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中国神经科学学会第十届全国学术会议

作者： DY Huang HL Zhang n gamper Department of Phamacology Hebei Medical University

T-type calcium channels(Cav3.1,Cav3.2 and Cav3.3) make one of the families of the voltage-gated calcium channels(VGCC).T-type channels are distinct from other VGCC types in that they are activated at very negative voltages(activation threshold near-60 mV) Thus,in excitable cells T-type channel activity contributes to the control of excitability by setting up an action potential firing *** evidence indicates that the T-type calcium channels are expressed in the receptive fields of peripheral sensory neurons,suggesting that they may play an important role in *** until now the mechanism of the regulation of the T-type calcium channels are still largely *** investigated regulation of T-type Ca channels by inflammatory *** application of bradykinin(200 nM) did not significantly affected the amplitude of currents though Cav3.2 heterologousely erexpressed in HEK293 cells,but induced a leftward shift the channel voltage *** inflammatory mediator,substance P(10 uM) acutely inhibited CaV3.2 current in HEK293 cells and the native T-type Ca current in cultured DRG neurons by 30.2%±6.8%(n = 11,Pnd by 25.9%±5.3%(n = 11,Pnhibition was not reversible upon washout but was completely reversed by the application of reducing agent DTT(1mM) suggesting that SP effect on T-type channels is mediated by the oxidative *** support of this conclusion substitution of redox sensitive histidine at the position 191 in Cav3.2 by glutamine completely abohshed SP-induced *** further experiments we found that pretreatment of cultured rat DRG neurons with a cocktail of inflammatory mediators(bradykinin,50 nM;ATP,2 uM;prostaglandin E2,0.5 μM;norepinephrine,0.5 μM) overnight strongly increased the T-type Ca current density(from 64.1±7.4 pA to 105.6 ± 16.5 pA,n=28 and n = 37,Pnd a proportion of neurons which express T-type Ca current(from 28/63 to 37/63).Our results put forward ne

关键词： T-type Ca2+ channel Substance P bradykinin inflammation sensory neuron

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Ionic Mechanisms for the Acute nociceptive Signals Induced by Bradykinin

Ionic Mechanisms for the Acute Nociceptive Signals Induced b...

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第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： Linley JE Ooi L gamper n Institute of Membrane and Systems Biology Faculty of Biological ScienceUniversity of Leeds

＜正＞Bradykinin is an inflammatory mediator and one of the most potent endogenous pain-inducing *** released at the site of tissue damage or inflammation or

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Ionic Mechanisms for the Acute nociceptive Signals Induced by Bradykinin

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生物物理学报 2009年第S1期25卷 51-51页

作者： Linley JE Ooi L gamper n Institute of Membrane and Systems Biology Faculty of Biological Science University of Leeds Leeds UK

Bradykinin is an inflammatory mediator and one of the most potent endogenous pain-inducing substances. When released at the site of tissue damage or inflammation

关键词： Ionic Mechanisms for the Acute nociceptive Signals Induced by Bradykinin DRG

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The Puzzle of the La I Lines 6520.644 A and 6519.869 A

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Spectral Analysis Review 2014年第3期2卷 10-18页

作者： Laurentius Windholz Bettina gamper Przemyslaw Glowacki Jerzy Dembczyński Institut für Experimentalphysik Technische Universitat GrazGrazOsterreich Laboratory of Quantum Engineering and Metrology Faculty of Technical PhysicsPoznań University of TechnologyPoznańPoland Institute of Control and Information Engineering Faculty of Electrical EngineeringPoznań University of TechnologyPoznańPoland

The strong La line 6520.644 ? is present in a Fourier Transform Spectrum (signal to noise ratio of 240), but its wavelength in commonly used tables (e.g. [1]) is given as 6520.770 ?, while in [2] the wavelength is given as 6520.74 ?, unclassified, with the remark “h” (hazy). The line could not be classified using known energy levels of the La atom (La I) and its first ion (La II). It appears as a single broadened peak. By a combination of laser optogalvanic spectroscopy, laser-induced fluorescence and Doppler-reduced saturation spectroscopy we could introduce a new even parity La I energy level, 35449.041 cm -1, J = 13/2, with hyperfine (hf) constants A = ?8.0(5) MHz, B = 10(10) MHz. For a second, up to now unknown neighbouring La I line (wavelength 6519.869 ?) we introduced another even parity energy level involved in the formation of the line, 41207.994 cm?-1, J = 13/2, A = 91.6(5) MHz, B = 170(50) MHz. We tried also to explain why in old tables the wavelength given was so different.

关键词： Lanthanum Energy Levels Laser Spectroscopy

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