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猪瘟病毒跨细胞膜内化分子机制及猪瘟的防控研究进展

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中国兽医学报 2024年第7期44卷 1556-1562页

作者：邹宏程鹏郭建华罗干黄石磊重庆三峡职业学院动物科技学院重庆万州404100 西南大学动物医学院重庆荣昌402460 重庆市万州区畜牧产业发展中心重庆万州404100

猪瘟(CSF)是由猪瘟病毒(CSFV)引起的一种猪的临床上以高热稽留和广泛性出血为主要特征的传染病,是WOAH通报性疫病。CSFV作为一种单链RNA囊膜病毒,在适应外界环境压力的过程中,已经演变出一套吸附和侵入细胞的策略,但具体的分子机制尚不... 详细信息

猪瘟(CSF)是由猪瘟病毒(CSFV)引起的一种猪的临床上以高热稽留和广泛性出血为主要特征的传染病,是WOAH通报性疫病。CSFV作为一种单链RNA囊膜病毒,在适应外界环境压力的过程中,已经演变出一套吸附和侵入细胞的策略,但具体的分子机制尚不完全清楚。研究表明,CSFV主要通过网格蛋白介导的跨细胞膜内化,在胞质内以胞内体的形式存在,在一定条件下胞内体囊膜融合释放基因组进行病毒增殖。此间CSFV依赖与宿主蛋白发生相互作用,抑制宿主干扰素的合成分泌,调控宿主细胞凋亡、自噬、焦亡和炎症反应等生命活动,逃避宿主的天然免疫,从而促进病毒在宿主体内进一步复制,但具体的机制有待进一步研究。本文就CSFV跨细胞膜内化的分子机制和CSF的防控难题展开概述,以期为CSF的净化提供理论依据。

关键词：猪瘟病毒跨细胞膜内化分子机制

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我国山地民族体育旅游绿色低碳化研究

辽宁体育科技 2024年第5期46卷 123-128页

作者：余弦盘劲呈罗赣贵州大学旅游与文化产业学院贵州贵阳550025 贵州财经大学体育学院新体育研究中心贵州贵阳550025 贵州大学体育学院贵州贵阳550025

旅游业低碳化转型是我国实现低碳目标的必然要求,也是抢抓全球低碳经济发展新机遇的主动作为。近年来,山地民族体育旅游在山地旅游的基础上蓬勃发展,立足于绿色低碳化要求的现实基础,对山地民族体育旅游绿色低碳化的影响因素进行分析,... 详细信息

旅游业低碳化转型是我国实现低碳目标的必然要求,也是抢抓全球低碳经济发展新机遇的主动作为。近年来,山地民族体育旅游在山地旅游的基础上蓬勃发展,立足于绿色低碳化要求的现实基础,对山地民族体育旅游绿色低碳化的影响因素进行分析,提出绿色低碳化的实施路径,旨在丰富我国山地民族体育旅游的可持续发展研究的同时,促进经济、社会与环境的和谐发展,实现人与自然的和谐共生。

关键词：山地旅游体育旅游民族传统体育绿色低碳

基于数据挖掘探讨全仁夫教授治疗强直性脊柱炎用药规律

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中国医药导报 2024年第9期21卷 32-35,40页

作者：辛大伟罗淦裘世杰杭州市萧山区中医院骨科浙江杭州311201

目的探讨全仁夫教授治疗强直性脊柱炎(AS)的用药规律。方法筛选整理2020年8月至2022年1月在杭州市萧山区中医院全仁夫教授门诊治疗AS患者的临床处方,运用中医传承计算平台(V3.0)分析药物频次、性味、归经及功效,并采用关联规则、聚类... 详细信息

目的探讨全仁夫教授治疗强直性脊柱炎(AS)的用药规律。方法筛选整理2020年8月至2022年1月在杭州市萧山区中医院全仁夫教授门诊治疗AS患者的临床处方,运用中医传承计算平台(V3.0)分析药物频次、性味、归经及功效,并采用关联规则、聚类分析对组方规律进行挖掘。结果本研究共收录处方85首,涉及药物116种,其中高频中药26味,药性以温性为主,药味以甘、辛、苦味居多,药物主入肝、肾、脾经,药物功效主要为祛风湿类和补虚类。得出常用药物模式14个及关联性用药组合20个,分析获得聚类处方组合4个。结论全仁夫教授治疗AS的用药规律为祛风湿与补肝肾并用,标本兼治;主张温督散寒、行气活血;同时重视补养脾胃。

关键词：强直性脊柱炎中医传承计算平台数据挖掘用药规律全仁夫

Effect of nitrobenzene on the performance and bacterial community in an expanded granular sludge bed reactor treating high-sulfate organic wastewater

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Frontiers of Environmental Science & Engineering 2019年第1期13卷 63-72页

作者： Jun Li Wentao Li gan luo Yan Li Aimin Li State Key Laboratory of Pollution Control and Resources Reuse School of the Environment Nanjing University Nanjing 210023 China Nanjing University & Yancheng Academy of Environmental Protection Technology and Engineering Yancheng 224000 China

Nitrobenzene (NB) is frequently found in wastewaters containing sulfate and may affect biological sulfate reduction process, but information is limited on the responses of sulfate reduction efficiency and microbial community to the increased NB contents. In this study, a laboratory-scale expanded granular sludge bed reactor was operated continuously to treat high-sulfate organic wastewater with increased NB contents. Results successfully demonstrated that the presence of more than 50 mg/L NB depressed sulfate reduction and such inhibition was partly reversible. Bath experiments showed that the maximum specific desulfuration activity (SDA) decreased from 135.80 mg SO4^2-/gVSS/d to 30.78 mg SO4^2-/gVSS/d when the NB contents increased from none to 400 mg/L. High-throughput sequencing showed that NB also greatly affected bacterial community structure. Bcicteroidetes dominated in the bioreactor. The abundance of Proteobacteria increased with NB addition while Firmicutes presented an opposite trend. Proteobacteria gradually replaced Finnicutes for the dominance in response to the increase of influent NB *** genus Desulfovibrio was the dominant sulfate-reducing bacteria (SRB) with absence or presence of NB, but was inhibited under high content of NB. The results provided better understanding for the biological sulfate reduction under NB stress.

关键词： Nitrobenzene (NB) Sulfate-reducing bacteria (SRB) Bacterial community Sulfate reduction High-throughput sequencing

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禹门口隧道洞口崩塌灾害危险性评价

河南科技 2024年第17期51卷 101-105页

作者：张振江周峰明罗干内蒙古呼和浩特抽水蓄能发电有限责任公司内蒙古呼和浩特010000 南阳豫资投资发展有限公司河南南阳473000 华北水利水电大学河南郑州450045

【目的】位于中国山西的禹门口隧道在建设过程中发现隧道口上方的陡崖存在较多岩石崩塌掉落现象,严重威胁浩吉铁路的正常运行。为保护工程区域,需进行岩崩灾害综合分析。【方法】利用RocPro3D理论及方法结合现场调查,运用无人机高精度... 详细信息

【目的】位于中国山西的禹门口隧道在建设过程中发现隧道口上方的陡崖存在较多岩石崩塌掉落现象,严重威胁浩吉铁路的正常运行。为保护工程区域,需进行岩崩灾害综合分析。【方法】利用RocPro3D理论及方法结合现场调查,运用无人机高精度航拍影像数据,对发现的64个危岩体失稳问题进行数值模拟研究,分析危岩体的三维运动路径、速度、弹跳高度、频率和停驻点等参数。构建了上述4个参数作为评价因子的崩塌危险性评价模型。【结果】研究区域的桥梁锚锭和桥隧工程区的危险性都处于中等及以上水平,而龙虎公路受影响段的危险性则在低至高之间。【结论】模拟结果与实际调查相结合,可为选择崩塌落石防治措施提供合理依据。

关键词：危岩体数值模拟 RocPro3D 危险性评价

Synergistic refining mechanism of Mg-3%Al alloy refining by carbon inoculation combining with Ca addition

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Journal of Magnesium and Alloys 2020年第4期8卷 1090-1101页

作者： Chengbo Li Shuqing Yang Jun Du HengBin Liao gan luo Department of Metallic Materials School of Materials Science and EngineeringSouth China University of TechnologyWu Shan Road 381Tianhe DistrictGuangzhou 510640China

Mg-3%Al alloy was refined by carbon inoculation combining with 0.2%Ca *** grain refining efficiency was obtained and the synergistic refining mechanism was deeply discussed in the present ***-C-O particles,actually Al4C3 particles,were formed in the carbon-inoculated Mg-3%A1 alloy acting as nuclei forα-Mg *** addition had no obvious effect on size distribution of the nucleating *** segregation was proved on Al4C3 particles,which should reduce the interfacial energy of nuclei/*** constitutional undercooling in front of nucleus/liquid was increased from 0.12℃to 0.15℃induced by 0.2%Ca *** synergistic grain refining efficiency can be attributed to the higher constitutional undercooling and lower the interface energy of nucleus/Mg induced by Ca *** nucleating particles with small size could be activated acting as potent nuclei ofα-Mg ***,Mg-3%Al alloy could be effectively refined due to the synergistic effect induced by carbon inoculation combining with Ca.

关键词： Mg-Al alloys Grain refinement Carbon inoculation Synergistic refinement.

文商旅体融合发展助力“贵阳贵安”世界级旅游城市建设研究

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贵州师范学院学报 2024年第7期40卷 70-77页

作者：罗赣何选润盘劲呈贵州大学体育学院贵州贵阳550025 贵州财经大学新体育研究中心贵州贵阳550025

2023年贵州提出重大发展战略,全力打造“世界级旅游目的地”。此背景下,基于AHP层次分析法、田野调查法、专家访谈法,分别对文化、商贸、旅游、体育四产业融合发展助力“贵阳贵安”世界级旅游城市建设的机理进行系统性分析,构建四产业... 详细信息

2023年贵州提出重大发展战略,全力打造“世界级旅游目的地”。此背景下,基于AHP层次分析法、田野调查法、专家访谈法,分别对文化、商贸、旅游、体育四产业融合发展助力“贵阳贵安”世界级旅游城市建设的机理进行系统性分析,构建四产业融合评价指标体系。研究发现:文化产业、商贸产业、旅游产业、体育产业在“贵阳贵安”文商旅体融合发展能力评价指标中,分别占比26.7%、25.7%、32.2%、15.4%,认为:文化产业是四产业融合发展的基础、商贸产业是保障、旅游产业丰富发展环境、体育产业提高发展韧性。提出:加快完善四产业融合发展顶层设计、以旅游产业为品牌打造融合发展路径、以文化夯实四产业的融合发展内在基础、以旅游项目丰满四产业融合发展资源、以科技引领四产业高质量发展,加快“贵阳贵安”世界级旅游城市建设进程。

关键词：贵阳贵安世界级旅游城市文商旅体产业融合

Scale-up of a high shear wet granulation process using a nucleation regime map approach

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Particuology 2017年第2期15卷 87-94页

作者： gan luo Bing Xu Yi Zhang Xianglong Cui Jianyu Li Xinyuan Shi Yanjiang Qiao Research Center of Traditional Chinese Medicine Information Engineering Beijing University of Chinese Medicine Beijing 100029 China Institute of Chinese Materia Medica China Academy of Chinese Medical Science Beijing 100700 China Beijing Key Laboratory of Traditional Chinese Medicine Manufacturing Process Control and Quality Evaluation Beijing Municipal Science & Technology Commission Beijing 100029 China

Scale-up of the high shear wet granulation （HSWG） process is considered a challenge because HSWG is complex and influenced by numerous factors, including equipment, formulation, and process variables. For a system of microcrystalline cellulose and water, HSWG experiments at three scales （1, 2, and 4 L working vessel） were conducted with a granulator. Scale-up was implemented on the basis of a nucleation regime map approach. To keep dimensionless spray flux and drop penetration time constant, water addition time at three processing scales were 300, 442, and 700 s, respectively. The other process parameters were kept unchanged. Granule size distributions were plotted and compared, and scanning electron microscopy was used to analyze granule surface morphology. Physical characterization was undertaken using a modified SeDeM method. At nearly all scales, granule yield was greater than 85% and all the cosine values were larger than 0.89. At the same experiment points, granules at all scales had similar surface morphology and similar physical characteristics. The results demonstrate that a rational scaling-up of the HSWG process is feasible using a regime map approach.

关键词： High shear wet granulation Quality by design Regime map Scale-up Microcrystanine cellulose

A comprehensive review on deep learning approaches in wind forecasting applications

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CAAI Transactions on Intelligence Technology 2022年第2期7卷 129-143页

作者： Zhou Wu gan luo Zhile Yang Yuanjun Guo Kang Li Yusheng Xue College of Automation Chongqing UniversityChongqingChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenGuangdongChina School of Electronic and Electrical Engineering University of LeedsLeedsUK State Grid Electric Power Research Institute NanjingJiangsuChina

The effective use of wind energy is an essential part of the sustainable development of human society,in particular,at the recent unprecedented pressure in shaping a low carbon energy *** wind resource and power forecasting play a key role in improving the wind ***,it has not been well adopted in the real-world applications due to the strong stochastic characteristics of wind *** recent years,the application boost of deep learning methods provides new effective tools in wind *** paper provides a comprehensive overview of the forecasting models based on deep learning in the field of wind *** approaches include timeseries-based recurrent neural networks,restricted Boltzmann machines,convolutional neural networks as well as auto-encoder-based *** addition,future development directions of deep-learning-based wind energy forecasting have also been discussed.

关键词： deep learning deep neural networks learning(artificial intelligence)