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De novel heterozygous copy number deletion on 7q31.31-7q31.32 involving TSPAN12 gene with familial exudative vitreoretinopathy in a Chinese family

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 1952-1961页

作者： Shuang Zhang Hai-Ming Yong gang zou Mei-Jiao Ma Xue Rui Shang-Ying Yang Xun-Lun Sheng People’s Hospital of Ningxia Hui Autonomous Region Ningxia Medical UniversityNingxia Eye HospitalNingxia Clinical Research Center on Diseases of Blindness in EyeYinchuan 750001Ningxia Hui Autonomous RegionChina

AIM:To investigate the genetic and clinical characteristics of patients with a large heterozygous copy number deletion on 7q31.31-7q31.32.METHODS:A family with familial exudative vitreoretinopathy(FEVR)phenotype was included in the study.Whole-exome sequencing(WES)was initially used to locate copy number variations(CNVs)on 7q31.31-31.32,but failed to detect the precise breakpoint.The long-read sequencing,Oxford Nanopore sequencing Technology(ONT)was used to get the accurate breakpoint which is verified by quantitative real-time polymerase chain reaction(QPCR)and Sanger Sequencing.RESULTS:The proband,along with her father and younger brother,were found to have a heterozygous 4.5 Mb CNV deletion located on 7q31.31-31.32,which included the FEVRrelated gene TSPAN12.The specific deletion was confirmed as del(7)(q31.31q31.32)chr7:g.119451239_123956818del.The proband exhibited a phase 2A FEVR phenotype,characterized by a falciform retinal fold,macular dragging,and peripheral neovascularization with leaking of fluorescence.These symptoms led to a significant decrease in visual acuity in both eyes.On the other hand,the affected father and younger brother showed a milder phenotype.CONCLUSION:The heterozygous CNV deletion located on 7q31.31-7q31.32 is associated with the FEVR phenotype.The use of long-read sequencing techniques is essential for accurate molecular diagnosis of genetic disorders.

关键词： familial exudative vitreoretinopathy copy number variation copy number deletion TSPAN12 longread sequencing

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基于插件形式的空空雷达仿真建模方法

兵工自动化 2024年第7期43卷 69-73,90页

作者：王志乐孙忠云邹刚海军航空大学青岛校区山东青岛266041

针对火控雷达仿真的主要功能结构,建立雷达多种搜索跟踪仿真模型,设计模拟训练通用火控雷达目标搜索跟踪算法。基于插件形式以基类对象指针实现继承类对象为参数的系统交互方式,利用抽象工厂模式架构,建立雷达交互的数据模型、逻辑模型... 详细信息

针对火控雷达仿真的主要功能结构,建立雷达多种搜索跟踪仿真模型,设计模拟训练通用火控雷达目标搜索跟踪算法。基于插件形式以基类对象指针实现继承类对象为参数的系统交互方式,利用抽象工厂模式架构,建立雷达交互的数据模型、逻辑模型,并通过雷达可视化测试环境进行试验分析。实验结果表明:该方法能实现模拟训练通用火控雷达空空模式仿真模型,以及模型的复用性和重构性。

关键词：火控雷达仿真模型搜索跟踪算法模拟训练逻辑模型

面向航空发动机的虚拟多人拆装任务的驱动方法

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系统仿真学报 2024年第1期36卷 220-231页

作者：曾秋玮胡兆勇王志乐张锐林邹刚广东工业大学广东省计算机集成制造重点实验室广东广州510006 海军航空大学青岛校区山东青岛266041

为满足虚拟多人协同拆装系统不同拆装任务的快速开发需求,提出一种可配置任务序列的数据驱动方法。以某型航空发动机样机为研究对象,研究了多人协同拆装的任务要素,对任务进行基于JS对象图谱(JavaScript Object notation,JSON)的参数化... 详细信息

为满足虚拟多人协同拆装系统不同拆装任务的快速开发需求,提出一种可配置任务序列的数据驱动方法。以某型航空发动机样机为研究对象,研究了多人协同拆装的任务要素,对任务进行基于JS对象图谱(JavaScript Object notation,JSON)的参数化设计与表达,以JSON参数化文件驱动任务序列,定义每一步任务的交互操作。实践表明:该方法运用于多人协同拆装系统中,使系统具备可配置性,能根据自定义任务序列驱动任务流程;在多端大任务量的情况下,有效提升部署效率。

关键词：虚拟拆装多人协同航空发动机参数化模型任务驱动

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光储系统并网功率波动平抑及储能优化配置

发电技术 2024年第3期45卷 423-433页

作者：赵斌梁告姜孟浩邹港王力长沙理工大学电气与信息工程学院湖南省长沙市410114 深圳本贸科技股份有限公司广东省深圳市518057

【目的】电池储能是保证光伏发电系统可靠性、提高光伏发电利用率的有效手段之一,但在光储电站中存在功率波动平抑难、储能容量配置不合理等问题,为解决这些问题,开展了相关研究。【方法】针对能量型电池储能,分析了调度模式和自主模式... 详细信息

【目的】电池储能是保证光伏发电系统可靠性、提高光伏发电利用率的有效手段之一,但在光储电站中存在功率波动平抑难、储能容量配置不合理等问题,为解决这些问题,开展了相关研究。【方法】针对能量型电池储能,分析了调度模式和自主模式特性,提出了一种基于储能运行在调度模式的光储系统限功率平抑策略,以实现功率平抑和减少储能充放电频繁切换。建立了以最小光储系统弃电损失为优化目标,以功率波动越限概率等作为约束条件的优化模型,并利用算法对储能配置进行求解和优化。以西藏朗明桑珠孜50 MW光储电站为例,验证了所提平抑策略的有效性。【结果】所提平抑策略在不增加储能充放电切换次数的前提下,将光储系统并网功率波动越限概率由25.64%降至6.41%,且并网功率波动越限概率为5%时,该50 MW并网光伏电站储能系统最优配置为14.5 MW/94 MW·h。【结论】所提抑策略及储能优化配置方法可为并网光储电站优化设计和运行提供技术参考。

关键词：光伏发电光储系统电池储能系统波动平抑优化配置

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基于故障树的排故策略制定

兵工自动化 2024年第6期43卷 56-60页

作者：王文鹏邹刚梁佐堂于光辉海军航空大学青岛校区一系山东青岛266041

针对舰载机维护中底事件发生概率不能得到最快排故策略的问题,提出一种结合故障概率和检查时间的重要度指标,用来制定排故策略。用包含底事件发生概率和检查时间的公式计算排故重要度和第二排故重要度;以拦阻钩放不下来的故障为例,制定... 详细信息

针对舰载机维护中底事件发生概率不能得到最快排故策略的问题,提出一种结合故障概率和检查时间的重要度指标,用来制定排故策略。用包含底事件发生概率和检查时间的公式计算排故重要度和第二排故重要度;以拦阻钩放不下来的故障为例,制定排故策略,并用蒙特卡罗方法进行验证。验证结果表明,该排故重要度方法排故总时间较短。

关键词：故障树重要度排故拦阻钩

基于注意力增强与特征融合的中文医学实体识别

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计算机工程 2024年第7期50卷 324-332页

作者：王晋涛秦昂张元陈一飞王廷凤谢承霖邹刚中北大学计算机科学与技术学院山西太原030051 湖南省肿瘤医院湖南长沙410031 湖南省中医药研究院附属医院湖南长沙410006 湖南中科助英智能科技研究院湖南长沙410076

针对基于字符表示的中文医学领域命名实体识别模型嵌入形式单一、边界识别困难、语义信息利用不充分等问题,一种非常有效的方法是在Bret底层注入词汇特征,在利用词粒度语义信息的同时降低分词错误带来的影响,然而在注入词汇信息的同时... 详细信息

针对基于字符表示的中文医学领域命名实体识别模型嵌入形式单一、边界识别困难、语义信息利用不充分等问题,一种非常有效的方法是在Bret底层注入词汇特征,在利用词粒度语义信息的同时降低分词错误带来的影响,然而在注入词汇信息的同时也会引入一些低相关性的词汇和噪声,导致基于注意力机制的Bret模型出现注意力分散的情况。此外仅依靠字、词粒度难以充分挖掘中文字符深层次的语义信息。对此,提出基于注意力增强与特征融合的中文医学实体识别模型,对字词注意力分数矩阵进行稀疏处理,使模型的注意力集中在相关度高的词汇,能够有效减少上下文中的噪声词汇干扰。同时,对汉字发音和笔画通过卷积神经网络(CNN)提取特征,经过迭代注意力特征融合模块进行融合,然后与Bret模型的输出特征进行拼接输入给Bi LSTM模型,进一步挖掘字符所包含的深层次语义信息。通过爬虫等方式搜集大量相关医学语料,训练医学领域词向量库,并在CCKS2017和CCKS2019数据集上进行验证,实验结果表明,该模型F1值分别达到94.90%、89.37%,效果优于当前主流的实体识别模型,具有更好的识别效果。

关键词：实体识别中文分词注意力稀疏特征融合医学词向量库

Maintenance Management Research of a Large-span Continuous Rigid Frame Bridge Based on Reliability Assessment by Using Strain Monitored Data

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Journal of Architectural Environment & Structural Engineering Research 2021年第2期4卷 20-31页

作者： Yinghua Li Kesheng Peng Junyong He Qiangjun Shuai gang zou Shixing County Bureau of transportation Shixing CountyShaoguan CityGuangdong Province512500China HARDA(XIAMEN)PLASTIC CO. LTDNo.37Huili ZoneTongAn Industrial AreaXiamenChina Guangdong College of Industry and Commerce No.1O98Guangzhou North RoadTianhe DistrictGuangzhouChina 48-13B Baohe road 81Long Gang DistrictShenzhenGuangdongChina 54-28D Yi Jin YuanLong Cheng StreetLong Gang DistrictShenzhenGuangdongChina

When the bridge components needing maintenance are the world problem at present,and the health monitoring system is considered to be a very helpful tool for solving this problem.In this paper,a large number of strain data acquired from the structural health monitoring system(SHMS)installed on a continuous rigid frame bridge are adopted to do reliability assessment.Firstly,a calculation method of punctiform time-dependent reliability is proposed based on the basic reliability theory,and introduced how to calculate reliability of the bridge by using the stress data transformed from the strain data.Secondly,combined with“Three Sigma”principle and the basic pressure safety reserve requirement,the critical load effects distribution function of the bridge is defined,and then the maintenance reliability threshold for controlling the unfavorable load state which appears in the early operation stage of this type bridge is suggested,and then the combination of bridge maintenance management and health monitoring system is realized.Finally,the transformed stress distribution certifies that the load effects of concrete bridges practically have a normal distribution;as for the concrete continuous rigid frame bridge with C50 strength grade concrete,the retrofit reliability threshold should be valued at 6.13.The methodology suggested in this article can help bridge engineers do effective maintenance of bridges,which can effectively extend the service life of the bridge and bring better economic and social benefits.

关键词： Structural health monitoring Punctiform time-varying reliability Critical load effects distribution function Maintenance reliability threshold Continuous rigid frame bridge “Three Sigma”principle

Genetic Variation of Multiple Serotypes of Enteroviruses Associated with Hand, Foot and Mouth Disease in Southern China

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Virologica Sinica 2021年第1期36卷 61-74页

作者： Yonghong Zhou Le Van Tan Kaiwei Luo Qiaohong Liao Lili Wang Qi Qiu gang zou Ping Liu Nguyen To Anh Nguyen Thi Thu Hong Min He Xiaoman Wei Shuanbao Yu Tommy Tsan-Yuk Lam Jie Cui H.Rogier van Doorn Hongjie Yu School of Public Health Fudan UniversityKey Laboratory of Public Health SafetyMinistry of EducationShanghai 200032China Oxford University Clinical Research Unit Ho Chi Minh City 700000Vietnam Hunan Provincial Center for Disease Control and Prevention Changsha 410005China Division of Infectious Disease Key Laboratory of Surveillance and Early-warning on Infectious DiseaseChinese Centre for Disease Control and PreventionBeijing 102206China Institut Pasteur of Shanghai Chinese Academy of SciencesShanghai 200032China Anhua County Center for Disease Control and Prevention Anhua 413000China CAS Key Laboratory of Special Pathogens and Biosafety Center for Emerging Infectious DiseasesWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Centre of Influenza Research&State Key Laboratory of Emerging Infectious Diseases School of Public HealthThe University of Hong KongHong Kong SAR 999077China CAS Key Laboratory of Molecular Virology and Immunology Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200032China Centre for Tropical Medicine Nuffield Department of MedicineUniversity of OxfordOxford OX37DQUK

Enteroviruses(EVs)species A are a major public health issue in the Asia–Pacific region and cause frequent epidemics of hand,foot and mouth disease(HFMD)in China.Mild infections are common in children;however,HFMD can also cause severe illness that affects the central nervous system.To molecularly characterize EVs,a prospective HFMD virological surveillance program was performed in China between 2013 and 2016.Throat swabs,rectal swabs and stool samples were collected from suspected HFMD patients at participating hospitals.EVs were detected using generic real-time and nested reverse transcription-polymerase chain reactions(RT-PCRs).Then,the complete VP1 regions of enterovirus A71(EV-A71),coxsackievirus A16(CVA16)and CVA6 were sequenced to analyze amino acid changes and construct a viral molecular phylogeny.Of the 2836 enrolled HFMD patients,2,517(89%)were EV positive.The most frequently detected EVs were CVA16(32.5%,819),CVA6(31.2%,785),and EV-A71(20.4%,514).The subgenogroups CVA16B1 b,CVA6D3 a and EV-A71C4 a were predominant in China and recombination was not observed in the VP1 region.Sequence analysis revealed amino acid variations at the 30,29 and 44 positions in the VP1 region of EV-A71,CVA16 and CVA6(compared to the respective prototype strains Br Cr,G10 and Gdula),respectively.Furthermore,in 21 of 24(87.5%)identified EV-A71 samples,a known amino acid substitution(D31 N)that may enhance neurovirulence was detected.Our study provides insights about the genetic characteristics of common HFMD-associated EVs.However,the emergence and virulence of the described mutations require further investigation.

关键词： Enteroviruses(EVs) Hand foot and mouth disease(HFMD) Enterovirus A71(EV-A71) Coxsackievirus A16(CVA16) Coxsackievirus A6(CVA6)

基于红外测温技术的高压电气设备运行检修方法

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电工技术 2024年第5期 131-133页

作者：杨国涛邹刚曹冲袁新喜韩涛国网六安供电公司安徽六安237000

为及时有效地实现对处于运行状态的电气设备故障的感知,引入红外测温技术,以某高压电气设备为例,对运行状态下高压电气设备的检修方法展开研究。根据检修需求,基于红外测温技术对电气设备运行状态下的表面温度进行检测;测量并计算高压... 详细信息

为及时有效地实现对处于运行状态的电气设备故障的感知,引入红外测温技术,以某高压电气设备为例,对运行状态下高压电气设备的检修方法展开研究。根据检修需求,基于红外测温技术对电气设备运行状态下的表面温度进行检测;测量并计算高压电气设备运行状态下的温度损耗,并对测量温度进行补偿;以高压电气设备运行相关标准为参照,明确技术规范中提出的电气设备运行热失效要求,设置高压电气设备运行过程中的异常温升预警值,据此实现高压电气设备运行状态下的异常温升计算与故障检修。实例应用结果表明,该方法可在提高运行状态下电气设备红外图谱温度感知准确性的基础上,实现对设备运行中故障的精准排查与检修,确保电力系统中电气设备运行的稳定性与可靠性。

关键词：红外测温技术温度损耗高压电气设备