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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Dietary carbohydrate intake and risk of type 2 diabetes:a 16-year prospective cohort study

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Science china Life Sciences 2025年

作者： Lu gan Yi Yang Bin Zhao Kai Yu Kehua Guo Fang Fang Zhiguang Zhou Demetrius Albanes Jiaqi Huang Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University CSU-Sinocare Research Center for Nutrition and Metabolic Health Xiangya School of Public Health Central South UniversityFurong Laboratory Division of Cancer Epidemiology and Genetics National Cancer Institute NIH Department of Health and Human Services School of Computer Science and Engineering Central South University Institute of Environmental Medicine Karolinska Institute National Clinical Research Center for Metabolic Diseases Key Laboratory of Diabetes Immunology Ministry of Education and Department of Metabolism and Endocrinology The Second Xiangya Hospital of Central South University

Despite considerable research underscoring the importance of carbohydrate intake in relation to the risk of type 2 diabetes(T2D), a comprehensive assessment of this relationship is currently lacking. We aimed to examine the associations of various types and food sources of dietary carbohydrate intake with the risk of T2D, to evaluate potential effect modification by other factors, including genetic susceptibility,and to explore the potential mediators for such associations. The present study included 161,872 participants of the UK Biobank who were free of prevalent cancer, cardiovascular disease, or diabetes, and had at least one validated 24-h dietary recall assessment. Multivariableadjusted age-stratified Cox proportional hazard regression models were applied to estimate hazard ratios(HRs) and 95% confidence intervals(CI) for the associations of various types and food sources of dietary carbohydrate intake with risk of T2D. During a median follow-up of13.6 years, 4,176 incident cases of T2D were identified. In the multivariable-adjusted models, a greater intake of fiber, carbohydrates from whole grains, and carbohydrates from non-starchy vegetables was significantly associated with a lower risk of T2D(highest vs. lowest quantile, HR [95% CI]=0.70 [0.62–0.79], 0.74 [0.67–0.82], and 0.83 [0.75–0.92], respectively, all P for trend ch and carbohydrate from starchy vegetables was associated with an increased risk of T2D(highest vs. lowest quantile, HR [95%CI]=1.31 [1.16–1.48] and 1.19 [1.09–1.31], respectively, both P for trend ng one serving of refined grains or starchy vegetables with an equal amount of whole grains or non-starchy vegetables was associated with 4% to 10% lower risk of T2D(all P values ng individuals with different genetic susceptibility to T2D. Mediation analyses of the inverse association between T

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Evaluation of solubility of polycyclic aromatic hydrocarbons in ethyl lactate/water versus ethanol/water mixtures for contaminated soil remediation applications

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Journal of Environmental Sciences 2012年第6期24卷 1064-1075页

作者： chiew Lin Yap Suyin gan Hoon Kiat ng Department of chemical and Environmental Engineering The University of Nottingham Malaysia CampusJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Mechanical Materials and Manufacturing Engineering The University of Nottingham l~lalaysia Campus Jalan Broga 43500 Semenyih Selangor Darul Ehsan Malaysia

Solubility data of recalcitrant contaminants in cosolvents is essential to determine their potential applications in enhanced soil *** solubilities of phenanthrene,anthracene,fluoranthene and benzo[a]pyrene in ethyl lactate/water and ethanol/water mixtures were measured using equilibrium *** cosolvency powers derived from solubility data were then applied to the model developed from the solvophobic approach to predict the capability of ethyl lactate and ethanol in enhancing the desorption of contaminants from *** ethyl lactate and ethanol cosolvents were shown to be able to enhance the solubilisation of the tested four polycyclic aromatic hydrocarbons by 〉 4 orders of magnitude above the levels obtained with water ***,ethyl lactate demonstrated a greater capacity to enhance PAH solubility than *** cosolvency powers of ethyl lactate/water system obtained from the end-to-end slope （σ） and the end-to-half slope （σ 0.5） of the solubilisation curve were 1.0-1.5 and 2.0-2.9 higher than ethanol/water system *** line with this,ethyl lactate/water was demonstrated to enhance the desorption of contaminants from soil by 20%-37% and 18%-61% higher compared to ethanol/water system in low organic content and high organic content soils respectively,with a 2：1 （V/W） ratio of solution：soil and with cosolvent fraction as low as *** the exception of benzo[a]pyrene,the experimental desorption results agreed fairly with the predicted values,under an applied solution：soil ratio that was enough to hold the capacity of released contaminants.

关键词： polycyclic aromatic hydrocarbon solubility desorption ethyl lactate ethanol

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Improved gan grown on Si(111) substrate using ammonia flow modulation on SiN_x mask layer by MOCVD

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Science china(Technological Sciences) 2009年第9期52卷 2758-2761页

作者： ng KaiWei LAU KeiMay Department of Electrical and Electronic Engineering Hong Kong University of Science & Technology Clear Water BayKowloon Hong Kong China

In this paper,1 μm n-gan was grown by using varied and fixed ammonia flow (NH3) on SiNx mask layer on Si(111) substrate using metal organic chemical vapor deposition (MOCVD). In-situ optical reflectivity traces of gan growth show that the three-to two-dimensional process has been prolonged by using varied ammonia flow on SiNx mask layer method compared with that grown by fixing ammonia flow. Structural and optical properties were characterized by high-resolution X-ray diffraction and photolu-minescence,and compared with the sample grown by fixing ammonia flow,gan grown using the varied ammonia flow on SiNx mask layer showed better structure and optical quality. It was assumed that the low NH3 flow in the initial growth stage considerably increased the gan island density on the nano-porous SiNx layer by enhancing vertical growth. Lateral growth was significantly favored by high NH3 flow in the subsequent step. As a result,the improved crystal and optical quality was achieved utilizing NH3 flow modulation for gan buffer growth on Si(111) substrate.

关键词： gan epilayer MOCVD NH3 modulation

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Mechanism of Bragg Diffraction-Assisted Light Extraction in gan-based Light-Emitting Diodes Based on a Self-Consistent Model

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Communications in Theoretical Physics 2009年第9期52卷 545-548页

作者： LIU Wen-De gan Zi-Zhao National Institute of Metrology Beijing 100013 China School of Physics and State Key Laboratory for Artificial Microstructures and Mesoscopic Physics Peking University Beijing 100871 China

By introducing the distribution of the light energy density in gan-based light-emitting diode (LED),theLED model based on the incoherent regime and the light extraction efficiency are *** energy density asa function of the angle of incidence is calculated to demonstrate the mechanism of the light *** deviationbetween the tendencies of the transmissivity of the output layer and the extraction efficiency is also demonstrated.

关键词： light-emitting diodes extraction efficiency Bragg diffraction photonic crystals

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The role of humic acid in Fenton reaction for the removal of aliphatic fraction of total petroleum hydrocarbons(diesel range)in soil

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Environmental Science and Ecotechnology 2021年第3期7卷 29-34页

作者： Seyedeh Pegah Jalilian Ahmadkalaei Suyin gan Hoon Kiat ng Suhaimi Abdul Talib Department of chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500SemenyihSelangor Darul EhsanMalaysia Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham MalaysiaJalan Broga43500SemenyihSelangor Darul EhsanMalaysia Faculty of Civil Engineering Universiti Teknologi MARA40450Shah AlamSelangor Darul EhsanMalaysia

This study investigated the role of humic acid in Fenton reaction for the total petroleum hydrocarbons(TPH)(diesel)in *** reactions were conducted at varying humic acid dosages and *** the lowest molecular weight diesel contaminants,a humic acid dosage of 10 mg/l produced the favourable effect of reducing Fe3t to Fe2t which continued for higher humic acid dosages of 50,100 and 150 mg/***,for higher molecular weight diesel contaminants,the negative effect of hydroxyl radicals consumption by the humic acid was more significant than its reduction of Fe^(3+) to Fe^(2+).The positive role of humic acid on Fenton reaction increased with increasing humic acid dosage for the overall TPH,with an optimum dosage of 150 mg/*** higher pH,the removal efficiencies increased or reduced depending on the molecular weight of *** power law and pseudo-first-order kinetic models fitted the experimental kinetic data well.

关键词： Diesel Fenton Humic acid Soil remediation TPH

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东北典型盐碱湿地碳排放的水深临界阈值及其温度依赖性

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湖泊科学 2025年第1期37卷 159-170,I0015-I0017页

作者：李姝臻刘强甘罗扬武海涛王波北京师范大学环境学院水环境模拟国家重点实验室北京100875 北京师范大学环境学院教育部水沙科学重点实验室北京100875 中国科学院长春分院长春130022 吉林莫莫格国家级自然保护区白城137316

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(ch_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量... 详细信息

作为全球重要的碳库,湿地在缓解气候变化方面发挥了重要作用。然而在全球变暖背景下,湿地的碳排放(尤其是甲烷(ch_(4))排放)存在高度变异性和不确定性,极大地削弱了湿地碳库功能的发挥。为了探究不同水深梯度下东北盐碱湿地碳排放通量的特征,本研究以莫莫格湿地为主要研究区,选取5种代表性植被(芦苇(Phragmites australis)、扁秆藨草(Bolboschoenus planiculmis)、三江藨草(Schoenoplectus nipponicus)、香蒲(Typha orientalis ***)和碱蓬(Suaeda glauca)),布设Marsh Organ中型实验生态系统模拟不同水深生境,揭示ch_(4)和二氧化碳(CO_(2))排放通量变化及其环境影响因子。结果表明,莫莫格湿地-10~50 cm水深范围内5种代表性植被生长季ch_(4)排放通量范围为0.07~86.74 mg/(m^(2)·h),平均值为8.89 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量;在研究水深范围内,代表性植被生长季CO_(2)排放通量范围为10.59~1891.08 mg/(m^(2)·h),平均值为450.12 mg/(m^(2)·h),其主要环境影响因素为水深、气温和表层10 cm土壤含水量。不同植被对碳排放的贡献量有所差异,具体来说,芦苇和香蒲的ch_(4)排放通量最高,而藨草的CO_(2)排放通量最高。碳排放随水深变化呈现分段规律,ch_(4)排放随水深变化呈现先增加后减少的趋势,而CO_(2)则呈现相反规律,随水深变化先减小后增加,其水深临界阈值均出现在22 cm处。在不同水深范围内,CO_(2)排放对于水深的敏感性均大于ch_(4),且当水深大于22 cm时,ch_(4)和CO_(2)均呈现出更高的水深敏感性。碳排放在不同水深范围对温度的敏感程度不同,当水深小于22 cm时,ch_(4)和CO_(2)均呈现出更高的温度敏感性,然而当水深大于22 cm时,二者对温度均不敏感。结果表明升温背景下,东北典型盐碱湿地水陆过渡区关键生态系统在不同水深范围内呈现出不对称的响应模式,频繁的水位波动会极大地改变湿地碳排放格局,从而影响到湿地碳功能的稳定发挥。

关键词：碳排放水深温度依赖性莫莫格湿地阈值

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The viability of using gasoline-integrated biodiesel-diesel mixtures in engines as a solution to greenhouse gas emissions:a review

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Clean Energy 2022年第6期6卷 848-868页

作者： Mohammad Zandie Hoon Kiat ng Suyin gan Mohd Farid Muhamad Said Xinwei ch.ng Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Automotive Development Center(ADC) Faculty of EngineeringUniversiti Teknologi Malaysia(UTM)81310 Johor BahruMalaysia School of Mechanical and Aerospace Engineering Queen’s University BelfastBelfastUK

The implementation of alternative fuels,such as biodiesel,in engines has been shown to be a feasible strategy to control greenhouse gas(GHG)*** blending of biodiesel with diesel can reduce emissions of carbon monoxide(CO)and carbon dioxide and reduce soot ***,biodiesel combustion comes with low thermal efficiency,elevated emissions of nitrogen oxides(NOx)and carbon deposition ***,the addition of gasoline to diesel-biodiesel blends has been proposed to compensate for the downsides of biodiesel *** the current review,the viability of using this ternary fuel blend in engines is thoroughly *** review first assesses the environmental and health issues caused by conventional fuels,mitigation schemes to control GHG emissions and alternative fuels as a decarbonizing *** combustion and emissions characteristics of diesel-bio-diesel-gasoline mixtures are discussed in ***,the status,challenges and prospects of applying the alternative fuel mixture in engines are *** work has revealed that the mixing of gasoline with diesel-biodiesel blends brings about elongated ignition delay,increased heat release rate and in-cylinder pressure at high ***,by adding gasoline,the combustion duration is shortened and soot,CO and unburned hydrocarbon emissions are suppressed,while NOx emissions are slightly *** stability is found to be partially disrupted in the presence of gasoline whereas fuel economy(at medium and high loads)is improved by the addition of *** support the wider deployment and commercialization of this fuelling strategy in the transportation sector,favourable legislation and/or fiscal incentives are needed in countries around the *** would encourage researchers,fuel producers and engine manufacturers alike to solve challenges such as biodiesel feedstock costs,fuel quality,fuel storage management and engine warranty issues.

关键词： biodiesel-diesel-gasoline blends combustion characteristics improvement engine performance enhancement net-zero emissions targets alternative fuels adaptation greenhouse gas control climate ch.nge

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Low limit of detection of the Algan/gan-based sensor by the Kelvin connection detection technique

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Microsystems & Nanoengineering 2021年第4期7卷 35-44页

作者： Hanyuan Zhang Ying gan Shu Yang Kuang Sheng Ping Wang College of Electrical Engineering Zhejiang University310027 HangzhouChina Biosensor National Special Laboratory Department of Biomedical EngineeringZhejiang University310027 HangzhouChina Hangzhou Global Scientific and Technological Innovation Center Zhejiang University310027 HangzhouChina

The Algan/gan-based sensor is a promising POCT(point-of-care-testing)device featuring miniaturization,low cost,and high *** is an effective protein biomarker for the early diagnosis of HF(heart failure).In this work,a novel Algan/gan device with the Kelvin connection structure and the corresponding detection technique was *** technique can effectively suppress the background noise and improve the SNR(signal-to-noise ratio).A BNP detection experiment was carried out to verify the effectiveness of this *** is shown that compared with that of the traditional detection method,the LOD(limit of detection)was improved from 0.47 ng/mL to 1.29 pg/*** BNP detection experiment was also carried out with a traditional electrochemical Au-electrode sensor with the same surface functionalization *** Algan/gan sensor showed a better LOD than the Au-electrode ***,the influence of Algan/gan sensor package on background noise was investigated with the mechanism of the noise source ***,based on the optimized package,the optimal SNR quiescent operating point of the Algan/gan sensor was *** biasing the sensor at the optimal quiescent operating point and immobilizing the magnetic beads with anti-BNP on the gate of the Algan/gan sensor,the LOD for BNP detection was further improved to 0.097 pg/mL.

关键词： Algan/gan limit noise

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Correlate light-matter interactions in different spectral regimes

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Light(Science & Applications) 2022年第4期11卷 455-456页

作者： Qiaoqiang gan Material Science Engineering Physical Science EngineeringKing Abdullah University of Science and TechnologyThuwalSaudi Arabia Electrical Engineering University at BuffaloThe State University of New YorkBuffaloNYUSA

Using mid-infrared plasmons to trigger visible surface enhanced Raman spectroscopy signals within a nanocavity represents new opportunities for fundamental investigation of light-matter interaction within quantum regimes,requiring improved sensing capabilities enabled by well-designed nano/microstructures and characterization systems.

关键词： light cavity visible

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