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Effect of freeze-thaw cycles on mechanical behavior of clay-gravel mixtures

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Journal of Mountain Science 2022年第12期19卷 3615-3626页

作者： ZHANG Yong-gan LIU Si-hong deng gang FANG Bin-xin ZHANG Yan-yi LU Yang College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Key Laboratory of Construction and Safety of Water Engineering of the Ministry of Water Resources China Institute of Water Resources and Hydropower ResearchBeijing 100048China

The use of clay-gravel mixtures(i.e.,adding excavated or natural gravel particles into clay soil matrix)as the main filling materials is increasing in the anti-seepage system of high Earth Core Rockfill Dams(ECRDs).With the continuous construction of high ECRDs in the Chinese plateaus and cold regions,it is of great urgency and importance to understand the physical and mechanical characteristics of compacted clay-gravel mixtures under freeze-thaw action.To this end,laboratory freezing-thawing tests,computed tomography(CT),and triaxial compression tests were conducted to evaluate the effects of freezethaw cycles on moisture loss,pore structure characteristics,stress-strain behavior,failure strength,elastic modulus,cohesion,and internal friction angle of compacted clay-gravel mixtures.The results demonstrate that,1)the freeze-thaw cycle significantly changed the mechanical characteristics of the clay-gravel mixture samples,but the shape of the stress-strain curve is less sensitive to it.2)The failure strength of samples exhibits a significant decrease after the first freeze-thaw cycle,but shows a certain increase as the number of freeze-thaw cycles increases from 1 to 2.3)The elastic modulus of samples first decreases and then increases with increasing freeze-thaw cycle,and the most severe deterioration was observed after the first freeze-thaw cycle.4)Regardless of the number of freeze-thaw cycles,there is a linear relationship between failure strength and elastic modulus for a sample that has suffered freeze-thaw weathering.5)The cohesion of samples decreases firstly and then slightly increases with increasing freeze-thaw cycles,while the internal friction angle is hardly affected.

关键词： Earth core rockfill dam Clay-gravel mixtures Freeze-thaw cycles Computed tomography Mechanical behavior

Endoscopic extraction of a submucosal esophageal foreign body piercing into the thoracic aorta:A case report

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World Journal of Clinical Cases 2022年第8期10卷 2484-2490页

作者： Zhi-Cao Chen Gui-Quan Chen Xiao-Chun Chen Chang-Ye Zheng Wei-Dong Cao gang-Hao deng Department of Gastroenterology Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina Department of Radiology Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina Department of Cardiovascular Surgery Affiliated Dongguan HospitalSouthern Medical UniversityDongguan 523000Guangdong ProvinceChina

BACKGROUND Aorto-esophageal injury is a rare but life-threatening complication of esophageal foreign bodies,which typically requires open surgery.The best way to treat patients with this condition remains unclear.To date,few reports have described an aortic wall directly penetrated by a sharp foreign body.Here,we present a rare case of a fishbone completely embedded in the esophageal muscularis propria and directly piercing the aorta,which was successfully treated by endoscopy and thoracic endovascular aortic repair(TEVAR).CASE SUMMARY We report the case of a 71-year-old man with a 1-d history of retrosternal pain after eating fish.No abnormal findings were observed by the emergency esophagoscopy.Computed tomography showed a fishbone that had completely pierced through the esophageal mucosa and into the aorta.The patient refused to undergo surgery for personal reasons and was discharged.Five days after the onset of illness,he was readmitted to our hospital.Endoscopy examination showed a nodule with a smooth surface in the middle of the esophagus.Endoscopic ultrasonography confirmed a fishbone under the nodule.After performing TEVAR,we incised the esophageal mucosa under an endoscope and successfully removed the fishbone.The patient has remained in good condition for 1 year.CONCLUSION Incising the esophageal wall under endoscope and extracting a foreign body after TEVAR may be a feasible option for cases such as ours.

关键词： Endoscopy Esophageal foreign body Esophageal perforation Aortic penetration Case report

基于CT的可视化三维成像在后腹腔镜肾根治性切除术中的应用

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国际泌尿系统杂志 2024年第1期44卷 114-117页

作者：邢力永刘志飞蔡启亮朱研峰邓刚唐山市人民医院泌尿外科唐山063000 天津医科大学第二医院泌尿外科(天津市泌尿外科研究所) 天津300211

目的探讨基于CT的可视化三维成像在后腹腔镜肾根治性切除术中的应用价值。方法回顾性分析2019年1月至2020年3月唐山市人民医院收治的40例行后腹腔镜肾根治性切除术患者的临床资料,根据是否行基于CT的可视化三维模型重建的术前评估将患... 详细信息

目的探讨基于CT的可视化三维成像在后腹腔镜肾根治性切除术中的应用价值。方法回顾性分析2019年1月至2020年3月唐山市人民医院收治的40例行后腹腔镜肾根治性切除术患者的临床资料,根据是否行基于CT的可视化三维模型重建的术前评估将患者分为研究组和对照组,每组各20例。研究组通过三维模型行术前评估,对照组通过强化CT、CT肾动脉血管造影(CTA)行术前评估,比较两组患者的术中出血量、手术时间、转开放手术例数、术后并发症、住院时间、术后肿瘤复发等临床资料。结果两组患者的年龄、性别、肿瘤大小、肿瘤分期、患侧比例、肾动静脉变异、术后并发症情况比较,差异均无统计学意义(均P>0.05)。研究组的手术时间、术中出血量、住院时间、术中转开放手术率均显著低于对照组(均P<0.05)。两组患者术后均未发生肿瘤复发与转移。结论腹腔镜肾根治性切除术患者术前进行基于CT的可视化三维重建,可明显减少术中副损伤发生,避免中转开放,缩短手术和住院时间,减少出血量。

关键词：肾肿瘤肾切除术腹腔镜检查体层摄影术 X线计算机

Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt

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World Journal of Gastroenterology 2013年第43期19卷 7778-7787页

作者： gang deng Xiang-Jun Huang Hong-Wu Luo Fei-Zhou Huang Xun-Yang Liu Yong-Heng Wang Department of Hepatobiliary and Pancreatic Surgery the Third Xiangya Hospital of Central South University

AIM:To investigate whether a virus constitutively expressing active Akt is useful to prevent cirrhosis induced by carbon tetrachloride(CCl4).METHODS:Using cre-loxp technique,we created an Ad-myr-HA-Akt virus,in which Akt is labeled by a HA tag and its expression is driven by myr promoter.Further,through measuring enzyme levels and histological structure,we determined the efficacy of this Ad-myrHA-Akt virus in inhibiting the development of cirrhosis induced by CCl4in rats.Lastly,using western blotting,we examined the expression levels and/or phosphorylation status of Akt,apoptotic mediators,endothelial nitric oxide synthase(eNOS),and markers for hepatic stellate cells activation to understand the underlying mechanisms of protective role of this virus.RESULTS:The Ad-myr-HA-Akt virus was confirmed using polymerase chain reaction amplification of inserted Akt gene and sequencing for full length of inserted fragment,which was consistent with the sequence reported in the GenBank.The concentrations of Admyr-HA-Akt and adenoviral enhanced green fluorescent protein(Ad-EGFP)virus used in the current study were5.5×1011vp/mL.The portal vein diameter,peak velocity of blood flow,portal blood flow and congestion index were significantly increased in untreated,saline and Ad-EGFP cirrhosis groups when compared to normal control after the virus was introduced to animal through tail veil injection.In contrast,these parameters in the Akt cirrhosis group were comparable to normal control group.Compared to the normal control,the liver function(Alanine aminotransferase,Aspartate aminotransferase and Albumin)was significantly impaired in the untreated,saline and Ad-EGFP cirrhosis groups.The Akt cirrhosis group showed significant improvement of liver function when compared to the untreated,saline and Ad-EGFP cirrhosis groups.The Hyp level and portal vein pressure in Akt cirrhosis groups were also significantly lower than other cirrhosis groups.The results of HE and Van Gieson staining indicated that Akt group has better preservation of h

关键词： Adenovirus Akt Gene transfer Apoptosis Cirrhosis Carbon tetrachloride Rat

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核电钢制安全壳埋弧横焊工艺研究

金属加工（热加工） 2024年第5期 47-52页

作者：孙健邓刚王建明曾凡勇程茁刘征中核辽宁核电有限公司辽宁葫芦岛125199 中国核工业第二二建设有限公司湖北武汉430050 中国核电工程有限公司北京100840

核电钢制安全壳筒体环缝焊接量较大,采用埋弧横焊工艺可有效提升焊接效率、保证焊接质量。针对42mm厚度的SA-738Gr.B钢板材开展了埋弧横焊工艺研究。结果表明:相比于K形坡口,采用X形坡口进行打底焊接更容易避免气孔和夹渣缺陷,分析认为... 详细信息

核电钢制安全壳筒体环缝焊接量较大,采用埋弧横焊工艺可有效提升焊接效率、保证焊接质量。针对42mm厚度的SA-738Gr.B钢板材开展了埋弧横焊工艺研究。结果表明:相比于K形坡口,采用X形坡口进行打底焊接更容易避免气孔和夹渣缺陷,分析认为采用气体保护焊打底+埋弧焊填充的焊接方式可有效保证打底焊接质量;采用不同热输入大小的焊接参数进行了埋弧横焊工艺试验,当热输入太小时,焊缝成形不良且容易产生未熔合缺陷;对不同热输入下的焊接接头进行了冲击韧度试验和硬度检测,结果均满足标准要求。通过本项研究,证明了钢制安全壳埋弧焊焊接质量可靠,焊接接头性能满足标准要求,为核电现场新工艺的推广应用提供了一定的指导。

关键词：钢制安全壳埋弧横焊焊接工艺接头性能

Study on Chemical Constituents of Ethanol Extract from Yao Medicine Cissampelopsis spelaeicola

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Medicinal Plant 2020年第2期11卷 21-24,29页

作者： Shuang LIANG Wenfang MA Kewen LIANG Lichun ZHAO gang deng Dongyang XIE College of Pharmacy Guangxi University of TCM Nanning 530001 China Guangxi Jianfeng Pharmaceutical Co. Ltd. Nanning 530104 China Guilin Niutai Biological Technology Co. Ltd. Guilin 541004 China

[Objectives]The research aimed to study the chemical constituents of ethanol extract from Yao medicine Cissampelopsis spelaeicola.[Methods]The petroleum ether,ethyl acetate and n-butanol fractions from 75%ethanol extract of C.spelaeicola were isolated and purified by silica gel,SephadexLH-20 gel column and AB-8 macroporous resin column,etc.The structures of the compounds were analyzed and identified by physicochemical properties and spectral data(mass spectrometry,hydrogen spectrum and carbon spectrum).[Results]Twelve compounds were isolated and identified from 75%ethanol extract of C.spelaeicola.β-sitostero(I)and stigmasterol(II)were isolated from petroleum ether fraction;p-hydroxybenzoic acid(III),β-daucossterol(IV),protocatechuic acid(V),6β-hydroxyeremophi-7(11)-en-12,8β-olide(VI),10β-hydroxyeremophil-7(11)-en-8,12-olide(VII),10β-hydroxyeremophi-7(11),8(9)-dien-8,12-olide(VIII),quercetin(IX),hyperin(X)and 4α-hydroxy-eudesman-11-ene(XI)were isolated from ethyl acetate fraction;quercetin-3-O-robinobioside(XII)was isolated from n-butanol fraction.Compounds I-XII were isolated from C.spelaeicola for the first time.[Conclusions]The study can lay material foundation for activity study of C.spelaeicola.

关键词： Cissampelopsis spelaeicola Chemical constituents Isolation and identification Structural identification

基于应用柔性开关的国产数据库迁移策略与实践

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民航学报 2024年第3期8卷 159-162页

作者：闫凯邓罡王婧贤梁策付雷王晔王东航中国民航信息网络股份有限公司

本文详述了一项针对民航关键信息系统中“旅客服务系统”的关键组成部分——开放消息交换引擎(OMSE)的国产数据库迁移工作。在面临成本上升和技术依赖风险的背景下,本项目成功实现了从成本高昂的Oracle和SQL Server数据库向成本效益更... 详细信息

本文详述了一项针对民航关键信息系统中“旅客服务系统”的关键组成部分——开放消息交换引擎(OMSE)的国产数据库迁移工作。在面临成本上升和技术依赖风险的背景下,本项目成功实现了从成本高昂的Oracle和SQL Server数据库向成本效益更高的国产数据库的平滑过渡。通过采用厂商提供的同步工具和开源ETL工具DataX,该项目在确保数据一致性的同时,对OMSE应用进行了改造,包括增加了数据源柔性切换功能,以实现业务的高可用性和连续性。此外,论文还介绍了全面的测试策略,确保了迁移过程的高质量和服务性能。这一成功案例不仅降低了成本,还提供了面对类似挑战的企业一种新的解决思路。

关键词：数据库迁移数据源切换业务连续性 OMSE

Activating Receptor NKp80 Involves in NK cell Activation and Cytotoxicity

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吴茱萸次碱对脂多糖致小鼠神经炎症和认知功能障碍的作用研究

第八届全国免疫学学术大会

作者： gang deng Rui Sun Institute of Immunology School of Life Sciences University of Science and Technology of China

NKp80, which is also termed KLRF1, the type II activating receptor on NK cell surface as NKG2 D, is thought to play a relevant role in NK cell mediated killing of malignant myeloid cells or infected cells.AICL, a ligand of NKp80, was defined as a myeloid-specific activating receptor that is up-regulated by Toll-like receptor stimulation during pathogen infection.Engagement of NKp80 and AICL is discussed not only to promote cytolysis of myeloid cells, but is also critically involved in the mutual activation of NK cells and monocytes through mediating inflammatory reaction and promoting cytokine release by autologous NK cells and monocytes.Although NKp80 was found and identified in previous work, the mechanism of mutual recognition between NKp80 and AICL in activating of NK and monocytes remains unclear.To address the role of NKp80 and AICL in cross-talk between NK cell and specific target cell, we achieved the ectodomains of NKp80 and AICL molecules with partial activity by soluble expression in E.coli system.In our previous work, the activities of soluble ectodomains of NKp80 and AICL expressed in E.coli system have already been identified.Toeliminate undefined factors in humanized protein expression by prokaryotic system, we achieved C-terminal NKp80-ED(ectodomain) and N-terminal h Ig G1-Fc fusion chimera by eukaryotic expression.Signal sequence from h IL-2 was placed at N-terminal for secretory expression.The chimera from highly-expression tranfected cell colonies cultured in serum-containing and serum-free supernatant was assessed to be productive as an expected dimer form.On the other hand, the specific expression and distribution of AICL mRNA and protein were detected positively in human cervix epithelial carcinoma cell line He La and human leukemic monocyte lymphoma cell line U937 among various tumor cell lines, which indicated the possibility of AICL as a mediator in NK cell cytosis of AICL-expressing malignant myeloid cells or tumor cells.Also, flow cytometry analysis of kinds of human NK cell lines showe

关键词： activating receptor NKp80 NK cell cytotoxicity

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世界中西医结合杂志 2024年第1期19卷 97-101页

作者：刘昌福邓钢龙春频刘星林欧阳敏萍乡卫生职业学院江西萍乡337000

目的研究吴茱萸次碱对脂多糖诱发的C57BL/6N小鼠学习记忆障碍的改善作用及其作用机制探讨。方法将54只7周龄C57BL/6N小鼠经水迷宫筛选合格后按随机数字表法分为对照组、模型组、多奈哌齐组、吴茱萸次碱低、中、高剂量组。除正常组注射... 详细信息

目的研究吴茱萸次碱对脂多糖诱发的C57BL/6N小鼠学习记忆障碍的改善作用及其作用机制探讨。方法将54只7周龄C57BL/6N小鼠经水迷宫筛选合格后按随机数字表法分为对照组、模型组、多奈哌齐组、吴茱萸次碱低、中、高剂量组。除正常组注射等体积生理盐水外,其他组腹腔注射2 mg/kg脂多糖溶液。造模成功后,正常组和模型组给予等体积0.9%生理盐水,多奈哌齐组给予5 mg/kg多奈哌齐、吴茱萸次碱低、中、高剂量组分别给予0.97 mg/kg、3.03 mg/kg、9 mg/kg吴茱萸次碱。连续给药2周后,以Morris水迷宫评价小鼠空间记忆能力。取脑进行HE和Tunel染色并以试剂盒测定脑组织中TNF-α、MDA、GSH-PX、GSH、IL-6、IL-10水平。结果与对照组比较,模型组C57BL/6N小鼠穿台次数明显减少,上台时间和距离明显增加,TNF-α、MDA、IL-6、IL-10水平明显升高,GSH-px和GSH水平和海马神经细胞明显减少。与模型组比较,5 mg/kg多奈哌齐和0.97 mg/kg、3.03 mg/kg、9.00 mg/kg吴茱萸次碱给药后使穿越平台次数明显增加,上台时间和距离明显降低,使脑内TNF-α、MDA、IL-10、IL-6水平明显降低,减少神经细胞的损伤,而5 mg/kg多奈哌齐和3.03 mg/kg、9.00 mg/kg吴茱萸次碱给药使GSH-px、GSH明显升高。结论吴茱萸次碱可以通过下调大脑内的炎症反应、氧化应激及修复海马的损伤来改善C57BL/6N小鼠的学习记忆障碍。

关键词：吴茱萸次碱记忆障碍炎症