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Preoperative blood markers and intra-abdominal infection after colorectal cancer resection

World Journal of Gastrointestinal Surgery 2024年第2期16卷 451-462页

作者： Chang-Qing Liu Zhong-Bei Yu Jin-Xian gan Tian-Ming Mei Department of Gastrointestinal Anorectal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)has one of the highest morbidity and mortality rates among digestive tract ***-abdominal infection(IAI)is a common postoperative complication that affects the clinical outcomes of patients with CRC and hinders their rehabilitation ***,the factors influencing abdominal infection after CRC surgery remain unclear;further,prediction models are rarely used to analyze preoperative laboratory indicators and postoperative *** To explore the predictive value of preoperative blood markers for IAI after radical resection of *** The data of 80 patients who underwent radical resection of CRC in the Anorectal Surgery Department of Suzhou Hospital affiliated with Anhui Medical University were *** patients were categorized into IAI(n=15)and non-IAI groups(n=65)based on whether IAI *** factors were compared;general data and laboratory indices of both groups were *** relationship between the indicators was ***,a nomogram prediction model was developed and evaluated;its utility and clinical applic-ability were *** The risk factors for IAI after radical resection of CRC were neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),systemic immune-inflammation index(SII),and carcinoembryonic antigen(CEA)*** was correlated with PLR and SII(r=0.604,0.925,and 0.305,respectively),while PLR was correlated with SII(r=0.787).The nomogram prediction model demonstrated an area under the curve of 0.968[95%confidence interval(CI):0.948-0.988]in the training set(n=60)and 0.926(95%CI:0.906-0.980)in the validation set(n=20).The average absolute errors of the calibration curves for the training and validation sets were 0.032 and 0.048,respectively,indicating a good model *** decision curve analysis curves demonstrated high net income above the 5%threshold,indicating the clinical practicality of the *** The nomogram model constructed

关键词： Radical resection of colorectal cancer Inflammatory factors Intra-abdominal infection Predictive model Blood markers

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Self-powered flexible fingerprint-recognition display based on a triboelectric nanogenerator

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Nano Research 2024年第4期17卷 3021-3028页

作者： Wandi Chen Haonan Wang Yibin Lin Xinyan gan Heng Tang Yongai Zhang Qun Yan Tailiang Guo Xiongtu Zhou Chaoxing Wu School of Physics and Information Engineering Fuzhou UniversityFuzhou 350108China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350116China

In the time of Internet of Things(IoT),alternating current electroluminescence(ACEL)has unique advantages in the fields of smart display and human–computer ***,their reliance on external high-voltage AC power supplies poses challenges in terms of wearability and limits their practical *** paper proposed an innovative scheme for preparing a feather triboelectric nanogenerator(F-TENG)using recyclable and environmentally friendly *** highest open-circuit voltage,short-circuit current,and transferred charge of SF6-treated F-TENGs can reach 449 V,63μA,and 152 nC,which enables easy lighting of BaTiO_(3)^(-)doped ACEL *** a human electrical potential,a single-electrode F-TENG is combined with ACEL device for self-powered fingerprint recognition *** works achieve self-powered flexible wearable ACEL devices,which are not only efficient and portable but also have good application prospects in the human–computer interaction,functional displays,and wearable electronic devices.

关键词： alternating current electroluminescent triboelectric nanogenerator feather reactive ion etching fingerprint recognition

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Prediction of suitable water content in granulation of sintering mixture based on Litster's model

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Journal of Iron and Steel Research International 2024年第3期31卷 552-560页

作者： Fang-lei Dai Xiao-hui Fan Xiao-xian Huang Xu-ling Chen Min gan Zhi-yun Ji Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Suitable water content plays a decisive role in the granulation of sintering ***,a method was proposed to predict the suitable water content for effective granulation on the basis of Litster's granulation *** granulation effectiveness of a sintering mixture was predicted by the model,with the allowance error of±10%.The effects of the water absorption properties,particle size composition and content of adhesive particles on the suitable water content were *** results showed that the allowable error of prediction was within±0.5%compared to the experimentally determined suitable water *** an increase in adhesive powder content of mixtures with higher water absorption,the suitable water content increased to achieve similar granulation ***,as the amount of concentrates increased,the suitable water content first increased and then remained *** influence of the water absorption characteristics of the adhesive particles on the suitable water content was less than that of their particle size composition in the mixture.

关键词： Adhesive particle Sintering mixture Granulation effectiveness Suitable water content

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Natural sources,refined extraction,biosynthesis,metabolism,and bioactivities of dietary polymethoxyflavones(PMFs)

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Food Science and Human Wellness 2024年第1期13卷 27-49页

作者： Renyou gan Yi Liu Hang Li Yu Xia Huan Guo Fang Geng Qiguo Zhuang Huabin Li Dingtao Wu Research Center for Plants and Human Health Institute of Urban AgricultureChinese Academy of Agricultural SciencesChengdu National Agricultural Science and Technology CenterChengdu 610213China Key Laboratory of Coarse Cereal Processing Ministry of Agriculture and Rural AffairsSichuan Engineering and Technology Research Centre of Coarse Cereal IndustralizationSchool of Food and Biological EngineeringChengdu UniversityChengdu 610106China China-New Zealand Belt and Road Joint Laboratory on Kiwifruit Sichuan Provincial Academy of Natural Resource SciencesChengdu 610213China Guangdong Provincial Key Laboratory of Food Nutrition and HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China

Polymethoxyflavones(PMFs)are a type of uncommon dietary flavonoids,characterized by more than one methoxy group,which exist in limited plant species,like Citrus species and Kaempferia *** addition,different PMFs,such as nobiletin,sinensetin,tangeretin,and casticin,have been isolated from these natural *** have received increasing attention due to their multiple bioactivities,such as antioxidant,anti-inflammatory,anti-cancer,metabolic regulatory,immunoregulatory,neuroprotective,and skin protective *** bioactivities of PMFs should be associated with the regulation of critical molecular targets and the interaction with gut *** order to provide a comprehensive and updated review of PMFs,their natural sources,refined extraction,biosynthesis,metabolism,and bioactivities are summarised and discussed,with the emphasis on the molecular mechanisms of PMFs on regulating different chronic ***,PMFs may be promising flavonoids to the forefront of nutraceuticals for the prevention and/or treatment of certain human chronic diseases.

关键词： Nobiletin O-Methyltransferases Gut microbiota Bioactivities Molecular mechanism

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Digital Transformation Trend of the Pharmaceutical Distribution Industry in the Context of New Infrastructure in China

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Asian Journal of Social Pharmacy 2024年第2期19卷 159-167页

作者： gan Xingzhi School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To study the pharmaceutical distribution industry against the background of new infrastructure construction since it is vital to the health and life of the public,and to offer some suggestions to further improve the industry quality and achieve industry *** The national strategies for new infrastructure as well as the underlying logic for enterprise digital transformation were analyzed to provide the outlook on the digital transformation trend of the pharmaceutical distribution *** and Conclusion In the future,the pharmaceutical distribution industry shall transform the pattern,channel,management and control,and experience in the entire business chain in a digital way by focusing on connection efficiency,data efficiency and decision-making efficiency.

关键词： pharmaceutical distribution digital transformation new infrastructure trend

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Evolutionary analysis of green credit and automobile enterprises under the mechanism of dynamic reward and punishment based on government regulation

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中国科学技术大学学报 2024年第5期54卷 49-62,I0007页

作者： Yu Dong Xiaoyu Huang Hongan gan Xuyang Liu School of Economics and Management Anhui University of Science and TechnologyHuainan 232001China School of Management University of Science and Technology of ChinaHefei 230026China

To explore the green development of automobile enterprises and promote the achievement of the“dual carbon”target,based on the bounded rationality assumptions,this study constructed a tripartite evolutionary game model of gov-ernment,commercial banks,and automobile enterprises;introduced a dynamic reward and punishment mechanism;and analyzed the development process of the three parties’strategic behavior under the static and dynamic reward and punish-ment *** PLE was used for numerical simulation *** results indicate that the system could not reach a stable state under the static reward and punishment mechanism.A dynamic reward and punishment mechanism can effectively improve the system stability and better fit real *** the dynamic reward and punishment mechan-ism,an increase in the initial probabilities of the three parties can promote the system stability,and the government can im-plement effective supervision by adjusting the upper limit of the reward and punishment ***,the implementa-tion of green credit by commercial banks plays a significant role in promoting the green development of automobile enter-prises.

关键词： automobile enterprises green credit system dynamics reward and punishment mechanism

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Wireless sequential dual light delivery for programmed PDT in vivo

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Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-Joon Kim Shu Uin gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

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Towards optimized tensor code generation for deep learning on sunway many-core processor

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Frontiers of Computer Science 2024年第2期18卷 1-15页

作者： Mingzhen LI Changxi LIU Jianjin LIAO Xuegui ZHENG Hailong YANG Rujun SUN Jun XU Lin gan Guangwen YANG Zhongzhi LUAN Depei QIAN State Key Laboratory of Software Development Environment Beijing 100191China School of Computer Science and Engineering Beihang UniversityBeijing 100191China National University of Singapore Singapore 119077Singapore State Key Laboratory of Mathematical Engineering and Advanced Computing Wuxi 214000China Science and Technology on Special System Simulation Laboratory Beijing Simulation Center Beijing 100854China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China

The flourish of deep learning frameworks and hardware platforms has been demanding an efficient compiler that can shield the diversity in both software and hardware in order to provide application *** the existing deep learning compilers,TVM is well known for its efficiency in code generation and optimization across diverse hardware *** the meanwhile,the Sunway many-core processor renders itself as a competitive candidate for its attractive computational power in both scientific computing and deep learning *** paper combines the trends in these two ***,we propose swTVM that extends the original TVM to support ahead-of-time compilation for architecture requiring cross-compilation such as *** addition,we leverage the architecture features during the compilation such as core group for massive parallelism,DMA for high bandwidth memory transfer and local device memory for data locality,in order to generate efficient codes for deep learning workloads on *** experiment results show that the codes generated by swTVM achieve 1.79x improvement of inference latency on average compared to the state-of-the-art deep learning framework on Sunway,across eight representative *** work is the first attempt from the compiler perspective to bridge the gap of deep learning and Sunway processor particularly with productivity and efficiency in *** believe this work will encourage more people to embrace the power of deep learning and Sunwaymany-coreprocessor.

关键词： sunway processor deep learning compiler code generation performance optimization

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A nonenzymatic electrochemical sensor for the detection of hydrogen peroxide in vitro and in vivo fibrosis models

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Chinese Chemical Letters 2024年第3期35卷 394-398页

作者： Hongyao Liu Yan Yu Taixiong Xue Cailing gan Yuting Xie Doudou Wang Peilin Li Zhiyong Qian Tinghong Ye Department of Gastroenterology and Hepatology Sichuan University-University of Oxford Huaxi Joint Centre for Gastrointestinal Cancer and Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Fibrosis occurs due to the excessive deposition of extracellular matrix caused by cell *** various types of tissue injury,the dysregulation of the internal response can eventually lead to the destruction of organ structure and *** is increasing evidence that oxidative stress,which is characterized by excessive production of hydrogen peroxide(H_(2)O_(2)),is an important cause of ***,we synthesized a biosensitive and efficient electrochemical H_(2)O_(2)sensor based on PtNi nanoparticle-doped N-reduced graphene oxide(PtNi-N-rGO)to detect H_(2)O_(2)released from transforming growth factorβ1(TGFβ1)-induced *** addition,the sensor could easily detect changes in H_(2)O_(2)in the lung and bronchoalveolar lavage fluid(BALF)of mice with pulmonary ***,the sensor could also detect H_(2)O_(2)in activated hepatic stellate cells and the liver of carbon tetrachloride(CCl_(4))-induced liver ***,the alterations in H_(2)O_(2)detected by the sensor were consistent with nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)protein expression and the staining results of pathological *** together,these results highlight the use of H_(2)O_(2)sensors for the rapid detection of fibrosis and facilitate the rapid evaluation of antifibrotic drug candidates.

关键词： Fibrosis H_(2)O_(2) Electrochemical sensor NOX4 Nintedanib

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Advances in the kinetics of heat and mass transfer in near-continuous complex flows

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Frontiers of physics 2024年第4期19卷 187-234页

作者：许爱国张德佳甘延标 National Key Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsP.O.Box 8009-26Beijing 100088China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China HEDPS Center for Applied Physics and Technologyand College of EngineeringPeking UniversityBeijing 100871China State Key Laboratory for GeoMechanics and Deep Underground Engineering China University of Mining and TechnologyBeijing 100083China National Key Laboratory of Shock Wave and Detonation Physics Mianyang 621999China Hebei Key Laboratory of Trans-Media Aerial Underwater Vehicle School of Liberal Arts and SciencesNorth China Institute of Aerospace EngineeringLangfang 065000China

The study of macro continuous flow has a long ***,the exploration of heat and mass transfer in small systems with a particle number of several hundred or less has gained significant interest in the fields of statistical physics and nonlinear ***,due to absence of suitable methods,the understanding of mesoscale behavior situated between the aforementioned two scenarios,which challenges the physical function of traditional continuous fluid theory and exceeds the simulation capability of microscopic molecular dynamics method,remains considerably *** greatly restricts the evaluation of effects of mesoscale behavior and impedes the development of corresponding regulation *** access the mesoscale behaviors,there are two ways:from large to small and from small to *** the necessity to interface with the prevailing macroscopic continuous modeling currently used in the mechanical engineering community,our study of mesoscale behavior begins from the side closer to the macroscopic continuum,that is from large to *** on some fundamental challenges encountered in modeling and analysis of near-continuous flows,we review the research progress of discrete Boltzmann method(DBM).The ideas and schemes of DBM in coarse-grained modeling and complex physical field analysis are *** relationships,particularly the differences,between DBM and traditional fluid modeling as well as other kinetic methods are *** verification and validation of the method,some applied researches including the development of various physical functions associated with discrete and non-equilibrium effects are *** directions of DBM related studies are indicated.

关键词： near-continuous flow non-equilibrium kinetics discrete Boltzmann method complex physical field analysis

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