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Numerical simulation on recrystallization behavior and microstructure evolution during hot continuous rolling process of 38CrMoAl steel rod

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Journal of Iron and Steel Research International 2022年第10期29卷 1633-1645页

作者： Fei Li Li-wen Zhang Chi Zhang Kang-jie Song Pei-gang mao School of Materials Science and Engineering Dalian University of TechnologyDalian116024LiaoningChina

The control of microstructure during hot rolling process of steel is of great importance and will affect the properties of the steel *** to the production line,a three-dimensional multi-field coupled finite element model of 24-pass continuous hot rolling process of 38CrMoAl steel rod is established using the finite element software *** on the recrystallization kinetics model and the grain growth model,a subroutine written in Fortran is introduced to calculate the recrystallization behavior and microstructure evolution of 38CrMoAl steel during the entire rolling *** distribution and evolution of variables such as strain,temperature and recrystallization fractions during the rolling process are *** temperature variations and grain sizes at both the center and surface of the tested steel are compared with the experimental *** it is found that the simulation results are in good agreement with the experimental ones,confirming the reliability of the established model.

关键词： 38CrMoAl steel Recrystallization Microstructure evolution Hot rolling process Numerical simulation

Thermal Conductivity of Complex Plasmas Using Novel Evan-Gillan Approach

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Communications in Theoretical Physics 2018年第6期69卷 704-710页

作者： Aamir Shahzad Syed Irfan Haider Muhammad Kashif Muhammad Shahzad Shifa Tariq Munir mao-gang He Molecular Modeling and Simulation Laboratory Department of PhysicsGovernment College University Faisalabad(GCUF)Allama Iqbal RoadFaisalabad 38040Pakistan Key Laboratory of Thermo-Fluid Science and Engineering Ministry of Education(MOE)Xi'an Jiaotong UniversityXi'an 710049China

The thermal conductivity of complex fluid materials （dusty plasmas） has been explored through novel Evan-Gillan homogeneous non-equilibrium molecular dynamic （HNEMD） algorithm. The thermal conductivity coefficient obtained from HNEMD is dependent on various plasma parameters （T,k）. The proposed algorithm gives accurate results with fast convergence and small size effect over a wide range of plasma parameters. The cross microscopic heat energy current is discussed in association with variation of temperature （1/Г） and external perturbations （Pz）. The thermal conductivity obtained from HNEMD simulations is found to be very good agreement and more reliable than previously known numerical techniques of equilibrium molecular dynarnic, nonequilibrium molecular dynamic simulations. Our new investigations point to an effective conclusion that the thermal conductivity of complex dusty plasmas is dependent on an extensive range of plasma coupling （P） and screening parameter （k） and it varies by the alteration in these parameters. It is also shown that a different approach is used for computations of thermal conductivity in 2D complex plasmas and can be appropriate method for behaviors of complex systems.

关键词： complex dusty plasma homogenous nonequilibrium molecular dynamics canonical ensemble scaling law thermal conductivity Yukawa liquids

Exosomes derived from microRNA-540-3p overexpressing mesenchymal stem cells promote immune tolerance via the CD74/nuclear factor-kappaB pathway in cardiac allograft

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World Journal of Stem Cells 2024年第12期16卷 1022-1046页

作者： Ji-gang He Xin-Xin Wu Si Li Dan Yan Gao-Peng Xiao Fu-gang mao Department of Cardiovascular Surgery The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Yunnan University of Traditional Chinese Medicine Kunming 650500Yunnan ProvinceChina Department of Medical Intensive Care Unit The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Department of Anaesthesia The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Department of Ultrasonic The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina

BACKGROUND Heart transplantation is a crucial intervention for severe heart failure,yet the challenge of organ rejection is *** marrow mesenchymal stem cells(BMSCs)and their exosomes have demonstrated potential in modulating T cells,dendtitic cells(DCs),and cytokines to achieve immunomodulatory ***,as key antigen-presenting cells,play a critical role in shaping immune responses by influencing T-cell activation and cytokine *** this modulation,BMSCs and their exosomes enhance graft tolerance and prolonging *** To explore the immunomodulatory effects of exosomes derived from BMSCs overexpressing microRNA-540-3p(miR-540-3p)on cardiac allograft tolerance,focusing on how these exosomes modulating DCs and T cells activity through the CD74/nuclear factor-kappaB(NF-κB)*** Rat models were used to assess the impact of miR-540-3p-enhanced exosomes on immune tolerance in cardiac ***-540-3p expression was manipulated in BMSCs,and derived exosomes were collected and administered to the rat models post-heart *** study monitored expression levels of major histocompatibility complex II,CD80,CD86,and CD274 in DCs,and quantified CD4^(+)and CD8^(+)T cells,T regulatory cells,and cytokine *** Exosomes from miR-540-3p-overexpressing BMSCs lead to reduced expression of immune activation markers CD74 and NF-κB p65 in DCs and T *** treated with these exosomes showed decreased inflammation and improved cardiac function,indicated by lower levels of pro-inflammatory cytokines(interleukin-1β,interferon-γ)and higher levels of anti-inflammatory cytokines(interleukin-10,transforming growth factorβ1).Additionally,miR-540-3p skewed the profiles of DCs and T cells towards immune tolerance,increasing the ratio of T regulatory cells and shifting cytokine secretion to favor graft *** Exosomes derived from BMSCs overexpressing miR-540-3p significantly enhance immune tolerance and prolo

关键词： Bone marrow mesenchymal stem cells Exosomes MicroRNA-540-3p Cardiac allograft Immune tolerance

DRBin:metagenomic binning based on deep representation learning

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Journal of Genetics and Genomics 2022年第7期49卷 681-684页

作者： gang mao Yulin Wu Yang Zhang Xuan Wang Yan Zhu Bo Liu Yadong Wang Junyi Li School of Computer Science and Technology Harbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055China College of Science Harbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055China Technology(Shenzhen) ShenzhenGuangdong 518055China Center for Bioinformatics School of Computer Science and TechnologyHarbin Institute of TechnologyHarbinHeilongjiang 150001China

Metagenomic binning is the process of sorting genome or contig sequences obtained by metagenomic sequencing of environmental DNA or genetically heterogeneous groups of organisms into categories representing the individual species or genetically homogenous groups (e.g., strains) from which they originated (Rasheed and Rangwala, 2013). Conventionally, whole-genome sequencing of single species requires culture and isolation of microorganisms.

关键词： originated representing sorting

Localized Surface Plasmons Enhanced Ultraviolet Emission of ZnO Films

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Chinese Physics Letters 2011年第5期28卷 256-259页

作者： LIU Yan-Song LU Hai-Fei XU Xiao-Liang GONG mao-gang LIU Ling YANG Zhou Department of Physics University of Science and Technology of ChinaHefei 230026

ZnO and ZnO/Agfilms are grown on Si(111)substrates by rf magnetron sputtering at room *** annealing,it is found that the ultraviolet(UV)emission of ZnO/Ag films strongly depends on the thickness of the initial internal Ag *** the annealing process,Ag nanoparticles are formed and diffused into the ZnO *** resonant coupling between localized surface plasmons(LSPs)of Ag nanoparticles and ZnO enhances the UV *** largest UV enhancement over 12 times is found when the initial internal Ag layer is *** is also observed that the diffusion of Ag nanoparticles destroys the ZnO crystal quality in different grades,depending on the sizes of the Ag *** poor crystal quality induces bad UV *** is concluded that the UV emission is the result of the competition between the LSP enhancement and the thermal diffusion destroying effect from Ag nanoparticles.

关键词： nanoparticles Si(111) annealing

Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents

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Chinese Chemical Letters 2014年第4期25卷 589-592页

作者： Xiu-Jun Wang Ming-Li Yang Lan-Ping Zhang Tong Yao Cheng Chen Lian-gang mao Yin Wang Jie Wu The 716th Institute of CSIC JARI Pharmaceutical Co. Ltd. Department of Pharmaceutical Engineering Wuhan Bioengineering Institute

A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95μmol/L （mononuclear tumor cell line （U937）） and 5.58 μmol/L （cervical cancer cell （HeLa））. Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA.

关键词： Bis-benzimidazole Anti-tumor DNA minor groove

LDFF,the large molecular weight DNA fragmentation factor,is responsible for the large molecular weight DNA degradation during apoptosis in Xenopus egg extracts

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Cell Research 2004年第2期14卷 134-140页

作者： Zhi gang LU, Chuan mao ZHANG~*, Zhong He ZHAI~* Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, China. Department of Cell Biology and Genetics College of Life Sciences Peking University Beijing China

DNA degradation is a biochemical hallmark in apoptosis. It has been demonstrated in many cell types that there are two stages of DNA fragmentation during the apoptotic execution. In the early stage, chromatin DNA is cut into large molecular weight DNA fragments, although the responsible nuclease(s) has not been recognized. In the late stage, the chromatin DNA is cleaved further into short oligonucleosomal fragments by a well-characterized nuclease in apoptosis, the caspase-activated DNase (CAD/DFF40). In this study, we demonstrate that large molecular weight DNA fragmentation also occurs in Xenopus egg extracts in apoptosis. We show that the large molecular weight DNA fragmentation factor (LDFF) is not the Xenopus CAD homolog XCAD. LDFF is activated by caspase-3. The large molecular weight DNA fragmentation activity of LDFF is Mg2+-dependent and Ca2+-independent, can occur in both acidic and neutral pH conditions and can tolerate 45℃ treatment. These results indicate that LDFF in Xenopus egg extr

关键词： apoptosis caspase-activated DNase (CAD) large molecular weight DNA fragmentation factor (LDFF).

Single-stage Posterior Spondylectomy, Circumferential Decompression and Reconstruction Using Mesh Cage for Spinal Tumors

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Chinese Medical Sciences Journal 2009年第3期24卷 172-177页

作者： Yong Zhu Hong Zhao Giu-xing Qiu Jian-guo Zhang Ye Tian Shu-gang Li Suo-mao Yuan Department of Orthopedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To explore the feasibility and clinical results of circumferential decompression and three column reconstruction through single-stage posterior transpedicular approach for spinal tumor treatment. Methods Totally, 24 patients with spinal tumor underwent tumor resection and spinal reconstruc tion through single-stage posterior transpedicular approach. Preoperatively, according to the Frankel classification, 12 patients were grade E, 9 grade D, and 3 grade C. Anterior column was reconstructed with non-expandable titanium cages. Posterior segmental instrumentation was used to maintain the stability of spine in all cases. Anterior and posterolateral fusion was performed with autograft and allogenic bone. The following data were followed up in these patients: deformity angle, local recurrence, neurological function, and spinal bony fusion. Results The average operating time and blood loss was 5.6 hours and 3 400 ml respectively. No intraoperative and postoperative complications were observed in this group. Postoperatively, 21 patients were Frankel grade E, 2 grade D, and 1 grade C. Four patients reported significant functional restoration and twenty patients reported complete resolution of pain. At follow-up (range, 6-42 months), implant failure or recurrent neurological symptoms was not found. Conclusions The tumor resection and spinal reconstruction through single-stage posterior transpedicular approach is a safe and effective technique for the treatment of spinal tumor. It can fully decompress the neurological structures, correct the kyphosis, and achieve early weight-bearing. This technique can improve life quality for the patients with spinal tumor.

关键词： spinal tumor vertebrectomy spinal reconstruction

Prospective study of transsphenoidal pituitary surgery： is tumor volume a predictor for the residual tumor？

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Chinese Medical Journal 2012年第14期125卷 2444-2448页

作者： Resha Shrestha QI Lei BAO gang WANG mao-de Department of Neurosurgery First Affiliated Hospital of MedicalSchool Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background The presence of residual tumor after surgery for pituitary adenoma may necessitate further treatment. The suprasellar and parasellar extension of the tumor have been widely considered as the predictors for residual tumor. However there is scarcity of studies regarding the preoperative tumor volume and residual tumor. This study was conducted to evaluate if tumor volume could predict the outcome of transsphenoidal pituitary surgery. Methods A prospective study was designed and 48 patients who underwent transsphenoidal pituitary surgery within 1 year in the First Affiliated Hospital of Xi＇an Jiaotong University were included in this study. The preoperative tumor volume and immediate postoperative tumor volume （within 4-7 days） were calculated in the contrast magnetic resonance imaging by using the formula of ellipsoid. All these volumes were divided into three subgroups, i.e. group 1, group 2 and group 3 with preoperative volume of less than 4 cm3, 4-8 cm3, and more than 8 cm3 respectively. The parasellar and suprasellar extension of the tumor were also classified by Knosp and modified Hardy＇s classifications. Results Baseline characteristics were comparable. The preoperative tumor volume of more than 8 cm3 （group 3, （12.1±1.1） cm3） had increased risk on postoperative tumor residue （P 〈0.01） than the other two groups （（2.1±0.3） cm3 and （6.1±0.3） cm3 in groups 1 and 2）. The mean postoperative volume in group 3 patients （（2.2±0.1） cm3） was significantly higher than the other two groups （P 〈0.01）. Conclusion Preoperative volume of more than 8 cm3 can be considered as a predictor for postoperative residual volume.

关键词： pituitary neoplasms, transsphenoidal approach, tumor volume, residual volume predictor