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A new oxyapatite red phosphor Eu^(3+)-doped Ca_(3)Y_(7)(BO_(4))(SiO_(4))_(5)O:Synthesis,structure and luminescence properties

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Journal of Rare Earths 2022年第5期40卷 709-716,I0002页

作者： Tian Tian Wei liu Qi liu Yan Zhang Yaoqing Chu gan liu Jiayue Xu Institute of Crystal Growth School of Materials Science and EngineeringShanghai Institute of TechnologyShanghai 201418China Jiangsu Technology Innovation&C-V2X Academy Co. Ltd.Nanjing 210014China

A series of new oxyapatite red phosphors Ca_(3) Y_(7)(BO_(4)) (SiO_(4))_(5) O doped with different concentrations of Eu^(3+)were successfully synthesized by high temperature solid state *** X-ray diffraction(XRD)Rietveld refinement results show that the structure of the phosphor belongs to space group P6_(3)/m and Eu^(3+)ion replaces Y^(3+)*** emission spectrum consists of the characteristic emission peaks corresponding to Eu^(3+)under the excitation of 274 nm and the dominant emission peak is at 614 nm(^(5)D_(0)→^(7)F_(2) of Eu^(3+)).The concentration quenching effect occurs and the optimized Eu^(3+)concentration is 4.0 mol%.The energy level diagram for luminous mechanism is also given and the non-radiative energy transfer mechanism between Eu^(3+)is mainly exchange *** CIE coordinate is close to the ideal red light and the color purity is higher than 99.79%.Moreover,the phosphor exhibits moderate thermal stability because the photoluminescence intensity at 423 K is still maintained at higher than 78.97%of that at room *** internal quantum efficiency of Ca_(3) Y_(7)(BO_(4)) (SiO_(4))_(5) O:4.0 mol%Eu^(3+)phosphor is 58.2%.A red light emitting diode(LED)device based on it can emit bright red *** CCT values of the device are basically unchanged when driven by various bias *** results show that Ca_(3) Y_(7)(BO_(4)) (SiO_(4))_(5) O:Eu^(3+)is a new type of oxyapatite red fluorescent material with good comprehensive performances.

关键词： Red phosphor Oxyapatite structure Eu3+ions doping LED device Rare earths

Preparation of Tin Oxide Nanoparticles Using a Sol-Gel Process Based on Tin Dichloride and Absolute Ethanol

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稀有金属材料与工程 2006年第A3期35卷 578-580页

作者： Dongxiang Zhou Lu gan Huan liu Shuping Gong Department of Electronic Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Tin oxide nanoparticles with the average size of 17.4 nm (firing at 600℃for 2 h) have been successfully prepared through a sol-gel process starting with tin dichloride and absolute ethanol as *** particles were char... 详细信息

关键词： sol-gel tin oxide nanoparticle gas sensors

Cation exchange resin supported nanoscale zero-valent iron for removal of phosphorus in rainwater runoff

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 463-470页

作者： Bangmi XIE Jiane ZUO Lili gan Fenglin liu Kaijun WANG State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China

Self-made cation exchange resin supported nanoscale zero-valent iron （R-nZVI） was used to remove phosphorus in rainwater runoff. 80% of phosphorus in rainwater runoff from grassland was removed with an initial concentration of 0.72 mg. L-1 phosphorus when the dosage of R-nZVl is 8 g per liter rainwater, while only 26% of phosphorus was removed when using cation exchange resin without supported nanoscale zero-valent iron under the same condition. The adsorption capacity of R-nZVI increased up to 185 times of that of the cation exchange resin at a saturated equilibrium phosphorous concentration of 0.42 mg. L-1. Various techniques were implemented to characterize the R-nZVI and explore the mechanism of its removal of phosphate. Scanning electron microscopy （SEM） indicated that new crystal had been formed on the surface of R-nZVI. The result from inductive coupled plasma （ICP） indicated that 2.1% of nZVI was loaded on the support material. The specific surface area was increased after the load of nanoscale zero-valent iron （nZVI）, according to the measurement of BET-N2 method. The result of specific surface area analysis also proved that phosphorus was removed mainly through chemical adsorption process. X-ray photoelectron spectroscopy （XPS） analysis showed that the new product obtained from chemical reaction between phosphate and iron was ferrous phosphate.

关键词： nanoscale zero-valent iron(R-nZVI) cation exchange resin rainwater runoff phosphorus adsorption

Prolonging the plasma circulation of proteins by nano- encapsulation with phosphorylcholine-based polymer

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Nano Research 2016年第8期9卷 2424-2432页

作者： Linlin Zhang Yang liu gan liu Duo Xu Sheng Liang Xinyuan Zhu Yunfeng Lu Hui Wang Department of Nuclear Medicine Xinhua Hospital Affiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University Shanghai 200092 China Department of Chemical and Biomolecular Engineering University of California Los Angeles California 90095 USA The Shenzhen Key Laboratory of Gene and Antibody Therapy Center for Biotechnology and Biomedicine and Division of Life and Health Sciences Tsinghua University Shenzhen 518055 China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Key Laboratory of Functional Polymer Materials Ministry of Education Institute of Polymer Chemistry Nankai University Tianjin 300071 China

Short in vivo circulation is a major hindrance to the widespread adoption of protein therapeutics. Protein nanocapsules generated by encapsulating proteins with a thin layer of phosphorylcholine-based polymer via a two-step encapsulation process exhibited significantly prolonged plasma half-life. Furthermore, by constructing nanocapsules with similar sizes but different surface charges and chemistry, we demonstrated a generic strategy for prolonging the plasma half-life of therapeutic proteins. In an in vitro experiment, four types of bovine serum albumin （BSA） nanocapsules were incubated with fetal bovine serum （FBS） in phosphate buffer saline （PBS）; the cell uptake by HeLa cells was monitored to systematically evaluate the characteristics of the surface chemistry during drculation. Single positron emission tomography-computed tomography （SPECT） was employed to allow real-time observation of the BSA nanoparticle distribution in vivo, as well as quantification of the plasma concentration after intravenous administration. This study offers a practical method for translating a broad range of proteins for clinical use.

关键词： phosphorylcholine-basedpolymer nano-encapsulation function protein delivery protein therapy long-circulation

Up-converted ultraviolet luminescence of Er3＋：BaGd2Zn05phosphors for healthy illumination

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Frontiers of Materials Science 2016年第3期10卷 328-333页

作者： Ya ZHANG Qingzhi CUI Zhanyong WANG gan liu Tian TIAN Jiayue XU Institute of Crystal Growth School of Materials Science and Engineering Shanghai Institute of Technology Shanghai 201418 China Nanjing SKY Traffic Safety Technology Stock Co. Ltd. Nanjing 210014 China

Moderate level of exposure to the solar irradiation containing UV component is essential for health care. To incorporate the UV-emitting phosphors into the commercial YAG-based white light-emitting diode introduces the possibilities of healthy illumination to individuals＇ daily lives. 1 mol.% E3＊-doped BaGd2ZnO5（BGZ） particles were synthesized via sol-gel method and efficient up-converted luminescence peaked at 380 nm was detected under 480 nm excitation. The mixed phosphors with varied mass ratio of Er3＋：BGZ and Ce3＋：YAG particles were encapsulated to form LEDs. The study of the LEDs indicated that the introduction of BGZ component favored the enhancement of color-rendering index and the neutralization of the white light emitting. The WLED with the BGZ/YAG ratio of 8：2 was recommendable for its excellent overall white light luminous performances and UV intensity of 84.55 mW/cm2. The UV illumination dose of the WLEDs with mixed YAG and BGZ was controllable by adjusting the ratio, the illumination distance and the illumination time. Er3＋：BGZ phosphors are promising UV- emitting phosphors for healthy indoor illumination.

关键词： Er3+:BaGd2ZnOs up-converted ultraviolet LED healthy illumination

Heterobifunctional PEG-grafted black phosphorus quantum dots: “Three-in-One”nano-platforms for mitochondria-targeted photothermal cancer therapy

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Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 222-235页

作者： Junyang Qi Yue Xiong Ke Cheng Qi Huang Jingxiu Cao Fumei He Lin Mei gan liu Wenbin Deng School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Department of Chemistry City University of Hong KongHong KongChina School of Material Science and Engineering and Institute for Advanced Study Nanchang UniversityNanchang 330031China Department of Biochemistry and Molecular Medicine School of MedicineUniversity of California at DavisSacramento CA 95817USA

Black phosphorus(BP)nano-materials,especially BP quantum dots(BPQDs),performs outstanding photothermal antitumor effects,excellent biocompatibility and ***,there are several challenges to overcome before offering real benefits,such as poor stability,poor dispersibility as well as difficulty in tailoring other ***,a“three-in-one”mitochondria-targeted BP nano-platform,called as BPQD-PEG-TPP,was *** this nano-platform,BPQDs were covalently grafted with a heterobifunctional PEG,in which one end was an aryl diazo group capable of reacting with BPQDs to form a covalent bond and the other end was a mitochondria-targeted triphenylphosphine(TPP)*** addition to its excellent near-infrared photothermal properties,BPQD-PEG-TPP had much enhanced stability and dispersibility under physiological conditions,efficient mitochondria targeting and promoted ROS production through a photothermal *** in vitro and in vivo experiments demonstrated that BPQD-PEG-TPP performed much superior photothermal cytotoxicity than BPQDs and BPQD-PEG as the mitochondria targeted *** this“three-in-one”nanoplatform fabricated through polymer grafting,with excellent stability,dispersibility and negligible side effects,might be a promising strategy for mitochondria-targeted photothermal cancer therapy.

关键词： Mitochondria-target Black phosphorus quantum dots Photothermal therapy Heterobifunctional PEG Three-in-one

Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins

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Nano Research 2016年第4期9卷 1022-1031页

作者： Sheng Liang Yang liu Xin Jin gan liu Jing Wen Linlin Zhang Jie Li Xubo Yuan Irvin S.Y. Chen Wei Chen Hui Wang Linqi Shi Xinyuan Zhu Yunfeng Lu Department of Nuclear Medicine Xinhua HospitalAffiliated to Shanghai Jiao Tong University Shanghai Jiao Tong University Shanghai 200092 China Department of Chemical and Biomolecular Engineering University of California Los Angeles CA 90095 USA Department of Microbiology Immunology and Molecular Genetics University of California Los Angeles CA 90095 USA Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Key Laboratory of Functional Polymer Materials of Ministry of Education and State Key Laboratory of Medicinal Chemical Biology Institute of Polymer Chemistry Nankai University Tianjin 30007 I China School of Chemistry and Chemical Engineering ShanghaiJiao Tong University Shanghai 200240 China School of Materials Science and Engineering Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300072 China Beiiina Institute ofBiatechnoloav. Beiiina 100071. China

Protein therap34 wherein therapeutic proteins are delivered to treat disorders, is considered the safest and most direct approach for treating diseases. However, its applications are highly limited by the paucity of efficient strategies for delivering proteins and the rapid clearance of therapeutic proteins in vivo after their administration. Here, we demonstrate a novel strategy that can significantly prolong the circulation time of therapeutic proteins as well as minimize their immunogenicity. This is achieved by encapsulating individual protein molecules with a thin layer of crosslinked phosphorylcholine polymer that resists protein adsorption. Through extensive cellular studies, we demonstrate that the crosslinked phosphorylcholine polymer shell effectively prevents the encapsulated protein from being phagocytosed by macrophages, which play an essential role in the clearance of nanoparfides in vivo. Moreover, the polymer shell prevents the encapsulated protein from being identified by immune cells. As a result, immune responses against the therapeutic protein are effectively suppressed. This work describes a feasible method to prolong the circulation time and reduce the immunogenicity of therapeutic proteins, which may promote the development and application of novel protein therapies in the treatment of diverse diseases.

关键词： protein nanocapsule,protein delivery,protein therapy long-circulation,stealth therapeutic

Professor Zhou Jin-huang,a pioneer in the pharmacologyintegrating traditional Chinese medicineand western medicine

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中国药理学与毒理学杂志 1989年第3期3卷 161-162页

作者： liu gan-zhong( Professor of Pharmacology,Dept Materia Medico and Pharmacology,China-Japan Friendship Hospital)

Professor Zhou was born in 1909 when the lastdriperial dynasty, Qing dynasty, went near its end andmodern sciences including medical sciences began totake root in China. Modern schools and universitieswere established to substitute the old private tutoringsystem in which only one teacher was needed to handlea group of young pupils of different ages. Zhou re-ceived both types of education and was finally

关键词：周全黄中西医结合药理学家

基于响应面法的碎石道床离散元模型参数研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第9期20卷 685-700页

作者： Jie-ling XIAO gan-zhong liu Jian-xing liu Jia-cheng DAI Hao liu Ping WANG MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong UniversityChengdu610031China School of Civil Engineering Southwest Jiaotong UniversityChengdu610031China Railway Engineering Research Institute China Academy of Railway Sciences Group Co.Ltd.Beijing100081China

目的:采用响应面方法研究特级道砟休止角的离散元参数仿真试验,建立多次回归模型并对其进行优化,以及对道砟接触参数进行优选。通过多参数的响应面法为碎石道床离散元参数的快速标定提供有效途径。创新点:1.基于响应面法对离散元道砟接... 详细信息

目的:采用响应面方法研究特级道砟休止角的离散元参数仿真试验,建立多次回归模型并对其进行优化,以及对道砟接触参数进行优选。通过多参数的响应面法为碎石道床离散元参数的快速标定提供有效途径。创新点:1.基于响应面法对离散元道砟接触参数进行统计分析,提出道砟最优参数的回归方程及回归曲面。2.以道砟堆积体在多个正交平面的均值为道砟休止角,构建基于一致线性描述方式的道砟休止角实测试验与离散元仿真试验。3.提出道砟参数的动态标定思想。方法:1.通过道砟休止角的室内试验,测量出道砟休止角度的有效均值。2.以实测结果为目标,采用响应面法对道砟离散元仿真参数进行优选。3.验证所提方法的可行性和有效性。结论:1.通过采用休止角的4个正交面取均值的方法对中国特级道砟休止角进行实测所得到的平均值为(39.78±1.27)°。2.以实测结果为目标,采用响应面方法对特级道砟离散元仿真参数进行优选,由方差分析可得2个显著的一次项参数(静摩擦系数和滚动摩擦系数)以及多个显著的多次项参数组合;最优参数组合为:泊松比为0.24,密度为2600 kg/m^3,杨氏模量为5.45×1010 Pa,碰撞恢复系数为0.72,静摩擦系数为0.56,滚动摩擦系数为0.27。3.利用特级道砟离散元最优参数建立了离散元轨排模型,并进行了轨枕横向阻力试验;仿真结果与室内试验实测阻力曲线趋势基本一致,表明响应面法获得的接触参数取值可用于碎石道床相关的离散元仿真。

关键词：有砟轨道道砟离散元参数标定响应面法