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Frequency of IL-10-producing regulatory B cells associated with disease activity in thyroid-associated orbitopathy

International Journal of Ophthalmology(English edition) 2018年第9期11卷 1458-1462页

作者： Yun-gang ding Guo Chen Qian Li Xiao-Feng Wen Lai Wei Hua-Sheng Yang State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Qindao Ludong Eye Hospital Qingdao 266600Shandong ProvinceChina Ningxia Eye Hospital People's Hospital of Ningxia Hui Autonomous Regionthe First Clinical College of Northwest University for Nationalitiesthe Cooperative Teaching Hospital of North Minzu UniversityYinchuan 750001Ningxia Hui Autonomous RegionChina

AIM： To investigate the association between IL-10-producing regulatory B（B10） cells and the clinical features of thyroid-associated orbitopathy（TAO）. METHODS： A total of 30 patients with TAO were recruited at Zhongshan Ophthalmic Center from May 2015 to December 2015. Peripheral blood mononuclear cells（PBMCs） were separated from blood samples of 30 TAO patients and 16 healthy controls and stimulated with CD40 ligand and CpG for 48h. The frequency of IL-10＋ B cells was examined by flow cytometry and the correlation between the frequency of IL-10＋ B cells and clinical features of TAO was analyzed by SPSS. RESULTS： The frequency of IL-10＋ B cells among CD19＋ B cells in TAO patients was significantly lower than in healthy controls（TAO： 4.66%±1.88% vs healthy control： 6.82%±2.40%, P〈0.01）. The frequency of IL-10＋ B cells showed a positive correlation with disease activity of TAO measured by Clinical Activity Score（CAS）（r=0.50, P〈0.01）, and became higher in TAO patients with family history of Graves＇ disease（GD）（P=0.04）. CONCLUSION： The decrease of the frequency of IL-10＋ B cells in TAO patients indicates the deficiency of B10 cells in TAO, and the positive association with disease activity suggests its important role in TAO inflammation regulation.

关键词： thyroid-associated orbitopathy regulatory B cells interleukin-10 flow cytometry

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Possible interpretation of disciplinary issues in education

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Frontiers of Education in China 2009年第1期4卷 1-9页

作者： ding gang School of Education Science East China Normal UniversityShanghai 200062China

Education must go beyond the borders of the disciplines and educators must make individual learning development a top priority for education if they wish to fulfill their mission in theory and practice,and in order to promote the social development by cultivating and developing the different individual *** individual development is a public issue,not a personal affair,it is also a social ***,educational research bases itself on each type of development,as well as to its existence in the mosaic of social and cultural understanding of the ***,theoretical concept and empirical study combine an intrinsic pedagogical paradigm *** as a theoretical approach to methodology,awareness of the value of education and method-related activities,pedagogy becomes a special way of seizing the world.

关键词： education individual learning research paradigm

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Association of Red Meat Usual Intake with Serum Ferritin and the Risk of Metabolic Syndrome in Chinese Adults: A Longitudinal Study from the China Health and Nutrition Survey

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Biomedical and Environmental Sciences 2020年第1期33卷 19-29页

作者： HUANG Li Na WANG Hui Jun WANG Zhi Hong ZHANG Ji Guo JIA Xiao Fang ZHANG Bing ding gang Qiang National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective The present study aimed to investigate the association of red meat usual intake with metabolic syndrome(Met S),and explore the contribution of red meat usual intake to serum *** Based on the data from the longitudinal China Health and Nutrition Survey(CHNS),2,797 healthy adults aged 18–75 years without hypertension,diabetes,and Met S were selected in 2009 as subjects and follow-up studies were carried out till *** used the National Cancer Institute(NCI)method to estimate the usual intake of *** logistic regressions were performed to evaluate the association between red meat usual intake and the risk of Met *** regression analysis was used to study the relationship between red meat consumption and serum ferritin *** After adjusting for potential confounders,red meat,and fresh red meat were positively associated with the risk of Met S(RR=1.41,95%CI:1.05–1.90 and RR=1.37,95%CI:1.02–1.85,respectively).These relationships showed increasing trend(P<0.05).The level of serum ferritin increased significantly with the number of Met S components(P<0.05).The quantile regression analysis showed that red meat and fresh red meat usual intake had a significant positive association with serum ferritin levels across the entire conditional serum ferritin distribution(P<0.05).Processed red meat did not exhibit a similar *** Higher red meat usual intake was associated with an increased risk of Met S and elevated serum ferritin levels.

关键词： Usual intake Red meat Metabolic syndrome Serum ferritin

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去甲基化药物治疗中高危骨髓增生异常综合征的效果观察

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实用临床医药杂志 2024年第5期28卷 75-78,84页

作者：颜宗海吴燕明丁刚李承君孙光宇安徽医科大学附属巢湖医院血液内科安徽巢湖238000

目的观察去甲基化药物(HMAs)治疗中高危骨髓增生异常综合征(MDS)患者的临床效果。方法回顾性选取58例中高危MDS患者作为研究对象,研究组25例患者采用阿扎胞苷或地西他滨行去甲基化治疗,对照组33例患者接受常规对症支持治疗,观察并比较2... 详细信息

目的观察去甲基化药物(HMAs)治疗中高危骨髓增生异常综合征(MDS)患者的临床效果。方法回顾性选取58例中高危MDS患者作为研究对象,研究组25例患者采用阿扎胞苷或地西他滨行去甲基化治疗,对照组33例患者接受常规对症支持治疗,观察并比较2组患者的临床疗效、血常规指标水平、生存质量、不良反应发生情况等。结果治疗后,研究组完全缓解率、客观缓解率、疾病控制率均高于对照组,疾病进展率低于对照组,差异有统计学意义(P0.05)。治疗后,2组血红蛋白、白细胞、血小板水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组患者生存质量(躯体功能、认知功能、情绪功能、角色功能、社会功能)评分高于对照组,差异有统计学意义(P<0.05)。结论HMAs治疗对中高危MDS患者的临床疗效优于常规对症支持治疗,不仅能改善患者的生存质量,而且安全性良好。

关键词：去甲基化药物骨髓增生异常综合征中高危阿扎胞苷地西他滨生存质量

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Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator

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Neuroscience Bulletin 2014年第1期30卷 21-32页

作者： Feng Jiang Li-Ming Hua Yun-Lu Jiao Pin Ye Jin Fu Zhi-Jun Cheng gang ding Yong-Hua Ji Xinhua Hospital (Chongming) Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Chongming Xinhua Translational Medical Institute for Cancer Pain Lab of Neuropharmacology and Neurotoxicology Shanghai University

The mammalian target of rapamycin （mTOR） pathway is essential for maintenance of the sensitivity of certain adult sensory neurons. Here, we investigated whether the mTOR cascade is involved in scorpion envenomation-induced pain hypersensitivity in rats. The results showed that intraplantar injection of a neurotoxin from Buthus martensii Karsch, BmK I （10 pg）, induced the activation of mTOR, as well as its downstream molecules p70 ribosomal S6 protein kinase （p70 S6K） and eukaryotic initiation factor 4E-binding protein 1 （4E-BP1）, in lumbar 5-6 dorsal root ganglia neurons on both sides in rats. The activation peaked at 2 h and recovered 1 day after injection. Compared with the control group, the ratios of p-mTOR/p-p70 S6K/p-4E- BP1 in three types of neurons changed significantly. The cell typology of p-mTOR/p-p70 S6K/p-4E-BP1 immuno-reactive neurons also changed. Intrathecal administration of deforolimus, a specific inhibitor of mTOR, attenuated BmK I-induced pain responses （spontaneous flinching, paroxysmal pain-like behavior, and mechanical hypersensitivity）. Together, these results imply that the mTOR signaling pathway is mobilized by and contributes to experimental scorpion sting-induced pain.

关键词： BmK I mTOR p70 ribosomal S6 protein kinase 4E-binding protein 1 pain dorsal rootganglion

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High sensitivity C-reactive protein and cardfiac resynchronization therapy in patients with advanced heart failure

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Journal of Geriatric Cardiology 2014年第4期11卷 296-302页

作者： Chi CAI Wei HUA Li-gang ding Jing WANG Ke-Ping CHEN Xin-Wei YANG Zhi-Min LIU Shu ZHANG Cardiac Arrhythmia Center Fuwai Hospital Beilishi road No. 167 Xicheng district Beijing 100037 China

Background The data on the prognostic values of high sensitivity C-reactive protein （hsCRP） levels in patients with advanced symp-tomatic heart failure （HF） receiving cardiac resynchronization therapy （CRT） are scarce. The aim of present study was to investigate the association of serum hsCRP levels with left ventricle reverse remodeling after six months of CRT as well as long-term outcome. Methods A total of 232 CRT patients were included. The assessment of hsCRP values, clinical status and echocardiographic data were performed at baseline and after six months of CRT. Long-term follow-up included all-cause mortality and hospitalizations for HF. Results During the mean follow-up periods of 31.3 ± 31.5 months, elevated hsCRP （〉3 mg/L） prior to CRT was associated with a significant 2.39-fold increase （P=0.006） in the risk of death or HF hospitalizations. At 6-month follow-up, patients who responded to CRT showed significant reductions or maintained low in hsCRP levels （–0.5 ± 4.1 mg/L reduction） compared with non-responders （1.7 ± 6.1 mg/L increase, P=0.018）. Com-pared with patients in whom 6-month hsCRP levels were reduced or remained low, patients in whom 6-month hsCRP levels were increased or maintained high experienced a significantly higher risk of subsequent death or HF hospitalizations （Log-rank P〈0.001）. The echocardio-graphic improvement was also better among patients in whom 6-month hsCRP levels were reduced or remained low compared to those in whom 6-month hsCRP levels were raised or maintained high. Conclusions Our findings demonstrated that measurement of baseline and follow-up hsCRP levels may be useful as prognostic markers for timely potential risk stratification and subsequent appropriate treatment strategies in patients with advanced HF undergoing CRT.

关键词： Cardiac resynchronization therapy Clinical outcome Heart failure High sensitivity C-reactive protein

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基于时变阈值过程神经网络的太阳黑子数预测

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物理学报 2007年第2期56卷 1224-1230页

作者：丁刚钟诗胜哈尔滨工业大学机电工程学院哈尔滨150001

太阳黑子活动直接影响着外层空间环境的变化,为保证航天飞行任务的安全必须对其进行有效预测.为此,提出了一种基于时变阈值过程神经网络的时间序列预测模型.为简化模型的计算复杂度,开发了一种基于正交基函数展开的学习算法.文中分析了... 详细信息

太阳黑子活动直接影响着外层空间环境的变化,为保证航天飞行任务的安全必须对其进行有效预测.为此,提出了一种基于时变阈值过程神经网络的时间序列预测模型.为简化模型的计算复杂度,开发了一种基于正交基函数展开的学习算法.文中分析了模型的泛函逼近能力,并以Mackey-Glass时间序列预测为例验证了所提模型及其学习算法的有效性.最后,将该预测模型用于太阳活动第23周太阳黑子数平滑月均值预测,取得了满意的结果,应用结果同时表明:所提预测方法与其他传统预测方法相比预测精度有所提高,具有一定的理论和实用价值.

关键词：太阳黑子数时变阈值过程神经网络时间序列预测泛函逼近

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A special issue on Optoelectronics in Australia

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Frontiers of Optoelectronics 2018年第1期11卷 1-1页

作者： gang-ding PENG Photonics and Optical Communications School of Electrical Engineering and Telecommunications University of New South Wales (UNSW) Sydney 2052 Australia

I am very pleased to be the guest editor of the special issue,at the invitation by Frontiers ofOptoelectronics.I thank Frontiers of Optoelectronics for providing us the great opportunity to present the latest Australi...

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Predictors of super-response to cardiac resynchronization therapy： the significance of heart failure medication, pre-implant left ventricular geometry and high percentage of biventricular pacing

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Journal of Geriatric Cardiology 2017年第12期14卷 737-742页

作者： Han JIN Min GU Wei HUA Xiao-Han FAN Hong-Xia NIU Li-gang ding Jing WANG Cong XUE Shu ZHANG The Cardiac Arrhythmia Center State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

Background Super-responders （SRs） are defined as patients who show crucial cardiac function improvement after cardiac resynchro- nization therapy （CRT）. The purpose of this study is to identify and validate predictors of SRs after CRT. Methods This study enrolled 201 patients who underwent CRT during the period from 2010 to 2014. Clinical and echocardiographic evaluations were conducted before CRT and 6 months after. Patients with a decrease in New York Heart Association （NYHA） fimctional class 〉 1, a decrease in left ventricular end-systolic volume （LVESV） ≥ 15%, and a final left ventricular ejection fraction （LVEF） ≥ 45% were classified as SRs. Results 29% of the 201 patients who underwent CRT were identified as SRs. At baseline, SRs had significantly smaller left atrial diameter （LAD）, LVESV, left ventricular end-diastolic volume （LVEDV） and higher LVEF than the non-super-responders （non-SRs）. The percentage of patients using angiotensin-converting enzyme inhibitors or angiotensin receptor blockers （ACEI/ARB） was higher in SRs than non-SRs. Most SRs had Biventricular （BiV） pacing percentage greater than 98% six months after CRT. In the multivariate logistic regression analysis, the independ- ent predictors of SRs were lower LVEDV [odd ratios （OR）： 0.93; confidence intervals （CI）： 0.90-0.97], use of ACEI/ARB （OR： 0.33; CI： 0.13~3.82） and BiV pacing percentage greater than 98% （OR： 0.29; CI： 0.16~.87）. Conclusion Patients with a better compliance of ACEI/ARB and a less ectatic ventricular geometry before CRT tends to have a greater probability of becoming SRs. Higher percentage of BiV pacing is essential for becoming SRs.

关键词： Biventricular pacing Cardiac resynchronization therapy Heart failure Super-responders

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“三位一体”人才培养模式下带传动虚拟仿真实验设计与教学实践

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现代信息科技 2024年第15期8卷 194-198页

作者：郑春辉郭丰杨清香张锋丁刚孙厚涛魏莉哈尔滨工业大学机电工程学院黑龙江哈尔滨150001

为解决带传动实体实验在教学中存在的不足,建设了带传动虚拟仿真实验项目。虚拟仿真实验项目的建设从学生知识、能力、素质培养出发,进行了实验教学内容设计,构建出V带设计单元和虚拟仿真单元两大模块。技术实现依托Web前端技术,使用**... 详细信息

为解决带传动实体实验在教学中存在的不足,建设了带传动虚拟仿真实验项目。虚拟仿真实验项目的建设从学生知识、能力、素质培养出发,进行了实验教学内容设计,构建出V带设计单元和虚拟仿真单元两大模块。技术实现依托Web前端技术,使用***框架构建带传动虚拟仿真三维场景。教学实践表明,带传动虚拟仿真实验能够提升学生分析问题、解决问题的能力,有利于提高学生的学习成效。

关键词：带传动 V带设计虚拟仿真教学设计

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