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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 236-244页

作者： Hital Shah Tejal gandhi Gujarat Technological University AhmedabadGujarat 382424India Department of Pharmacology Anand Pharmacy CollegeAnandGujarat 388001India

Objective:To investigate the cardioprotective potential of betulin in isoproterenol(ISO)-induced myocardial injury in ***:wistar rats were divided into five groups(n=10):normal,ISO,nebivolol 5 mg/kg,and betulin(20&40 mg/kg).Nebivolol and betulin were administered orally for 29 ***(85 mg/kg)was administered subcutaneously on day 27 and day 28 to induce myocardial *** day 29,blood was collected for determination of cardiac markers,and hemodynamic parameters were *** levels of oxidative stress markers and the gene expressions of apoptotic markers and inflammatory mediators were ***,2,3,5-triphenyltetrazolium chloride staining and histopathological analysis were also ***:Betulin reduced the size of myocardial infarction,decreased elevated levels of cardiac enzymes,and maintained hemodynamic *** also inhibited ISO-induced upregulation of Bax,caspase-3,NF-κB,and IL-6,enhanced endogenous antioxidant enzymes,and reduced lipid ***,pretreatment with betulin alleviated myocardial ischemic damage,as reflected by reduced myonecrosis,edema,and inflammatory ***:Betulin exhibits strong cardioprotective activity against ISO-induced myocardial injury by anti-inflammatory,anti-apoptotic,and antioxidant activities.

关键词： NF-κB Isoproterenol Betulin Myocardial injury Oxidative stress Inflammation Apoptosis

杏仁核的功能连接与情绪性疼痛易化的个体差异相关

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中国疼痛医学杂志 2020年第12期26卷 891-893页

作者：昝志(译) 顾楠(校) gandhi w Rosenek NR Harrison R 空军军医大学第986医院疼痛科空军军医大学西京医院疼痛科不详

疼痛是一种复杂的体验,人与人之间的感知不同,甚至同一个人在不同情境下的感受也不一样。情绪状态可以调节疼痛体验,正性情绪缓解疼痛,而负性事件则易化疼痛感知。疼痛综合征和情感障碍的高共病率反映出了情绪和疼痛之间的密切关系。抑... 详细信息

疼痛是一种复杂的体验,人与人之间的感知不同,甚至同一个人在不同情境下的感受也不一样。情绪状态可以调节疼痛体验,正性情绪缓解疼痛,而负性事件则易化疼痛感知。疼痛综合征和情感障碍的高共病率反映出了情绪和疼痛之间的密切关系。抑郁症病人罹患慢性疼痛的可能性是正常人的两倍。慢性疼痛病人常伴有类似于快感缺失的症状,包括疲惫感以及对以前愉悦活动参与的减少。

关键词：抑郁症病人疼痛综合征疲惫感负性事件慢性疼痛正性情绪情绪状态杏仁核

Priority Based Energy Efficient MAC Protocol by Varying Data Ratefor wireless Body Area Network

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Computer Systems Science & Engineering 2024年第2期48卷 395-411页

作者： R.Sangeetha Usha Devi gandhi School of Information Technology and Engineering Vellore Institute of TechnologyVelloreTamil Nadu632014India

wireless Body Area Network(wBAN)is a cutting-edge technology that is being used in healthcare applications to monitor critical events in the human *** is a collection of in-body and on-body sensors that monitor human physical parameters such as temperature,blood pressure,pulse rate,oxygen level,body motion,and so *** sense the data and communicate it to the Body Area Network(BAN)*** main challenge for the wBAN is energy *** issues can be addressed by implementing an effective Medium Access Control(MAC)protocol that reduces energy consumption and increases network *** purpose of the study is to minimize the energy consumption and minimize the delay using IEEE 802.15.4 *** our proposed work,if any critical events have occurred the proposed work is to classify and prioritize the *** gave priority to the highly critical data to get the Guarantee Tine Slots(GTS)in IEEE 802.15.4 standard superframe to achieve greater energy *** proposed MAC provides higher data rates for critical data based on the history and current condition and also provides the best reliable service to high critical data and critical data by predicting node *** an outcome,we proposed a MAC protocol for Variable Data Rates(MVDR).when compared to existing MAC protocols,the MVDR performed very well with low energy intake,less interruption,and an enhanced packet-sharing ratio.

关键词： wireless Body Area Network(wBAN) IEEE 802.15.4 energy efficiency MAC protocol ZigBee

Fabrication and evaluation of carboxymethyl guar gum-chitosan interpenetrating polymer network (IPN) nanoparticles for controlled drug delivery

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Medicine in Novel Technology and Devices 2024年第2期22卷 73-79页

作者： Chandrani Roy Arijit gandhi Sreejan Manna Sougata Jana Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol713301West BengalIndia Department of Pharmaceutical Technology Brainware UniversityBarasatKolkataWest Bengal700125India Department of Health and Family welfare Directorate of Health ServicesKolkataIndia

Guar gum(GG)has drawn more interest from researchers in the last several decades for the controlled delivery of *** aim of the research is to fabricate and evaluate an interpenetrating polymer network(IPN)based nanocarriers system employing chemically modified GG to achieve controlled release of *** present study,we have reported the synthesis of carboxymethyl GG-chitosan IPN nanoparticles for controlled release of metformin *** guar gum(CMGG)was synthesized and employed for developing IPN nanoparticles in combination with chitosan in varying polymeric ratios.A cross-linking agent,sodium tripolyphosphate(Na-TPP)was used for the synthesis of IPN colloidal suspension of nanoparticles which was lyophilized to obtain *** carboxymethylation of GG was confirmed through Fourier transform infra-red spec*** mean particle size was 440.6 nm indicating a polydispersity index of *** drug entrapment efficiency was found to vary between 67.461.64%to 88.232.02%.The differential scanning calorimetry study revealed the presence of amorphous metformin hydrochloride as a homogenous dispersion in nanoparticles(NPs)*** vitro drug release study indicated controlled release ability of developed IPN matrix.A2 formulation(chitosan:CMGG-1:1)exhibited 78.110.27%release after 8 *** evaluation performed in alloxan-treated diabetic rat model exhibited a prolonged hypoglycemic efficacy over 6 h,for A2 formulation treated group,compared to the group receiving only metformin HCl,which demonstrated a reduction in blood glucose levels for up to 4 *** study findings demonstrated the efficacy of the CMGG-chitosan based IPN nanoparticulate system for sustained delivery of therapeutic agents.

关键词： Carboxymethyl guar gum Chitosan Interpenetrating polymer network Nanoparticles Controlled release Metformin hydrochloride

Accelerated intermetallic phase amorphization in a Mg-based high-entropy alloy powder

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Journal of Magnesium and Alloys 2024年第5期12卷 1792-1798页

作者： Prince Sharma Purvam Mehulkumar gandhi Kerri-Lee Chintersingh Mirko Schoenitz Edward L.Dreizin Sz-Chian Liou Ganesh Balasubramanian Institute for Functional Materials&Devices Lehigh UniversityBethlehemPA 18015USA Center of Materials for Advanced Energetics New Jersey Institute of TechnologyNewarkNJ 07102USA

we describe a novel mechanism for the synthesis of a stable high-entropy alloy powder from an otherwise immiscible Mg-Ti rich metallic mixture by employing high-energy mechanical *** presented methodology expedites the synthesis of amorphous alloy powder by strategically injecting entropic disorder through the inclusion of multi-principal elements in the alloy *** from first principles and materials theory corroborate the results from microscopic characterizations that reveal a transition of the amorphous phase from a precursor intermetallic *** transformation,characterized by the emergence of antisite disorder,lattice expansion,and the presence of nanograin boundaries,signifies a departure from the precursor intermetallic ***,this phase transformation is accelerated by the presence of multiple principal elements that induce severe lattice distortion and a higher configurational *** atomic size mismatch of the dissimilar elements present in the alloy produces a stable amorphous phase that resists reverting to an ordered lattice even on annealing.

关键词： High-entropy alloy High-energy milling Antisite disorder Amorphous Intermetallic

Does topical vancomycin prevent fracture-related infections in closed fractures undergoing open reduction and internal fixation?A randomised controlled trial

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Chinese Journal of Traumatology 2024年第2期27卷 71-76页

作者： Mohit gandhi Gopisankar Balaji Jagdish Menon Ruben Raj Thomas Department of Orthopaedics Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Purpose:The role of topical vancomycin in fracture-related infection(FRI)is *** few studies have reported their efficacy in open and high-risk extremity *** study aimed to assess topical vancomycin's role in reducing FRI in closed fractures undergoing open surgical intervention with an ***:This prospective randomized cohort study was carried out between February 2021 to January *** with isolated closed fractures,who were planned for open reduction and internal fixation within 2 weeks from the time of injury were included for this *** data collected included age,gender,socioeconomic status,mechanism of injury,diagnosis,Tscherne classification,and time interval to take up for *** were randomized into the intervention and control groups using the block randomization *** control group received only systemic antibiotic prophylaxis,whereas the intervention group received topical application of vancomycin powder in the surgical wound alongside systemic antibiotic *** primary outcome measure was the incidence of FRI among these *** and radiological findings and culture reports(in cases with infection)were recorded during the post-operative period and at 6 weeks of *** relevant statistical calculations were done using STATA statistical/data analysis-parallel edition version 16.0(StataCorp LLC).The quantitative variables like age and duration of the surgery were assessed for normalcy by Shapiro-wilk w *** independent samples t-test with equal variances was applied to the age ***'s exact test was used for the analysis of the primary outcome measure(presence of FRI following surgery),and"Risk of FRI"and"Risk difference"between the 2 groups was *** strength of the association between qualitative variables was assessed using the Fisher's exact and Chi-square tests,***:There were 88 patients included in this *** statistical si

关键词： Infections Antibiotics Vancomycin Fractures

Unveiling resveratrol’s potential:Navigating the landscape of autoimmune diseases

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Clinical Traditional Medicine and Pharmacology 2024年第3期5卷 87-95页

作者： Keshava Jetha Arya Vyas Ashutosh Tripathi Jeet gandhi Vivek Chavda Department of Pharmaceutics and Pharmaceutical Technology L.M.College of PharmacyAhmedabad380009GujaratIndia Ph.D.Section Gujarat Technological UniversityAhmedabad382424GujaratIndia Ph.D.Section Kadi Sarva VishvavidyalayaGandhinagar382024GujaratIndia

Background:Autoimmune diseases pose a multifaceted challenge in the realm of medical science,warranting in-novative approaches for their ***,a naturally ccurring compound found in various dietary sources,has captured attention for its potential immunomodulatory and anti-inflammatory ***-standing the interplay between autoimmune diseases and resveratrol is crucial for exploring novel therapeutic ***:This review aims to explore the intricate relationship between autoimmune diseases and *** seeks to provide insights into the mechanistic underpinnings of autoimmune diseases,emphasizing the necessity for innovative therapeutic ***,it aims to comprehensively discuss the pharmacological properties of resveratrol and its potential applications in managing autoimmune ***:A structured review approach was employed to organize the content into distinct *** literature searches were conducted to gather information on autoimmune diseases,the pharmacology of resvera-trol,and its effects on immune regulation,inflammation,and oxidative *** and clinical evidence regarding the efficacy of resveratrol in managing specific autoimmune diseases was critically ***:Resveratrol demonstrates immunomodulatory,anti-inflammatory,and antioxidant effects,which are rel-evant to autoimmune disease *** properties impact immune cell regulation,pro-inflammatory cytokines,inflammatory mediators,and oxidative stress,potentially ameliorating autoimmune *** studies present promising evidence for the efficacy of resveratrol in conditions such as rheumatoid arthri-tis,systemic lupus erythematosus,multiple sclerosis,and inflammatory bowel disease,albeit further research is necessary to determine its safety and optimal ***:The review underscores the promising potential of resveratrol in autoimmune disease *** targeting k

关键词： Autoimmune diseases Resveratrol Immunomodulation Anti-inflammatory Antioxidant Clinical trials Translational research

Effect of KiwiBiotic on functional constipation and related symptoms:A prospective,single-center,randomized,comparative,crossover study

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world Journal of Gastrointestinal Pharmacology and Therapeutics 2024年第5期15卷 40-49页

作者： Ashwin D Porwal Paresh M gandhi Deepak K Kulkarni Gajanan B Bhagwat Pravin P Kamble Department of Proctology Healing Hands ClinicMahārāshtraPune 411001India R&D Center Healing Hands and Herbs Pvt.Ltd.MahārāshtraPune 411002India

BACKGROUND Functional constipation(FC)is a common gastrointestinal disorder characterized by abdominal pain and bloating,which can greatly affect the quality of life of *** treatments often yield suboptimal results,leading to the exploration of alternative therapeutic *** To evaluate the efficacy of KiwiBiotic in the management of FC and related *** This prospective,interventional,single-center,crossover study compared the safety and effectiveness of KiwiBiotic®vs psyllium husk in managing FC,abdominal pain,and *** diagnosed with FC were randomly assigned to receive KiwiBiotic or psyllium husk during the two treatment periods,with a 14-day washout period between *** Seventy participants were enrolled,32 of whom received KiwiBiotic followed by psyllium husk,and 33 received *** showed superiority over psyllium husk in alleviating abdominal pain and bloating,as evidenced by significantly lower mean ***,KiwiBiotic resulted in more than 90.0%of patients experiencing relief from various constipation symptoms,while psyllium husk showed comparatively lower *** KiwiBiotic is an effective treatment option for FC,abdominal pain,and bloating,highlighting its potential as a promising alternative therapy for patients with FC and its associated symptoms.

关键词： KiwiBiotic Psyllium husk Constipation Abdominal pain Bloating

Comprehensive analysis of uncertainty quantification for the^(58)Ni(n,p)^(58)Co reaction cross section

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Chinese Physics C 2024年第9期48卷 170-175页

作者： Mahesh Choudhary Aman Sharma Namrata Singh Mahima Upadhyay Punit Dubey A.gandhi Akash Hingu G Mishra Sukanya De L.S.Danu Ajay Kumar R.G.Thomas Saurav Sood Sajin Prasad S.Mukherjee I.N.Ruskov Yu.N.Kopatch A.Kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest 077125Romania Department of Physics The Maharaja Sayajirao University of BarodaVadodara 390002India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Electrical Power Engineering Brno University of TechnologyBrno 61600Czech Republic Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofia 1784Bulgaria Joint Institute for Nuclear Research(JINR) Dubna 141980Russia

In this study,we measured the^(58)Ni(n,p)^(58)Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques andγ-ray spectroscopy,and it was compared with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for^(58)Ni(n,p)^(58)Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the optical model and level density parameters to calculate uncertainties in the theoretical cross *** theoretical calculations were performed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model input as well as different experimental variables used to obtain the values of reaction cross section.

关键词： ^(58)Ni(n p)^(58)Co reaction γ-ray spectroscopy uncertainty quantification of cross section covariance analysis

Pharmacological adjuvants for diabetic vitrectomy surgery

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world Journal of Methodology 2024年第4期14卷 84-90页

作者： Ramesh Venkatesh Chaitra Jayadev Vishma Prabhu Priyanka gandhi Rupal Kathare Naresh K Yadav Ayushi Choudhary Jay Chhablani Department of Ophthalmology Narayana NethralayaBangalore 560010India Department of Retina Narayana Nethralaya Eye InstituteBangalore 560010India Department of Vitreo Retina Narayana NethralayaRetina ServSuper Specialty Eye Hospital and Post Graduate Institute of OphthalmologyBangalore 560010India Department of Retina University of Pittsburg School of MedicinePittsburgPA 15213United States

Diabetic vitrectomy is a highly intricate surgical procedure performed during the advanced stages of diabetic retinopathy(DR).It is used to treat conditions such as tractional or combined retinal detachment,vitreous hemorrhage,and subhyaloid hemorrhage,which are all severe manifestations of proliferative *** results of the surgery are uncertain and *** surgery has made significant progress since the early stages of *** the past ten years,advancements in intravitreal pharmacotherapy have emerged,offering new possibilities to improve the surgical results for our *** the realm of medical terminology,an"adjunct"refers to a pharmaceutical or substance employed to aid or expedite the primary therapeutic intervention for a particular *** introduction has broadened the range of therapeutic choices that are accessible prior to,during,and following surgical *** review article will specifically analyze the pharmacological adjuncts used in diabetic vitrectomy surgery,with a focus on their role in facilitating or aiding specific steps of the *** implementation of this system of categorization offers benefits to the surgeon by allowing them to foresee potential difficulties that may occur during the surgical procedure and to choose the appropriate pharmacological agent to effectively tackle these challenges,thus enhancing surgical success rates.

关键词： Diabetic retinopathy Vitrectomy Intravitreal injections Anti-vascular endothelial growth factor Adjuvants Outcomes