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Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds

Advances in Biological Chemistry 2020年第3期10卷 86-98页

作者： Moraes Fabricio Tarso galvão anderson dourado Fortaleza Dário Batista Amorin Kelly Aparecida da Encarnação Sousa Claudia Cristina Honorio-França Adenilda Cristina França Eduardo Luzia Costa Daniel Tizo Santos Wagner Batista Institute of Exact Sciences and Earth Federal University of Mato Grosso Barra do Garcas/MT Brazil Institute of Biological and Health Sciences Federal University of Mato Grosso Barra do Garcas/MT Brazil UniRv-University of Rio Verde Rio Verde/Go Brazil

To synthesize, characterize and evaluate the antitumor potential derived from ruthenium compounds was generated in this study, from the precursor K[RuCl4(bipy)] a route in a simple and reproducible synthesis for a novel compound of coordinating Ru+3 with bipy and L-trip. The spectroscopic characterization in the middle infrared region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the displacement of the carboxylate ion band for higher energies, and also by the displacements of aliphatic amine bands, suggesting that bidentate coordination of the L-trip ligand occurred. Analysis of the results obtained with thermoanalytical techniques showed that the minimum formula of the compound, [RuCl2(bipy)(L-trip)]1/2H2O. Evaluation of the antitumor potential of precursor K[RuCl4(bipy)] showed the toxic effects on MCF-7 cell line, but did not show selectivity and not reached PBMC cells to the same extent. The evaluation of the antitumor potential of the newly synthesized compound, [RuCl2ont-family:Verdana;">(bipy)(L-trip)], demonstrated that the insertion of an L-tryptophan molecule into the precursor coordination sphere made it selective when compared to PBMC cells, for MCF-7 type tumor cells.

关键词： Ruthenium Compounds Pyridine Ligands Antitumor Activity Tryptophan Amino Acid MCF-7 Cells Ligand N-Heterocyclic

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Synthesis, Characterization and Analysis of Leishmanicide Ability of the Compound [Ru(Cl)3(H2o)2(gly)]

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open Journal of Inorganic Chemistry 2017年第4期7卷 89-101页

作者： Marcio Adriano S. Chagas anderson dourado galvã o Fabricio Tarso de Moraes A. T. B. N. Ribeiro Adriano Buzutti de Siqueira I. C. C. de Assis Salama Wagner Welber Arrais-Silva Katia Meirelles Duarte de Sousa Claudia Cristina de Sousa Pereira Wagner Batista dos Santos Federal University of Mato Grosso Barra do Gar&ccedil as Brazil Federal University of Sergipe S&atilde o Cristovã o Brazil

Studies of coordinated compounds containing ruthenium (Ru2+ and Ru3+) have shown very effective in vitro results for the treatment of cancer and neglected diseases such as leishmaniasis. In this paper, we present the synthesis of the compound [Ru(Cl)3(H2o)2(gly)], which was characterized by spectroscopic (Ultraviolet-visibleand infrared) and thermal analysis (Thermogravimetry/Derived Thermogravimetry and Thermogravimetry/Differential Thermal Analysis). The analysis of the compound in the Ultraviolet-visibleregion showed a 290 nm band λmax (ε= 1.685 × 103 L·cm-1·mol-1), attributed to the ligand metal charge transfer (LMCT). The spectroscopy (IR) showed major vibrational bands at δa (-Coo-) 1664 cm-1, δs (-Coo-) 1388 cm-1, δs () 1571 cm-1 and δs (CCN) 889 cm-1. The thermal analysis by TG/DTG and TG-DTA indicated that the complex has five consecutive stages of decomposition: at 115°C (TG = 12.18%;Calculated = 11.32%) H2o (coordinating water), exothermic peaks at 230°C, 307°C, 440°C and 463°C due to oxidative decomposition of glycine, followed by the formation of RuClo residue at 665°C (TG = 41.11%;Calculated = 40.81%). The thermal characterization suggested the stoichiometry of the complex [RuCl3(H2o)2(gly)]. The antileishmanial capacity of this compound was also evaluated and the results indicated a 31% decrease in the parasitic infection of macrophages and a 1.5 to 3 fold reduction in the number of parasites per cell after treatment with 100 μg/mL of the complex. These results support the possible use of this compound as a therapeutic alternative against medical and veterinary parasites.

关键词： Ruthenium Glycine Spectroscopy Infrared TG/DTG and TG/DTA Amino Acid

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Structural and Production Characteristics of PiatãGrass Forage Submitted to Levels of Nitrogen

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American Journal of Plant Sciences 2015年第5期6卷 693-701页

作者： Ronaldo Liberato dourado Alexandre Lima de Souza anderson de Moura Zanine Fabio Luiz Buranelo Toral Daniele de Jesus Ferreira Joadil Goncalves de Abreu Department of Science and Technology Federal Institute of EducationBrasiliaBrazil Department of Animal Science Federal University of Mato GrossoCuiabáBrazil Department of Animal Science Federal University of Minas GeraisBelo HorizonteBrazil

Piatã grass (Brachiaria brizantha cv. Piatã) is a tropical grass cultivating in pasture production system. The aim of this study was to evaluate the effects of nitrogen levels (0, 125, 250, 375 and 500 kg·N·ha-1) on structural characteristics and forage production of Piatã grass. The experiment comprised of twenty grass parcels arranged in randomised completely casualties design. This study was carried out between November of 2007 and April of 2008, with 175 experimental days. A quadratic effect (P ·m-2 at a nitrogen dose of 357 kg·ha-1. A quadratic effect (P ·ha-1·year-1?for nitrogen levels of 411 and 384 kg·ha-1, respectively. However, a considerable portion of forage production obtained by nitrogen addition occurred from stem production. The productions of green leaf blade dry matter, tiller density, leaf blade length and leaf blade index are all variables related to structural aspects and pasture quality, with all attaining their highest values at a mean nitrogen application level of 380 kg·ha-1.

关键词： Forage Accumulation Frequencies Cuts Leaf Area Index Tiller Density

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Synthesis and Characterization of a New Compound of Cobalt Ⅱ with Isonicotinamide and Evaluation of the Bactericidal Potential

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open Journal of Inorganic Chemistry 2019年第2期9卷 11-22页

作者： anderson dourado galvao Fabricio Tarso de Moraes Claudia Cristina de Sousa Katia Meirelles Duarte de Sousa Patricia Gelli Feres de Marchi Adenilda Cristina Honorio Franca Eduardo Luzia Franca Wagner Batista dos Santos Federal University of Mato Grosso—Barra do Garcas/MT Brazil

In this work, the isonicotinamide was coordinated to the Cobalt ion in oxidation state +2. The relevance of this work is the investigation of the in vitro bactericidal potential of the synthesized complex when tested in Gram-positive and negative bacteria strains. This study is motivated by the need to obtain new materials that have antibiotic properties and that, in the future, may become an effective drug against resistant bacteria. A new coordination compound of Cobalt and isonicotinamide, [Co(H2o)(isn)3](BF4)2, was synthesized and described. The compound was characterized by thermoanalytical techniques TG-DTG and TG-DSC, where it was possible to propose the mechanism of thermal decomposition. Through the spectroscopy in the region of the medium infrared (FTIR), it is possible to infer the site of connection between isonicotinamide and metal. The bactericidal activity of [Co(H2o)(isn)3](BF4)2, CoCl2 and free Isonicotinamide were tested for the bacteria Streptococcus mutans (Gram+) and Escherichia coli (Gram−) and the synthesized compound showed to be sensitive for both bacteria.

关键词： Cobalt Isonicotinamide Spectroscopy Infrared TG/DTG and TG/DTA Bactericidal Activity

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