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Alternative Splicing of OsCYL4 Controls Drought Resistance via Regulating Water Loss and Reactive Oxygen Species-Scavenging in Rice

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Rice science 2024年第1期31卷 1-5,I0001-I0008页

作者： SHA gan SHEN Xin WU Zini XU Xiaocan XU Xin TAN Yanping LIU Xinqiong TANG Xianyin WANG Chuntai QIN Yonghua Hubei Provincial Key Laboratory for Protection and Application of Special Plants in Wuling Area College of Life SciencesSouth Central Minzu UniversityWuhan 430074China Huazhong Agricultural University Wuhan 430070China

A rice cyclase gene,OsCYL4b,identified as an alternative splice variant of the cyclase gene OsCYL4a,is involved in the regulation of drought stress and oxidative *** with OsCYL4a,OsCYL4b lacks the second exon,which is located in the conserved motif 3,and may be a functionally important *** results suggested that OsCYL4b was responsive to multiple abiotic stresses,and was localized to both the cytoplasm and plasma *** overexpression of OsCYL4b resulted in significantly enhanced drought and osmotic stress tolerance,reduced water loss,and increased abscisic acid(ABA)content compared with the wild type(WT).

关键词： drought Oxygen stress

Clinical and genetic heterogeneity of adult polyglucosan body disease caused by GBE1 biallelic mutations in China

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Genes & Diseases 2024年第5期11卷 17-20页

作者： Yikun Chen Yan Shi Yuan Gao Yan Hu Linying Zhou Jingmei Hong Shirui gan Xiang Lin Wanjin Chen Guorong Xu Jin He Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Fujian Key Laboratory of Molecular Neurology Institute of NeuroscienceFujian Medical UniversityFuzhouFujian 350005China Electron Microscopy Lab of Public Technology Service Center Fujian Medical UniversityFuzhouFujian 350005China

Adult polyglucosan body disease(APBD)is a rare and highly heterogeneous glycogen storage disorder due to biallelic variants in GBE1.1 Typical APBD presentations include gait abnormalities with polyneuropathy,leukodystrophy,neurogenic bladder,and mild cognitive *** diagnosis of APBD encompasses a large spectrum of conditions including axonal and demyelinating sensorimotor polyneuropathy,progressive spastic paraparesis,and leukodystrophies.

关键词： GBE bladder diagnosis

Influence of extraction voltage on electron and ion behavior characteristics

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Chinese Physics B 2024年第4期33卷 553-559页

作者：徐翱甘娉娉石元杰陈磊 Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang 621999China

The characteristics of the extracted ion current have a significant impact on the design and testing of ion source *** this paper,a 2D in space and 3D in velocity space particle in cell(2D3V PIC)method is utilized to simulate plasma motion and ion extraction characteristics under various initial plasma velocity distributions and extraction voltages in a Cartesian coordinate *** plasma density is of the order of 10^(15)m^(-3)-10^(16)m^(-3)and the extraction voltage is of the order of 100 V-1000 *** study investigates the impact of various extraction voltages on the velocity and density distributions of electrons and positive ions,and analyzes the influence of different initial plasma velocity distributions on the extraction *** simulation results reveal that the main reason for the variation of extraction current is the spacecharge force formed by the relative aggregation of positive and negative net *** lays the foundation for a deeper understanding of extraction beam characteristics.

关键词： extraction voltage plasma ion beam ion current

Narciclasine induces colon carcinoma cell apoptosis by inhibiting the IL-17A/Act1/TRAF6/NF-kB signaling pathway

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Genes & Diseases 2024年第5期11卷 428-441页

作者： Huiming Deng Qiang Liu Siman Yu Lifan Zhong Lianfang gan Huiquan Gu Qianru Wang Ruxin Cheng Yong Liu Li Liu Ling Huang Ronghua Xu Department of Gastrointestinal Surgery Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518000China Research Center for Drug Safety Evaluation of Hainan Province HaikouHainan 571199China Department of Pharmacology Hainan Medical UniversityHaikouHainan 571199China Department of Pathology Guangzhou Panyu Central HospitalGuangzhouGuangdong 511400China Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research Hainan Medical UniversityHaikouHainan 571199China Hainan Center for Drug and Medical Device Evaluation and Service Hainan Medical Products AdministrationHaikouHainan 570216China

IL-17 A is a promoter of colorectal cancer initiation and *** is a polyhydroxy alkaloid compound isolated from Narcissus plants,which has potent anti-inflammatory and antitumor *** effects of narciclasine on colorectal tumors were evaluated,with a focus on IL-17 *** reduced the growth of HCT-116 and SW-480 colon cancer cells in vitro and in vivo in murine *** results of flow cytometry on JC-1 and Annexin V/PI revealed that narciclasine significantly reduced the mitochondrial membrane potential and induced apoptosis,findings confirmed by western blotting results of reduced Bcl2 and enhanced Bax expression,as well as accumulation of cleaved Caspase-3,Caspase-8,Caspase-9,and cytoplasmic *** narciclasine incubation,IL-17 A,Act1,and TRAF6 were down-regulated,while p-P65(Ser536)accumulated in the cytoplasm,a finding confirmed by laser scanning confocal ***17A substitution could partly reverse these narciclasine effects while they were elevated by IL17A ***,IL-17 A,Act1,and TRAF6 were significantly expressed to greater extents in human colorectal cancer compared to normal adjacent tissue specimens and were closely linked with a poor *** study provided evidence that narciclasine may be a useful therapeutic drug for colorectal cancer treatment through its actions in down-regulating the L-17A/Act1/TRAF6/NF-kB anti-apoptotic signaling pathway.

关键词： Act1 Apoptosis Colonrectal cancer IL-17A Narciclasine NF-kB

Efficacy of radiofrequency ablation combined with sorafenib for treating liver cancer complicated with portal hypertension and prognostic factors

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World Journal of Gastroenterology 2024年第11期30卷 1533-1544页

作者： Li-Min Yang Hong-Juan Wang Shan-Lin Li Guan-Hua gan Wen-Wen Deng Yong-Sheng Chang Lian-Feng Zhang Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Gastroenterology Zhoukou Central Hospital of Henan ProvinceZhoukou 466000Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453000Henan ProvinceChina

BACKGROUND Patients with liver cancer complicated by portal hypertension present complex challenges in *** To evaluate the efficacy of radiofrequency ablation in combination with sorafenib for improving liver function and its impact on the prognosis of patients with this *** Data from 100 patients with liver cancer complicated with portal hypertension from May 2014 to March 2019 were analyzed and divided into a study group(n=50)and a control group(n=50)according to the treatment *** research group received radiofrequency ablation(RFA)in combination with sorafenib,and the control group only received *** short-term efficacy of both the research and control groups was *** function and portal hypertension were compared before and after ***-fetoprotein(AFP),glypican-3(GPC-3),and AFP-L3 levels were compared between the two groups prior to and after *** occurrence of adverse reactions in both groups was *** 3-year survival rate was compared between the two *** data were compared between the survival and non-surviving *** identify the independent risk factors for poor prognosis in patients with liver cancer complicated by portal hypertension,multivariate logistic regression analysis was *** When comparing the two groups,the research group's total effective rate(82.00%)was significantly greater than that of the control group(56.00%;P<0.05).Following treatment,alanine aminotransferase and aspartate aminotransferase levels increased,and portal vein pressure decreased in both *** degree of improvement for every index was substantially greater in the research group than in the control group(P<0.05).Following treatment,the AFP,GPC-3,and AFP-L3 levels in both groups decreased,with the research group having significantly lower levels than the control group(P<0.05).The incidence of diarrhea,rash,nausea and vomiting,and fatigue in the research group was significantly great

关键词： Radiofrequency ablation Sorafenib Liver cancer Portal hypertension Efficacy Prognosis analysis

小型模块式轻水堆燃料组件临界热流密度研究进展

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原子能科学技术 2024年第S2期58卷 320-331页

作者：解衡朱淦清华大学核能与新能源技术研究院先进核能技术协同创新中心先进反应堆工程与安全教育部重点实验室

小型模块化反应堆（SMR）在“双碳”大背景下具有广阔的应用前景，对实现能源低碳化转型和能源技术变革等方面具有重要意义。它与常规轻水堆（压水堆和沸水堆）相比堆芯设计差异大，主要表现在小型堆运行功率低、压力低、流速低、堆芯... 详细信息

小型模块化反应堆（SMR）在“双碳”大背景下具有广阔的应用前景，对实现能源低碳化转型和能源技术变革等方面具有重要意义。它与常规轻水堆（压水堆和沸水堆）相比堆芯设计差异大，主要表现在小型堆运行功率低、压力低、流速低、堆芯高度低以及功率分布更畸形等，从而导致水冷SMR燃料组件临界热流密度（CHF）研究面临更多难点和挑战。本文综述了CHF机理模型研究、经验关系式研究、子通道分析程序开发等三个方面的发展现状，分析了小型模块式轻水堆CHF研究的特点和难点，并以清华大学研发的一体化全功率自然循环小型压水堆NHR200-Ⅱ为例，介绍了其临界热流密度分析的关键方法研究。

关键词：小型模块化反应堆 NHR200-Ⅱ燃料组件临界热流密度试验设计准则临界热流密度预测方法临界热流密度机理

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Broadband light-active optoelectronic FeFET memory for in-sensor non-volatile logic

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Science China(Information Sciences) 2024年第9期67卷 346-347页

作者： Yong ZHANG Dongxin TAN Cizhe FANG Zheng-Dong LUO Qiyu YANG Qiao ZHANG Yu ZHANG Xuetao gan Yan LIU Yue HAO Genquan HAN State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Hangzhou Institute of Technology Xidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information Technology School of Physical Science and TechnologyNorthwestern Polytechnical University

Machine vision has become crucial in the modern intelligence era, especially in rapidly developing applications such as autonomous vehicles and robotic visual sensors [1].With the ever-increasing requirements of visua... 详细信息

关键词： Ferroelectric RAM

Dual-functional microneedle with programmatic regulation of macrophage for autoimmune psoriasis treatment

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Nano Research 2024年第8期17卷 7436-7448页

作者： Ze Qiang Zhao Bo Zhi Chen Jia Li gan Yun Hao Feng Ling Liang Lingyun Yu Zi Yi Wang Samin Abbaszadeh Mohammad-Ali Shahbazi Ruixing Yu Xin Dong Guo State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Beijing Laboratory of Biomedical Materials College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China China-Japan Friendship Hospital Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmaceutical Biomaterials School of PharmacyZanjan University of Medical SciencesZanjan 45139-56184Iran Department of Biomaterials and Biomedical Technology University Medical Center GroningenUniversity of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University of GroningenAntonius Deusinglaan 19713 AV GroningenThe Netherlands

Modulating the immune microenvironment to establish sustained positive feedback within immune pathways represents a promising avenue for the treatment of ***,the precise and efficient delivery of therapeutic systems to the subcutaneous basal layer to modulate immune disorders is a major challenge in the treatment of autoimmune *** this project,we introduce a dual-functional microneedle(DF-MN)designed to combine MNs with multiple release kinetics and immunotherapy,the programmed treatment is achieved through segmented design of the MN structure,realizing the unification of rapid and long-lasting treatment of autoimmune *** vivo imaging results showed that GelMA@M-CSF showed fluorescent signals after 5 days of delivery to subcutaneous tissues,whereas HA@IL-13 showed minimal fluorescent signals after 2 *** multistage release behavior of MNs and the diffusion mechanism of drugs were explained at the molecular level,in combination with coarse-grained molecular ***,DF-MN can successfully induce macrophage reprogramming in vitro and ameliorate overall symptoms in a psoriasis mice model,suggesting that it has the potential to be an effective strategy for the treatment of psoriasis and portends to be a transformative platform for the treatment of other autoimmune diseases.

关键词： microneedle psoriasis M2 macrophage immunoregulation

PriChain: Efficient Privacy-preserving Finegrained Redactable Blockchains in Decentralized Settings

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Chinese Journal of Electronics 2024年

作者： Hongchen GUO Weilin gan Mingyang ZHAO Chuan ZHANG Tong WU Liehuang ZHU Jingfeng XUE School of Computer Science and Technology Beijing Institute of Technology School of Cyberspace Science and Technology Beijing Institute of Technology School of Computer and Communication Engineering University of Science and Technology Beijing

Recently, redactable blockchain has been proposed and leveraged in a wide range of real systems for its unique properties of decentralization, traceability, and transparency while ensuring controllable on-chain data redaction. However, the development of redactable blockchain is now obstructed by three limitations, which are data privacy breaches, high communication overhead, and low searching efficiency, respectively. In this paper, we propose PriC hain, the first efficient privacy-preserving fine-grained redactable blockchain in decentralized settings. PriChain provides data owners with rights to control who can read and redact on-chain data while maintaining downward compatibility, ensuring the one who can redact will be able to read. Specifically, inspired by the concept of multi-authority attribute-based encryption, we utilize the isomorphism of the access control tree, realizing fine-grained redaction mechanism, downward compatibility, and collusion resistance. With the newly designed structure, PriChain can realize O（n） communication and storage overhead compared to prior O（n2） schemes. Furthermore, we integrate multiple access trees into a tree-based dictionary, optimizing searching efficiency. Theoretical analysis proves that PriC hain is secure against the chosen-plaintext attack and has competitive complexity. The experimental evaluations show that PriChain realizes 10× efficiency improvement of searching and 100× lower communication and storage overhead on average compared with existing schemes.

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