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Endoscopic ultrasound fine needle aspiration vs fine needle biopsy in solid lesions:A multi-center analysis

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World Journal of Clinical Cases 2021年第34期9卷 10507-10517页

作者： Diogo Turiani Hourneaux Moura Thomas r McCarty Pichamol Jirapinyo Igor Braga ribeiro galileu f.r.eir. ayala f.r.as Antonio Coutinho Madruga-Neto Marvin ryou Christopher C Thompson Gastrointestinal Endoscopy Unit University of Sao Paulo School of MedicineSão PauloSP 05403-010Brazil Division of Gastroenterology Hepatology and EndoscopyBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Division of Gastrointestinal Endoscopy University of São Paulo Medical SchoolSão PauloSP 01246-903Brazil

BACKGrOUND While endoscopic ultrasound(EUS)-guided fine needle aspiration(fNA)is considered a preferred technique for tissue sampling for solid lesions,fine needle biopsy(fNB)has recently been *** To compare the accuracy of fNB vs fNA in determining the diagnosis of solid *** A retrospective,multi-center study of EUS-guided tissue sampling using fNA vs fNB *** outcomes included diagnostic test characteristics(i.e.,sensitivity,specificity,accuracy),use of rapid on-site evaluation(rOSE),and adverse *** analyses were performed by type of lesion and diagnostic yield with or without rOSE.A multivariable logistic regression was also *** A total of 1168 patients with solid lesions(n=468 fNA;n=700 fNB)underwent EUS-guided *** age was 65.02±12.13 ***,sensitivity,specificity and accuracy were superior for fNB vs fNA(84.70%vs 74.53%;99.29%vs 96.62%;and 87.62%vs 81.55%,respectively;Proup analyses,sensitivity,specificity,and accuracy of fNB alone were similar to fNA+rOSE[(81.66%vs 86.45%;P=0.142),(100%vs 100%;P=1.00)and(88.40%vs 85.43%;P=0.320].There were no difference in diagnostic yield of fNB alone vs fNB+rOSE(P>0.05).Multivariate analysis showed no significant predictor for better *** subgroup analyses,fNB was superior to fNA for non-pancreatic lesions;however,there was no difference between the techniques among pancreatic *** adverse event was reported in each *** fNB is superior to fNA with equivalent diagnostic test characteristics compared to fNA+rOSE in the diagnosis of non-pancreatic solid *** results suggest that EUS-fNB may eliminate the need of rOSE and should be employed as a first-line method in the diagnosis of solid lesions.

关键词： Endoscopic ultrasound-guided tissue acquisition fine needle aspiration fine needle biopsy Solid lesions Endoscopic ultrasound Cancer

flowback and early-time production modeling of unconventional gas wells using an improved semi-analytical method

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Petroleum Science 2023年第6期20卷 3441-3449页

作者： Miao Zhang Kien Nguyen Zhi-Qiang Wang Luis f.ayala College of Petroleum Engineering China University of PetroleumBeijing102249China University of Tulsa USA The Pennsylvania State University USA

Multiple fractured horizontal wells (MfHWs) currently are the only possible means of commercial production from the low and ultra-low permeability unconventional gas reservoirs. In early production time, flowback fluid, which constitutes of hydraulic water and gas flow within fractures, is collected and analyzed. flowback analysis has been shown to be a useful tool to estimate key properties of the hydraulic fracture such as conductivity and pore volume. Until date, most tools of flowback analysis rely on empirical and approximate methods. This study presents an improved Green-function-based semi-analytical solution for performance analysis of horizontal gas wells during flowback and early production periods. The proposed solution is derived based on coupling the solutions of two domains: a rigorously derived Green’s function-based integral solution for single-phase gas flow in matrix, and a finite-difference, multiphase solution for gas–water two-phase flow in the fracture. The validity of proposed semi-analytical solution is verified by finely gridded numerical models built in a commercial simulator for a series of synthetic cases considering a variety of fluid and reservoir property combinations, as well as various different production constraints. Comparisons against available empirical and approximate methods are also provided for these cases.

关键词： Hydraulic fractures flowback Unconventional gas wells

reagent-free determination of amikacin content in amikacin sulfate injections by fTIr derivative spectroscopy in a continuous flow system

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Journal of Pharmaceutical Analysis 2014年第2期4卷 125-131页

作者： José f.Ovalles Máximo Gallignani María r.Brunetto rebeca A.rondón Carlos ayala Departamento de Análisis y Control Facultad de Farmacia y BioanálisisUniversidad de Los AndesMérida 5101AVenezuela Laboratorio de Espectroscopia Molecular Departamento de QuímicaFacultad de CienciasUniversidad de Los AndesMérida 5101AVenezuela

The quantitative estimation of amikacin （AMK） in AMK sulfate injection samples is reported using fTIr-derivative spectrometric method in a continuous flow system. fourier transform of mid-Ir spectra were recorded without any sample pretreatment. A good linear calibration （r40.999, %rSDo 2.0） in the range of 7.7-77.0 mg/mL was found. The results showed a good correlation with the manufacturer＇s and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.

关键词： Amikacin flrIr derivative spectro-metry Continuous flow system Pharmaceuticalpreparation Injection Sulfate

A two-phase type-curve method with multiscale fluid transport mechanisms in hydraulically fractured shale reservoirs

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Petroleum Science 2023年第4期20卷 2253-2267页

作者： feng-Yuan Zhang Lin-Jun Zou Zhen-Hua rui Hamid Emami-Meybodi Luis f.ayala Zheng-Xin Zhang College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China National Key Laboratory of Petroleum resources and Engineering China University of Petroleum(Beijing)Beijing102249China Oil and Gas Technology research Institute PetroChina Changqing Oilfield CompanyXi'an710000ShaanxiChina College of Carbon Neutrality future Technology China University of Petroleum(Beijing)Beijing102249China College of Petroleum China University of Petroleum(Beijing)at KaramayKaramay834000XinjiangChina College of Earth and Mineral Sciences The Pennsylvania State University(University Park)State CollegePA16802USA

The quantitative understanding of hydraulic fracture(Hf)properties guides accurate production forecasts and reserve *** curve is a powerful technique to characterize Hf and reservoir properties from flowback and long-term production ***,two-phase flow of water and hydrocarbon after an Hf stimulation together with the complex transport mechanisms in shale nanopores exacerbate the nonlinearity of the transport equation,causing errors in type-curve ***,we propose a new two-phase type-curve method to estimate Hf properties,such as Hf volume and permeability of fracture,through the analysis of flowback data of multi-fractured shale *** proposed type curve is based on a semianalytical solution that couples the two-phase flow from the matrix with the flow in Hf by incorporating matrix influx,slippage effect,stress dependence,and the spatial variation of fluid properties in inorganic and organic *** the first time,multiple fluid transport mechanisms are considered into two-phase type-curve analysis for shale *** analyze the flowback data from a multi-fractured horizontal well in a shale gas reservoir to verify the field application of the proposed *** results show that the fracture properties calculated by the type-curve method are in good agreement with the long-time production data.

关键词： Type curve Two-phase flow flowback analysis fluid transport mechanisms Shale reservoir

Grass-root Coaches Knowledge, Understanding, Attitude And Confidence to Deliver Injury Prevention Training in Youth Soccer: a Comparison of Coaches in Three EU Countries

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Journal of Science in Sport and Exercise 2020年第4期2卷 367-374页

作者： Mark De Ste Croix f.ayala S.Hernandez Sanchez M.Lehnert J.Hughes School of Sport and Exercise University of GloucestershireCheltenham GL502RHUK Department of Sport Sciences Sport Research CentreMiguel Hernandez University of ElcheElche 03202Spain Department of Pathology and Surgery Physiotherapy Area Miguel Hernandez University of ElcheElche 03202Spain Department of Sport and Physical Culture Palacky UniversityOlomouc 77200Czech Republic

Purpose It is well recognised that injury prevention training can reduce injury incidence,however current coach education pathways do not provide grass-root coaches with the knowledge and confidence to deliver such training to youth *** aim of this study was to explore differences in knowledge,understanding,attitude and confidence to deliver such injury prevention training in three European *** A total of 269 grass-root soccer coaches from 3 European countries(Czech republic,UK,Spain)were recruited for this study.A validated questionnaire exploring knowledge,understanding,attitude towards and confidence to deliver youth injury prevention training was completed prior to a 2 h workshop on injury prevention *** between countries was examined using Bayesian factors to quantify the evidence for and against the hypothesis of independence(H0)by assuming a Poisson sampling scheme(as there was no a priori restriction on any cell count,nor on the grand total)(Bf10 Poisson).results Current knowledge,attitude and confidence to deliver injury prevention training to youth players was poor across all three European *** few coaches were currently using injury prevention training in their coaching sessions(23%).There were some country specific differences for attitude towards injury prevention training and confidence to deliver injury training,with Spanish coaches reporting a more positive attitude and confidence to deliver such *** fewer coaches in the UK were using injury prevention training compared to coaches in Spain and the Czech *** As coaches identified a need for coach education and few were delivering injury prevention training,there is a clear need to embed and implement this programme into the grassroots coaching framework of sports governing bodies to improve adoption,implementation and maintenance.

关键词： Youth Injury prevention training Coach education Movement competency

Peroral endoscopic myotomy vs laparoscopic myotomy and partial fundoplication for esophageal achalasia: A single-center randomized controlled trial

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World Journal of Gastroenterology 2022年第33期28卷 4875-4889页

作者： Eduardo Turiani Hourneaux de Moura Jose Jukemura Igor Braga ribeiro galileu f.r.eir. ayala f.r.as Aureo Augusto de Almeida Delgado Lara Meireles Azeredo Coutinho Diogo Turiani Hourneaux de Moura rubens Antonio Aissar Sallum Ary Nasi Sergio A Sanchez-Luna Paulo Sakai Eduardo Guimaraes Hourneaux de Moura Departamento de Gastroenterologia Faculdade de MedicinaUniversidade de Sao PauloServico de Endoscopia Gastrointestinal do Hospital das Clinicas HCFMUSPSao Paulo 05403-010Brazil Division of Esophageal Surgery Hospital das ClinicasUniversity of Sao Paulo School of MedicineSao Paulo 05403-010Brazil Departamento de Gastroenterologia Faculdade de MedicinaUniversidade de Sao PauloHospital das ClinicasUniversity of Sao Paulo School of MedicineSao Paulo 05403-010Brazil Department of Internal Medicine The University of Alabama at Birmingham Heersink School of MedicineBasil I.Hirschowitz Endoscopic Center of ExcellenceDivision of Gastroenterology and HepatologyBirminghamAL 35233United States

BACKGrOUND Achalasia is a rare benign esophageal motor disorder characterized by incomplete relaxation of the lower esophageal sphincter(LES). The treatment of achalasia is not curative, but rather is aimed at reducing LES pressure. In patients who have failed noninvasive therapy, surgery should be considered. Myotomy with partial fundoplication has been considered the first-line treatment for non-advanced achalasia. recently, peroral endoscopic myotomy(POEM), a technique that employs the principles of submucosal endoscopy to perform the equivalent of a surgical myotomy,has emerged as a promising minimally invasive technique for the management of this *** To compare POEM and laparoscopic myotomy and partial fundoplication(LM-Pf) regarding their efficacy and outcomes for the treatment of *** forty treatment-naive adult patients who had been diagnosed with achalasia based on clinical and manometric criteria(dysphagia score ≥ II and Eckardt score > 3) were randomized to undergo either LM-Pf or POEM. The outcome measures were anesthesia time, procedure time, symptom improvement, reflux esophagitis(as determined with the Gastroesophageal reflux Disease Questionnaire), barium column height at 1 and 5 min(on a barium esophagogram), pressure at the LES, the occurrence of adverse events(AEs), length of stay(LOS), and quality of life(QoL).rESULTS There were no statistically significant differences between the LM-Pf and POEM groups regarding symptom improvement at 1, 6, and 12 mo of follow-up(P = 0.192, P = 0.242, and P = 0.242, respectively). However, the rates of reflux esophagitis at 1, 6, and 12 mo of follow-up were significantly higher in the POEM group(P = 0.014, P respectively). There were also no statistical differences regarding the manometry values, the occurrence of AEs, or LOS. Anesthesia time and procedure time were significantly shorter in the POEM group than in the LM-Pf group(185.00 ± 56.89 and 95.70 ± 30.47 min v

关键词： Esophageal achalasia Gastroesophageal reflux Deglutition disorders Heller myotomy fundoplication randomized controlled trial

Slope Instability on Pyroclastic Deposits: Landslide Distribution and risk Mapping in Zacapoaxtla, Sierra Norte De Puebla, Mexico

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Journal of Mountain Science 2006年第1期3卷 1-19页

作者： Borja-Baeza r.C. Esteban-Chávez O Marcos-López J. Pea-Garnica r.J. Alcántara-ayala I. Institute of Geography UNAM Circuito Exterior C.U. Coyoacan 04510 Mexico D.f. Institute of Geography UNAM Circuito Exterior C.U. Coyoacan 04510 Mexico D.F.Institute of Geography UNAM Circuito Exterior C.U. Coyoacan 04510 Mexico D.F.Institute of Geography UNAM Circuito Exterior C.U. Coyoacan 04510 Mexico D.F.Institute of Geography UNAM Circuito Exterior C.U. Coyoacan 04510 Mexico D.F.

In October 1999, rainfall induced landslides devastated different communities of the Sierra Norte, Puebla, causing more than 250 victims and economic losses greater than $ 450 million. The town of Zacapoaxtla was one of the sectors most affected by slope instability due to the existing geological features and geomorphic characters determined by material properties, landforms and processes. Extensive areas formed by pyroclastic piedmonts developed on the Quaternary volcanic ignimbrite deposits highly dissected by marginal gully erosion combined with an extreme rainfall event played a significant role as an ideal scenario for the occurrence of landsliding. Distribution of landslides triggered by rainfall within the main sector of the Zacapoaxtla municipality was analyzed by using IKONOS images in terms of exploring the likely relationship between mass movement incidence and levels of vegetation density. The later was undertaken by means of producing an NDVI and applying a fragmentation algorithm. finally, a map of potential areas of mass movements risk was produced based on the combination of a socio-economic vulnerability index, geologic and geomorphological maps and the spatial landslide distribution.

关键词： rainfall landslides IKONOS vegetation density risk Mexico

Huu S. TIEU request for fDA to Establish regenerating Human Cells as Law on December 13, 2016 President Barack H. Obama Signed the 21st Century CUrES Act into fDA regulation and Law

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Open Journal of regenerative Medicine 2022年第3期11卷 55-62页

作者： Huu S. Tieu Martin f. Loeffler Edgar A. ayala Golden Sunrise Nutraceutical Inc. Porterville USA

Background and Aims: On November 24, 2009, Huu S. TIEU and Golden Sunrise Pharmaceutical, Inc. (Golden Sunrise) applied for the Technology and Innovation to be reviewed and evaluated by the U.S. food and Drug Administration (fDA). In the review and evaluation, it was requested by Golden Sunrise designated the new indications for this application under Serious or Life-threatening conditions or diseases. Discussions followed with the fDA, Huu S. TIEU, and Golden Sunrise for fDA approval on new products and new indications on existing new Medical Technology and Innovation. It was agreed in Year-2015 that the fDA would take the request for new indications to the United States Congress to establish into fDA regulation and law. At that time the following was the fDA Guidance—“Emergency Use of a Test Article” is exempt from prior Institutional review Board or Advisory Committee evaluation and approval, provided that such emergency use is reported to the Institutional review Board within five working days after use. Expedited Institutional review Board or Advisory Committee approval is not permitted in emergency use. There has been no funding to the authors for the writing or publication of this article. Methods: It was requested by Huu S. TIEU and Golden Sunrise in documents given to the fDA to have Serious or Life-threatening conditions or diseases indication be recognized by law. On August 08, 2015, the fDA responding to this request took the documentation produced by Golden Sunrise to the United States Congress on behalf of Golden Sunrise and Huu S. TIEU. This article encompasses the fDA regulatory method as well as the discussion and results of the establishment of the fDA and the 21st Century Cures Act. results: On December 13, 2016, H.r.34—114th United States Congress (2015-2016) 21st Century CUrES Act was signed into law by President Barack H. Obama which included the Serious or Life-threatening indication to be written into the CUrE

关键词： Huu S. TIEU request for fDA to Establish regenerating Human Cells as Law on December 13 2016 President Barack H. Obama Signed the 21st Century CUrES Act into fDA regulation and Law

Deep learning for land use and land cover classification from the Ecuadorian Paramo.

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International Journal of Digital Earth 2022年第1期15卷 1001-1017页

作者： Marco Castelo-Cabay Jose A.Piedra-fernandez rosa ayala Applied Computing Group University of AlmeriaAlmeriaSpain

The paramo,plays an important role in our ecosystems as They balance the water resources and can retain substantial quantities of *** research was carried out in the province of Tungurahua,specifically the Quero *** aim is to develop a classification of the land use land cover(LULC)in the paramo using satellite imagery using several classifiers and determine which one obtains the best performance,for which three different approaches were applied:Pixel-Based Image Analysis(PBIA),Geographic Object-Based Image Analysis(GEOBIA),and a Deep Neural Network(DNN).Various parameters were used,such as the Normalized Difference Vegetation Index(NDVI),the Bare Soil Index(BSI),texture,altitude,and *** classes were used:paramo,pasture,crops,herbaceous vegetation,urban,shrubrainland,and forestry *** data was obtained with the help of onsite technical experts,using geo-referencing and reference *** the models used the highest-ranked was DNN with an overall precision of 87.43%,while for the paramo class specifically,GEOBIA reached a precision of 95%.

关键词： Classification land use and land cover pixel-based image analysis geographic object-based image analysis deep neural network