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Determination of Mitochondrial Functional State in v.tal Tissues by Cytobiochemical Analysis of Peripheral Blood Lymphocytes

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Open Journal of Endocrine and Metabolic Diseases 2013年第2期3卷 10-13页

作者： galina A. Frelikh Elena A. Yanov.kaya Natalia Yu. Polomeev. Maxim S. Timofeev.v.adimir A. Slepichev.Olga S. Bryushinina Yulia G. Zyuz’kov. Roman v. Gurto Alexander S. v.sil’ev.Elena v. Semiglazov. v.adimir v. Udut Laboratory of Physiology Molecular and Clinical Pharmacology Federal Governmental Budgetary Organization “Research Institute of Pharmacology” Siberian Branch of the Russian Academy of Medical Sciences Tomsk Russia

In the work, we offer a brief report by research results demonstrating correlations between energy status of peripheral blood lymphocytes and functional state of v.tal tissues mitochondria. Basing on our preliminary data, showing correlations between succinate dehydrogenase (SDH) activ.ty in peripheral blood lymphocytes and speed or duration of pyridine nucleotides reduction in mitochondria of rat brain and liv.r tissues, we propose an idea of using cytobiochemical method of SDH estimation in peripheral blood lymphocytes for ev.luation of tissue mitochondria status. The method could be successfully used in clinical practice for early rev.aling of energy metabolism disturbances that allows prev.nting disease dev.lopment and optimizing the diseases therapy.

关键词： Mitochondria Energy Metabolism Lymphocyte Succinate Dehydrogenase Cytobiochemical

Indicators of success for smart law enforcement in protected areas:A case study for Russian Amur tiger(Panthera tigris altaica)reserv.s

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Integrativ. Zoology 2016年第1期11卷 2-15页

作者： Michiel H.H.HÖTTE Igor A.KOLODIN Sergei L.BEREZNUK Jonathan C.SLAGHT Linda L.KERLEY Sv.tlana v.SOUTYRINA galina P.SALKINA Olga Y.ZAUMYSLOv. Emma J.STOKES Dale G.MIQUELLE Wildlife Conserv.tion Society BronxNew YorkUSA Phoenix Fund VladivostokRussian Federation Zoological Society of London Regent’s ParkLondonEngland Sikhote-Alin Biosphere Zapov.dnik Primorskii KraiRussian Federation Lazov.kii State Nature Zapov.dnik Primorskii KraiRussian Federation Department of Ecology Far Eastern Federal UniversityAyaksRusski Island

Although considerable conserv.tion resources hav. been committed to dev.lop and use law enforcement monitoring and management tools such as SMART,measures of success are ill-defined and,to date,few reports detail results ***,we present 4 case studies from protected areas with Amur tigers(Panthera tigris altaica)in Russia,in which indicators of success were defined and ev.luated at *** ultimate goal was an increase in tiger numbers to 1 indiv.dual/100 km^(2)at each *** predicted that improv.ments in law enforcement effectiv.ness would be followed by increases in prey numbers and,subsequently,tiger *** used short-term and long-term indicators of success,including:(i)patrol team effort and effectiv.ness;(ii)catch per unit effort indicators(to measure reductions in threats);and(iii)changes in target species *** addition to implementing a monitoring system,we focused on improv.ng law enforcement management using an adaptiv. management *** 4 years,we noted clear increases in patrol effort and a partial reduction in *** we did not detect clear trends in ungulate numbers,tiger populations remained stable or increased,suggesting that poaching of tigers may be more limiting than prey *** effectiv.ness is needed before a clear reduction in threats can be noted,and more time is needed before detecting responses in target ***,delineation of concrete goals and indicators of success prov.de a means of ev.luating progress and *** monitoring should be a central component of law enforcement strategies for protected areas.

关键词： adaptiv. patrol management Amur tiger anti-poaching law enforcement monitoring SMART

Efficacy of the new therapeutic approach in curing malignant neoplasms on the model of human glioblastoma

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Cancer Biology & Medicine 2021年第3期18卷 910-930页

作者： Ev.eniya v.Dolgov. Oleg M.Andrushkev.ch Polina E.Kisaretov. Anastasia S.Proskurina Genrikh S.Ritter Tatyana D.Dubatolov. Margarita v.Romanenko Oleg S.Taranov.Yaroslav.R.Efremov.Ev.eniy L.Zav.alov.Alexandr v.Romaschenko Sergey v.Mishinov.Sv.tlana S.Kirikov.ch Ev.eniy v.Lev.tes Ekaterina A.Potter Alexandr A.Ostanin Elena R.Chernykh Stanislav.Yu.Roshchin Anatoliy v.Berv.tskiy galina I.Moysak Jamil A.Rzaev.Sergey S.Bogachev Institute of Cytology and Genetics SB RAS Novosibirsk 630090Russia A.I.Ev.okimov.Moscow State Univ.rsity of Medicine and Dentistry Moscow 127473Russia Institute of Molecular and Cellular Biology Novosibirsk 630090Russia Nov.sibirsk State Univ.rsity Novosibirsk 630090Russia The State Research Center of v.rology and Biotechnology"v.ctor" KoltsovoNovosibirsk 630559Russia First Department of Neurosurgery Ya.L.Tsivian Novosibirsk Research Institute of Traumatology and OrthopaedicsNovosibirsk 630091Russia Institute of Fundamental and Clinical immunology Novosibirsk 630099Russia Sklifosov.ky Research Institute of Emergency Medicine Moscow 129010Russia Federal Center of Neurosurgery Novosibirsk 630048Russia

Objectiv.:Glioma is a highly inv.siv. tumor,frequently disposed in essential areas of the brain,which makes its surgical excision extremely difficult;meanwhile adjuv.nt therapy remains quite ***:In the current report,a new therapeutic approach in curing malignant neoplasms has been performed on the U87 human glioblastoma *** approach,termed"Karanahan",is aimed at the eradication of cancer stem cells(CSCs),which were recently shown to be capable of internalizing fragments of extracellular double-stranded *** being internalized,these fragments interfere in the process of repairing interstrand cross-links caused by exposure to appropriate cytostatics,and such an interference results either in elimination of CSCs or in the loss of their tumorigenic *** of the approach requires a scheduled administration of cytostatic and complex composite double-stranded DNA ***:U87 cells treated in v.tro in accordance with the Karanahan approach completely lost their tumorigenicity and produced no grafts upon intracerebral transplantation into immunodeficient *** SCID mice with dev.loped subcutaneous grafts,the treatment resulted in reliable slowing down of tumor growth rate(Pv.loped graft and subsequent therapeutic treatment,the Karanahan approach was shown to reliably slow down the tumor growth rate and increase the median surv.v.l of the mice twofold relativ. to the ***:The effectiv.ness of the Karanahan approach has been demonstrated both in v.tro and in v.v. in treating dev.loped subcutaneous grafts as well as orthotopic grafts after surgical excision of the tumor.

关键词： Glioblastoma U87 cell line mytomycin C cancer stem cells TAMRA

全球变化:地理研究的若干概念和问题(苏联—美国研究计划的一些结果)

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地理译报 1991年第1期10卷 1-4页

作者： John R.Mather galina v.Sdasyuk 李世玢

苏美全球变化研究计划专著的作者们,在概括阐述了国际地圈一生物圈计划的背景后得出结论:要充分了解全球变化,就必须对现今的景观进行比较精确的模拟,分析特定区域内人为变化的因果,评价社会可能对这些变化的新认识作出反应的条件,以及... 详细信息

苏美全球变化研究计划专著的作者们,在概括阐述了国际地圈一生物圈计划的背景后得出结论:要充分了解全球变化,就必须对现今的景观进行比较精确的模拟,分析特定区域内人为变化的因果,评价社会可能对这些变化的新认识作出反应的条件,以及具有基于具体研究场所的大大加强的地理信息系统。苏联和美国的地理学家参加了全球变化研究的地理学途径,由国际科学联盟理事会倡议,在其国际地圈一生物圈计划中曾列入了关于研究世界环境重大变化的新项目。作为该项目的一部分,苏美地理学家审查了有关的地理学经验。

关键词：全球变化地圈-生物圈

A comparison of food habits and prey preference of Amur tiger(Panthera tigris altaica)at three sites in the Russian Far East

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Integrativ. Zoology 2015年第4期10卷 354-364页

作者： Linda L.KERLEY Anna S.MUKHACHEv. Dina S.MATYUKHINA Elena S.ALMANOv. galina P.SALKINA Dale G.MIQUELLE Zoological Society of London Regent’s ParkLondonUK Sikhote-Alin Biosphere Zapov.dnik TerneiPrimorskii KraiRussia FSBI“Land of Leopard ”VladivostokPrimorskii KraiRussia FSBI“United Lazov.kii State Nature Zapov.dnik named after“Kaplanov.and Zov.Tigra National Park ”Primorskii KraiRussia Wildlife Conserv.tion Society BronxNew YorkUSA

Prey av.ilability is one of the principal driv.rs of tiger distribution and ***,formulating effectiv. conserv.tion strategies requires a clear understanding of tiger *** used scat analysis in combination with data on the abundance of sev.ral prey species to estimate Amur tiger diet and preference at 3 sites in the Russian Far *** also examined the effect of pseudoreplication on estimates of tiger *** collected 770 scats across the 3 *** to prev.ous studies,we found that tigers primarily preyed on medium to large ungulates,with wild boar,roe,sika and red deer collectiv.ly comprising 86.7%of total biomass consumed on *** to Jacobs’index,tigers preferred wild boar,and av.ided sika *** in preference indices deriv.d from these scat analyses compared to indices deriv.d from kill data appear to be due to adjustments in biomass intake when sex–age of a killed indiv.dual is known:a component missing from scat ***(multiple samples collected from a single kill site)also skewed results deriv.d from scat *** analysis still appears useful in prov.ding insight into the diets of carniv.res when the full spectrum of prey species needs to be identified,or when sample sizes from kill data are not *** sample sizes of kill data are large(as is now possible with GPS-collared animals),kill data adjusted by sex–age categories probably prov.des the most accurate estimates of prey biomass *** results prov.de further confirmation of the centrality of medium ungulates,in particular wild boar,to Amur tiger diet,and suggest that the protection of this group of species is critical to Amur tiger conserv.tion.

关键词： Amur tiger diet Jacobs’index predation Russian Far East

Linagliptin allev.ates fatty liv.r disease in diabetic db/db mice

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World Journal of Diabetes 2016年第19期7卷 534-546页

作者： Sv.tlana v.Michurina Irina Ju Ishenko v.dim v.Klimontov.Sergey A Archipov.Natalia E Myakina Marina A Cherepanov. Eugenii L Zav.alov.galina v.Koncev.ya v.adimir I Konenkov Laboratory of Functional Morphology Scientific Institute of Clinical and Experimental Lymphology Laboratory of Endocrinology Scientific Institute of Clinical and Experimental Lymphology SPF-v.v.rium Institute of Cytology and Genetics of Siberian Branch of Russian Academy of Sciences Laboratory of Clinical Immunogenetics Scientific Institute of Clinical and Experimental Lymphology

AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liv.r disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(***-Dock7m+/+Leprdb/J) aged 10 wk receiv.d the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gav.ge for 8 wk. Intact db/db mice serv.d as controls. Structural changes in the liv.r were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liv.r microv.sculature and lymphatic roots. Hepatic staining for lymphatic v.ssel endothelial hyaluronan receptor-1(LYv.-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liv.r steatosis(predominantly microv.sicular and mediov.sicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood v.ssels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% v. 64.9% ± 5.8% per field of v.ew, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% v. 50.4% ± 3.1%, P = 0.0007). We observ.d heterogeneous hepatocytes and relativ.ly preserv.d cell structures in the linagliptin group. Dilation of blood and lymphatic v.ssels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were allev.ated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYv.-1 was observ.d in the endothelial cells of interlobular lymphatic v.ssels and on the membranes of some endothelial sinusoidal cells. We observ.d an enlarged LYv.-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improv.ment in the structural parameters of the liv.r in linagliptin-treated mice was independe

关键词： Diabetes Obesity Non-alcoholic fatty liv.r disease Dipeptidyl peptidase 4 Linagliptin

Microfungal communities in soil polluted with fluoride

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Natural Science 2010年第9期

作者： galina A. Ev.okimov. Maria v. Korneykov.

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基于知识的仿真系统

计算机与数字工程 1996年第3期24卷 59-66页

作者： galina v.Merkuryev.. Yury A.Merkuryer 赵炯

一、引言基于知识的仿真系统(KBSS)代表了运用仿真理论的一个较新的发展方向。它的历史大约只有十年时间。把仿真与专家系统技术互相结合起来对基于知识的仿真系统进行开发称为知识工程。KBSS的目标是尽可能把所要求的知识和经验溶入... 详细信息

一、引言基于知识的仿真系统(KBSS)代表了运用仿真理论的一个较新的发展方向。它的历史大约只有十年时间。把仿真与专家系统技术互相结合起来对基于知识的仿真系统进行开发称为知识工程。KBSS的目标是尽可能把所要求的知识和经验溶入到软件中。此类系统的建立和运用将有可能使工程师、科学家和管理人员正确、容易地从事仿真研究,而无需对编程语言、仿真理论以及与现有仿真项目有关的其它技术进行专门训练。

关键词：仿真系统专家系统知识工程

Differentiation of wild boar and domestic pig populations based on the frequency of chromosomes carrying endogenous retrov.ruses

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Natural Science 2010年第6期2卷 527-534页

作者： Sergey v. Nikitin Nikolay S. Yudin Sergey P. Knyazev.Ruslan B. Aitnazarov.v.taliy A. Bekenev.v.lentina S. Deev. galina M. Goncharenko v.ctor F. Kobzev.Margarita A. Sav.na v.ktor I. Ermolaev 不详

Analysis of the frequencies of chromosomes carrying v.rious classes of porcine endogenous retrov.ruses (PERv.) and combinations of these classes was performed in the swine species Sus scrofa L. by using maps constructed in two principal component coordinates. Four population clusters can be recognized in the maps. Cluster 1 is formed by wild boars,cluster 2 by domestic meat breeds, cluster 3 by meat-and-lard (univ.rsal) breeds, and cluster 4 by miniature pigs. The maps indicate that modern domesticated swine meat breeds are the closest to the wild type. Meat-and-lard domestic swine breeds are more distant from wild boars, and miniature pigs are div.rged the most. The maps showed that microev.lution processes associated with PERv.carriership frequency had two basic dimensions, or v.ctors: the v.ctor of fat deposition v.riation and the “minus” selection v.ctor (determination of commercial traits). Thus, PERv. may cause v.riation in pig physiology.

关键词： Sus Scrofa Endogenous Retrov.ruses Pig Genetics Microev.lution Genetic Distance De-termination