liang DU AnDao SHI YuRuo Facuty of Earth Resources China University of Geosciences Wuhan 430074 China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074 China No. 2 Geological Team Tibet Bureau of Geology and Exploration Lhasa 850003 China National Geological Analytical and Testing Center Chinese Academy of Geological Sciences Beijing 100037 China Beijing Ion Microprobe Center of the Chinese Academy of Geological Sciences Beijing 100037 China

In situ zircon U-Pb ages for the recently discovered Zhunuo porphyry copper deposit in the western part of the Gangdese metallogenic belt in Tibet were determined by sensitive high-resolution ion mi-croprobe(SHRIMP) . The ages can be divided into two separate groups,reflecting more than four major tectono-magmatic events in the area. The 62.5±2.5 Ma age of inherited zircons may be related to the volcanic eruption of the Linzizong Group formed shortly after the India-Asia continental collision. The 50.1±3.6 Ma age most likely corresponds to the time of underplating of mantle-derived mafic magma in Gangdese. The 15.6±0.6 Ma age obtained from magmatic zircons is interpreted as the age of crystalli-zation of the Zhunuo ore-forming porphyry. Finally,a molybdenite Re-Os isochron age of 13.72±0.62 Ma is consistent with another zircon U-Pb age of 13.3 ±0.2 Ma,representing the time of copper mineraliza-tion. These ages,in combination with available literature data,indicate that magmatic crystallization and copper mineralization in the Gangdese metallogenic belt became gradually younger westward,and further suggest that the Zhunuo porphyry copper deposit was formed in the same tectonic stage as other porphyry copper deposits in the eastern and central Gangdese belt. This conclusion provides critical information for future exploration of porphyry copper deposits in western Gangdese.

关键词：斑岩铜堆积物西藏锝

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Application of dietary fiber in clinical enteral nutrition: A meta-analysis of randomized controlled trials

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World Journal of Gastroenterology 2005年第25期11卷 3935-3938页

作者： gangyang Xiao-TingWu YongZhou Ying-LiWang DepartmentofGeneralSurgery WestChinaHospitalSichuanUniversityChengdu610041SichuanProvinceChina

AIM: To evaluate the effects of dietary fiber (DF) as a part of enteral nutrition (EN) formula on diarrhea, infection, and length of hospital stay. METHODS: Following electronic databases were searched for randomized controlled trials about DF: Chinese Biomedicine Database (CBM), MEDLINE, EMBASE and Cochrane Controlled Trials Register. RevMan 4.1 was used for statistical analysis. RESULTS: Seven randomized controlled trials with 400 pat-ients were included. The supplement of DF in EN was compared with standard enteral formula in five trials. Combined analysis did not show a significant reduction in occurrence of diarrhea, but there were valuable results for non-critically ill patients. Combined analysis of two trials observing the infection also did not show any valid evidence that DF could decrease the infection rate, though the length of hospital stay was reduced significantly. CONCLUSION: Based on the current eligible randomized controlled trials, there is no evidence that the value of DF in the diarrhea can be proved. Though length of hospital stay was shortened by the use of DF, there is no available evidence in preventing infection by DF. Further studies are needed for evaluating the value of DF in EN.

关键词： Dietary fiber Enteral nutrition Meta-analysis

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Inhibition of hepatitis B virus surface antigen expression by small hairpin RNA in vitro

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World Journal of Gastroenterology 2005年第4期11卷 498-502页

作者： Zheng-gangyang ZhiChen QinNi NingXu Jun-BinShao Hang-PingYao InstituteofInfectiousDiseases FirstAffiliatedHospitalSchoolofMedicineZhejiangUniversityHangzhou310003ZhejiangProvinceChina

AIM: To explore the anti-hepatitis B virus effect of RNA interference (RNAi) using small hairpin RNA (shRNA)expression ***: Hepatitis B virus surface antigen green fluorescent protein (HBs-GFP) fusion vector and shRNA expression vectors were constructed and cotransfected transiently into HepG2 cells. mRNAs extracted from HepG2 cells were detected by real-time PCR. Fluorescence of HBs-GFP protein was detected by fluorescence-activated cell sorting (FACS). The effective shRNA expression vector was transfected into HepG2.2.15 cells. HBsAg and HBeAg in HepG2.2.15 cells were analyzed by radioimmunoassay (RIA) ***: FACS revealed that shRNA targeting at HBsAg reduced the GFP signal by 56% compared to the ***-time PCR showed that HBs-GFP mRNA extracted from HepG2 cells cotransfected with pAVU6+27 and HBs-GFP expression plasmids decreased by 90% compared to the empty vector control. The expressions of HBsAg and HBeAg were also inhibited by 43% and 64%, ***: RNAi using shRNA expression vector can inhibit the expression of HBsAg, providing a fresh approach to screening the efficient small interfering RNAs (siRNAs).

关键词： Hepatitis B Surface Antigens Small hairpin RNA RNA interference Gene expression

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Inhibition of human La protein by RNA interference downregulates hepatitis B virus mRNA in 2.2.15 cells

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World Journal of Gastroenterology 2004年第14期10卷 2050-2054页

作者： QinNi ZhiChen Hang-PingYao Zheng-gangyang Ke-ZhouLiu Ling-LingWu InstituteofInfectiousDiseases FirstAffiliatedHospitalSchoolofMedicineZhejiangUniversityHangzhou310003ZhejiangProvinceChina DepartmentofClinicalMedicine MedicalCollegeZhejiangUniversityHangzhou310031ZhejiangProvinceChina

AIM: To investigate the role of human La protein in HBV mRNA ***: Three human La protein (hLa) specific siRNA expression cassettes (SECs) containing U6+1 promoter were prepared via one-step overlapping extension PCR. After transfection with SECs into HepG2 cells, inhibition effects on hLa expression were analyzed by semi-quantitative RT-PCR and Western blotting. Then, effective SECs were screened out and transfected into 2.2.15 cells, a stable HBV-producing cell line. HBV surface antigen(HBsAg) and e antigen (HBeAg) secretions into culture media were detected by microparticle enzyme immunoassay (MEIA) and HBs and HBe mRNA levels were analyzed by semi-quantitative ***: SEC products containing U6+1 snRNA promoter,and 3 sites of hLa mRNA specific siRNA were obtained successfully by one-step overlapping extension PCR and could be directly transfected into HepG2 cells, resulting in inhibition of La protein expression in both mRNA and protein levels, among which U6+l-hLa833 was the most efficient,which reduced 18.6-fold mRNA and 89% protein level respectively. In 2.2.15 cells, U6+l-hLa833 was also efficient on inhibition of hLa expression. Furthermore, semi-quantitative RT-PCR showed that HI3s and HBe mRNA levels were significantly decreased by 8-and 66-fold in U6+l-hLa833 transfected cells compared to control. Accordingly, HBsAg and HBeAg secretions were decreased partly posttransfection with ***: PCR-based SECs can be used to mediate RNAi in mammalian cells and provide a novel approach to study the function of La protein. The inhibition of La protein expression can result in a significant decrease ofHBV mRNA, which implies that the hLa protein is also involved HBV RNA metabolism as one of the HBV RNA-stabilizing factors in human cells.

关键词：抑制作用 La蛋白 RNA调节戊型肝炎病毒 HEV mRNA 2.2.15细胞 SECs

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Effects of n-3 fatty acid,fructose-l,6-diphosphate and glutamine on mucosal cell proliferation and apoptosis of small bowel graft after transplantation in rats

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World Journal of Gastroenterology 2003年第6期9卷 1323-1326页

作者： Xiao-TingWu Jie-ShouLi Xiao-FeiZhao NingLi Yu-KuiMa WenZhuang YongZhou gangyang DepartmentofGeneralSurgery WestChinaHospitalSichuanUniversityChengdu610041SichuanProvinceChina ResearchInstituteofGeneralSurgery NanjingGeneralHospitalofPLAClinicalSchoolofMedicalCollegeNanjingUniversityNanjing210002JiangsuProvinceChina SichuanReproductiveHealthInstitute Chengdu610041SichuanProvinceChina

AIM:To evaluate the effects of n-3 fatty acids (n-3FA), fructose-1,6-diphosphate (FDP) and glutamine (GLN) on mucosal cell proliferation and apoptosis of small bowel graft. METHODS:One hundred and ninety-six inbred strain Wistar rats were grouped as donors and recipients,and underwent heterotopic small bowel transplantation (SBT).n-3FA,FDP and GLN were administered via gastric tube as well as venous infusion for 10 days before and after surgery,respectively. The proliferation and apoptosis of mucosal cells were analyzed with flow cytometry and in situ cell death detection kits. RESULTS:Apparent apoptosis and minor proliferation of mucosal cells of small bowel graft after transplantation were observed.A higher mucosal cell proliferative index and lower apoptotic index were found in all small bowel grafts after supplying with n-3FA,FDP and GLN. CONCLUSION:Nutritional support with n-3FA,FDP and GLN promotes mucosal cell proliferation significantly,and prevents mucosal cell from undergoing apoptosis with different *** regulatory effects on the apoptosis alter the structure and absorption function of transplanted small bowel favorably.

关键词： n-3脂肪酸果糖 6-二磷酸谷氨酸盐小肠移植营养支持

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5 - 7 Design of a Small Size Nuclear Physics Data Acquisition System

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IMP & HIRFL Annual Report 2012年第1期 225-226页

作者： Zhou Wenxiong Wang Yanyu Nan gangyang Zhang Jianchuan

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高模数硅酸钾溶液及其富锌涂料的制备

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涂料工业 2011年第8期41卷 27-30页

作者：彭刚阳瞿金清华南理工大学化学与化工学院广州510640

以低模数硅酸钾溶液、碱性硅溶胶为主要原料,采用有机硅氧烷作为改性剂制备了稳定的高模数硅酸钾溶液,与锌粉按30∶70的质量比例配制富锌涂料。探讨了模数、固含量、有机硅氧烷的种类以及添加量对高模数硅酸钾溶液贮存稳定性和富锌涂料... 详细信息

以低模数硅酸钾溶液、碱性硅溶胶为主要原料,采用有机硅氧烷作为改性剂制备了稳定的高模数硅酸钾溶液,与锌粉按30∶70的质量比例配制富锌涂料。探讨了模数、固含量、有机硅氧烷的种类以及添加量对高模数硅酸钾溶液贮存稳定性和富锌涂料性能的影响。结果表明:硅酸钾溶液的模数在5.5、固含量在25%、γ-缩水甘油醚丙基三甲氧基硅烷(Z-6040)占总质量的3%时,贮存稳定期超过30 d(50℃),由改性后的高模数硅酸钾溶液所配制的富锌涂料涂膜致密且防腐性能优异,可作为长效重防腐涂料使用。

关键词：高模数硅酸钾富锌涂料硅氧烷改性

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HIRFL-CSR Water Leakage Detection and Alarm System

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IMP & HIRFL Annual Report 2011年第1期 206-207页

作者： Wang Yanyu Zhou Detai Zhou Wenxiong Li Yunjie Yin Jia Zhang Jianchuan Nan gangyang Lin Fuyuan Li Lili

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