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Chinese Chemical Letters 2024年第5期35卷 207-212页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao Li Fu Yuanyuan Hou gang bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300000China College of Life Health Dalian UniversityDalian 116622China Dalian Fusheng Pharmaceutical Co. Ltd.Dalian 116000China

The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and *** studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(PH)domain of ***,the combined synergistic effect of relieving the inflammatory response has yet to be *** on high sensitivity,specificity and fast-responsibility fluorescent sensors,the Förster resonance energy transfer(FRET)technique offers a route to provide clear insights into physiological and pathological *** the study,molecular docking,the fluorescent probes of Phi and Swe for FRET were designed and *** analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT,*** combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced *** lipopolysaccharides(LPS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(NF-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and *** conclusion,FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

关键词： FRET Swertiamarin Phillygenin AKT Anti-inflammation Combinatorial drug

Ethnopharmacology,phytochemistry,pharmacology and product application of Platycodon grandiflorum:A review

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Chinese Herbal Medicines 2024年第3期16卷 327-343页

作者： Lanying Zhang Xinrui Wang Jingze Zhang Dailin Liu gang bai Tianjin University of Traditional Chinese Medicine Tianjin 301617China Nankai University Tianjin 300353China Tianjin Modern Innovation Chinese Medicine Technology Co. Ltd.Tianjin 300380China

Platycodonis Radix(Jiegeng in Chinese)is a well-known traditional Chinese medicine used for both medicinal and culinary *** historical use as an antitussive and expectorant has been extensively ***,to date,have identified 219 chemical constituents in Platycodon grandiflorum(Jacq.)***,encompassing 89 saponins,11 flavonoids,21 polysaccharides,14 phenolic acids,six polyacetylenes,five sterols,34 fatty acids,17 amino acids,and 22 trace *** exhibits diverse pharmacological effects,including antitussive and anti-phlegm properties,anti-cancer activity,anti-inflammatory effects,immune regulation,antioxidant properties,anti-obesity,and antidiabetic ***,Jiegeng shows potential in protecting the heart and *** its medicinal benefits,Jiegeng is highly esteemed in culinary applications,and its global demand is on the *** utilization has expanded beyond medicine and food to encompass daily necessities,cosmetics,agricultural supplies,and other ***,there are 18272 patents related to *** comprehensive review summarizes the latest research published over the past 20 years,providing a robust foundation for further exploration of the medicinal and health benefits of ***.

关键词： application chemical constituents Jiegeng medicine and food homology Platycodon grandiflorum(Jacq.)A.DC

Predictive modeling for postoperative delirium in elderly patients with abdominal malignancies using synthetic minority oversampling technique

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1227-1235页

作者： Wen-Jing Hu gang bai Yan Wang Dong-Mei Hong Jin-Hua Jiang Jia-Xun Li Yin Hua Xin-Yu Wang Ying Chen Intensive Care Unit Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Anesthesia and Perioperative Medicine Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Postoperative delirium,particularly prevalent in elderly patients after abdominal cancer surgery,presents significant challenges in clinical *** To develop a synthetic minority oversampling technique(SMOTE)-based model for predicting postoperative delirium in elderly abdominal cancer *** In this retrospective cohort study,we analyzed data from 611 elderly patients who underwent abdominal malignant tumor surgery at our hospital between September 2020 and October *** incidence of postoperative delirium was recorded for 7 d *** were divided into delirium and non-delirium groups based on the occurrence of postoperative delirium or not.A multivariate logistic regression model was used to identify risk factors and develop a predictive model for postoperative *** SMOTE technique was applied to enhance the model by oversampling the delirium *** model’s predictive accuracy was then *** In our study involving 611 elderly patients with abdominal malignant tumors,multivariate logistic regression analysis identified significant risk factors for postoperative *** included the Charlson comorbidity index,American Society of Anesthesiologists classification,history of cerebrovascular disease,surgical duration,perioperative blood transfusion,and postoperative pain *** incidence rate of postoperative delirium in our study was 22.91%.The original predictive model(P1)exhibited an area under the receiver operating characteristic curve of *** comparison,the SMOTE-based logistic early warning model(P2),which utilized the SMOTE oversampling algorithm,showed a slightly lower but comparable area under the curve of 0.856,suggesting no significant difference in performance between the two predictive *** This study confirms that the SMOTE-enhanced predictive model for postoperative delirium in elderly abdominal tumor patients shows performance equivalent to that of tradi

关键词： Elderly patients Abdominal cancer Postoperative delirium Synthetic minority oversampling technique Predictive modeling Surgical outcomes

F?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期 233-238页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao Li Fu Yuanyuan Hou gang bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University College of Life Health Dalian University Dalian Fusheng Pharmaceutical Co. Ltd.

The clinical benefit of combination therapy is significant, but it is not easy to define the mechanism of complexity and diversity. Previous studies illustrate that phillygenin(Phi) binds in the allosteric inhibit pocket of protein kinase B(AKT), and swertiamarin(Swe) acts on the pleckstrin homology(PH) domain of AKT. However, the combined synergistic effect of relieving the inflammatory response has yet to be elucidated. Based on high sensitivity, specificity and fast-responsibility fluorescent sensors, the F?rster resonance energy transfer(FRET) technique offers a route to provide clear insights into physiological and pathological processes. In the study, molecular docking, the fluorescent probes of Phi and Swe for FRET were designed and synthesized. FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT, respectively. The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration. In lipopolysaccharides(LPS)-induced mice and cells, the combination arrested AKT activation, nuclear factor kappa-B(NF-κB)phosphorylation, and the expression of tumor necrosis factor-α(TNF-α), interleukin(IL)-6 and IL-8. In conclusion, FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

关键词：

Clinical feasibility of laparoscopic left lateral segment liver resection with magnetic anchor technique:The first clinical study from China

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1336-1343页

作者： Miao-Miao Zhang Ji-gang bai Dong Zhang Jie Tao Zhi-Min Geng Zhuo-Qun Li Yu-Xiang Ren Yu-HanZhang Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Zonglian College Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Qide College Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Magnetic anchor technique(MAT)has been applied in laparoscopic cholecystectomy and laparoscopic appendectomy,but has not been reported in laparoscopic partial *** To evaluate the feasibility of the MAT in laparoscopic left lateral segment liver *** Retrospective analysis was conducted on the clinical data of eight patients who underwent laparoscopic left lateral segment liver resection assisted by MAT in our department from July 2020 to November *** Y-Z magnetic anchor devices(Y-Z MADs)was independently designed and developed by the author of this paper,which consists of the anchor magnet and magnetic grasping *** time,intraoperative blood loss,intraoperative accidents,operator experience,postoperative incision pain score,postoperative complications,and other indicators were evaluated and *** All eight patients underwent a MAT-assisted laparoscopic left lateral segment liver resection,including three patients undertaking conventional 5-port and five patients having a transumbilical single-port *** mean operation time was 138±34.32 min(range 95-185 min)and the mean intraoperative blood loss was 123±88.60 mL(range 20-300 mL).No adverse events occurred during the *** Y-Z MADs showed good workability and maneuverability in both tissue and organ *** particular,the operators did not experience either a“chopstick”or“sword-fight”effect in the single-port laparoscopic *** The results show that the MAT is safe and feasible for laparoscopic left lateral segment liver resection,especially,exhibits its unique abettance for transumbilical single-port laparoscopic left lateral segment liver resection.

关键词： Magnetosurgery/magnetic surgery Magnetic anchor technique Laparoscopic hepatectomy Transumbilical singleport laparoscopy Magnet

《资本论》的时间辩证法:资本逻辑的时间叙事及其解放

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中南大学学报（社会科学版） 2024年第4期30卷 14-24页

作者：白刚王世强吉林大学哲学社会学院吉林长春130012

《资本论》的时间概念与资本批判紧密相连。马克思在该书中分析指出,时间在资本的作用下呈现出具体和抽象的二重性质。具体时间与个体的社会劳动结合在一起,抽象时间则表现为价值的独立运动。资本周转与时间转化交织浸润,资本逻辑的建... 详细信息

《资本论》的时间概念与资本批判紧密相连。马克思在该书中分析指出,时间在资本的作用下呈现出具体和抽象的二重性质。具体时间与个体的社会劳动结合在一起,抽象时间则表现为价值的独立运动。资本周转与时间转化交织浸润,资本逻辑的建构体现为从具体转化为抽象的时间规范。作为一种将时间抽象化的强制力量,资本将个体的生命时间统摄于它的结构之内,这导致劳动者无可规避地处于被奴役和支配的异化状态。除了建构时间的抽象统治结构,资本主义还造就了一种瓦解资本逻辑的历史动力——从抽象还原到具体的自由时间。资本增殖的空间来源于劳动者被压缩的可支配的自由时间,只有对资本的批判“代表一个阶级”,劳动者才能真正推翻时间的抽象统治。要完全超越资本,必须要在整个社会范围内解放自由时间。只有在社会主义社会中,时间才能从异化劳动的空间转化为自由发展的空间。马克思在《资本论》中的上述分析,不仅解开了“资本之谜”,也解开了“时间之谜”和“自由之谜”,在揭示资本逻辑限度的同时,为当代社会主义世界中人的自由解放指明了方向。

关键词：《资本论》资本逻辑具体时间抽象时间自由时间

建设金融强国:理论解构、实践问题与破局路径

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中州学刊 2024年第6期 51-60页

作者：吕鹏白刚东北师范大学马克思主义学部、教育部习近平新时代中国特色社会主义思想研究中心吉林长春130000 吉林大学哲学基础理论研究中心暨哲学社会学院吉林长春130012

“建设金融强国”为金融更好赋能经济高质量发展指明了方向,如何从金融大国向金融强国迈进,是我国当前金融工作的核心内容。对金融强国的理论基础和目标体系进行梳理,为金融强国理论的发展提供了明确方向。在金融强国建设进程中我国尚... 详细信息

“建设金融强国”为金融更好赋能经济高质量发展指明了方向,如何从金融大国向金融强国迈进,是我国当前金融工作的核心内容。对金融强国的理论基础和目标体系进行梳理,为金融强国理论的发展提供了明确方向。在金融强国建设进程中我国尚面临金融体系存在结构性风险隐患、金融基础设施建设存在短板、资源整合配置能力显著不足等问题。党的领导是建设金融强国的根本保证,坚持以习近平新时代中国特色社会主义思想为指导是金融强国建设的根本遵循。建设金融强国,需要创新科技金融,奠定金融强国的科技支柱;赋能绿色金融,打造金融强国可持续之基;推广普惠金融,实现金融强国全民共享愿景;健全养老金融,筑牢金融强国民生安全网;推动数字金融,引领金融强国数字化进程。

关键词：金融强国科技金融绿色金融普惠金融养老金融

Targeting CXCR4 and EDN1 for the treatment of recurrent miscarriage using stearic acid from traditional Chinese medicine

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Traditional Medicine Research 2024年第11期9卷 65-75页

作者： Fang Liu Dong-Mei Shi Wen-Ye Ma Da-Wei Tang gang bai Xin-You Yu Reproductive Center of Yinchuan Maternal and Child Health Hospital Yinchuan 750001China Prenatal Diagnosis Center of Ningxia Medical University General Hospital Yinchuan 750004China

Background:Recurrent miscarriage(RM)affects an estimated 1-3%of couples attempting to conceive,and its molecular components stay ineffectively caught *** study aims to explore potential therapeutic targets for RM by examining gene expression patterns and biological pathways in both mouse and human RM ***,explore relevant traditional Chinese medicine(TCM)components targeting potential therapeutic ***:We utilized the GSE211251 mouse and the GSE26787 human datasets,employing gene set enrichment analysis and gene metaphysics analysis to examine differentially expressed genes and enriched ***-cell RNA analysis uncovered cellular heterogeneity and arranged pharmacology-mapped potential drug-target *** employed molecular docking strategies to assess the affinity of TCM components for key ***:In the mouse model,genes such as Ly6f1 and Gpr26 were upregulated,while Stc5a and Galca exhibited *** set enrichment analysis identified key pathways,including the tumor necrosis factor-mediated signaling *** human samples,Gene Ontology analysis highlighted processes such as apoptosis and cell ***-cell RNA analysis revealed distinct cellular populations between normal and RM *** pharmacology identified C-X-C motif chemokine receptor 4(CXCR4)and endothelin 1(EDN1)as potential key targets,and molecular docking confirmed that stearic acid from TCM appears to regulate these ***:This study presents a comprehensive analysis of the genetic and cellular underpinnings of RM,identifying CXCR4 and EDN1 as promising therapeutic *** acid from TCM could provide targeted treatment by modulating these key proteins,paving the way for new RM treatment strategies.

关键词： RM gene expression single-cell RNA analysis CXCR4 EDN1 stearic acid

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财产权的张力:洛克与马克思

学习与探索 2024年第8期 27-35,180页

作者：白刚程远航吉林大学哲学基础理论研究中心吉林大学哲学社会学院

洛克作为近代政治哲学财产权思想的开创者,在《政府论》中从自然权利论说出发,提出“劳动创造价值”的劳动所有权思想。马克思继承了洛克劳动所有权思想的核心,在劳动价值论的基础上发现剩余价值,揭露资本家对劳动者剩余价值的无偿占有... 详细信息

洛克作为近代政治哲学财产权思想的开创者,在《政府论》中从自然权利论说出发,提出“劳动创造价值”的劳动所有权思想。马克思继承了洛克劳动所有权思想的核心,在劳动价值论的基础上发现剩余价值,揭露资本家对劳动者剩余价值的无偿占有,开启了财产权的资本逻辑批判。在《资本论》中,马克思发现资本主义财产权是以劳动所有权为外在形式,背后隐匿着否定自我所有的资本所有权,揭示了财产权的现代分离。马克思将洛克的劳动所有权发展为劳动力所有权,在重建个人所有制中实现人的自我所有,完成了对财产权的正义建构。

关键词：财产权劳动所有权劳动价值论资本所有权劳动力所有权

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崩解与重构:旧世界的终结与新世界的未来

东方学刊 2024年第1期 2-10页

作者：白钢复旦大学思想史研究中心

康德在《纯粹理性批判》中提出理性的三个问题:“我能知道什么(Was kann ich wissen)?”“我应当做什么(Was soll ich tun)?”“我可以希望什么(Was darf ich hoffen)?”处在16世纪以来世界体系加速失效进而走向失序的历史时刻,上述三... 详细信息

康德在《纯粹理性批判》中提出理性的三个问题:“我能知道什么(Was kann ich wissen)?”“我应当做什么(Was soll ich tun)?”“我可以希望什么(Was darf ich hoffen)?”处在16世纪以来世界体系加速失效进而走向失序的历史时刻,上述三个问题皆具有超越纯粹思辨旨趣的现实意味。本文试图从世界体系之演化来回应上述三问,特别是对“我可以希望什么?”这一问题的期待。

关键词：《纯粹理性批判》三问 16世纪