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Natural Biopolymers for Bone Tissue Engineering:A Brief Review

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再生工程(英文) 2023年第2期4卷 193-204页

作者： Sheersha Pramanik Shubham Kharche Namdev More Deepak Ranglani gajendra singh Govinda Kapusetti Department of Medical Devices National Institute of Pharmaceutical Education and Research(NIPER)AhmedabadOpposite Air force Station PalajGandhinagar382355GujaratIndia Department of Biotechnology Bhupat and Jyoti Mehta School of BiosciencesIndian Institute of Technology MadrasChennaiTamil Nadu 600036India

Tissue engineering is a well-proven technique for the creation of functional alternatives for regenerative medicine and plays a critical role in patient *** natural-origin biopolymers such as chitosan,hyaluronic acid,gelatin,collagen,*** extensively explored for various biomedical ***,these polymers are exclusively investigated in tissue engineering applications due to their highly favorable properties,such as high biocompatibility,slow degradation,mechanical tenability,structural similarity with native tissues,bioactivity,*** present review summarizes the recent advances of biopolymers in bone tissue engineering It also covers the topic of natural polymer modification to achieve superior characteristics primarily mechanical properties towards bone regeneration and discussed the best methods for dealing with ***,the review can drive the development of biomimetic materials for futuristic applications.

关键词： Biopolymer Bone regeneration Tissue engineering Biomimetic polymers Chitosan

The clinical outcomes of laser with suction device in mini-percutaneous nephrolithotomy

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Asian Journal of Urology 2022年第1期9卷 63-68页

作者： Abhishek gajendra singh Sundaram Palaniappan Shrikant Jai Gopal Tak Arvind Ganpule Ravindra Sabnis Mahesh Desai Department of Urology Muljibhai Patel Urological HospitalVirendradesai MargNadiadGujaratIndia

Objective:To evaluate the safety,efficacy and feasibility of laser with suction device in mini-percutaneous nephrolithotomy(mini-PCNL).Methods:A retrospective study was conducted including 200 patients who underwent mini-PCNL for renal *** patients underwent PCNL using Electro-Medical Systems *** addition to the laser in 100 patients,a suction device was used(laser with suction[LWS]).In the other 100,suction device was not used(laser with no additional suction[LOS]).Mini-PCNL was performed using standard technique and Karl Storz minimally invasive PCNL-medium system was *** end point was stone ***:Both the groups were comparable in terms of demographic *** stone size was 15.24±5.90 mm and 16.16±5.53 mm in LWS and LOS,*** Hounsfield unit of stone was 1285.64 and 1206.79 in LWS and LOS,*** time was less in LWS group(56.89±19.65 min)as compared to LOS(62.01±28.81 min).At one-month follow-up,radiological complete clearance was 96%in LWS and 92%in *** subgroup analysis of stones larger than 18 mm,the clearance rate was in favour of LWS(85.7%vs.100%)and also the need for nephrostomy placement was less in LWS ***:LWS device is safe and efficacious when used with *** stones greater than 18 mm,it has a better stone free rate as compared to using no suction.

关键词： Mini-percutaneous nephrolithotomy Laser with suction Stone clearance

Prediction of Antagonistic Activity of β-Carboline and Its Derivatives Using Topological Descriptors

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Open Journal of Applied Sciences 2021年第5期11卷 577-584页

作者： Anil Kumar Soni gajendra Pal singh Vishnu Kumar Sahu Department of Chemistry Shia Post Graduate College Lucknow India Department of Chemistry Bareilly College Bareilly India Department of Chemistry Maharani Lal Kunwari Post Graduate College Balrampur India

Prediction of antagonistic activity of β-carboline and its thirteen derivatives has been made using topological descriptors viz, connectivity index, and kappa shape index of different orders. For evaluation of values of descriptor, molecular modeling and geometry optimization of all the compounds were carried out with CAChe Pro software by opting semiempirical PM3 method using MOPAC 2002. For prediction of activity multiple linear regression analysis (MLR) was performed. MLR analysis has been made by Project Leader Software associated with CAChe by using the above descriptors as independent variables and biological activity as dependent variables. We were performed leave-one-out methods and the result reflected a direct relationship between biological activity and connectivity index of zero order, while indirect relationship with connectivity index of second order and thus connectivity index is a reliable descriptor to predict the biological activity of β-carboline and its various derivatives.

关键词： β–carboline antagonistic activity PM3 connectivity index and kappa shape index

Synthesis and Biological Activity Study of Novel N1-(4-Hydroxy Benzoyl)-3-Methyl-5-Phenyl-4(N-4-Chlorophenylazo)-1,2-Diazole and Its Derivatives

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Pharmacology & Pharmacy 2017年第1期8卷 1-14页

作者： Sumit Bhatt gajendra singh Sanjeev Kumar Rachna Paliwal Jeet singh Jangwan Chandra Pal singh Department of Chemistry SRT Campus Badshahi Thaul Tehri Garhwal University Campus of HNB Garhwal Central University Shrinagar (Uttarakhand) India Sahu Jain P.G. College Najibabad Department of Chemistry MJP Rohilkhand University Bareilly (Uttar Pradesh) India Hindu College Moradabad Department of Chemistry MJP Rohilkhand University Bareilly (Uttar Pradesh) India

A series of sulpha/substituted derivatives of phenyl azo-1,2-diazole have been synthesized and tested as an anti-inflammatory and anti-bacterial activity in mature albino rats hind paw by taking Diclofenac sodium as standard. N1-(4-hydroxy benzoyl)-3-methyl-5-phenyl-4(N-4-chlorophenylazo)-1,2-diazole is synthesized by a two-step process. In the first step, synthesis of N1-4-chlorophenyl hydrazono-1-methyl-3-phenyl propane-1,3-dione by the reciprocal action of 1-methyl-5-phenylpropane-1,3-dione and diazonium salt solution of phenyl-chloride interacts with 4-hydroxybenzoic acid hydrazide to form the final compound. These diazoles, the heterocyclic compounds which contained electron withdrawing groups, were screened for analgesic activity by acetic acid induced writing method, and for anti-inflammatory activity carried on carrageenan-induced paw edema. The synthesized substituted Chlorophenylazo-1,2-diazole nucleus exhibited significant anti-bacterial, anti-cancer, anti-inflammatory activity, muscle relaxing and moderate activity in anti-proliferative studies.

关键词： 1 2-Diazole Diuretic Activity Muscle Relaxing Anti-Inflammatory Analgesic Antibacterial Activity Anti-Proliferative Studies

Blue emission in Ce3+and Eu2+activated Lithium fluoro borate phosphors

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Journal of Modern Physics 2011年第12期2卷 1560-1566页

作者： S. P. Puppalwar S. J. Dhoble gajendra singh Animesh Kumar 不详

Using a simple combustion process, rare earth doped novel compounds like fluorides LiBF4 and Li3BF6 can be prepared. Combustion synthesis furnishes a quick method for preparation of these phosphors. The prepared phosphors were characterized by the photoluminescence (PL) techniques. It is suggested that borofluoride based materials can be developed as low-cost phosphors. Formation of single phase compounds was confirmed by XRD. It is observed that prepared phosphors exhibited intense and characteristic Ce3+ and Eu2+ photoluminescence emission in blue visible region. This article summarizes fundamentals and possible applications of optically useful inorganic fluoride materials, with visible photoluminescence of Ce3+ and Eu2+ doped ions.

关键词： Lithium Fluoroborate Phosphors Combustion Synthesis XRD and Photoluminescence

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植物生长调节剂对芒果瘿木虱引起虫瘿的影响

世界热带农业信息 1989年第3期 26-28页

作者： gajendra singh 陆有通

1979年至1983年,在印度潘蒂纳哈(Pantnagar)就2,4—敌(5—250毫克/升)、2,4,5—涕(5—250毫克/升)、萘乙酸(5—500毫克/升)、矮壮素(50,100毫克/升)、马来酰肼(50,100毫克/升),脱落酸(10,50毫克/升)、赤霉酸和二甲胺基虎珀酸(10和50毫克... 详细信息

1979年至1983年,在印度潘蒂纳哈(Pantnagar)就2,4—敌(5—250毫克/升)、2,4,5—涕(5—250毫克/升)、萘乙酸(5—500毫克/升)、矮壮素(50,100毫克/升)、马来酰肼(50,100毫克/升),脱落酸(10,50毫克/升)、赤霉酸和二甲胺基虎珀酸(10和50毫克/升)对芒果瘿木虱(Apsylla Cisteltata Buekton)引起芒果虫瘿的影响进行了试验。2,4—滴超过100毫克/升和2,4,5—涕的150毫克/升时,对虫瘿形成数量无影响,但会形成畸形、疏松、长的虫瘿,木虱的若虫不能在其中生存,从而对此害虫产生控制作用。在没有若虫的小枝上无花序抽出。

关键词：植物生长调节剂芒果脱落酸赤霉酸矮壮素木虱若虫二甲胺基虫瘿形成花序

Prediction of Antagonistic Activity of β -Carboline and Its Derivatives Using Topological Descriptors

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Primary Malignant Melanoma of Female Urethra:A Case Report and Review of Literature

Open Journal of Applied Sciences（应用科学） 2021年第5期

作者： Anil Kumar Soni gajendra Pal singh Vishnu Kumar Sahu

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Journal of Oncology Research 2019年第3期1卷 13-16页

作者： Shashank Agrawal Tak GR Aditya Parikh Arvind Prakash Ganpule Abhishek gajendra singh Ravindra Bhalchandra Sabnis Mahesh Ramanlal Desai MBBS MSDNB(UROLOGY MBBS MSDNBMNAMS(Vice Chairman MBBS MSM.chDNB MBBS MSMch(Chairman MBBS MSFRCSFRCS(Medical Director

We report a very rare case report of female diagnosed with primary malignant melanoma.A 65 years old diabetic elderly postmenopausal female presented with a history of intermittent blood spots on undergarments for few *** examination revealed a single,tan colored,soft chestnut size and polypoidal non ulcerated mass lesion protruding through the urethral *** biopsy revealed poorly differentiated epithelial malignancy and immuno-histological analysis revealed positive with HMB 45 and protein S-100 suggestive of *** work up for the malignancy was *** urethrectomy with Mitrofanoff procedure with inguinal lymph node dissection was *** examination was suggestive of malignant melanoma of *** we discuss the clinicopathological features and management option possible in this scenario.

关键词： Female urethra melanoma

Estimation of optimum sample size allocation:An illustration with body mass index for evaluating the effect of a dietetic supplement

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International Journal of Biomathematics 2019年第8期12卷 75-86页

作者： Carlos N.Bouza-Herrera Sira M.Allende-Alonso gajendra K.Vishwakarma Neha singh Departamento de Matemdtica Aplicada Universidad de La Habana Cuba Department of Mathematics and Computing Indian Institute of Technology Dhanbad India

In many medical researches,it is needed to determine the optimal sample size allocation in a heterogeneous *** paper proposes the algorithm for optimal sample size *** consider the optimal allocation problem as an optimization problem and the solution is obtained by using Bisection,Secant,Regula-Falsi and other numerical *** performance of the algorithm for different numerical methods are analyzed and evaluated in terms of computing time,number of iterations and gain in accuracy using *** efficacy of algorithm is evaluated for the response in terms of body mass index(BMI)to the dietetic supplement with diabetes mellitus,HIV/AIDS and cancer post-operatory recovery patients.

关键词： Optimal sample allocation Body Mass Index diabetes HIV/AIDS cancer