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利用制革工业中含蛋白的固体废弃物培育的铜绿假单胞菌生产碱性蛋白酶的研究

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北京皮革（中外皮革信息版）（中） 2008年第10期 77-80页

作者： A.ganesh kumar[印度] S.Swarnalatha[印度] B.Sairam[印度] 王睿（编译）不详四川大学皮革化学与工程教育部重点实验室成都610065

动物的肉（Animal fleshing ANFL），制革工业中丢弃的主要含蛋白质的固体废弃物，可以作为底物生产铜绿假单胞菌碱性蛋白酶。选定从制革厂废水中分离到的菌种，因为它有能力生产活力范围在（1160～1175）U／ml的蛋白酶。运用扫描电子... 详细信息

动物的肉（Animal fleshing ANFL），制革工业中丢弃的主要含蛋白质的固体废弃物，可以作为底物生产铜绿假单胞菌碱性蛋白酶。选定从制革厂废水中分离到的菌种，因为它有能力生产活力范围在（1160～1175）U／ml的蛋白酶。运用扫描电子显微镜（SEM）证实在水解过程中蛋白酶选择性的从动物肉中除去了非纤维蛋白质。通过高效液相色谱（HPLC）测定释放到***的发酵液中氨基酸分析也证实了ANFL遭到破坏。

关键词：碱性蛋白酶动物N(ANFL) 铜绿假单胞菌氨基酸酶抑制

Stem cell therapy: A paradigm shift in breast cancer treatment

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World Journal of Stem Cells 2021年第7期13卷 841-860页

作者： Sabiha Khan Moushumi Suryavanshi Jasamrit Kaur Debadatta Nayak Anil Khurana Raj kumar Manchanda Chanderdeep Tandon Simran Tandon Amity Institute of Molecular Medicine and Stem Cell Research Amity UniversityNoida 201313Uttar PradeshIndia Department of Pathology Rajiv Gandhi Cancer Institute and Research CentreNew Delhi 110085India Department of Chemistry Goswami Ganesh Dutta Sanatan Dharma CollegeChandigarh 160030India Central Council for Research in Homeopathy New Delhi 110058India Department of AYUSH Karol BaghNew Delhi 110011India Amity Institute of Biotechnology Amity UniversityNoida 201313Uttar PradeshIndia

As per the latest Globocan statistics,the high prevalence rate of breast cancer in low-and middle-income countries has led to it becoming the most common cancer to be diagnosed,hence posing a major public health *** per this data,more than 11.7%of the estimated new cancer cases in 2020 were due to breast cancer.A small but significant subpopulation of cells with self-renewing ability are present in the tumor stroma and have been given the nomenclature of cancer stem cells(CSCs).These cells display a high degree of plasticity owing to their ability to transition from the slowly cycling quiescent phase to the actively proliferating *** attribute of CSCs allows them to differentiate into various cell types having diverse *** CSCs have a pivotal role in development,metastasis,treatment resistance and relapse of breast *** review focuses on the pathways regulating breast CSC maintenance and the current strategies that are being explored for directing the development of novel,targeted,therapeutic approaches for limiting and eradicating this aberrant stem cell population.

关键词： Molecular genomics Breast cancer stem cells Tumor microenvironment Molecular pathways Targeted therapy Inhibitors

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

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中国药理学与毒理学杂志 2015年第S1期29卷 80-80页

作者： Feng Li Muthu K. shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117957 Cancer Science Institute of Singapore Centre for Translational Medicine Singapore 117957 Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610 Genome Institute of Singapore Agency for Science Technology and Research (A*STAR) Singapore Jawaharlal Nehru Centre for Advanced Scientific Research Molecular Biology and Genetics Unit Transcription and Disease Laboratory Bangalore 560064 India School of Biomedical Sciences Faculty of Health Sciences Curtin University Western Australia 6009 Australia Department of Biological Sciences University of North Texas Denton Texas 76203 Department of Haematology-Oncology National University Health System Singapore 117957 College of Korean Medicine Kyung Hee University Seoul 130-701 Republic of Korea

OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to *** The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse *** We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by *** the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and *** pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,*** Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers.

关键词： HNSCC chemoresistance NF-κB proliferation garcinol

Medicinal Plant Using Ground State Stabilization of Natural Antioxidant Curcumin by Keto-Enol Tautomerisation

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Natural Products and Bioprospecting 2018年第5期8卷 369-390页

作者： S.Manimaran K.Sambath kumar R.Gayathri K.Raja N.Rajkamal M.Venkatachalapathy G.Ravichandran C.Lourdu EdisonRaj P.G&Research Department of Physics Thanthai Hans Roever College(Autonomous)PerambalurTamil Nadu 621220India Post Graduate and Research Department of Physics (NANO Science Divisions)A.A.Govt.Arts CollegeVillupuramTamil Nadu 605602India Post Graduate and Research Department of Physics Cauvery College for WomenTiruchirappalliTamil NaduIndia Post Graduate and Research Department of Physics Dr.R.K.Shanmugam College of Arts&ScienceKallakurichiTamil Nadu 606213India Post Graduate and Research Department of Physics Thiru.A.Govindasamy Govt Arts CollegeTindivanamTamil Nadu 604002India Post Graduate and Research Department of Chemistry A.A.Govt.Arts CollegeVillupuramTamil Nadu 605602India

Curcumin is a medicinal agent that exhibits anti-cancer properties and bioactive pigment in Turmeric has a huge thera-peutic *** has a keto-enol moiety that gives rise to many of its chemical properties.A recent study has shown thatketo-enol tautomerisation at this moiety is implicated the effect of *** tautomerisation of curcumin in *** and acetonitrile are used in nuclear magnetic resonance(^(1)H,^(13)C)*** was characterized using UV,IRand Raman spectral *** molecular electrostatic potential surface of the Curcumin has been visualized in elec-tropositive potential in the region of the CH^(3+) group and most electronegative potential in the two oxygen atom has verystrong binding *** the following,the modality of structural and thermo dynamical parameters,electrophilicity(ω).chemical potential(μ),chemical hardness(η) and electronic charge transfer confirms the local *** rate constantof tautomerisation of curcumin shows strong temperature *** electrostatic potential and Temperature dependence of various thermodynamic properties like(C^(0)_(p,m),S^(0)_(m),and H^(0)_(m))is increase with increase in temperature formonomer and dimer of various electrical fields.

关键词： Curcumin NMR.Uv HOMO-LUMO.MEP