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Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome

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World Journal of Gastroenterology 2009年第41期15卷 5211-5217页

作者： Xiao-Peng Ma Lin-Ying Tan Yun Yang Huan-gan Wu Bin jiang Hui-Rong Liu Ling Yang Shanghai Institute of Acupuncture-Moxibustion and Meridian Shanghai 200030 China

AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum （CR）. An abdominal withdrawal reflex （AWR） scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells （MC）, changes of substance P （SP） and substance P receptor （SPR） in colon and change of corticotropin-releasing hormone （CRH） in hypothalamus. RESULTS： The threshold of visceral sense was significantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was significantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION： EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS.

关键词： Electro-acupuncture Corticotropin-releasing hormone Irritable bowel syndrome Substance P Substance P receptor

Clinical characteristics of testicular torsion and factors influencing testicular salvage in children:A 12-year study in tertiary center

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World Journal of Clinical Cases 2024年第7期12卷 1251-1259页

作者： Xiang-Hui gang Yuan-Yuan Duan Bin Zhang Zheng-gan jiang Rong Zhang Jun Chen Xiang-Yu Teng Duo-Bing Zhang Department of Urology Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Ultrasound Diagnosis Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of Urology The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

BACKGROUND Testicular torsion is the most common acute scrotum worldwide and mainly occurs in children and *** have demonstrated that the duration of symptoms and torsion grade lead to different outcomes in children diagnosed with testicular *** To predict the possibility of testicular salvage(TS)in patients with testicular torsion in a tertiary *** We reviewed the charts of 75 pediatric patients with acute testicular torsion during a 12-year period from November 2011 to July 2023 at the Suzhou Hospital of Anhui Medical *** and multivariate logistic regression analyses were used to determine independent predictors of testicular *** data included clinical findings,physical examinations,laboratory data,color Doppler ultrasound findings,operating results,age,presenting institution status,and follow-up *** Our study included 75 *** was possible in 57.3%of all patients;testicular torsion occurred mostly in winter,and teenagers aged 11-15 years old accounted for 60%.Univariate logistic regression analyses revealed that younger age(P=0.09),body mass index(P=0.004),torsion angle(P=0.013),red blood cell count(P=0.03),neutrophil-to-lymphocyte ratio(P=0.009),and initial presenting institution(P<0.001)were associated with *** multivariate analysis,only the initial presenting institution predicted TS(P<0.05).CONCLUSION The initial presenting institution has a predictive value for predicting TS in patients with testicular *** with scrotal pain should be admitted to a tertiary hospital as soon as possible.

关键词： Testicular torsion Testicular salvage Pediatrics Predictors Case report

The shape effect of reconstituted high-density lipoprotein nanocarriers on brain delivery and Aβ clearance

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Nano Research 2018年第10期11卷 5615-5628页

作者： Huahua Song Xinyi Ma Jianrong Xu Qingxiang Song Meng Hu Xiao Gu Qian Zhang Lina Hou Lepei Chen Yukun Huang Ping Yu Dayuan Wang gan jiang Meng Huang Jun Chen Hongzhuan Chen Xiaoling Gao Department of Pharmacology and Chemical Biology Faculty of Basic Medicine School of Medicine Shanghai.liao Tong University Shanghai 200025 China Key Laboratory of Smart Drug Delivery Ministry of Education School of Pharmacy Fudan University Lane 826 Zhangheng Road Shanghai 201203 China Department of Pharmacy Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Accumulation of extracellular β-amyloid （Aβ） is crucial for the pathogenesis of Alzheimer＇s disease （AD）, and the development of novel therapeutic agents that can both accelerate Aβ clearance and inhibit the subsequent pathological cascades is regarded as a promising strategy for AD management. In our previous study, we have constructed discoidal apolipoprotein E3-reconstituted high-density lipoprotein （ApoE3-rHDL） as an efficient nanoplatform that can penetrate the blood-brain barrier and accelerate Aβ clearance for a combination treatment of AD. To further improve its drug loading capacity, we hypothesized that spherical rHDL might serve as a more powerful nanocarrier if it has the same brain delivery and Aβ clearance abilities as the discoidal rHDL does. To evaluate the potential of spherical rHDL as a promising alternative for the combination therapy for AD, here, we investigated the effect of the shape of rHDL on its brain delivery, Aβ clearance, and anti-AD efficacy. We found that spherical rHDL had stronger Aβ-binding affinity than discoidal rHDL did, more effectively facilitated microglial uptake and degradation of Aβ-42, achieved better brain distribution after intravenous administration, and more powerfully reduced Aβ deposition, decreased microglia activation, attenuated neurological damage, and rescued memory deficits in a mouse model of AD. Among the rHDLs evaluated, monosialotetrahexosyl ganglioside-incorporated spherical rHDL exerted the best effect. The findings of this study for the first time show a shape effect of an rHDL nanocarrier on its biological functions and suggest that a spherical lipoprotein-mimic nanocarrier may serve as a more efficient multifunctional nanoplatforrn for AD therapy.

关键词： reconstituted high density lipoprotein β-amyloid apolipoprotein E spherical discoidal Alzheimer's disease

Nanopolyphenol rejuvenates microglial surveillance of multiple misfolded proteins through metabolic reprogramming

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Acta Pharmaceutica Sinica B 2023年第2期13卷 834-851页

作者： Dayuan Wang Xiao Gu Xinyi Ma Jun Chen Qizhi Zhang Zhihua Yu Juan Li Meng Hu Xiaofang Tan Yuyun Tang Jianrong Xu Minjun Xu Qingxiang Song Huahua Song gan jiang Zaiming Tang Xiaoling Gao Hongzhuan Chen Department of Pharmacology and Chemical Biology State Key Laboratory of Oncogenes and Related GenesShanghai Universities Collaborative Innovation Center for Translational MedicineShanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Smart Drug Delivery Ministry of EducationSchool of PharmacyFudan UniversityShanghai 201203China Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghai201203China

Microglial surveillance plays an essential role in clearing misfolded proteins such as amyloid-beta,tau,andα-synuclein aggregates in neurodegenerative ***,due to the complex structure and ambiguous pathogenic species of the misfolded proteins,a universal approach to remove the misfolded proteins remains ***,we found that a polyphenol,α-mangostin,reprogrammed metabolism in the disease-associated microglia through shifting glycolysis to oxidative phosphorylation,which holistically rejuvenated microglial surveillance capacity to enhance microglial phagocytosis and autophagy-mediated degradation of multiple misfolded *** ofα-mangostin efficiently deliveredα-mangostin to microglia,relieved the reactive status and rejuvenated the misfolded-proteins clearance capacity of microglia,which thus impressively relieved the neuropathological changes in both Alzheimer’s disease and Parkinson’s disease model *** findings provide direct evidences for the concept of rejuvenating microglial surveillance of multiple misfolded proteins through metabolic reprogramming,and demonstrate nanoformulatedα-mangostin as a potential and universal therapy against neurodegenerative diseases.

关键词： Microglia Metabolism Misfolded proteins Phagocytosis Degradation Polyphenol Nanoparticles Neurodegenerative diseases

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含氟/硅丙烯酸酯核壳型乳液的合成及性能

高等学校化学学报 2008年第1期29卷 187-192页

作者：和玲徐岩朱江安梁军艳西安交通大学理学院应用化学系西安710049

采用半连续种子乳液聚合法，在十二烷基硫酸钠（SDS）／辛基苯基聚氧乙烯醚（Tx-10）复合乳化剂的作用下，合成了以丙烯酸丁酯（BA）为核，以甲基丙烯酸甲酯（MMA）、甲基丙烯酸十二氟庚酯（DFHMA）、3-（甲基丙烯酰氧）丙基三甲氧基硅... 详细信息

采用半连续种子乳液聚合法，在十二烷基硫酸钠（SDS）／辛基苯基聚氧乙烯醚（Tx-10）复合乳化剂的作用下，合成了以丙烯酸丁酯（BA）为核，以甲基丙烯酸甲酯（MMA）、甲基丙烯酸十二氟庚酯（DFHMA）、3-（甲基丙烯酰氧）丙基三甲氧基硅烷（MPTMS）和甲基三甲氧基硅烷（MTMS）为壳的核壳型含氟／硅丙烯酸酯聚合物乳液．利用FTIR，TEM，SEM—EDX和DSC等手段对乳液组成、乳胶粒子结构、膜表面及断面形态等进行了表征，讨论了氟／硅含量对聚合物膜性能的影响．结果表明，核-壳粒子尺寸为20～30nm，乳液膜的性能与膜表面氟和硅的含量及相容性有较大的相关性，当m（氟）：m（硅单体）=3：1时，形成的膜均匀透明，吸水率较低，尺寸稳定性较好．

关键词：半连续种子乳液聚合含氟/硅丙烯酸酯聚合物核壳结构膜性能

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蜂窝状块体硅胶/分子筛复合物吸附性能

化工学报 2008年第10期59卷 2536-2540页

作者：蒋赣方玉堂张紫超广东药学院药科学院广东广州510006 华南理工大学传热强化与过程节能教育部重点实验室广东广州510640

采用静态法测定了蜂窝状块体硅胶/分子筛复合物的吸附性能,并采用吸附床结构模拟转轮除湿过程,测定了复合物动态吸附性能;探讨了复合物在吸附过程中温、湿度分布;研究了处理风参数(风速,进口温度、湿度)对块体吸附剂吸附性能的影响。结... 详细信息

采用静态法测定了蜂窝状块体硅胶/分子筛复合物的吸附性能,并采用吸附床结构模拟转轮除湿过程,测定了复合物动态吸附性能;探讨了复合物在吸附过程中温、湿度分布;研究了处理风参数(风速,进口温度、湿度)对块体吸附剂吸附性能的影响。结果表明:块体硅胶/分子筛复合物的除湿性能明显高于硅胶,尤其在较高温度和较低湿度条件下。在处理风温度较低、风速较小及处理风湿度较大的前提下,块体复合物除湿性能较好。

关键词：蜂窝状块体硅胶/分子筛复合物吸附性能除湿