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Twelve Months Clinical Outcomes after Percutaneous Coronary Intervention with Bare Metal Stents in Unselected Real-Life Patients with Coronary Artery Disease: Results from FLEXUS Study

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World Journal of Cardiovascular Diseases 2016年第10期6卷 342-351页

作者： Durgaprasad Rajasekhar Velam Vanajakshamma gajjala obul reddy Akkulagari Vamsidhar Kasala Latheef Pathakota Sudhakar reddy Department of Cardiology Sri Venkateswara Institute of Medical Sciences (SVIMS) Tirupati India

Background: Though drug-eluting stent is widely used during coronary angioplasty, still there are conditions in which bare metal stents possess a priority role. Objectives: The aim of FLEXUS study is to investigate the safety and efficacy of Flexinnium stent in unselected real-life patients. Methods: The FLEXUS is a single-centric, observational, non-randomized, retrospective study performed from January to August 2014 in 216 patients who received Flexinnium stent. The end-point of study included device-oriented and patient-oriented clinical outcomes as per Academic Research Consortium consensus. These end-points were observed at in-hospital stay and 12-month follow-up. Results: Of 216 patients, 174 (80.6%) patients were male;there were 76 (35.2%) and 84 (38.9%) patients of diabetes and hypertension, respectively. Type B2 and C lesions accounted for 27 (11.3%) and 122 (50.8%), respectively. A total of 241 Flexinnium stents were implanted with an average diameter and length of 2.7 ± 0.2 mm and 21.6 ± 8.0 mm, respectively. The cumulative device-oriented composite at 12-month follow-up included 2.31% cardiac death, 1.39% myocardial infarction (MI) attributed to the target vessel, and 3.70% target lesion revascularization (TLR). Conclusion: FLEXUS study gives an idea about favorable safety and efficacy of the Flexinnium in unselected real-life patients with both simple and complex coronary lesions.

关键词： Bare Metal Stent Coronary Artery Disease Percutaneous Coronary Intervention

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Synthesis,isolation,identification and characterization of new process-related impurity in isoproterenol hydrochloride by HPLC,LC/ESI-MS and NMR

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Journal of Pharmaceutical Analysis 2017年第6期7卷 394-400页

作者： Neeraj Kumar Subba Rao Devineni Prasad reddy gajjala Shailendra Kumar Dubey Pramod Kumar Chemical Research Department Micro Labs LtdAPI DivisionBommasandra-Jigani Link RoadKIADB INDL AreaBommasandraBangalore 560105KarnatakaIndia

One unknown impurity （Imp-II） during the analysis of laboratory batches of isoproterenol hydrochloride was detected in the level ranging from 0.04% to 0.12% by high performance liquid chromatography with UV detection. The unknown impurity structure was proposed as 4-[2-（propan-2oylamino）ethyl]benzene-l,2-diol （Imp-II） using the liquid chromatography-mass spectrophotometry （LC-MS） analysis. Imp-II was isolated by semi-preparative liquid chromatography from the impurity-enriched reaction crude sample. Its proposed structure was confirmed by nuclear magnetic spectroscopy such as 1H, 13C, DEPT （1D NMR）, HSQC （2D NMR） and infrared spectroscopy （IR）, and retention time and purity with HPLC followed by the chemical synthesis. Due to less removable nature of Imp-II during the purification, the synthetic process was optimized proficiently to control the formation of Imp-II below to the limit 〈 0.12% in the course of reaction. The new chemical route was developed for the preparation of this impurity in required quantity with purity to use as reference standard. The most probable mechanism for the formation of Imp-II was discussed in details.

关键词： Isoproterenol hydrochloride Impurities HPLC NMR

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Transcription factor TFE3 enhances cell cycle and cancer progression by binding to the hTERT promoter

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Cancer Communications 2021年第12期41卷 1423-1426页

作者： Beiping Miao Chaoyang Zhang Nadine Stroh Lukas Brenner Katrin Hufnagel Jörg DHoheisel obul reddy Bandapalli Division of Functional Genome Analysis German Cancer Research Center(DKFZ)HeidelbergBaden-Württemberg 69120Germany Medical Faculty Heidelberg Heidelberg UniversityHeidelbergBaden-Württemberg 69120Germany Molecular Genetic Epidemiology German Cancer Research Center(DKFZ)HeidelbergBaden-Württemberg 69120Germany

Dear Editor,Telomeres are located at the ends of chromosomes and are essential for chromosome stability and *** progressively get shorter with cell division,eventually resulting in cell proliferation *** process is considered a barrier to tumor occurrence[1,2].Abnormally activated telomerase with constitutive telomerase reverse transcriptase(TERT)expression is a hallmark of almost all human tumors[3].Some genomic alterations in the human TERT(hTERT)promoter are associated with activation of hTERT transcription in various cancer types[4].

关键词： alterations cancer eventually

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