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Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord

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Neural Regeneration Research 2013年第15期8卷 1383-1389页

作者： Changwei Song Shiqiang Fang gang lv Xifan Mei Vertebral Column Ward Department of Orthopedics First Affiliated Hospital of Liaoning Medical University

Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen＇s method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury.

关键词： neural regeneration spinal cord injury gastrodin brain-derived neurotrophic factor microenvironment traditional Chinese medicine spinal structure animal behavior central nervoussystem injury grants-supported paper neuroregeneration

Characterization of ceramic coating on ZK60 magnesium alloy prepared in a dual electrolyte system by micro-arc oxidation

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Rare Metals 2013年第5期32卷 459-464页

作者： Ze-Xin Wang Wei-gang lv Jing Chen Sheng Lu Provincial Key Laboratory of Advanced Welding Technology Jiangsu University of Science and Technology Zhenjiang Naisi New Materials Co. Ltd.

Micro-arc oxidation （MAO） process was cartied out in an optimized dual electrolyte system to fabricate a compact, smooth, and corrosion resistant coating on ZK60 Mg alloy. The microstructural characteristics of coating were investigated by scanning electron microscopy （SEM） coupled with an energy dispersive spectrometer （EDS） and X-ray diffraction （XRD）. Test of mass loss was conducted at a 3.5 % NaCl solution to assess the resistance to corrosion. The bonding strength between the coating and ZK60 substrate was evaluated using scratch experiment. The results reveal that MgA1204 and MgO are the main phases of ceramic coating obtained in the dual electrolyte system. The corrosion rate of coating prepared in the optimized dual electrolyte is only 0.0061 g.m-2.h-1, which demonstrates excellent corrosion resistance. This is mainly due to the compact, uniform coating with high bonding strength.

关键词： ZK60 magnesium alloys Micro-arc oxidation Characterization Dual electrolyte system

Three-dimensional Analytical Modeling of Axial Flux Permanent Magnets Maglev Motor

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CES Transactions on Electrical Machines and Systems 2022年第4期6卷 438-444页

作者： Wei Qin gang lv Yuhua Ma IEEE the School of Electrical Engineering BeijingJiao Tong UniversityBeijing 100044China the Taiyuan Institute of China Coal Technology and Engineering Group Taiyuan 030006China

The three-dimensional(3D)analytical model of the magnetic field in an Axial Flux Permanent Magnets Maglev Motor(AFPMMM)is proposed and investigated the influence of the structural parameters on electromagnetic ***,the topology and working principle of the AFPMMM is introduced,and the model is transferred into a mathematical model in 3D cartesian ***,the volume integral method and equivalent current sheets model is applied to find the 3D magnetic field distribution function of Halbach rotor.A unified form expression can be obtained by two dimensional discrete fourier transform(2-D DFT)is applied on the 3D magnetic field distribution ***,the conductive and nonconductive regions of AFPMMM will be formulated by the second order vector potential(SOVP)to built the 3D analytic *** expression of the lift force,torque and power losses was ***,the relationship between electromagnetic characteristics and structural parameters of the AFPMMM were analyzed based on 3D analytic model and validated using the 3D finite element analysis(FEA).Finally,the experiments based on a small scale prototype are carried out to verify the analytical results.

关键词： Axial flux Permanent magnet machines Maglev Analytical model Electromagnetic performance

Three-dimensional Electromagnetic Characteristics Analysis of Novel Linear Synchronous Motor under Lateral and Yaw Conditions of MAGLEV

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CES Transactions on Electrical Machines and Systems 2022年第1期6卷 29-36页

作者： gang lv Zhixuan Zhang Xiaodong Li IET School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China IEEE Macao University of Science and Technology Faculty of Innovation EngineeringMacao999078China

Dynamic stability analysis of superconducting electro-dynamic maglev train under lateral and yawing motion condition is the key research *** novel three-dimensional electromagnetic model of integrated linear synchronous motor in electro-dynamic maglev train with yawing operation condition is proposed,which can not only simultaneously achieve the propulsion,levitation and guidance performances of maglev vehicle,but also analyze the dynamic stability performance of train with yawing *** three-dimensional analytical method is introduced for analyzing the electromagnetic force characteristics of the linear synchronous motor with the yawing operation ***,the topology structure and operation principle of the linear synchronous motor with yawing attitude are ***,the three-dimensional analytical model and expressions of electromagnetic characteristics are obtained by equivalent circuit method and Fourier decomposition method,such as levitation force,guidance force,propulsion force and yawing torque,***,the three-dimensional electromagnetic characteristics of the linear synchronous motor are calculated under yawing operation conditions of maglev train,and the correctness of the analytical theory is verified by the finite element analysis and measured data on the test line.

关键词： electro-dynamic maglev system linear synchronous motor propulsion levitation and guidance three-dimensional electromagnetic characteristics

Study on the mechanism of NH3-selective catalytic reduction over CuCexZr1-x/TiO2

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Frontiers of Materials Science 2016年第2期10卷 211-223页

作者： Xujuan CHEN Xiaoliang SUN Cairong GONG gang lv Chonglin SONG School of Materials Science and Engineering Tianjin University Tianjin 300072 China State Key Laboratory of Engines Tianjin University Tianjin 300072 China

Copper-cerium-zirconium catalysts loaded on Ti02 prepared by a wet impregnation method were investigated for NHz-selective catalytic reduction （SCR） of NOx. The reaction mechanism was proposed on the basis of results from in situ diffuse reflectance infrared transform spectroscopy （DRIFT）. When NH3 is introduced, ammonia bonded to Lewis acid sites is more stable over CuCe0.25Zr0.75/TiO2 at high temperature, while Brensted acid sites are more important than Lewis acid sites at low temperature. For the NH3＋NO＋O2 co-adsorption, NH3 species occupy most of activity sites on CuCe0.25Zr0.75/TiO2 catalyst, and mainly exist in the forms of NH4＋（at low temperature） and NH3 coordinated （at high temperature）, playing a crucial role in the NHz-SCR process. Two different reaction routes, the L-H mechanism at low temperature （〈 200℃） and the E-R mechanism at high temperature （〉200℃）, are presented for the SCR reaction over C uCe0.25Zr0.75/TiO2 catalyst.

关键词： CuCe0.25Zr0.75/TiO2 catalyst selective catalytic reduction (SCR) diffusereflectance infrared transform spectroscopy (DRIFT) reaction mechanism

Variant of Guillain-Barrésyndrome with anti-sulfatide antibody positivity and spinal cord involvement:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6274-6279页

作者： Hua Liu Hui-gang lv Rong Zhang Department of Neurology Yixing Hospital of Traditional Chinese MedicineYixing 214200Jiangsu ProvinceChina Department of Neurology The First People's Hospital of Shizuishan CityShizuishan 753200Ningxia Hui Autonomous RegionChina

BACKGROUND Guillain-Barrésyndrome(GBS)is an acute autoimmune-mediated *** have increasingly reported the presence of anti-sulfatide antibody positivity with varying clinical symptoms in patients with ***,spinal cord involvement is relatively rare in these *** SUMMARY A 68-year-old woman was admitted to the hospital with weakness of the limb for more than 3 *** symptoms included neck pain,progressive numbness in the distal extremities,urinary and fecal retention,and reduced perception of *** was diagnosed with an anti-sulfatide antibody-positive GBS variant and discharged after treatment with methylprednisolone and intravenous human immunoglobulin pulse *** common cases of anti-sulfatide antibody-positive GBS,this patient had atypical clinical symptoms of spinal cord *** similar cases have previously been reported in *** Although GBS is associated with a poor prognosis,a prompt diagnosis allows early administration of combined intravenous human immunoglobulin and methylprednisolone pulse therapy.

关键词： Guillain-Barrésyndrome spinal cord involvement anti-sulfatide antibodypositive Case report

Numerical Analysis of the Rotational Magnetic Springs for EDS Maglev Train

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CES Transactions on Electrical Machines and Systems 2022年第1期6卷 60-66页

作者： gang lv Yaqing Liu Zhixuan Zhang Xiaodong Li IET Sch.of E.E. Beijing Jiaotong Univ.Beijing 100044China Macao University of Science and Technology Faculty of Innovation EngineeringMacao999078China

Different from the traditional railway trains,the combined levitation and guidance EDS maglev train is more likely to rotate after being ***,the rotational electromagnetic stiffnesses are significant operating parameters for the *** this paper,the different effects of each translational offset generated in the rotational motion on the corresponding rotational electromagnetic stiffnesses in the EDS maglev train are analyzed and ***,a three-dimensional model of the maglev train is ***,based on the space harmonic method and the equivalent circuit of the levitation and guidance circuits,the formulas of rolling,pitching and yawing stiffness are ***,by comparing with the three-dimensional finite element simulation results,the key translational displacements in the rotational motion which has a great impact on the stiffness are ***,the three-dimensional analytical formula can be simplified and the computation can be *** addition,the accuracy of the calculation results is verified by comparing with the experimental data of Yamanashi test line.

关键词： Magnetic spring EDS maglev train electrodynamic rotational motion rolling stiffness pitching stiffness yawing stiffness

Time representation of mitochondrial morphology and function after acute spinal cord injury

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Neural Regeneration Research 2016年第1期11卷 137-143页

作者： Zhi-qiang Jia gang Li Zhen-yu Zhang Hao-tian Li Ji-quan Wang Zhong-kai Fan gang lv Department of Orthopedics First Affiliated Hospital of Liaoning Medical University

Changes in mitochondrial morphology and function play an important role in secondary damage after acute spinal cord injury. We recorded the time representation of mitochondrial morphology and function in rats with acute spinal cord injury. Results showed that mitochondria had an irregular shape, and increased in size. Mitochondrial cristae were disordered and mitochondrial membrane rupture was visible at 2–24 hours after injury. Fusion protein mitofusin 1 expression gradually increased, peaked at 8 hours after injury, and then decreased to its lowest level at 24 hours. Expression of dynamin-related protein 1, amitochondrial fission protein, showed the opposite kinetics. At 2–24 hours after acute spinal cord injury, malondialdehyde content, cytochrome c levels and caspase-3 expression were increased, but glutathione content, adenosine triphosphate content, Na＋-K＋-ATPase activity and mitochondrial membrane potential were gradually reduced. Furthermore, mitochondrial morphology altered during the acute stage of spinal cord injury. Fusion was important within the first 8 hours, but fission played a key role at 24 hours. Oxidative stress was inhibited, biological productivity was diminished, and mitochondrial membrane potential and permeability were reduced in the acute stage of injury. In summary, mitochondrial apoptosis is activated when the time of spinal cord injury is prolonged.

关键词： nerve regeneration spinal cord injury mitochondria fusion fission oxidative damage bioenergy mitochondrial permeability cytochrome c Caspase-3 apoptosis NSFC neural regeneration

p53 codon 72 polymorphism and liver cancer susceptibility: A meta-analysis of epidemiologic studies

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World Journal of Gastroenterology 2011年第9期17卷 1211-1218页

作者： Xi Chen Fei Liu Bo Li Yong-gang Wei lv-Nan Yan Tian-Fu Wen Department of Liver and Vascular Surgery West China Hospital Sichuan University 37 Guo Xue Road Chengdu610041 Sichuan Province China

AIM:To evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis. METHODS:Two investigators independently searched the Medline,Embase and Chinese Biomedicine *** odds ratios and 95%CI for p53 codon 72 polymorphism and liver cancer were calculated in fixedeffects model(Mantel-Haenszel method)and randomeffects model(DerSimonian and Laird method)when appropriate. RESULTS:This meta-analysis included 1115 liver cancer cases and 1778 *** combined results based on all studies showed that there was a statistically significant link between Pro/Pro genotype and liver cancer,but not between Arg/Arg or Pro/Arg genotype and liver *** stratifying for race,similar results were obtained,*** with liver cancer had a significantly higher frequency of Pro/Pro genotype than non-cancer patients among *** stratifying thevarious studies by control source,gender,family history of liver cancer and chronic hepatitis virus infection,we found that(1)patients among hospital-based studies had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer;(2)female patients with liver cancer had a significantly lower frequency of Arg/Arg and a higher frequency of Pro/Arg+Pro/Pro genotypes than female individuals without cancer;(3)subgroup analyses for family history of liver cancer did not reveal any significant association between p53 codon 72 polymorphism and liver cancer development;and(4) patients with negative hepatitis virus infection had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer. CONCLUSION:This meta-analysis suggests that the p53 codon 72 polymorphism may be associated with liver cancer among Asians.

关键词： Liver cancer p53 codon 72 Gene polymorphism Meta-analysis