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Linagliptin alleviates fatty liver disease in diabetic db/db mice

World Journal of Diabetes 2016年第19期7卷 534-546页

作者： Svetlana v Michurina Irina Ju Ishenko vadim v Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov galina v koncevaya vladimir I Konenkov Laboratory of Functional Morphology Scientific Institute of Clinical and Experimental Lymphology Laboratory of Endocrinology Scientific Institute of Clinical and Experimental Lymphology SPF-vivarium Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences Laboratory of Clinical Immunogenetics Scientific Institute of Clinical and Experimental Lymphology

AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(***-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYvE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYvE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYvE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independe

关键词： Diabetes Obesity Non-alcoholic fatty liver disease Dipeptidyl peptidase 4 Linagliptin

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Thermogravimetric,kinetic study and gas emissions analysis of the thermal decomposition of waste-derived fuels

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Journal of Environmental Sciences 2024年第3期137卷 155-171页

作者： vadim v.Dorokhov galina S.Nyashina Pavel A.Strizhak Heat and Mass Transfer Laboratory National Research Tomsk Polytechnic University30 Lenin AvenueTomsk 634050Russia

A wide range of wastes can potentially be used to generate thermal and electrical *** co-combustion of several types of waste as part of water-containing waste-derived fuels is a promising method for their *** this research,we use thermogravimetric analysis and differential scanning calorimetry to study the thermal behavior and kinetics of coal slime,biomass,waste oils,and blends on their *** also analyze the concentrations of gaseous *** results show that biomass,oils,and coal slime significantly affect each other in the course of their co-combustion when added to slurry *** preparation of coal-water slurry based on slime and water reduced the ignition and burnout temperature by up to 16%.Adding biomass and waste oils additionally stimulated the slurry ignition and burnout,which occurred at lower *** to dry coal slime,threshold ignition temperatures and burnout temperatures decreased by 6%–9%and 17%–25%,***,the use of biomass and waste oils as part of slurries inhibited NOхand SO_(2)emission by 2.75 *** to the kinetic analysis,added biomass and waste turbine oil provide a 28%–51%reduction in the activation energy as compared to a coal-water slurry without additives.

关键词： Coal-water slurry Water-containing composite fuels Combustion Emission Kinetic TGA-DSC

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PD-1^(+)and TIM-3^(+)T cells widely express commonγ-chain cytokine receptors in multiple myeloma patients,and IL-2,IL-7,IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells

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Oncology Research 2024年第10期32卷 1575-1587页

作者： EGOR v.BATOROv ALISA D.INESHINA TATIANA A.ARISTOvA vERA v.DENISOvA SvETLANA A.SIZIKOvA DARIA S.BATOROvA galina Y.USHAKOvA EKATERINA Y.SHEvELA ELENA R.CHERNYKH Laboratory of Cellular Immunotherapy Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia v.Zelman Institute of Medicine and Psychology Novosibirsk National Research State UniversityNovosibirsk630090Russia Department of Hematology and Bone Marrow Transplantation Research Institute of Fundamental and Clinical ImmunologyNovosibirsk630099Russia

Background:Immune checkpoint ligand-receptor interactions appear to be associated with multiple myeloma(MM)***,previous studies showed the possibility of PD-1 and TIM-3 expression on T cells upon stimulation with commonγ-chain family cytokines in vitro and during homeostatic *** aim of the present work was to study the impact of homeostatic proliferation on the expansion of certain T cell subsets upregulating PD-1 and TIM-3 checkpoint ***:The expression of CD25,CD122,CD127 commonγ-chain cytokine receptors,phosphorylated signal transducer and activator of transcription-5(pSTAT5)and eomesodermin(EOMES)was comparatively assessed with flow cytometry in PD-1-and TIM-3-negative and positive T cells before the conditioning and during the first post-transplant month in peripheral blood samples of MM ***:Substantial proportions of PD-1-and TIM-3-positive T lymphocytes expressed commonγ-chain cytokine receptors and *** of cytokine receptor expressing cells were significantly higher within TIM-3+T cells compared to PD-1+TIM-3−*** proportions of both PD-1-/TIM-3-negative and positive CD8+T cells express EOMES,while only moderate frequencies of CD4+PD-1+/TIM-3+T cells up-regulate this transcription ***,the surface presence of CD25 and intranuclear expression of EOMES in CD4+T cells were mutually exclusive regardless of PD-1 and TIM-3 *** stimulation with commonγ-chain cytokines up-regulates PD-1 and TIM-3 during the proliferation of initially PD-1/TIM-3-negative T cells but fails to expand initially PD-1+and TIM-3+T cell subsets in ***:Both PD-1 and TIM-3 expressing T cells appear to be able to respond to homeostatic cytokine *** in commonγ-chain cytokine receptor expression between PD-1+and TIM-3+T cells may reflect functional dissimilarity of these cell *** blockade appears to alleviate lymphopenia-induced prolif

关键词： Autologous hematopoietic stem cell transplantation(AHSCT) CD25 CD122 Eomesodermin(EOMES) Homeostatic proliferation

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Individual alcohol consumption by the population of Russia versus regional living conditions

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Global Health Journal 2024年第1期8卷 24-31页

作者： Sergey A.Maksimov Svetlana A.Shalnova galina A.Muromtseva Yuliya A.Balanova Svetlana E.Evstifeeva Anna v.Kapustina Oksana M.Drapkina National Medical Research Center for Therapy and Preventive Medicine Moscow 101990Russia

Background:There are substantial regional differences in drinking alcohol in Russia,both at the population and individual ***,the causes of these differences have not been studied ***:The goal of our study was to examine the effect of regional living conditions on individual alcohol consumption by the population of ***:For the analysis,we used data from a cross-sectional epidemiological study conducted in *** final analytical sample included 18,130 people aged 25-64 *** conducted the interviews face to face,based on which any drinking in the last year,as well as alcohol abuse,were considered as a *** abuse was recorded when the respondent consumed 5.75 or more grams of pure ethanol per day(75th percentile of average daily alcohol consumption among alcohol drinkers).The assessment of the regional living conditions was accomplished via integral indexing,which was previously performed based on publicly available data for *** were assessed using generalized scoring equations with unchanging standard *** associations were expressed by odds ratios(OR)and 95%confidence intervals(C).Results:Deterioration of social conditions and increase in demographic depression in the region of residence increased the odds of any drinking(OR 1.51,95%CI:1.33 to 1.72,Pvely).The odds of alcohol abuse increased with the deterioration of social living conditions and the growth of the industrial development in the region:OR 1.35,95%CI:1.14 to 1.59,Pving conditions on individual drinking alcohol in the population of Russia.

关键词： Alcohol Living environment Regional features Russia

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Olefin Polymerization Behavior of Titanium(Iv) Complexes with Fluorinated and Non-fluorinated Aliphatic Phenoxyimine Ligands

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Chinese Journal of Polymer Science 2024年第1期42卷 52-62,I0007页

作者： vladislav A.Tuskaev Kasim F.Magomedov Svetlana Ch.Gagieva Dmitry A.Kurmaev Yulia v.Nelyubina Evgenii K.Golubev Maria D.Evseeva viktor G.vasil'ev galina G.Nikiforova Mikhail I.Buzin vyacheslav S.Bogdanov Boris M.Bulychev Department of Chemistry M.V.Lomonosov Moscow State UniversityMoscow 119992Russian Federation A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of SciencesMoscow119991Russian Federation Enikolopov Institute of Synthetic Polymer Materials Russian Academy of SciencesMoscow 117393Russian Federation

A series of Ti(Ⅳ) dichloride and dialkoxide com plexes with phenoxyimine ligands containing fluorinated and nonfluorinated aliphatic imine fragments have been *** molecular structures of complexes 1 and 4 were established by single-crystal X-ray diffraction *** complexes adopt a distorted octahedral coordination structure around the titanium atom and two oxygen atoms are situated in trans position while two nitrogen atoms and two outgoing ligands(Cl or iPrO) are situated in cis *** of activators(MMAO-12 and combinations Et_nAICl_(3-n)+Bu_(2)Mg) and outgoing ligand(Cl or iPrO) nature on the catalytic activity and properties of the resulting polymers was *** Ti complexes,despite the nature of the outgoing ligands(Cl or iPrO) in the presence of Al/Mg activators,was found to display a high ethylene polymerization activity in the range 1600-3830 kg_(polymer)·mol_(Ti)^(-1)·h^(-1)·atm^(-1) with a viscosity average molecular weight(M_v) value in the range 1.1×10~6-7.1×10~6 Dalton(Da).The resulting UHMWPE can be processed by a solventless method into high-strength and high-modulus oriented *** rheological characteristics of a polymer melt have been *** absence of a cross-over point did not allow to compare the values of the molecular weight distribution of polymers obtained on fluorinated and non-fluorinated pre-catalysts,however,the estimation of the entanglement density is in good agreement with the mechanical characteristics of oriented film *** activation with methylalumoxane,the activity of the com plexes decreased very significantly;however,a polymer with a molecular weight of about 12 million Da was *** the process of ethylene/octene-1 copolymerization,fluorine-containing precatalysts showed a clear advantage over non-fluorinated analogues both in activity and in comonomer content.

关键词： FI catalysts Titanium(Iv) (Co)polymerization Al/Mg co-catalyst Ultra-high molecular weight polyethylene

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Role of the Rossiter-McLaughlin effect in the study of close binaries

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Research in Astronomy and Astrophysics 2019年第3期19卷 21-30页

作者： galina N.Dryomova vladimir v.Dryomov Russian Federal Nuclear Centre

This paper is devoted to binary stars belonging to the class of eclipsing-variable *** and spectroscopic analysis of eclipses allows us to determine geometric parameters of the orbit and physical characteristics of stellar components as well as inclinations of stellar equators to the orbital plane. Estimations of inclinations can be obtained from measurement of the Rossiter-McLaughlin effect, which is discussed using examples of some eccentric binaries with an anomalous apsidal effect. Our task is to find the complete spectrum of solutions of the equation of apsidal motion, depending on the inclinations of the polar axes of the components to the orbital one for these systems, based on their individual spectroscopic and photometric observational data. The matrix of solutions allows us to select those pairs of polar inclinations that provide agreement with the observational apsidal period.

关键词： Rossiter-McLaughlin effect: eclipsing-variable stars apsidal effect individual binaries: AI Hya,NY Cep,EW Ori,DI Her,AS Cam

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Effects of subsampling on characteristics of RNA-seq data from triple-negative breast cancer patients

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Chinese Journal of Cancer 2015年第10期34卷 427-438页

作者： Alexey Stupnikov galina v Glazko Frank Emmert-Streib Computational Biology and Machine Learning Laboratory Faculty of MedicineHealth and Life SciencesSchool of MedicineDentistry and Biomedical SciencesCenter for Cancer Research and Cell BiologyQueen's University Belfast Division of Biomedical Informatics University of Arkansas for Medical Sciences Computational Medicine and Statistical Learning Laboratory Department of Signal ProcessingTampere University of Technology

Background:Data from RNA-seq experiments provide a wealth of information about the transcriptome of an ***,the analysis of such data is very *** this study,we aimed to establish robust analysis procedures that can be used in clinical ***:We studied RNA-seq data from triple-negative breast cancer ***,we investigated the subsampling of RNA-seq ***:The main results of our investigations are as follows:(1) the subsampling of RNA-seq data gave biologically realistic simulations of sequencing experiments with smaller sequencing depth but not direct scaling of count matrices;(2) the saturation of results required an average sequencing depth larger than 32 million reads and an individual sequencing depth larger than 46 million reads;and(3) for an abrogated feature selection,higher moments of the distribution of all expressed genes had a higher sensitivity for signal detection than the corresponding mean ***:Our results reveal important characteristics of RNA-seq data that must be understood before one can apply such an approach to translational medicine.

关键词： RNA-seq data, Computational genomics, Statistical robustness, High-dimensional biology,Triple-negative breast cancer

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On Convergence of MRQI and IMRQI Methods for Hermitian Eigenvalue Problems

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Communications on Applied Mathematics and Computation 2021年第1期3卷 189-197页

作者： Fang Chen Cun-Qiang Miao galina v.Muratova School of Applied Science Beijing Information Science and Technology UniversityBeijing 100192China School of Mathematics and Statistics Central South UniversityChangsha 410083China Laboratory of Computational Mechanics I.I.Vorovich Institute of MathematicsMechanics and Computer ScienceSouthern Federal UniversityRostov-on-Don 344090Russia

Bai et *** the multistep Rayleigh quotient iteration(MRQI)as well as its inexact variant(IMRQI)in a recent work(***.77:2396–2406,2019).These methods can be used to effectively compute an eigenpair of a Hermitian *** convergence theorems of these methods were established under two conditions imposed on the initial guesses for the target eigenvalue and *** this paper,we show that these two conditions can be merged into a relaxed one,so the convergence conditions in these theorems can be weakened,and the resulting convergence theorems are applicable to a broad class of *** addition,we give detailed discussions about the new convergence condition and the corresponding estimates of the convergence errors,leading to rigorous convergence theories for both the MRQI and the IMRQI.

关键词： Hermitian eigenvalue problem MRQI IMRQI Convergence

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Stromatolites are the Potential Collectors of Oil and Gas

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地学前缘 2009年第S1期16卷 151-152页

作者： galina Samotorova E.v.Kozlova Geology Department Moscow State University

Stromatolite buildups are spread throughout the Earth and are known in sediments of different age. First stromatolite buildups were investigated in Shark-Bay in Western *** age is valued as 3.5 billion years,the same ... 详细信息

关键词： stromatolites buildups collector oil and gas

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A word about the teacher

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Research in Astronomy and Astrophysics 2019年第3期19卷 35-46页

作者： galina N.Dryomova Olga v.Eretnova Tatyana S.Polushina Russian Federal Nuclear Centre named after academician E.I.Zababakhin Chelyabinsk State University Ural Federal University named after the First President of Russia B.N.Yeltsin

This is a memorial report on the biography and scientific heritage of M.A. Svechnikov — an outstanding scientist and teacher, the founder of the Ural school of close binary stars and the author of the classification ... 详细信息

关键词： catalogs photometric-spectroscopic-stars eclipsing variables classification scheme-close binary stars

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