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新时代高职院校爱国主义教育:科学内涵、生成逻辑与实践路径

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职业技术教育 2024年第4期45卷 50-56页

作者：马宁符刚四川财经职业学院党政办成都610101 四川财经职业学院

2024年1月1日正式施行的《中华人民共和国爱国主义教育法》对新时代开展爱国主义教育明确了总体要求,强调各级各类学校应将爱国主义教育贯穿教育全过程,增强爱国主义教育的针对性、系统性和亲和力、感染力。高职院校作为培养专业技术人... 详细信息

2024年1月1日正式施行的《中华人民共和国爱国主义教育法》对新时代开展爱国主义教育明确了总体要求,强调各级各类学校应将爱国主义教育贯穿教育全过程,增强爱国主义教育的针对性、系统性和亲和力、感染力。高职院校作为培养专业技术人才的摇篮,肩负着为党育人、为国育才的重要使命,应从理想信念、精神力量、行为准则三个层面准确把握新时代爱国主义的科学内涵,深刻理解其历史逻辑、实践逻辑和价值逻辑,构建“五位一体”的协同育人机制,把握知信行循序渐进的内在转化逻辑,创新爱国主义教育方法与载体,推动爱国主义与技能教育融合共进,为中国式现代化建设培养具有家国情怀、堪当民族复兴大任的高素质技术技能人才。

关键词：《爱国主义教育法》爱国主义教育高职院校科学内涵生成逻辑实践路径

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中华肿瘤杂志 2024年第2期46卷 108-117页

作者：马刚梁寒张汝鹏孙意国家恶性肿瘤临床医学研究中心、天津市肿瘤防治重点实验室、天津市恶性肿瘤临床医学研究中心、天津医科大学肿瘤医院胃部肿瘤科天津300060 北京大学医学部基础医学院北京100191

目的探讨Ras相关结合蛋白23(RAB23)在食管鳞状细胞癌(简称食管鳞癌)细胞侵袭和迁移中的作用和机制。方法采用实时荧光定量聚合酶链反应检测16例配对食管鳞癌及癌旁正常组织中RAB23 mRNA的表达。比较基因表达综合(GEO)数据库的GSE20347... 详细信息

目的探讨Ras相关结合蛋白23(RAB23)在食管鳞状细胞癌(简称食管鳞癌)细胞侵袭和迁移中的作用和机制。方法采用实时荧光定量聚合酶链反应检测16例配对食管鳞癌及癌旁正常组织中RAB23 mRNA的表达。比较基因表达综合(GEO)数据库的GSE20347数据集中食管鳞癌和配对癌旁正常组织RAB23 mRNA的表达水平。免疫组织化学检测106例配对食管鳞癌和癌旁正常组织、33例淋巴结阳性与10例淋巴结阴性患者原发灶与淋巴结组织中RAB23蛋白含量。在食管鳞癌KYSE30和KYSE150细胞中瞬时敲降RAB23表达(转染si-RAB23-1和si-RAB23-9)或者稳定敲降RAB23表达(转染sh-RAB23), 采用Western blot法验证RAB23敲降效率, 采用细胞计数试剂盒8法和裸鼠皮下成瘤实验检测食管鳞癌细胞的增殖能力, 采用Transwell实验和裸鼠尾静脉-肺转移实验检测食管鳞癌细胞的侵袭和迁移能力, 采用细胞黏附实验检测食管鳞癌细胞的黏附能力, 采用转录组测序技术分析RAB23敲降后对细胞转录谱的影响, 并通过Western blot检测验证相关信号通路。结果 16例食管鳞癌组织中RAB23 mRNA表达水平为0.009 7±0.008 9, 高于癌旁正常组织[0.003 2±0.003 7, P=0.006]。对GEO数据库GSE20347数据集中食管鳞癌和配对癌旁正常组织表达谱的生信分析显示, 食管鳞癌组织中RAB23 mRNA表达水平为4.30±0.25, 高于癌旁正常组织(4.10±0.17, P=0.037)。106例食管鳞癌组织中, 51例RAB23低表达, 55例RAB23高表达;而配对癌旁正常组织中, 82例RAB23低表达, 24例RAB23高表达, 食管鳞癌组织中RAB23表达水平高于配对癌旁正常组织(P<0.001)。33例淋巴结阳性食管鳞癌组织中, 1例RAB23低表达, 32例RAB23高表达;10例淋巴结阴性的食管鳞癌组织中, 3例RAB23低表达, 7例RAB23高表达。淋巴结阳性食管鳞癌组织中RAB23表达水平高于淋巴结阴性食管鳞癌组织(P=0.024)。33例阳性淋巴结组织中, 1例RAB23低表达, 32例RAB23高表达, 而10例阴性淋巴结组织中均为RAB23低表达。阳性淋巴结组织中RAB23表达水平高于阴性淋巴结组织(P<0.001)。瞬时或稳定敲降RAB23后, KYSE30细胞体外和体内的增殖能力无明显变化, KYSE30细胞的细胞侵袭和迁移能力下降, 而KYSE150细胞仅侵袭能力下降, 迁移能力无明显变化。sh-RAB23组KYSE30细胞黏附细胞的数量为(313.75±89.34)个, 少于sh-NC组[(1 030.75±134.29)个, P<0.001]。sh-RAB23组KYSE150细胞的黏附细胞数为(710.5±31.74)个, 也少于sh-NC组[(1 005.75±61.09)个, P<0.001]。转录组测序分析显示, 敲降RAB23后, si-RAB23-1组和si-RAB23-9组KYSE30细胞中黏着斑相关信号通路均被削弱, sh-RAB23组KYSE30和KYSE150细胞中p-FAK和p-paxillin表达水平降低。结论 RAB23在食管鳞癌组织中高表达, 与淋巴结转移有关。敲低RAB23表达后能够削弱黏着斑相关信号通路, 进而抑制食管鳞癌细胞的侵袭、迁移和黏附。

关键词：食管鳞状细胞癌 Ras相关结合蛋白23 黏着斑侵袭迁移

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基于文献研究的精益建造与数字技术集成综述

同济大学学报（自然科学版） 2024年第1期52卷 145-156页

作者：刘刚马智亮李松阳清华大学土木水利学院北京100084 广联达科技股份有限公司北京100193

精益建造(LC)与数字技术集成是提高建筑业经济效益和生产效率的关键,也是近年来理论研究和实践创新的热点领域。鉴于目前尚无学者对精益建造与数字技术集成进行系统总结,针对国内外学术刊物发表的精益建造以及应用于建造领域与数字技术... 详细信息

精益建造(LC)与数字技术集成是提高建筑业经济效益和生产效率的关键,也是近年来理论研究和实践创新的热点领域。鉴于目前尚无学者对精益建造与数字技术集成进行系统总结,针对国内外学术刊物发表的精益建造以及应用于建造领域与数字技术相关的研究论文,采用文献计量学和重点文献分析等方法,进行系统分析和归纳。结果表明,数字技术(特别是建筑信息模型(BIM)技术)逐步成为精益建造应用推广的关键支撑,两者深度融合能产生正向协同效应,进一步提高项目管理效率并降低项目管理成本。

关键词：精益建造(LC)与数字技术集成建筑信息模型(BIM) 建造4.0 文献计量学分析

Reflection on micro RNAs in cancer: the next decade

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Science Bulletin 2015年第24期60卷 2142-2144页

作者： gang ma Zhihua Liu Department of Gastrointestinal Cancer Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy The State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

When researchers find molecules or pathways that are critical for development and homeostasis of cells,tumors always hijacked them for their own villainies.Thus,it is not surprising that dysregulation of micro RNAs in... 详细信息

关键词：下线服务迁移

植酸基生物涂层改善尼龙/棉混纺材料阻燃性能的研究

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塑料科技 2024年第5期52卷 62-65页

作者：王刚马丽包头轻工职业技术学院内蒙古包头014035

以植酸和L-半胱氨酸为原料,通过一锅法合成了植酸/半胱氨酸(PA/Cys)阻燃涂层,将制备的PA/Cys涂层喷涂到尼龙/棉混纺材料中,通过红外光谱法、热重分析仪、极限氧指数及垂直燃烧等测试,探究植酸基生物涂层对尼龙/棉混纺织物热稳定性、阻... 详细信息

以植酸和L-半胱氨酸为原料,通过一锅法合成了植酸/半胱氨酸(PA/Cys)阻燃涂层,将制备的PA/Cys涂层喷涂到尼龙/棉混纺材料中,通过红外光谱法、热重分析仪、极限氧指数及垂直燃烧等测试,探究植酸基生物涂层对尼龙/棉混纺织物热稳定性、阻燃性能和抑烟性能的影响。结果表明:PA/Cys喷涂能够显著改善尼龙/棉混纺材料的热稳定性、阻燃性能和抑烟性能。当PA/Cys喷涂两次时,尼龙/棉混纺材料的残炭率约为40%,较纯尼龙/棉混纺材料的残炭率提升了1.16倍。当PA/Cys喷涂两次时,尼龙/棉混纺织物的LOI值为26.6%,损毁长度为60 mm,续燃时间和阴燃时间均为0,TSP降至0.34 m^(2)。

关键词：植酸 L-半胱氨酸尼龙/棉混纺织物阻燃性能

maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late stroke.Indeed,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain tissue.Our previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently unclear.To simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic stroke.We found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous acid.Further,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid hydrazide.Our results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/reoxygenation.However,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and astrocytes.This suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion injury.Lower levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-catenin.By transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear translocation.Altogether,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

maslinic acid supplementation prevents di(2-ethylhexyl)phthalate-induced apoptosis via PRDX6 in peritubular myoid cells of Chinese forest musk deer

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Journal of Environmental Sciences 2024年第9期143卷 47-59页

作者： Heran Cao Zhenpeng Li Tianqi Jin Shuyang He Shujuan Liu Long Li Yang Wang Ye Gong gang Wang Fangxia Yang Wuzi Dong College of Animal Science and Technology Northwest A&F UniversityShaanxi 712100China College of Forestry Northwest A&F UniversityShaanxi 712100China Biology Research Centre of Qin-Mountains Wildlife Northwest A&F UniversityShaanxi 712100China Shaanxi Qiyuan-Times Agri-Tech Development Co.Ltd. Shaanxi 725000China

Chinese forest musk deer(FMD),an endangered species,have exhibited low reproductive rates even in captivity due to stress conditions.Investigation revealed the presence of di(2-ethylhexyl)phthalate(DEHP),an environmental endocrine disruptor,in the serum and skin of captive FMDs.Feeding FMDs with maslinic acid(ma)has been observed to alleviate the stress response and improve reproductive rates,although the precise molecular mechanisms remain unclear.Therefore,this study aims to investigate the molecular mechanisms underlying the alleviation of DEHP-induced oxidative stress and cell apoptosis in primary peritubular myoid cells(PMCs)through ma intake.Primary PMCs were isolated and exposed to DEHP in vitro.The results demonstrated that DEHP significantly suppressed antioxidant levels and promoted cell apoptosis in primary PMCs.Moreover,interfering with the expression of PRDX6 was found to induce excessive reactive oxygen species(ROS)production and cell apoptosis in primary PMCs.Supplementation with ma significantly upregulated the expression of PRDX6,thereby attenuating DEHP-induced oxidative stress and cell apoptosis in primary PMCs.These findings provide a theoretical foundation for mitigating stress levels and enhancing reproductive capacity of in captive FMDs.

关键词： maslinic acid Forest musk deer Di(2-ethylhexyl)phthalate Peritubular myoid cells PRDX6

Enhanced anomalous Hall effect in kagome magnet YbMn_(6)Sn_(6)with intermediate-valence ytterbium

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Chinese Physics B 2024年第5期33卷 43-50页

作者：李龙飞迟晟玮马文龙郭凯臻徐刚贾爽 International Center for Quantum materials School of PhysicsPeking UniversityBeijing 100871China Wuhan National High magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074China Interdisciplinary Institute of Light-Element Quantum materials and Research Center for Light-Element Advanced materials Peking UniversityBeijing 100871China Hefei National Laboratory Hefei 230088China

We report on the magnetization and anomalous Hall effect(AHE)in the high-quality single crystals of the kagome magnet YbMn_(6)Sn_(6),where the spins of the Mn atoms in the kagome lattice order ferromagnetically and the intermediate-valence Yb atoms are nonmagnetic.The intrinsic mechanism plays a crucial role in the AHE,leading to an enhanced anomalous Hall conductivity(AHC)compared with the other rare-earth RMn_(6)Sn_(6)compounds.Our band structure calculation reveals a strong hybridization between the 4f electrons of Yb and conduction electrons.

关键词： anomalous Hall effect kagome magnet intermediate valence

Regulating the intrinsic electronic structure of carbon nanofibers with high-spin state Ni for sodium storage with high-power density

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Journal of materials Science & Technology 2024年第4期171卷 16-23页

作者： Zhijia Zhang gang Xie Yuefang Chen Yanhao Wei Mengmeng Zhang Shulei Chou Yunxiao Wang Yifang Zhang Yong Jiang School of materials Science and Engineering Institute of Quantum Materials and DevicesState Key Laboratory of Separation Membrane and Membrane ProcessesTiangong UniversityTianjin 300387China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China Institute for Superconducting and Electronic materials University of WollongongWollongongNSW 2522Australia

Carbon nanofibers(CNFs)with high specific surface area show great potential for sodium storage as a hard carbon material.Herein,CNFs anchored with Ni nanoparticles(CNFs/Ni)were prepared through chemical vapor deposition and impregnation reduction methods,in situ growing on the three-dimensional porous copper current collector(3DP-Cu).The coupling effect of high-spin state Ni nanopar-ticles leads to the increase of defect density and the expansion of lattice spacing of CNFs.Meanwhile,the 3DP-Cu ensures a high loading capacity of CNFs and short ion/electron transport channels.As an integral binder-free anode,the 3DP-Cu/CNFs/Ni exhibits excellent electrochemical performance,which demon-strates a high specific capacity with 298.5 mah g^(-1)at 1000 ma g^(-1)after 1500 cycles,and a high power density with 200 mah g^(-1)over 1000 cycles at 5000 ma g^(-1).Density functional theory calculation re-sults show that the high-spin state Ni regulates the electronic structure of CNFs,which significantly reduces the adsorption energy for Na^(+)(-2.7 Ev)and thus enables high-rate capability.The regulation of the electronic structure of carbon materials by high-spin state metal provides a new strategy for developing high-power carbonaceous anode materials for sodium-ion batteries.

关键词： Carbon nanofibers Ni nanoparticles High-spin state Sodium-ion batteries Anode materials Density functional theory calculation