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Determining the Extratropical Transition Onset and Completion Times of Typhoons Mindulle (2004) and Yagi (2006) Using Four Methods

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Determining the Extratropical Transition Onset and Completio...

Patterns of lymph node metastasis are different in colon and rectal carcinomas

创新驱动发展提高气象灾害防御能力——第30届中国气象学会年会

作者： Qian Wang Qingqing Li gang fu National Meteorological Center of China Meteorological Administration Shanghai Typhoon Institute and Laboratory of Typhoon Forecast Technique/China Meteorological Administration Department of Marine Meteorology Ocean University of China

Four methods for determining the extratropical transition (ET) onset and completion times of Typhoons Mindulle (2004) and Yagi (2006) were compared using four numerically analyzed datasets. The open-w

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World Journal of Gastroenterology 2010年第42期16卷 5375-5379页

作者： Hao Wang Xian-Zhao Wei Chuan-gang fu fu-Ao Cao Rong-Hua Zhao Department of Colorectal Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China Department of Surgery College of Medicine University of Saskatchewan Saskatoon SK S7N0W8Canada

AIM:To describe patterns of lymph node metastasis in invasive colon and rectal carcinomas.METHODS:Clinical data of 2340 patients with colorectal carcinoma(stageⅠ to Ⅲ) who received radical resection,was retrospectively reviewed.Of the 2340 patients,1314 patients suffered from rectal carcinoma and 1026 from colon carcinoma.Patients with rectal cancer who received neoadjuvant chemoradiation therapy were excluded.Statistical analysis was performed using MannWhitney,χ 2 and Cochran's and Mantel-Haenszel tests(SPSS 15.0).A two-tailed P < 0.05 was considered statistically significant.RESULTS:Lymph node retrieval in the rectal carcinoma group was significantly lower than that in the colon carcinoma group(P < 0.001),while positive lymph node retrieval in the rectal carcinoma group was significantly higher than that in the colon carcinoma group(P < 0.001).The proportion of lymph node positive(N+) cases was higher(patients with one or more positive lymph nodes) in the rectal carcinoma group(P = 0.004).The number of N+ cases was compared at different T stages(T1-T4) to eliminate background bias and the results were confirmed(P < 0.001).In addition,the lymph node ratio(the ratio of number of positive lymph nodes over the number of lymph nodes examined) of stage Ⅲ cases in the rectal carcinoma group was significantly higher than that in the colon carcinoma group(P < 0.001).CONCLUSION:Rectal carcinomas seem more prone to metastasize to the lymph nodes than colon carcinomas,which may be of potential clinical significance.

关键词： Lymph node Metastasis Colon Rectum Neoplasms

Density functional Theory Study on Spin States of LaCoO3 at Room Temperature

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Chinese Journal of Chemical Physics 2014年第3期27卷 274-278页

作者： Xiang-bo Zhang gang fu Hui-lin Wan State Key Laboratory for Physical Chemistry of Solid Surfaces Department of Chemistry College ofChemistry & Chemical Engineering Xiamen University Xiamen 361005 China

在房间温度结构(293 K ) 的 perovskite LaCoO3 的电子结构被使用 PBE， PBE+U 和 HSE 计算。不同旋转配置被考虑了。我们的计算证明在在 HSE 的 DFT+U 和混合因素的 Hubbard U 参数的选择显著地象相对精力一样影响了乐队差距。因为旋... 详细信息

在房间温度结构(293 K ) 的 perovskite LaCoO3 的电子结构被使用 PBE， PBE+U 和 HSE 计算。不同旋转配置被考虑了。我们的计算证明在在 HSE 的 DFT+U 和混合因素的 Hubbard U 参数的选择显著地象相对精力一样影响了乐队差距。因为旋转退出了状态，为 U 的最佳的价值并且是 3.0 eV 并且 0.05 分别地。当时，我们的计算也强调了那 U5.0 eV， PBE+U 将导致无理的电子结构和精力顺序。

关键词： LaCoO3 密度泛函理论自旋态室温电子结构 PBE 计算表自旋结构

耐温480℃改性腈基树脂载体胶膜的制备及性能研究

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化学与粘合 2024年第4期46卷 330-334,367页

作者：张晓男王冠付刚吴鑫锐侯忠雨高堂铃吴健伟黑龙江省科学院石油化学研究院黑龙江哈尔滨150040 上海复合材料科技有限公司上海201112

采用自制的腈基化聚芳醚砜PESBPh、芳香胺S共改性联苯型邻苯二甲腈树脂DBPh,并将其与填料、促进剂等混合后与石英布复合制备出了一种耐温480℃、阻燃、低介电损耗的改性腈基树脂载体胶膜。研究结果表明,合成的PESBPh增韧树脂为目标产物... 详细信息

采用自制的腈基化聚芳醚砜PESBPh、芳香胺S共改性联苯型邻苯二甲腈树脂DBPh,并将其与填料、促进剂等混合后与石英布复合制备出了一种耐温480℃、阻燃、低介电损耗的改性腈基树脂载体胶膜。研究结果表明,合成的PESBPh增韧树脂为目标产物,适量的PESBPh和芳香胺S的加入改善了腈基树脂的成膜工艺性和韧性,冲击韧性提高至8.7 k J/m^(2)。胶膜经过250℃/6 h固化后,室温剪切强度为13.4 MPa,480℃剪切强度可达5.3 MPa,且在450℃连续使用60 min后,粘接强度保持率大于90%,胶膜介电损耗为0.013,阻燃达到V0级别。胶膜具有良好的自粘性并且室温适用期大于20 d,可作为耐温480℃等级粘接材料应用。

关键词：腈基树脂 480℃ 增韧低介电损耗阻燃

早期肠内营养支持对脓毒症患者营养状态、炎性反应及肠道菌群的影响

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临床医学工程 2024年第6期31卷 703-704页

作者：王建峰杨楠楠刘宁宁邢云飞付刚河南理工大学第一附属医院重症医学科河南焦作454000 河南理工大学第一附属医院病理科河南焦作454000

目的分析早期肠内营养支持在脓毒症患者治疗中的应用效果。方法20例脓毒症患者均给予常规治疗+早期肠内营养支持治疗,比较治疗前后的营养状态、炎性反应以及肠道菌群丰度。结果治疗后,脓毒症患者的HGB、Alb、TRF水平均高于治疗前,IL-6、... 详细信息

目的分析早期肠内营养支持在脓毒症患者治疗中的应用效果。方法20例脓毒症患者均给予常规治疗+早期肠内营养支持治疗,比较治疗前后的营养状态、炎性反应以及肠道菌群丰度。结果治疗后,脓毒症患者的HGB、Alb、TRF水平均高于治疗前,IL-6、TNF-α、PCT水平均低于治疗前,厌氧胞杆菌属丰度高于治疗前,梭菌属、考拉杆菌属、颤杆菌属、另枝菌属丰度均低于治疗前(P<0.05)。结论早期肠内营养支持可改善脓毒症患者的营养状态与炎性反应状态,调整肠道菌群丰度。

关键词：早期肠内营养支持脓毒症营养状态炎性反应肠道菌群

Microstructure, thermophysical property and ablation behavior of high thermal conductivity carbon/carbon composites after heat-treatment

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Chinese Journal of Aeronautics 2020年第5期33卷 1541-1548页

作者： Xue-Song LIU Qian-gang fu Hui WANG Qiang SONG State Key Laboratory of Solidification Processing Shannxi Province Key Laboratory of Fiber Reinforced Light Composite MaterialsNorthwestern Polytechnical UniversityXi'an 710072PR China

Uni-directional carbon/carbon composites with high thermal conductivity are suitable to supply continuous thermal protection for future reentry vehicles since they could reduce surface temperature and ablation rates simultaneously in harsh environments.In this work,the high thermal conductivity carbon/carbon composites were prepared by chemical vapor infiltration.After heat-treatment,both their open porosity and internal friction increase due to the fiber/matrix thermal expansion mismatch;while their thermal conductive performance become better due to more complete carbon structure.With raising heat-treatment temperature from 1800℃to 2450℃,the mass and linear ablation rates of C/C composites with fibers vertical to the oxyacetylene torch for 60 s decrease from 0.66 mg/s and 2.95μm/s to 0.51 mg/s and 2.05μm/s respectively.The improved ablation resistance is resulted from the increased thermal conductivity from 282 to 508 W/(m·K)and more carbon fibers exposed to the flame during ablation,which have better oxidation resistance than those of carbon matrix.While such ablation rates become larger for composites with fibers parallel to the flame,from 1.02 mg/s and 3.73μm/s to 1.28 mg/s and 5.0μm/s respectively since the ablation occurred more easily through gaps at the fiber/matrix interfaces,which become larger and are always exposed to the flame for this case.

关键词： Ablation Carbon/carbon composites Fiber orientation Heat treatment Thermal conductivity

材料组分对结构粘接用水基抑制腐蚀底胶性能影响

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化学与粘合 2024年第2期46卷 139-141,151页

作者：李文智王冠高堂铃付刚吴健伟苏帅王雪松航空工业直升机设计研究所江西景德镇333001 黑龙江省科学院石油化学研究院黑龙江哈尔滨150040

在铝合金零件的胶接工艺中,为延长粘接面的适用期限,改善粘接面的粘接性能,结构粘接用底胶应运而生。随着对环境友好型胶粘剂的要求日益提升,水基结构粘接用底胶受到日益关注。以实验室自制的环氧树脂水分散体为基体,以改性咪唑为促进剂... 详细信息

在铝合金零件的胶接工艺中,为延长粘接面的适用期限,改善粘接面的粘接性能,结构粘接用底胶应运而生。随着对环境友好型胶粘剂的要求日益提升,水基结构粘接用底胶受到日益关注。以实验室自制的环氧树脂水分散体为基体,以改性咪唑为促进剂,探究了固化剂、气相Si O2、偶联剂、抑制腐蚀剂对底胶性能的影响,并形成了一种相对优化的底胶制备方法。

关键词：水基结构粘接底胶性能分析

Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期35卷 207-212页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao Li fu Yuanyuan Hou gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300000China College of Life Health Dalian UniversityDalian 116622China Dalian fusheng Pharmaceutical Co. Ltd.Dalian 116000China

The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and diversity.Previous studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(PH)domain of AKT.However,the combined synergistic effect of relieving the inflammatory response has yet to be elucidated.Based on high sensitivity,specificity and fast-responsibility fluorescent sensors,the Förster resonance energy transfer(FRET)technique offers a route to provide clear insights into physiological and pathological processes.In the study,molecular docking,the fluorescent probes of Phi and Swe for FRET were designed and synthesized.FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT,respectively.The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration.In lipopolysaccharides(LPS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(NF-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8.In conclusion,FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

关键词： FRET Swertiamarin Phillygenin AKT Anti-inflammation Combinatorial drug

Thermo-hydro-poro-mechanical responses of a reservoir-induced landslide tracked by high-resolution fiber optic sensing nerves

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1018-1032页

作者： Xiao Ye Hong-Hu Zhu gang Cheng Hua-fu Pei Bin Shi Luca Schenato Alessandro Pasuto School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Computer Science North China Institute of Science and Technology(National Safety Training Center of Coal Mines)Beijing101601China State Key Lab of Coastal and Offshore Engineering Department of Geotechnical EngineeringDalian University of TechnologyDalian116024China National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy Department of Information Engineering University of PadovaPadova35131Italy

Thermo-poro-mechanical responses along sliding zone/surface have been extensively studied.However,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond the slip surface to progressive failure.Here,we aim to investigate the subsurface multiphysics of reservoir landslides under two extreme hydrologic conditions(i.***.wet and dry),particularly within sliding masses.Based on ultra-weak fiber Bragg grating(UWFBG)technology,we employ specialpurpose fiber optic sensing cables that can be implanted into boreholes as“nerves of the Earth”to collect data on soil temperature,water content,pore water pressure,and strain.The Xinpu landslide in the middle reach of the Three Gorges Reservoir Area in China was selected as a case study to establish a paradigm for in situ thermo-hydro-poro-mechanical monitoring.These UWFBG-based sensing cables were vertically buried in a 31 m-deep borehole at the foot of the landslide,with a resolution of 1 m except for the pressure sensor.We reported field measurements covering the period 2021 and 2022 and produced the spatiotemporal profiles throughout the borehole.Results show that wet years are more likely to motivate landslide motions than dry years.The annual thermally active layer of the landslide has a critical depth of roughly 9 m and might move downward in warmer years.The dynamic groundwater table is located at depths of 9e15 m,where the peaked strain undergoes a periodical response of leap and withdrawal to annual hydrometeorological cycles.These interface behaviors may support the interpretation of the contribution of reservoir regulation to slope stability,allowing us to correlate them to local damage events and potential global destabilization.This paper also offers a natural framework for interpreting thermo-hydro-poro-mechanical signatures from creeping reservoir bank slopes,which may form the basis for a landslide monitoring and early warning system.

关键词： Reservoir landslide Thermo-hydro-poro-mechanical response Ultra-weak fiber bragg grating(UWFBG) subsurface evolution Engineering geological interface Geotechnical monitoring