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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： Zhenzhen Fang gang shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang Anton Gao Weiwei Qi Xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic damage.Hyperlipidemia(HLP)is the leading risk factor for NAFLD.This study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were enrolled.The plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver injury.Further,KAL levels of NAFLD patients were significantly up-regulated.KAL transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)mice.In contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD rats.Mechanistically,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),respectively.CGl-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa induction.Meanwhile,hepatic CGl-58-overexpress reverses NASH in KAL transgenic mice.Further,free fatty acids up-regulated KAL against thyroid hormone in hepatocytes.Moreover,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating KAL.These results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

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Serum folate status among blood donors in south-central China

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Journal of Innovative Optical Health Sciences 2022年第2期15卷 42-48页

作者： Yan Ma Huan Deng Mingdi He Ru Yang gang shen Wuhan Blood Center-Huazhong University of Science and Technology United Hematology Optical Imaging Center Hubei Institute of Blood Transfusion Wuhan Blood Center WuhanHubei 430030P.R.China Wuhan Blood Center-Huazhong University of Science and Technology United Hematology Optical Imaging Center Britton Chance Center for Biomedical Photonics School of Optical and Electronic Information-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology 430074 P.R.China

Folate deficiency has been confirmed to be related to various diseases.Unfortunately,there are few reports on the folate status of Chinese adults.This study aims to evaluate the serum folate status of blood donors in south-central China.In this study,248 blood donors were included.The information on subjects was collected by a brief questionnaire concerning alcohol consumption habits,smoking habits,fruit and vegetable consumption and physical activity.The serum folate concentration was measured by electrochemiluminescence immunoassay.The geometric mean serum folate concentration was 13.4 nmoll-1(95%CI,12.7-14.1).The prevalence of serum folate concentrations below 6.8 nmoll-1 was 5.2%(95%CI,2.5-8.0).There were significant differences in serum folate concentrations with respect to sex(p-values<0.05),age(p-values<0.05),fruit and vegetable consumption(p-values<0.05),and alcohol consumption habits(p-values<0.05).The concentration of serum folate increased with age(p-values<0.05)and fruit and vegetable consumption(p-values<0.05).Individuals with an age of 30 years or younger were nearly 3.5 times as likely as those aged over 30 years to have an insufficient level of serum folate(OR=3.48;95%CI:1.01-11.99).An age of 30 years or younger was a risk factor for folate deficiency.Most blood donors had sufficient serum folate concentrations in south-central China.National surveys of folate status should be implemented in China.

关键词： Serum folate folate status folate de¯ciency blood donors folate concentrations

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Tribological study on the surface modification of metal-on-polymer bioimplants

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Frontiers of Mechanical Engineering 2022年第2期17卷 103-115页

作者： gang shen Jufan ZHANG David CULLITON Ruslan MELENTIEV Fengzhou FANG Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) School of Mechanical and Materials EngineeringUniversity College DublinDublin 4Ireland Department of Aerospace Mechanical and Electronic EngineeringInstitute of Technology CarlowCarlowIreland State Key Laboratory of Precision Measuring Technology and Instruments Centre of Micro/Nano Manufacturing Technology(MNMT)Tianjin UniversityTianjin 300072China

The tribological performance of artificial joints is regarded as the main factor of the lifespan of implanted prostheses. The relationship between surface roughness and coefficient of friction (COF) under dry and lubricated conditions is studied. Results show that under dry test, friction coefficient is not reduced all the time with a decrease in surface roughness. On the contrary, a threshold of roughness value is observed, and frictional force increases again below this value. This critical value lies between 40 and 100 nm in Sa (roughness). This phenomenon is due to the transfer of friction mechanisms from abrasion to adhesion. Under wet test, COF always decreases with reduction in surface roughness. This result is mainly attributed to the existence of a thin layer of lubricant film that prevents the intimate contact of two articulating surfaces, thus greatly alleviating adhesion friction. Furthermore, surface texturing technology is successful in improving the corresponding tribological performance by decreasing friction force and mitigating surface deterioration. The even-distribution mode of texturing patterns is most suitable for artificial joints. By obtaining the optimal surface roughness and applying texturing technology, the tribological performance of polymer-based bioimplants can be greatly enhanced.

关键词： artificial joints surface roughness friction surface texturing

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印文誊录与汉代地方行政:基于简牍公文书的讨论

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中州学刊 2024年第2期 132-140页

作者：沈刚吉林大学“古文字与中华文明传承发展工程”协同攻关创新平台、吉林大学古籍研究所吉林长春130012

汉代简牍文书誊录了一些印文内容,在文书作业的不同环节,各有特色。文书传行环节多数照实抄录,但有时简写印文或简述印文,比如机构和官称的省写,也有对印章责任人所做的描述性誊录,这些都以能准确辨识发文者为原则。西北地区简牍的收文... 详细信息

汉代简牍文书誊录了一些印文内容,在文书作业的不同环节,各有特色。文书传行环节多数照实抄录,但有时简写印文或简述印文,比如机构和官称的省写,也有对印章责任人所做的描述性誊录,这些都以能准确辨识发文者为原则。西北地区简牍的收文记录则几乎完全照录印文,而长沙东汉简牍中的收文记录则由发文者事先写就,比印文内容更翔实。传的印文也会被关吏忠实记录下来。汉代公文书印文誊录,反映了地方行政事务责任落实到人,秉承灵活务实原则,其流程不断优化,更加简洁、高效等特征。

关键词：汉代简牍印文地方行政

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Tribological Performance of Bioimplants: A Comprehensive Review

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Nanotechnology and Precision Engineering 2018年第2期1卷 107-122页

作者： gang shen Fengzhou Fang Chengwei Kang Centre of Micro/Nano Manufacturing Technology University College Dublin Centre of Micro/Nano Manufacturing Technology Tianjin University

Total joint replacements(TJR) have been a huge success for orthopaedic surgery in the past century and are gaining increasing importance today due to the aging population. However, the short longevity of artificial joints is one of the major problems in bioimplant industry and needs to be rectified since an increasing number of young people, with more active lifestyles, must receive TJR. Wear mechanisms are discussed in this paper to describe the root causes of the failures and to give some general ideas to increase the lifespan of artificial joints. The suitable material combination is of great importance for the wear resistance of bioimplants, and bioceramics will exert a crucial effect in their future progress. Other materials, such as metal alloys and polymers, are also discussed in this paper. Surface finish is another factor affecting the tribological performance of bioimplants. In recent years, surface texture technology has fascinated many researchers, and a good design of texture pattern requires a comprehensive understanding of wear mechanisms, material properties, and dynamic fluid theory. This review also covers a summary of in vitro wear tests, including simulators, lubricant, and testing parameters.

关键词： Total joints replacement Wear mechanisms Surface texture Wear tests

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late stroke.Indeed,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain tissue.Our previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently unclear.To simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic stroke.We found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous acid.Further,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid hydrazide.Our results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/reoxygenation.However,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and astrocytes.This suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion injury.Lower levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-catenin.By transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear translocation.Altogether,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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基于扩张滑模观测器的电液伺服系统鲁棒控制

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浙江大学学报（工学版） 2024年第3期58卷 611-621页

作者：臧万顺沈刚赵军臧克江青岛理工大学信息与控制工程学院山东青岛266520 安徽理工大学安徽省煤矿安全采掘装备制造业创新中心安徽淮南232001 安徽理工大学机电工程学院安徽淮南232001 山东科技大学交通学院山东青岛266590 龙岩学院物理与机电工程学院福建龙岩364012

为了提高电液伺服系统(EHSSs)控制性能,考虑外部干扰力、摩擦力、参数变动、结构振动及未建模特性等系统不确定性,构建系统状态空间模型.为了应对系统不确定性,提出新型扩张滑模观测器(ESMO),用于同时估计系统全状态和系统不确定性,并... 详细信息

为了提高电液伺服系统(EHSSs)控制性能,考虑外部干扰力、摩擦力、参数变动、结构振动及未建模特性等系统不确定性,构建系统状态空间模型.为了应对系统不确定性,提出新型扩张滑模观测器(ESMO),用于同时估计系统全状态和系统不确定性,并结合等值注入原理及饱和函数进行合理优化.利用系统不确定性的估计值,在反步控制设计中引入障碍Lyapunov函数,将系统的跟踪误差约束在一定范围内,结合参数自适应律,提高系统控制性能.为了验证所提控制方法的性能,在MATLAB/Simulink软件平台构建仿真模型,进一步地,搭建电液伺服系统实验台及实时控制系统,进行仿真和实验验证.结果表明所提方法的性能优于基于障碍Lyapunov函数的反步控制器及传统的反步控制器.

关键词：电液伺服系统系统不确定性扩张滑模观测器参数自适应障碍Lyapunov函数反步控制

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In vitro evaluation of artificial joints: a comprehensive review

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Advances in Manufacturing 2019年第1期7卷 1-14页

作者： gang shen Ju-Fan Zhang Feng-Zhou Fang Centre of Micro/Nano Manufacturing Technology (MNMTDublin) University College Dublin Dublin Ireland State Key Laboratory of Precision Measuring Technology and Instruments Centre of Micro/Nano Manufacturing Technology (MNMT) Tianjin University Tianjin 300072 People's Republic of China

Development of artificial joints is a great progress for joint replacement operations of human being, but the short longevity of prostheses has concerned both industries and researchers since the advent of modem implants. Thus, continuous improvements have been made alongside the clinical applications. The methodologies to inspect the potential properties of new designs have also seen many advances. The test machines have evolved from easy pin-on-disk configuration to the modem joint simulator. Besides, various wear traces provided by testing machines are investigated greatly, and multi-directional files are recommended as motion profiles for in vitro testing. The typical testing parameters, like sliding speed or loading profile, are discussed in this article, and their working mechanisms are described in detail. Meanwhile, the calf or bovine serum has been regarded as the gold standard for testing lubricant, and the future trend of fluid will be focused on investigating the effects of lubricant composites on the tribological properties. Hard particles and proteins are discussed as well, and their effects on the wear mechanisms are the focus. Finally, various approaches to measure the wear rate, wear factor and the thickness of lubricant film are presented, and suggestions are given for the development in future.

关键词： Artificial joint Methodology Testing parameter Wear rate

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单绳缠绕式矿井提升机制动瞬态冲击抑制策略

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华南理工大学学报（自然科学版） 2024年第3期52卷 141-150页

作者：解辉沈刚刘东汤裕朱真才中国矿业大学机电工程学院江苏徐州221000 安徽理工大学机电工程学院安徽淮南232000 中国船舶集团有限公司第七一三研究所河南郑州450015

在矿井提升机的制动控制中,制动瞬态冲击是影响矿井提升机安全可靠运行的关键问题。由于受到技术和经济成本的制约,目前包含贴闸/压紧的制动过程全程采用力闭环控制,这不可避免地导致闸瓦与闸盘刚性接触时的制动力瞬态冲击问题。针对矿... 详细信息

在矿井提升机的制动控制中,制动瞬态冲击是影响矿井提升机安全可靠运行的关键问题。由于受到技术和经济成本的制约,目前包含贴闸/压紧的制动过程全程采用力闭环控制,这不可避免地导致闸瓦与闸盘刚性接触时的制动力瞬态冲击问题。针对矿井提升机制动瞬态冲击问题,文中提出了一种基于滞回切换原理的混合贴闸/压紧制动控制策略。首先,分别利用非奇异快速终端滑模控制和反步控制设计了贴闸和压紧控制器;其次,为达到快速贴闸的目的,设计了一种基于离散积分器的在线贴闸轨迹再规划方法,有效地减小了制动器贴闸时间;然后,为实现由贴闸控制到压紧控制的安全切换,利用滞回切换原理,制定了混合贴闸/压紧控制稳态切换策略,大大减小了制动力瞬态冲击;最后,为验证提出方法的有效性,选择传统全程力闭环控制策略C1与混合贴闸/压紧直接切换策略C2作为对比方法,在单绳缠绕式提升试验台进行了对比实验,从贴闸时间、制动力最大跟踪误差和提升钢丝绳最大张力3个方面对实验结果进行了分析。实验结果表明:相较于C1控制策略,提出制动控制策略的贴闸时间缩短了64.5%,钢丝绳张力峰值减小了41 N;相较于C2控制策略,提出制动控制策略的制动力冲击减小了90.3%,钢丝绳张力峰值减小了88 N。上述结果表明本文提出的方法能有效改善制动瞬态冲击,减小制动空动时间,提高制动系统安全性,同时本研究也为一类需要混合力/位置控制的电液伺服系统提供了一种有效的解决方法。

关键词：矿井提升机制动系统瞬态冲击非线性控制混合力/位置控制约束轨迹规划

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Implementations of newly developed wheel and rail profile design methods

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Journal of Traffic and Transportation Engineering(English Edition) 2014年第3期1卷 221-227页

作者： gang shen Xiaobo Zhong Institute of Railway and Urban Mass Transit Tongji University

The developments of a series of wheel or CADF contact functions are briefly described. profile computer aided methods based on the RRDF Since 2001 the implementations of these methods are carded out according to different requirements for tramway vehicles, metro vehicles, and main line EMU vehicles etc. It is found that the main advantage of these new methods in wheel profile design is obtaining the proper wheel profiles to efficiently reduce the wears of wheel and rail and to improve the performances of both stability and curving performances. Moreover, post process of transfering a profile with discrete points to a profile with arc and line combinations is studied with a high precision.

关键词： wheel profile design method RRDF CADF

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