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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao Huang Xianglin Wu Yanan Huo Qin Wan Yingfen Qin ruying Hu Lixin shi Qing Su Xuefeng yu Li Yan Guijun Qin Xulei Tang gang Chen Min Xu Tiange Wang Zhiyun Zhao Zhengnan {2. Guixia Wang Feixia Shen Zuojie Luo Li Chen Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Tao Yang Huacong Deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu yuhong Chen Jieli Lu weiqing Wang Guang Ning yu Xu yufang Bi Mian Li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi provincial people’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang provincial Center for Disease Control and prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong university Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 104538 participants from the nationwide cohort of the risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1 h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

CEpC Technical Design report

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radiation Detection technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An rui An Daniele paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai {2. Bai Yang Bai Vipul Bairathi Csaba Balazs philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond p.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi {2.anjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai {2.chen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang {2.e Chang Zhe Chang Xin{2.an Chang wei Chao Auttakit Chatrabhuti Yimin Che {2.zhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-{2.an Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen shiqiang Chen Tianlu Chen wei Chen Xiang Chen Xiao{2. Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen {2.kai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng {2.nlong Chi pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhao{2.an Cui Brunella D'Anzi Ling-{2.n Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of science and {{2. Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational science research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass research Institute Co. LtdBeijing Beijing Institute of technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced science and {{2. Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geo{{2.s Beijing china university of Geo{{2.s WuhanHubei china university of Mining and {{2. XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CppM(AMU/IphU&CNrS/INp) Marseille Dalian Minzu university DalianLiaoning Dalian university of technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear problems of Joint Institute for Nuclear research(DLNp JINr) Dubna East china university Of {{2. And Technol

The Circular Electron positron Collider(CEpC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super proton proton Collider(SppC).The CEpC primarily serves as a Higgs *** its baseline design with synchrotron radiation(Sr)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(Ip),resulting in an integrated luminosity of 13 ab^(-1)for two Ips over a decade,producing 2.6 million Higgs *** the Sr power to 50 MW per beam expands the CEpC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design report(TDr)follows the preliminary Conceptual Design report(pre-CDr,2.15)and the Conceptual Design report(CDr,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,r&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

Accumulated Clinical Experiences from Successful Treatment of 1377 Severe and Critically Ill COVID-19 Cases

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Current Medical science 2020年第4期40卷 597-601页

作者： Yong gao Hai-bo QIU Shu ZHOU Zhen-ning WANG Jian-chu ZHANG Zheng-liang ZHANG Zhao-xin QIAN Hong-bo WANG shi-huan {2. Yi-feng LUO Ya dan WANG Zhuang LIU {2.-ci WANG Ming JIA Li-ming ZHANG {2. ZHANG Yang JIN Yong ZHANG Yong LIU Zi-hua ZHOU Ying SU Hui-qing LI {2.-min XIAO Kai HUANG ping HE gang LI Zhao-hui FU shi LIU Neng xing LIN Fan-jun CHENG Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Zhongda Hospital of Souheast university Nanjing 210009China The First Affiliated Hospital of china Medical university Shenyang 110001China The Second Affiliated Hospital of Xi'an Jiaotong university Xi'an 710004China Xiangya Hospital of Zhongnan university Changsha 410008China The First Afiliated Hospital of Harbin Medical university Harbin 150001China The First Affiliated Hospital of Sun Yat-sen university Guangzhou 510080China Beijing Friendship Hospital of Capital Medical university Beijing 100050China Beijing Anzhen Hospital of Capital Medical university Beijing 100029China Beijing Chaoyang Hospital of Capital Medical university Beiing 100020China

Summary:In late December 2.19,COVID-19 was firstly recognized in Wuhan,china and spread rapidly to all of the provinces of *** West Campus of Wuhan Union Hospital,the designated hospital to admit and treat the severe and critically ill COVID-19 cases,has treated a large number of such patients with great success and obtained lots of valuable experiences based on the Chinese guideline(V7.0).To standardize and share the treatment procedures of severe and critically ill cases,Wuhan Union Hospital has established a working group and formulated an operational recommendation,including the monitoring,early warning indicators,and several treatment principles for severe and critically ill *** treatment experiences may provide some constructive suggestions for treating the severe and critically ill COVID-19 cases all over the world.

关键词： 2.19-nCoV COVID-19 pneumonia treatment guidelines

Ameliorative effects of lutein on non-alcoholic fatty liver disease in rats

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World Journal of Gastroenterology 2015年第26期21卷 8061-8072页

作者： Xiang Qiu Dan-Hong gao Xiao Xiang yu-Fang Xiong Teng-{2. Zhu Lie-{2. Liu Xiu-Fa Sun Li-ping Hao Department of Nutrition and Food Hygiene School of Public HealthTongji Medical CollegeHuazhong University of Science and Technology Key Laboratory of Environment and Health Ministry of Education and Ministry of Environmental ProtectionHuazhong University of Science and Technology State Key Laboratory of Environmental Health (Incubating) School of Public HealthHuazhong University of Science and Technology Department of Biochemistry and Molecular Biology Tongji Medical CollegeHuazhong University of Science and Technology

AIM: To investigate the therapeutic effects of lutein against non-alcoholic fatty liver disease(NAFLD) and the related underlying ***: After 9 d of acclimation to a constant temperature-controlled room(2. ℃-2. ℃) under 12. light/dark cycles,male Sprague-Darley rats were randomly divided into two groups and fed a standard commercial diet(n = 8) or a high-fat diet(HFD)(n = 32. for 10 *** receiving HFD were then randomly divided into 4 groups and administered with 0,12.5,2.,or 50 mg/kg(body weight) per day of lutein for the next 45 *** the end of the experiment,the perinephric and abdominal adipose tissues of the rats were isolated and ***,serum and liver lipid metabolic condition parameters were measured,and liver function and insulin resistance state indexes were *** samples were collected and stained with hematoxylin eosin and Oil red O,and the expression of the key factors related to insulin signaling and lipid metabolism in the liver were detected using Western blot and real-time polymerase chain reaction ***: Our data showed that after being fed a high-fat diet for 10 d,the rats showed a significant gain in body weight,energy efficiency,and serum total cholesterol(TC) and triglyceride(TG) *** supplementation induced fat loss in rats fed a highfat diet,without influencing body weight or energy efficiency,and decreased serum TC and hepatic TC and TG ***,lutein supplementation decreased hepatic levels of lipid accumulation and glutamic pyruvic transaminase content,and also improved insulin *** administration also increased the expression of key factors in hepatic insulin signaling,such as insulin receptor substrate-2.phosphatidylinositol 3-kinase,and glucose transporter-2.at the gene and protein ***,high-dose lutein increased the expression of peroxisome proliferators activated receptor-α and sirtuin 1,which are associated with lipid metabolism and insul

关键词： Lutein Non-alcoholic fatty liver disease Insulin resistance Sirtuin 1 peroxisome proliferatorsactivated receptor-α

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese population:Findings from the china Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental sciences 2021年第1期34卷 9-18页

作者： ZHU yuan yue ZHENG rui Zhi WANG Gui Xia CHEN Li {2. Li Xin SU Qing XU Min XU yu CHEN yu Hong yu Xue Feng YAN Li WANG Tian Ge ZHAO Zhi yun QIN Gui Jun WAN Qin CHEN gang {2. Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU ru Ying WANG wei Qing NING Guang LI Mian LU Jie Li BI yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin university Changchun 130021JinlinChina Qilu Hospital of Shandong university Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai Jiaotong university school of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou university Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical university Luzhou 646099SichuanChina Fujian provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical university Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical university Nanning 530021GuangxiChina Jiangxi provincial people's Hospital Affiliated to Nanchang university Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical university Harbin 150086HeilongjiangChina Zhejiang provincial Center for Disease Control and prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai Jiading District Shanghai 201800China Jiangsu province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical university Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FpG),2.hour postload glucose(2.h-pG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The china Cardiometabolic Disease and Cancer Cohort Study.A total of 105,92. community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62.3.1 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FpG,2.h-pG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical research 2020年第3期7卷 249-282页

作者： Ying-Hui Jin Qing-yuan Zhan Zhi-Yong peng Xue-Qun ren Xun-Tao Yin Lin Cai yu-Feng yuan Ji-rong yue Xiao-Chun Zhang Qi-Wen Yang Jianguang Ji Jian Xia Yi-rong Li Fu-Xiang Zhou Ya-Dong gao Zhui yu Feng Xu Ming-Li Tu Li-Ming Tan Min Yang Fang Chen Xiao-Ju Zhang Mei Zeng yu Zhu Xin-Can Liu Jian Yang Dong-Chi Zhao yu-Feng Ding Ning Hou Fu-Bing Wang Hao Chen Yong-gang Zhang {2. Li Wen Chen yue-Xian shi Xiu-Zhi Yang Xue-Jun Wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui Li Lin-Lu Ma Hao Zi Na Wang yun-yun Wang Shao-Fu yu Lu-Yao Li Qiao Huang Hong Weng Xiang-Ying ren Li-Sha Luo Man-ru Fan Di Huang Hong-Yang Xue Lin-Xin yu Jin-ping gao Tong Deng Xian-Tao Zeng Hong-Jun Li Zhen-Shun Cheng Xiao-Mei Yao Xing-Huan Wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical research Center for respiratory Diseases China-Japan Friendship HospitalBeijing 100029China Department of pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China Departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China Department of radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for primary Health Care research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China Department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China Department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Emergency Medicine and Chest pain Center Qilu Hospital of Shandong UniversityJinan 250002China Department of respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina Department of Clinic pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2.SArS-CoV-2.is the cause of a rapidly spreading illness,coronavirus disease 2.19(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2.19 novel coronavirus(2.19-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 2. questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of recommendations,Assessment,Development and Evaluation(GrADE)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(rT-pCr),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SArS-CoV-2 recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

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遗传性耳聋基因治疗临床指南

实用医院临床杂志 2024年第2期21卷 39-44页

作者：齐洁玉谈方志张李燕陆玲王洪阳李文妍刘闻闻付小龙贺祖宏丁小琼孙珊方巧军董耀东朱学伟童步升曹现宝郭敏范欣淼汪芹马璐张天虹于亚峰李永新樊建刚崔勇吴佩娜张宏征唐杰郭维维查定军叶放蕾何双八曹卫杨见明钱晓云赵宇孙敬武陈晓巍孙宇夏明王秋菊袁慧军冯永孔维佳杨仕明王海波高下李华伟徐磊柴人杰东南大学数字医学工程全国重点实验室附属中大医院耳鼻咽喉头颈外科生命科学与技术学院生命与健康高等研究院江苏省生物医学高新技术研究重点实验室江苏南京210096 南通大学神经再生联合创新中心江苏南通226001 北京理工大学航天中心医院神经内科生命学院北京10081 南京大学医学院附属鼓楼医院耳鼻喉头颈外科江苏省医学重点学科(实验室)江苏南京210008 中国人民解放军总医院耳鼻咽喉头颈外科医学部北京100853 听觉与平衡觉全国重点实验室北京100853 国家耳鼻咽喉疾病临床医学研究中心北京100853 聋病教育部重点实验室北京100853 聋病防治北京市重点实验室北京100853 复旦大学附属眼耳鼻喉科医院医学神经生物学国家重点实验室教育部脑科学前沿研究中心上海200031 复旦大学生物医学研究所上海200032 国家卫健委听觉医学重点实验室上海200031 复旦大学脑科学研究院和脑科学协同创新中心上海200032 山东大学山东省耳鼻喉医院耳鼻咽喉头颈外科山东济南250022 山东省耳鼻喉研究所山东济南250022 山东第一医科大学/山东省医学科学院医学科技创新中心山东济南250000 武汉大学中南医院耳鼻咽喉头颈外科湖北武汉430071 东南大学附属中大医院耳鼻咽喉头颈外科江苏南京210009 复旦大学附属眼耳鼻喉科医院耳鼻喉科上海200032 安徽医科大学第二附属医院耳鼻咽喉头颈外科安徽合肥230601 中国医科大学附属盛京医院耳鼻咽喉头颈外科辽宁沈阳110004 吉林大学中日联谊医院耳鼻咽喉头颈外科吉林长春130033 安徽医科大学第一附属医院耳鼻咽喉头颈外科安徽合肥230022 云南省第一人民医院耳鼻喉科云南昆明650032 昆明医科大学第一附属医院耳鼻喉科云南昆明650032 中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科北京100730 中南大学湘雅二医院耳鼻咽喉头颈外科湖南长沙410008 南华大学衡阳医学院基础医学院细胞生物学与遗传学教研室细胞应激生物学衡阳市重点实验室湖南衡阳421001 哈尔滨医科大学附属第一医院黑龙江哈尔滨150001 苏州大学附属第一医院耳鼻咽喉科江苏苏州215006 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科北京100730 四川省医学科学院·四川省人民医院/电子科技大学附属医院耳鼻咽喉头颈外科四川成都610072 广东省人民医院耳鼻咽喉头颈外科/广东省医学科学院/南方医科大学广东广州510080 南方医科大学珠江医院耳鼻咽喉头颈外科广东广州510282 空军军医大学西京医院耳鼻咽喉-头颈外科陕西西安710032 郑州大学第一附属医院耳科河南郑州450000 东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科江苏南京211102 四川大学华西医院耳鼻咽喉头颈外科四川成都610041 中国科学技术大学附属第一医院耳鼻咽喉头颈外科安徽合肥230001 华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科湖北武汉430022 山东第一医科大学附属山东省立医院耳鼻咽喉科山东济南250021 山东省医学科学院医学科技创新中心山东济南250021 山东大学附属山东省立医院耳鼻咽喉科山东济南250021 国家卫生健康委耳鼻咽喉重点实验室山东济南250021 四川大学华西医院罕见病研究院四川成都6010041 南华大学衡阳医学院南华大学附属妇幼保健院湖南长沙410008 中南大学湘雅医院耳鼻咽喉头颈外科湖南长沙410008 上海人工耳蜗工程技术研究中心上海200031 东南大学深圳研究院广东深圳518063

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳... 详细信息

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳聋基因治疗的临床试验。其中,由东南大学附属中大医院牵头,联合国内多家医院成功开展的遗传性耳聋基因治疗临床试验,取得了显著的疗效,并积累了丰富的经验。为规范遗传性耳聋基因治疗并提供临床研究指导,全国多家医院的耳科专家讨论制定了遗传性耳聋基因治疗临床指南,内容涵盖了伦理审查、遗传性耳聋的诊断和入组标准、临床前准备、药物、疗效与安全性评估标准、术后言语康复等。本指南将为耳聋基因治疗的临床诊疗提供规范的理论和技术指导。

关键词：遗传性耳聋基因治疗临床指南

2.2.年中国九地区12.家医院住院患者血液制品使用情况调查分析

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临床药物治疗杂志 2022年第3期20卷 57-63页

作者：霍记平朱强杨莉高辉杨兴华李草石玉香赵志刚首都医科大学附属北京天坛医院药学部北京100070 首都医科大学附属北京天坛医院乳腺外科北京100070 首都医科大学附属北京天坛医院妇产科北京100070 首都医科大学公共卫生学院北京100069 华中科技大学同济医学院附属武汉中心医院病理科武汉430000

目的调查住院患者血液制品使用情况,为后续开展其合理性评价提供参考,促进临床合理用药。方法随机抽取中国九地区12.家医院2.2.年1月1日至2.2.年12.31日期间使用13种血液制品的住院患者临床数据,对血液制品处方量、使用数量、药品总费... 详细信息

目的调查住院患者血液制品使用情况,为后续开展其合理性评价提供参考,促进临床合理用药。方法随机抽取中国九地区12.家医院2.2.年1月1日至2.2.年12.31日期间使用13种血液制品的住院患者临床数据,对血液制品处方量、使用数量、药品总费用、科室分布等进行分析。结果本研究共抽取相关处方2.4357张,白蛋白类、免疫球蛋白类、凝血因子类分别占比80.86%、6.87%和12.2.%。九地区合计,人血白蛋白处方量、使用数量及药品总费用均位列首位,其次为人免疫球蛋白。在凝血因子类血液制品中,凝血酶处方量占比最高,其次是人纤维蛋白原、人凝血酶原复合物;重组人凝血因子类使用较少;人纤维蛋白原总费用最多。血液制品使用以重症医学科、外科系统为主,内科系统主要集中在血液内科和消化内科等少数科室。结论人血白蛋白处方量、使用数量及药品总费用占据血液制品首位,其次为人免疫球蛋白。凝血因子类制品中,凝血酶、人纤维蛋白原、人凝血酶原复合物使用较多,重组凝血因子类使用较少。

关键词：血液制品住院患者处方量药品费用

新型冠状病毒肺炎药物预防、诊断、治疗与出院管理循证临床实践指南(更新版)

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解放军医学杂志 2020年第10期45卷 1003-1031页

作者：靳英辉詹庆元彭志勇任学群尹训涛蔡林袁玉峰岳冀蓉张笑春杨启文纪建光夏剑李一荣周福祥高亚东余追徐峰涂明利谭力铭杨旻陈芳张晓菊曾玫朱渝刘新灿杨简赵东赤丁玉峰侯宁汪付兵陈昊张永刚李玮陈文施月仙杨秀芝王学军钟燕军赵明娟李柄辉马琳璐訾豪王娜王云云余绍福李路遥黄桥翁鸿任相颖罗丽莎范曼如黄笛薛竑飏余临心高锦萍邓通曾宪涛李宏军程真顺姚晓梅王行环无武汉大学中南医院循证与转化医学中心武汉430071 中日友好医院国家呼吸系统疾病临床研究中心北京100029 中日友好医院呼吸与危重症医学科北京100029 武汉雷神山医院武汉430200 武汉大学中南医院重症医学科武汉430071 河南大学循证医学与临床转化研究院河南开封475000 贵州省人民医院医学影像科贵阳550002 武汉大学中南医院骨科武汉430071 武汉大学中南医院肝胆外科武汉430071 四川大学华西医院国家老年疾病临床医学研究中心成都610041 四川大学华西医院老年医学中心成都610041 武汉大学中南医院医学影像中心武汉430071 中国医学科学院/北京协和医学院检验学系北京协和医院检验科北京100730 瑞典隆德大学临床研究中心/斯科讷大学医院马尔默25002 武汉大学中南医院急救中心武汉403371 武汉大学中南医院过敏反应科武汉403371 武汉大学中南医院肿瘤放化疗科武汉403371 武汉大学人民医院重症医学科武汉430060 山东大学齐鲁医院急诊科与胸痛中心济南250002 湖北医药学院附属随州市中心医院呼吸与重症医学科湖北随州441300 湖南省怀化市第二人民医院药学部湖南怀化418000 安徽医科大学第二附属医院重症医学科合肥230601 郑州大学医院内科郑州450001 河南省人民医院呼吸与危重症医学科郑州450003 复旦大学附属儿科医院感染传染科上海201102 四川大学华西第二医院感染科成都610041 河南中医药大学第一附属医院心内科郑州450000 三峡大学人民医院/宜昌市第一人民医院心内科湖北宜昌443000 武汉大学中南医院儿科武汉430071 华中科技大学同济医学院附属同济医院药学部武汉430030 山东第一医科大学附属省立医院/山东省立医院药学部济南250021 南京中医药大学教育部针药结合重点实验室南京210023 四川大学华西医院华西期刊社成都610041 青岛大学附属烟台毓璜顶医院检验医学中心山东烟台264000 十堰市太和医院(湖北医药学院附属医院)医学影像中心湖北十堰442000 北京大学护理学院北京100191 开封市中心医院呼吸与危重症医学科河南开封475000 北京电力医院急诊科北京100073 中南大学湘雅二医院重症医学科长沙410008 武汉大学中南医院泌尿科武汉430071 武汉大学中南医院血液科武汉430071 河南大学医学院护理与健康学院河南开封475000 山西医科大学护理学院太原030001 首都医科大学北京佑安医院放射诊断科北京100069 武汉大学中南医院呼吸与危重症医学科武汉430071 麦克马斯特大学卫生研究方法证据及影响系安大略省哈密尔顿市L8S 4L8加拿大中国医疗保健国际交流促进会循证医学分会中国研究型医院学会

严重急性呼吸综合征冠状病毒2.SArS-CoV-2.导致的新型冠状病毒肺炎(COVID-19)自暴发以来迅速在全球蔓延,造成数以千万人感染及数十万患者死亡。基于研究证据的临床实践指南是诊治COVID-19的有力武器。在疫情早期阶段,该团队制定并发布... 详细信息

严重急性呼吸综合征冠状病毒2.SArS-CoV-2.导致的新型冠状病毒肺炎(COVID-19)自暴发以来迅速在全球蔓延,造成数以千万人感染及数十万患者死亡。基于研究证据的临床实践指南是诊治COVID-19的有力武器。在疫情早期阶段,该团队制定并发布了《新型冠状病毒(2.19-nCoV)感染的肺炎诊疗快速建议指南(标准版)》。疫情暴发后大量相关临床研究陆续开展并发表,新的证据可能会改变以前的推荐意见,更新指南的时机已经成熟。因此,该团队成立了由临床专家和方法学家组成的工作组,通过咨询一线临床专家提出并确定了与COVID-19管理相关的2.个临床问题。通过系统检索有关COVID-19预防及诊疗的直接证据,使用GrADE方法评估证据质量并制订推荐意见,最终形成34条建议,其中6条强推荐,14条弱推荐,3条弱不推荐,11条为基于共识的建议;共涵盖4个方面,分别为药物预防,诊断(包括临床表现、rT-pCr检测、呼吸道标本、IgM和IgG抗体检测、CT检查、胸部X线片及无症状感染的CT特征),治疗方法[包括洛匹那韦-利托那韦、阿比朵尔、法匹拉韦、干扰素、瑞德西韦、抗病毒药的组合、羟氯喹/氯喹、白介素-6抑制剂、白介素-1抑制剂、糖皮质激素、清肺排毒汤、连花清瘟胶囊/颗粒、康复者血浆、肺移植、有创或无创通气、体外膜肺氧合支持(ECMO)]以及出院管理(包括复阳患者管理及出院标准)。此外,还制订了针对推荐意见的指南实施工具流程图,以期有力支持医护人员对COVID-19患者的照护。

关键词：新型冠状病毒肺炎 2.19新型冠状病毒感染性疾病临床实践指南循证医学