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Honeybee Worker（Apis mellifera ligustica） Larvae Have Diverse Hemolymph Proteome than Pupae

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Honeybee Worker（Apis mellifera ligustica） Larvae Have Dive...

档案职位专业化研究:现状与成因--基于西南地区2010-2019年公务员考试职位表的分析

中国养蜂学会蜜蜂饲养管理专业委员会第17次学术会议

作者：房宇 Dereje Woltedji 韩宾 Mao Feng Rongli Li Alemayehu gala Jianke Li Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology Ministry of AgricultureChinese Academy of Agricultural Science

＜正＞Background:The honeybee hemolymph is vital both for transportation of nutrients, ions and hormones as well as cellular and humoral immune responses to the invasion of micro-organisms or foreign ***-resolved studies of honeybee hemolymph changes have so far been limited to investigation of a particular life stage or a small number of proteins at a *** the present study,we elucidate the honeybee（Apis mellifera ligustica） hemolymph proteome changes from the newly hatched larvae to five-day-old pupae using two-dimensional electrophoresis,mass spectrometry,bioinformatics and western blot. Result:Of the 80 hemolymph protein spots that altered their abundances throughout the development from the larvae to pupae,62.5%and 37.5%were highly expressed by the larvae and the pupae,*** numbers of proteins involved in carbohydrate metabolism and energy production,folding activities,development, cytoskeleton and antioxidant system had high abundance in the larval hemolymph, whereas proteins related to food（energy） storage,metabolism of fatty acids and amino acids were abundantly expressed from the late larval to pupal development stage. Conclusion:The larval and the pupal hemolymph have essential differences in protein expression *** young larvae use multifaceted proteins as temporal humoral protection mechanisms until they establish the high levels of immunity with age *** pupae mainly use energy storage hemolymph proteins that are thought to be a non-diet driven preparation for the normal *** data reveals that the honeybee life transition matches with the indispensable functional adjustment of the hemolymph that serves as nutrition carrier and humoral immune system.

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档案管理 2020年第6期 99-101页

作者：李甜嘎拉森中国人民大学信息资源管理学院

文章以西南地区2010-2019年十年间公务员考试职位表信息为数据源,根据报考条件里的专业学科要求、学历要求、是否有专业科目考试相关要求,对档案职位的专业化程度进行定量与定性的综合分析,发现西南地区公务员考试中档案职位专业化程度... 详细信息

文章以西南地区2010-2019年十年间公务员考试职位表信息为数据源,根据报考条件里的专业学科要求、学历要求、是否有专业科目考试相关要求,对档案职位的专业化程度进行定量与定性的综合分析,发现西南地区公务员考试中档案职位专业化程度较低,档案专业知识与技能认可度不够,原因可总结为档案职位准入门槛低、专业知识与技能可替代性强、专业知识与技能习得成本低、档案专业人员关键技能缺失严重。

关键词：公务员考试档案职位职业专业化学科结构

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出血后液体复苏中钠和容量的相互作用

战伤参考资料 1993年第1期24卷 36-38页

作者： gala,GT 朱佩芳

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CFFF辐射炉内传输现象的模拟

磁流体发电情报 1989年第39期48卷 29-36页

作者： gala.,FL 袁永久

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分泌水貂IgG的水貂—鼠杂交瘤细胞

国外特种经济动植物 1990年第2期 5-7页

作者： gala.,NL 聂金珍

Comparative Analysis of Proteome and Phosphoproteome during the Embryo-larva Transition of Honeybee Worker（Apis mellifera ligustica）

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Comparative Analysis of Proteome and Phosphoproteome during ...

中国养蜂学会蜜蜂饲养管理专业委员会第17次学术会议

作者：冯毛 Alemayehu gala 房宇 Dereje Woltedji Lan Zhang Bin Han Jianke Li Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology Ministry of AgricultureChinese Academy of Agricultural Science

＜正＞In the life cycle of the honeybee,the development of the last day embryo to the first instar larva is a critical event that marks the essential part of early life ***,it is still unknown the molecular mechanism regulating the transition of embryo to ***,the proteome and phosphoproteome of last day embryos（72 h） and first instar larvae（24 h,post hatching） were analyzed using two-dimensional gel electrophoresis,followed by multiplex fluorescent staining,mass spectrometry,bioinformatics,and quantitative real-time polymerase chain reaction. Sixty-five proteins and 34 phosphoproteins showing differential expression were identified in which 54.5%and 45.5%were upregulated in the embryos and the larvae, *** related to energy metabolism,development and amino acid metabolism were strongly expressed in the *** suggests that the embryo requires high metabolic energy during active embryogenesis and particularly for muscle contraction and abdominal peristalsis upon *** fact that,higher levels of protein expression and phosphorylation were involved in cytoskeletal, biosynthesis,protein folding,fatty acid and oxidative metabolism in the newly hatched larvae indicates their roles to ensure the fast growing of hatchling larvae. Furthermore,56 proteins acted as key nodes in the interaction network of proteins during the transition of embryo to larva,of which eight proteins had the same expressional tendency with their encoding *** data provide first evidence that the change in the level of protein expression and protein phosphorylation status play key roles to support the developmental transition from embryo to *** unravels the molecular event behind the first life cycle transition of *** significantly extends our knowledge on honeybee developmental biology and potentially helps to provide candidate proteins for reverse genetics at the early stage of development,to generate productive and desirable

关键词： honeybee embryo larva proteome phosphoproteome hatching transition

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当生活发生意外时

科学新闻 2022年第3期 60-61页

作者： Julia gala De Pablo 倪伟波东京大学

我简直不敢相信自己的运气。那是2018年12月，我即将在英国完成博士学位，一位教授邀请我去面试他在日本实验室的博士后职位，我很兴奋能体验到一个完全不同的研究环境。在我去西班牙探亲期间，在视频会议软件Zoom上的面试进行得很顺利...

我简直不敢相信自己的运气。那是2018年12月，我即将在英国完成博士学位，一位教授邀请我去面试他在日本实验室的博士后职位，我很兴奋能体验到一个完全不同的研究环境。在我去西班牙探亲期间，在视频会议软件Zoom上的面试进行得很顺利。在我人生的这个阶段，每一年都比上一年好，我确信2019年也会如此。然而，在4月，母亲告诉我她正在经历一些奇怪的症状。我的家人喜欢旅行，所以我们认为她可能感染了热带疾病。“你的论文交了吗？”她问我。“快了，

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Pharmacokinetics/Pharmacodynamics study of Fixtral SB as compared to supra bioavailable itraconazole and conventional itraconazole

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World Journal of Pharmacology 2023年第1期12卷 1-11页

作者： Syed Mujtaba Hussain Naqvi Monil Yogesh Neena gala Snehal Muchhala Anand Arumugam Dhananjay Panigrahi Dipak Patil Rahul Rathod Amey Mane Medical Affairs Dr Reddy’s LaboratoriesHyderabad 500016India Global Clinical Management Dr Reddy’s LaboratoriesHyderabad 500016India Formulation Development Dr Reddy’s LaboratoriesHyderabad 500016India

BACKGROUND Itraconazole is a broad-spectrum triazole antifungal inhibiting fungal growth by inhibiting ergosterol synthesis and exhibits a nonlinear pharmacokinetic *** absorption pattern with wide fluctuations in blood levels causes inconsistent and unpredictable clinical behaviour of this drug despite its low minimum inhibitory concentration(MIC)as compared to other antifungal *** To compare the oral bioavailability and bioequivalence of Fixtral SB(supra bioavailable itraconazole)with reference product R2(supra bioavailable 2×50 mg itraconazole).METHODS The study population consisted of 54 healthy volunteers,aged between 18-45 years and randomized to receive a single oral dose of either test[T;Fixtral SB(supra bioavailable itraconazole)100 mg]or reference product(R1;Sporanox 100 mg×2 capsules and R2;Lozanoc capsules 50 mg×2 capsules).Blood samples were taken pre-dose and post-dose up to 96 *** study evaluated bioequivalence by comparing the oral bioavailability of the test product with reference product *** pharmacodynamic characteristics of the drug were evaluated by comparing the test product with reference product ***(PK)-PD comparative analysis[area under the concentration-time curve(AUC)/minimum inhibitory concentration(MIC)>25]was performed for conventional itraconazole 100 mg and supra bioavailable itraconazole 50 *** events(AEs)assessments were performed in each study period and post-study *** Statistical analysis of primary PK variables revealed bioequivalence,with confidence intervals being completely inside the acceptance criteria of 80%-125%.The peak concentration levels of itraconazole were achieved at 10 h(T)and 8.5 h(R2),*** parameter assessment showed that AUC/MIC for R1 are comparable to Fixtral SB 100mg for MIC levels up to 16mcg/mL(P>0.05 and observed P=0.3196).Six AEs were observed that were mild to moderate in severity and *** severe AE was reported.

关键词： Supra-Bioavailable itraconazole Conventional itraconazole Oral bioavailability Pharmacodynamics Efficacy Adverse events

微波消解/等离子体发射光谱法测定蒙药敖西根-18中的多种元素含量

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化学世界 2007年第2期48卷 78-80页

作者：萨嘎拉乌云照日格图内蒙古师范大学化学与环境科学学院内蒙古呼和浩特010022

采用高压密封微波消解,以体积比(5∶1)硝酸-高氯酸为溶样试剂,用电感耦合等离子体原子发射光谱法(ICP-AES)测定了蒙药敖西根-18中的镁、钙、铬、锰、铁、钴、镍、铜、锌、锶、银、镉、铅等金属元素的含量。测定结果表明:蒙药敖西根-18... 详细信息

采用高压密封微波消解,以体积比(5∶1)硝酸-高氯酸为溶样试剂,用电感耦合等离子体原子发射光谱法(ICP-AES)测定了蒙药敖西根-18中的镁、钙、铬、锰、铁、钴、镍、铜、锌、锶、银、镉、铅等金属元素的含量。测定结果表明:蒙药敖西根-18中含多种金属元素,尤其钙、镁、铁、锶、锰、锌的含量较高,含有害金属元素镉和银,未测到有害元素铅。加标回收率为98.5%-105.2%,RSD为0.4%-2.3%。

关键词：蒙药敖西根-18 微波消解等离子体发射光谱法元素