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Chronic lymphocytic leukemia in China

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Chinese Medical Journal 2022年第8期135卷 883-886页

作者： Robert Peter gale Haematology Research Centre Department of Immunology and InflammationImperial College LondonLondon SW72AZUK.

Chronic lymphocytic leukemia(CLL)is 10-to 20-fold less common in Han Chinese in China compared with persons of predominately european descent translating to inci-dences of 0.2 to 0.6 per 10e+5 population/year vs.4.6 per 10e+5 population/year.[1-3] Reason(s)for this markedly lower incidence and therefore prevalence in China is unknown but is shared with the other Asian nationalities ***,Koreans,and others,.+-61 Studies of large cohorts of Chinese with CLL are relatively rare and there are no population-based studies in the mainland of *** seeming differences between CLL in Chinese and persons of predominately european descent are reported such as younger age at diagnosis,different background genotypes,increased frequency of IGHV mutation,different stereotype use and different mutation topographies.7 However,in general,most cases of CLL in Han Chinese are like CLL in persons of predominately european descent.

关键词： lymphocytic markedly diagnosis

Optimization of micropatterned poly(lactic-coglycolic acid) films for enhancing dorsal root ganglion cell orientation and extension

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Neural Regeneration Research 2018年第1期13卷 105-111页

作者： Ching-Wen Li Brett Davis Jill Shea Himanshu Sant Bruce Kent gale.Jayant Agarwal Department of Mechanical engineering National Chung Hsing University Department of Surgery School of Medicine University of Utah Department of Mechanical engineering University of Utah

Nerve conduits have been a viable alternative to the ‘gold standard’ autograft for treating small peripheral nerve gap injuries. However, they often produce inadequate functional recovery outcomes and are ineffective in large gap injuries. Ridge/groove surface micropatterning has been shown to promote neural cell orientation and guide growth. However, optimization of the ratio of ridge/groove parameters to promote orientation and extension for dorsal root ganglion （DRG） cells on poly（lactic-co-glycolic acid）（PLGA） films has not been previously conducted. Photolithography and micro-molding were used to define various combinations of ridge/groove dimensions on PLGA films. The DRG cells obtained from chicken embryos were cultured on micropatterned PLGA films for cell orientation and migration *** of the films occurred during the test period, however, this did not cause deformation or distortion of the micropatterns. Results from the DRG cell orientation test suggest that when the ridge/groove ratio equals 1 （ridge/groove width parameters are equal, i.e., 10 μm/10 μm （even））, the degree of alignment depends on the size of the ridges and grooves, when the ratio is smaller than 1 （groove controlled） the alignment increases as the ridge size decreases, and when the ratio is larger than 1 （ridge controlled）, the alignment is reduced as the width of the grooves decreases. The migration rate and neurite extension of DRG neurons were greatest on 10 μm/10 μm and 30 μm/30 μm micropatterned PLGA films. Based on the data, the 10 μm/10 μm and 30 μm/30 μm micropatterned PLGA films are the optimized ridge/groove surface patterns for the construction of nerve repair devices.

关键词： nerve regeneration nerve repair neural cell migration neural cell alignment micropattern dorsal root ganglion topological cues neural regeneration

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现代行波测距技术及其应用

电力系统自动化 2001年第23期25卷 62-65页

作者：徐丙垠李京陈平陈羽董新洲葛耀中 P.F.gale 科汇电气有限公司山东淄博255031 清华大学电机系北京100084 西安交通大学电力系西安710049 Hathaway仪器公司

介绍了利用电压、电流行波进行线路故障测距的方法。单端法是测量故障产生的行波在故障点及母线之间往返一趟的时间来计算故障距离 ,双端法利用故障行波到达线路两端的时间差测距。阐述了故障行波信号的测量、超高速记录、行波脉冲的小... 详细信息

介绍了利用电压、电流行波进行线路故障测距的方法。单端法是测量故障产生的行波在故障点及母线之间往返一趟的时间来计算故障距离 ,双端法利用故障行波到达线路两端的时间差测距。阐述了故障行波信号的测量、超高速记录、行波脉冲的小波检测以及双端装置时间精确同步等关键技术问题的解决方案以及行波测距技术实际应用中的若干问题。

关键词：故障测距行波输电线路电力系统全球定位系统

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小麦抗白粉病基因Pm12的RFLP标记

中国科学（B辑） 1993年第6期23卷 589-594页

作者：贾继增 T. e. Miller S. M. Reader M. D. gale 中国农业科学院作物品种资源研究所北京100081 英国植物研究中心剑桥实验室Norwich NR4 7UJ

春小麦品系Line 31携带有一个来自斯卑尔脱山羊草的显性抗白粉病基因Pm 12(Miller等,1988)。16个RFLP(restriction fragment length polymorphism)探针用于鉴定Line 31及其亲本,结果表明Line 31是一个6B/6S易位系。用5个探针所进行的连... 详细信息

春小麦品系Line 31携带有一个来自斯卑尔脱山羊草的显性抗白粉病基因Pm 12(Miller等,1988)。16个RFLP(restriction fragment length polymorphism)探针用于鉴定Line 31及其亲本,结果表明Line 31是一个6B/6S易位系。用5个探针所进行的连锁分析进一步揭示Pm 12位于易位染色体的着丝点附近,与6S长臂上的α-淀粉酶位点(α-Amy-S1)紧密连锁,遗传距离仅为1.1 cM。本研究结果表明RFLP技术在鉴定小麦外源染色体及外源基因上具有广阔的应用前景。

关键词：小麦基因多态性抗白粉病

Sex differences in cognitive impairment in Alzheimer's disease

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World Journal of Psychiatry 2016年第1期6卷 54-65页

作者： Keith R Laws Karen Irvine Tim M gale School of Life and Medical Sciences University of Hertfordshire Hertfordshire Partnership University NHS Foundation Trust

Sex differences in neurocognitive abilities have been extensively explored both in the healthy population andin many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease(AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein e ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge.

关键词： Dementia Gender Sex differences Cognition

利用微机故障录波数据进行准确的高阻接地故障定位

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电力系统保护与控制 1989年第3期34卷 5-10页

作者：王绪昭 P.e.gale 华北电力学院英国C.S.D公司

本文针对国内生产的WXH型线路保护在高阻接地短路时可能出现较大误差的问题提出了两种事后修正算法,以取得较准确的故障定位。两种算法不需对现有装置的软硬件作任何改动,且应用简单,精确度高。对于任何不配有测距软件的数字式故障录仪... 详细信息

本文针对国内生产的WXH型线路保护在高阻接地短路时可能出现较大误差的问题提出了两种事后修正算法,以取得较准确的故障定位。两种算法不需对现有装置的软硬件作任何改动,且应用简单,精确度高。对于任何不配有测距软件的数字式故障录仪电,应用这些方法,都可以很简单地获得测距功能。

关键词：高阻接地故障故障录波数据线路保护故障定位故障距离故障点安装处零序修正算法双回线路

Inequalities in care in patients with acute myocardial infarction

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World Journal of Cardiology 2015年第12期7卷 895-901页

作者： Shabnam Rashid Alexander Simms Phillip Batin John Kurian Chris P gale Department of Cardiology Leeds General Infirmary Department of Cardiology Pinderfields General Hospital Department of Cardiology Bradford Royal Infir-mary Department of Cardiology University of Leeds

Coronary heart disease is the single largest cause of death in developed countries. Guidelines exist for the management of acute myocardial infarction(AMI),yet despite these,significant inequalities exist in the care of these patients. The elderly,deprived socioeconomic groups,females and non-caucasians are the patient populations where practice tends to deviate more frequently from the evidence base. elderly patients often had higher mortality rates after having an AMI compared to younger patients. They also tended to present with symptoms that were not entirely consistent with an AMI,thus partially contributing to the inequalities in care that is seen between younger and older patients. Furthermore the lack of guidelines in the elderly age group presenting with AMI can often make decision making challenging and may account for the discrepancies in care that are prevalent between younger and older patients. Other patients such as those from a lower socioeconomic group,i.e.,low income and less than high school education often had poorer health and reduced life expectancy compared to patients from a higher socioeconomic group after an AMI. Lower socioeconomic status was also seen to be contributing to racial and geographical variation is the care in AMI patients. Females with an AMI were treated less aggressively and had poorer outcomes when compared to males. However even when females were treated in the same way they continued to have higher in hospital mortality which suggests that gender may well account for differences in outcomes. The purpose of this review is to identify the inequalities in care for patients who present with an AMI and explore potential reasons for why these occur. Greater attention to the management and a better understanding of the root causes of these inequalities in care may help to reduce morbidity and mortality rates associated with AMI.

关键词： Coronary artery disease Dual antiplatelet therapy Inequalities Guidelines Myocardial infarction

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牛顿与科学革命

小麦大姆指矮矮化基因Rht3对株高、产量和粒质的影响

丛书名：牛津科学肖像系列

2001年

作者：（美）盖尔·e.克里斯汀森（gale.e. Christianson）陈明璐李麟译

本书主要内容包括：“怎样玩得科学”、“我更伟大的朋友”、天才、大火和瘟疫；开拓创新的教授；“燃烧的煤块”等。

ISBN: (数字)7530630768

ISBN: (纸本)7530630768

本书主要内容包括：“怎样玩得科学”、“我更伟大的朋友”、天才、大火和瘟疫；开拓创新的教授；“燃烧的煤块”等。

关键词：牛顿学科:传记

来源：汇雅图书（南通市图书馆... 评论

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麦类作物学报 1987年第1期 21-23页

作者： J. e. Flintham ,M. D. gale. ,王驰

一、引言大姆指矮矮化基因Rht3阻碍α-淀粉酶在萌发种子中的释放(gale.Marshall,1973),这一发现引起了人们对该基因在商用品种中潜在地位的重新估价.通常由穗发芽导致的麦类制粉用籽粒中所含的高水平淀粉分解酶,无论是在面包(Chamberla... 详细信息

一、引言大姆指矮矮化基因Rht3阻碍α-淀粉酶在萌发种子中的释放(gale.Marshall,1973),这一发现引起了人们对该基因在商用品种中潜在地位的重新估价.通常由穗发芽导致的麦类制粉用籽粒中所含的高水平淀粉分解酶,无论是在面包(Chamberlaim,1931)还是在面条商品加工过程中都会引起不良影响(Moss,1980).而Rht3则可为降低此种不良影响提供一个简单的遗传手段.

关键词：产量植株小穗结实率矮化 Rht3 小麦麦类作物烘烤品质沉淀值株高穗发芽基因