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Genome of striped eel catfish(Plotosus lineatus) provides insights into the adaptive evolution of amphidromous fish

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Zoological Research 2023年第2期44卷 349-352页

作者： Feng shao Ze-Chen Wu Yuan Xu Ping Li Zuo-gang Peng Key Laboratory of Freshwater Fish Reproduction and Development(Ministry of Education) Southwest University School of Life SciencesChongqing 400715China College of Fisheries Southwest UniversityRongchangChongqing 402460China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXiningQinghai 810008China

DEAR EDITOR,Dramatic changes in habitat can have a range of effects on organisms(Bi & Zhang, 2021). Plotosus lineatus is a representative fish within Ostariophysi showing adaptation from freshwater habitats to the ocean. Here, we sequenced the genome of P. lineatus using long-read and Hi-C sequencing technology. Based on the high-quality chromosome-level genome, we explored the molecular basis of various P. lineatus features, including large genome with fewer chromosomes, novel dendritic organ(DO).

关键词： technology evolution habitat

Evidence for Anticancer Effects of Chinese Medicine Monomers on Colorectal Cancer

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Chinese Journal of Integrative Medicine 2022年第10期28卷 939-952页

作者： GUO Tian-hao LI Yuan-yuan HONG Sheng-wei CAO Qian-yu CHEN Heng XU Yuan DAI Guo-liang shao gang The First Clinical Medical College Nanjing University of Chinese MedicineNanjing(210023)China Department of Clinical Pharmacology Afﬁliated Hospital of Nanjing University of Chinese MedicineNanjing(210029)China

Colorectal cancer is one of the most commonly occurring cancers worldwide. Although clinical reports have indicated the anticancer effects of Chinese herbal medicine, the multiple underlying molecular and biochemical mechanisms of action remain to be fully characterized. Chinese medicine(CM) monomers, which are the active components of CM, serve as the material basis of the functional mechanisms of CM. The aim of this review is to summarize the current experimental evidence from in vitro, in vivo, and clinical studies for the effects of CM monomers on colorectal cancer prevention and treatment, providing some useful references for future research.

关键词： colorectal cancer Chinese medicine monomer anticancer effect experimental evidence

Radio-granular hydrogels for image-guided tumor brachytherapy

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iLIVER 2023年第3期2卷 177-179页

作者： Shilong shao Xiao Xu Gan Lin gang Liu State Key Laboratory of Vaccines for Infectious Diseases Center for Molecular Imaging and Translational MedicineXiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchSchool of Public HealthXiamen UniversityXiamen 361005Fujian ProvinceChina State Key Laboratory of Cellular Stress Biology Innovation Center for Cell BiologySchool of Life SciencesXiamen UniversityXiamen 361005Fujian ProvinceChina Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM)&Amoy Hopeful Biotechnology Co. Ltd.Xiamen 361028Fujian ProvinceChina

Transarterial radioembolization(TARE),derived from transarterial chemoembolization,embolizes tumor blood vessels and elicits tumor brachytherapy by using radionuclide-loaded microspheres,a promising therapeutic modality for locally advanced hepatocellular carcinoma(HCC)[1,2].However,the implementation of TARE in the clinic has been hampered by the lack of efficient radioembolization agents[3,4].

关键词： Hepatocellular carcinoma TARE Conversion therapy Theranostics

Probing the intriguing frictional behavior of hydrogels during alternative sliding velocity cycles

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摩擦:英文版 2023年第12期11卷 2329-2341页

作者： Yiming ZHAO gang YI Jiuyu CUI Ziqian ZHAO Yonggan YAN Luxing WEI Jinlong shao Hongbo ZENG Jun HUANG Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education National Demonstration Center for Experimental Mechanical Engineering EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China Shandong Key Laboratory of Advanced Organosilicon Materials and Technologies Zibo 256401China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada Department of Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue RegenerationJinan 250061China Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Jinan 250012China

Understanding the friction behavior of hydrogels is critical for the long-term stability of hydrogelrelated bioengineering applications.Instead of maintaining a constant sliding velocity,the actual motion of bio-components(e.g.,articular cartilage and cornea)often changes abruptly.Therefore,it is important to study the frictional properties of hydrogels serving under various sliding velocities.In this work,an unexpected low friction regime(friction coefficientμ<10^(-4) at 1.05×10^(-3) rad/s)was observed when the polyacrylamide hydrogel was rotated against a glass substrate under alternative sliding velocity cycles.Interestingly,compared with the friction coefficients under constant sliding velocities,the measuredμdecreased significantly when the sliding velocity changed abruptly from high speeds(e.g.,105 rad/s)to low speeds(e.g.,1.05×10^(-3) rad/s).In addition,μexhibited a downswing trend at low speeds after experiencing more alternative sliding velocity cycles:the measuredμat 1.05 rad/s decreased from 2×10^(-2) to 3×10^(-3) after 10 friction cycles.It is found that the combined effect of hydration film and polymer network deformation determines the lubrication and drag reduction of hydrogels when the sliding velocity changes abruptly.The observed extremely low friction during alternative sliding velocity cycles can be applied to reduce friction at contacted interfaces.This work provides new insights into the fundamental understanding of the lubrication behaviors and mechanisms of hydrogels,with useful implications for the hydration lubrication related engineering applications such as artificial cartilage.

关键词： hydrogel friction alternative sliding velocity ultra-low friction coefficient drag reduction

Sphingosine-1-Phosphate Protects Against the Development of Cardiac Remodeling via Sphingosine Kinase 2 and the S1PR2/ERK Pathway

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Current Medical Science 2022年第4期42卷 702-710页

作者： Hui YAN Hu ZHAO shao-wei YI Hang ZHUANG Dao-wen WANG Jian-gang JIANG Gui-fen SHEN Wuhan No.4 Hospital Wuhan Puai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Division of Cardiology Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Rheumatology and Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Cardiac remodeling is a common pathological change in various cardiovascular diseases and can ultimately result in heart failure.Thus,there is an urgent need for more effective strategies to aid in cardiac protection.Our previous work found that sphingosine-1-phosphate(S1P)could ameliorate cardiac hypertrophy.In this study,we aimed to investigate whether S1P could prevent cardiac fibrosis and the associated mechanisms in cardiac remodeling.Methods:Eight-week-old male C57BL/6 mice were randomly divided into a sham,transverse aortic constriction(TAC)or a TAC+S1P treatment group.Results:We found that S1P treatment improved cardiac function in TAC mice and that the cardiac fibrosis ratio in the TAC+S1P group was significantly lower and was accompanied by a decrease inα-smooth muscle actin(α-SMA)and collagen type I(COL I)expression compared with the TAC group.We also found that one of the key S1P enzymes,sphingosine kinase 2(SphK2),which was mainly distributed in cytoblasts,was downregulated in the cardiac remodeling case and recovered after S1P treatment in vivo and in vitro.In addition,our in vitro results showed that S1P treatment activated extracellular regulated protein kinases(ERK)phosphorylation mainly through the S1P receptor 2(S1PR2)and spurred p-ERK transposition from the cytoplasm to cytoblast in H9c2 cells exposed to phenylephrine.Conclusion:These findings suggest that SphK2 and the S1PR2/ERK pathway may participate in the anti-remodeling effect of S1P on the heart.This work therefore uncovers a novel potential therapy for the prevention of cardiac remodeling.

关键词： sphingosine-l-phosphate cardiac remodeling sphingosine kinase 2 sphingosine-1-phosphate receptor extracellular regulated protein kinase

Exit morphology and mechanical property of FDM printed PLA: influence of hot melt extrusion process

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Advances in Manufacturing 2023年第1期11卷 56-74页

作者： Yan-Hua Bian gang Yu Xin Zhao shao-Xia Li Xiu-Li He Chong-Xin Tian Zhi-Yong Li Institute of Mechanics Chinese Academy of SciencesBeijing100190People’s Republic of China School of Engineering Science University of Chinese Academy of SciencesBeijing100049People’s Republic of China Research Institute of 3D Printing Beijing City UniversityBeijing100083People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049People’s Republic of China

In order to study the hot melt extrusion process in fused deposition modeling(FDM),this study mainly explores the effects of printing temperature,heated block length,feeding speed on the exit morphology and mechanical properties of FDM printed Polylactic acid(PLA)samples.High-speed camera is used to capture the exit morphology of molten PLA just extruded to the nozzle.According to exit morphology,the outlet states of extruded molten material can be divided into four categories,namely,bubbled state,coherent state,expanding state,and unstable state.Tensile test results show that printing temperature,heated block length and printing speed have significant influence on tensile properties and fracture mode of FDM printed samples.When the heated block length is 15 mm and 30 mm,there is a ductile-brittle transition in fracture mode with the increase of printing speed.The printing process window under different heated block lengths and printing temperatures has been figured out and the distribution of printing process window under different printing speeds has been discussed.There is a maximum printing process window under the heated block length of 30 mm.This finding provides a frame work for performance prediction of FDM printed parts and theoretical guidance for expanding the scope of printing process window.

关键词： Fused deposition modeling(FDM) Polylactic acid(PLA) Exit morphology Tensile property Printing process window

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品种对三七根系构型的影响及其与品质的关系

南方农业学报 2024年第3期55卷 784-793页

作者：王梦琦魏富刚夏青杨绍周王宝英张金波蔡祖聪赵军南京师范大学地理科学学院江苏南京210023 文山苗乡三七科技有限公司云南文山663000 江苏省土壤利用与农业可持续发展工程研究中心江苏南京210023 江苏省地理信息资源开发与利用协同创新中心江苏南京210023

【目的】分析不同品种三七的根系形态指标及主根皂苷含量差异,探究根系形态特征与三七生物量及皂苷含量和累积量的关系,为基于三七根系形态特征的高品质三七品种选育提供理论依据。【方法】以苗乡三七1号(M1)、苗乡7号(M7)、苗乡8号(M8... 详细信息

【目的】分析不同品种三七的根系形态指标及主根皂苷含量差异,探究根系形态特征与三七生物量及皂苷含量和累积量的关系,为基于三七根系形态特征的高品质三七品种选育提供理论依据。【方法】以苗乡三七1号(M1)、苗乡7号(M7)、苗乡8号(M8)和文院紫七1号(Z1)4个三七品种的2年生植株为研究对象,利用根系扫描仪测定三七的根系形态指标,通过高效液相色谱法测定三七主根中主要皂苷的含量,同时测定三七的地上部和地下部生物量,并分析根系形态指标与三七生物量、根冠比及皂苷含量和累积量的相关性。【结果】不同三七品种的地上部、地下部生物量及根冠比存在一定差异,其中Z1的地上部鲜重最高,M1的地下部鲜重和干重最高,而M8的根冠比最大;不同三七品种的根系形态特征也存在差异,M7、M8和Z1的总根长、总根尖数和分枝数均显著大于M1(P2mm)根表面积、根体积与三七地上部和地下部生物量及皂苷累积量的相关性大于细根(根直径≤2 mm)。【结论】不同三七品种的根系形态特征、生物量、皂苷含量及累积量存在一定差异,且三七的总根表面积、根平均直径、总根体积等根系形态指标与三七的生物量和皂苷累积量关系密切,良好的根系形态特征对三七生长和品质形成至关重要。

关键词：三七品种根系形态皂苷累积量品质

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Novel Antifungal Antibiotic, WB Produced by the Fungus Strain 38

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Chinese Chemical Letters 1998年第9期9卷 833-834页

作者： Jun YANG Xiu Lan QI gang shao Yue Hu PEI Xin Sheng YAO (Department of Natural Medicinal Chemistry, Shenyang Pharmaceutical University Shenyang 110015)Susumu KITANAKA (Department of Pharmacognosy, College of Pharmacy, Nihon University, Japan) Dept. of Natural Medicinal Chemistry Shenyang Pharmaceutical University Shenyang 110015 China Department of Pharmacognosy College of Pharmacy Nihon University Japan

WE, a new antifungal antibiotic, was isolated from the soil fungus strain 38 against Pyricularia oryzae, and its structure was elucidated as 2-[(E)-3,5-dimethyl-3,4-dihydroxy-1-eptylenyl]-4-chloro-5-oxo-6-methyl-6,7-d... 详细信息

关键词： antifungal antibiotic WB structure elucidation

间断性人工重力可减轻模拟失重大鼠股动脉血管平滑肌细胞的凋亡

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心脏杂志 2024年第3期36卷 307-312页

作者：邓雨笛李少华白云刚马进蔡越空军军医大学基础医学院学员二大队陕西西安710032 空军军医大学航空航天医学系航空航天生理教研室陕西西安710032 空军军医大学西京医院心内科陕西西安710032

目的探讨间断性人工重力(intermittent artificial gravity,IAG)对模拟失重大鼠股动脉血管平滑肌细胞(femoral artery smooth muscle cells,FASMC)凋亡及血管重塑的作用。方法将30只8周龄的SD大鼠随机分为3组,每组10只,包括对照组(control group,CON)、模拟失重组(tail-suspended group,SUS)及模拟失重大鼠每日站立1 h的间断性人工重力组(standing group,STD)。用M30及TUNNEL染色法检测大鼠FASMC的凋亡情况;用Western blot法检测各组大鼠股动脉组织中蛋白Caspase-3、Bad、FasL、Bcl2及增殖相关蛋白PCNA的表达。结果与CON组比较,SUS组和STD组大鼠FASMC M30及TUNNEL染色阳性率显著增加(P<0.05);STD组M30及TUNNEL染色阳性率较SUS组显著减少(P<0.05)。SUS组大鼠股动脉组织蛋白Bad、FasL及Caspase-3的表达较CON组和STD组显著增多(P<0.05),STD组Bad、FasL及Caspase-3的表达较CON组显著增加(P<0.05)。STD组凋亡抑制因子Bcl2及增殖相关蛋白PCNA的表达较CON组及SUS组皆显著增加(P<0.05)。结论IAG对抗可有效减轻模拟失重致FASMC的凋亡,表明IAG对抗在失重引起的大鼠股动脉血管适应性重建中发挥重要作用。

关键词：间断性人工重力模拟失重股动脉血管平滑肌细胞凋亡