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Reciprocal Association between Psychological Distress and PTSD and Their Relationship with Pre-Displacement Stressors among Displaced Women

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International Journal of Mental Health Promotion 2023年第5期25卷 699-710页

作者： erhabor S.Idemudia Babatola D.Olawa gail e.wyatt Norweeta G.Milburn Faculty of Humanities North-West UniversityMafikeng Campus34151South Africa Department of Psychiatry&Behavioural Sciences Jane&Terry Semel Institute for Neuroscience&Human BehaviourUniversity of California Los AngelesLos Angeles90095USA

It is established in the psychological literature that pre-displacement stressors,PTSD symptoms,and psycholo-gical distress are associated among internally displaced ***,existing studies have not demonstrated the mechanism underlying these *** study compared two explanatory models;one with PTSD symptoms severity explaining the indirect association between pre-displacement stressors and psychological dis-tress,and the other with psychological distress explaining the indirect relationship between pre-displacement stressors and PTSD symptoms *** a cross-sectional design,631 women(Mean age=31.18±8.59)were conveniently and purposely selected from the displaced women harboured in two camps in Borno State,Nigeria,due to the Boko-Haram *** were collected utilizing structured questionnaires and subjected to path *** demonstrated that PTSD symptoms severity and psychological distress indirectly explained their respective and independent association with pre-displacement ***,PTSD symptoms had a statis-tically larger standardized indirect effect size,greater indirect effect percentage,and bigger kappa-squared(k2)effect size than psychological *** symptoms and psychological distress may have a reciprocal inﬂuence on each other from pre-displacement ***,PTSD symptoms can better explain the association between pre-displacement stressors and psychological distress than the other way *** outcomes have important implications for the psychological treatment of displaced persons.

关键词： PTSD symptoms psychological distress traumatic stress internally displaced persons

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Roles of the eye care workforce for task sharing in management of diabetic retinopathy in Cambodia

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International Journal of Ophthalmology(english edition) 2018年第1期11卷 101-107页

作者： Mufarriq Shah gail M.Ormsby Ayesha Noor Rahul Chakrabarti Manfred Morchen Fakir MAmirul Islam CAlex Harper Jill e Keeffe Pakistan Institute of Community Ophthalmology Hayatabad Medical Complex Peshawar 25000Pakistan Centre for eye Research Australia Department of Ophthal-mologyUniversity of MelbourneRoyal Victorian Eye and Ear HospitalMelbourneVIC 302Australia Faculty of education Science and BusinessLifestyle Research CentreAvondale College of Higher EducationCooranbongNSW 2265Australia Vision and Dental Care Clinic Peshawar 25000Pakistan CARITAS Takeo eye Hospital Krong Doun Kaev 21151Cambodia Regional office Asia South east CBM International Unit 604 Alabang Business Tower 1216 Acacia AveMuntinlupa City 1799Philippines Statistics Data Science and EpidemiologySwinburne University of TechnologyHawthornVIC 3122Australia LV Prasad eye Institute Hyderabad 500034India

AIM： To identify the current roles of eye and health care workers in eye care delivery and investigate their potential roles in screening and detection for management of diabetic retinopathy（DR） through task ***： Purposive sampling of 24 participants including health administrators, members from non-government organizations and all available eye care workers in Takeo province were recruited. This cross sectional mixed method study comprised a survey and in-depth interviews. Data were collected from medical records at Caritas Takeo eye Hospital（CTeH） and Kiri Vong District Referral Hospital Vision Centre, and a survey and interviews with participants were done to explore the potential roles for task sharing in DR management. Qualitative data were transcribed into a text program and then entered into N-Vivo（version 10） software for data management and analysis. ReSULTS： From 2009 to 2012, a total of 105 178 patients were examined and 14 030 eye surgeries were performed in CTeH by three ophthalmologists supported by ophthalmic nurses in operating and eye examination for patients. Between January 2011 and September 2012, 151 patients（72 males） with retinal pathology including 125（83%） with DR visited CTeH. In addition 170 patients with diabetes were referred to CTeH for eye examinations from Mo Po Tsyo screening programs for people with diabetes. Factors favouring task sharing included high demand for eye care services and scarcity of ***： Task sharing and team work for eye care services is functional. Participants favor the potential role of ophthalmic nurses in screening for DR through task sharing.

关键词： task sharing diabetes diabetic retinopathy human resources Cambodia

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Language arts : patterns of practice 6th ed.

Language arts : patterns of practice

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2005年

作者： Tompkins gail e.

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The Presence but not the Location of an Appendicolith Affects the Success of Interval Appendectomy in Children with Ruptured Appendicitis

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Surgical Science 2011年第2期2卷 39-44页

作者： Iyore A. James Stephen Druhan Donna A. Caniano gail e. Besner 不详

Purpose: To determine whether the presence and/or location of an appendicolith can predict failure of initial non-operative management in children with ruptured appendicitis. Methods: A retrospective chart review of pediatric patients presenting with ruptured appendicitis was performed. Patients in whom the intent to treat was with initial non-operative management and interval appendectomy (IA) were selected (n = 117). One patient was excluded due to the presence of both intraluminal and extraluminal appendicoliths. Children who failed initial non-operative management were assigned to the “failure” group (n = 22). Children that improved and underwent elective IA were assigned to the “success” group (n = 94). Age, gender, duration of symptoms, presence of an appendicolith, appendicolith location (intraluminal/extraluminal), presence of a drainable abscess, and complications were reviewed. Results: There was an overall 18.8% failure rate for IA. Patients with an appendicolith had a 41.7% failure rate, and patients without an appendicolith had a 13% failure rate (p = 0.003). Patients with intraluminal or extraluminal appendicoliths each had a 41.7% failure rate. The presence or absence of a drainable in-tra-abdominal abscess did not affect the failure rate. Children in the failure group presented to the hospital earlier (6.57 ± 2.59 vs. 10.02 ± 7.21 days;p = 0.030). Conclusions: The presence of an appendicolith increases the likelihood of failure of initial non-operative management of ruptured appendicitis in children;however, the location of the appendicolith is not a predictor of failure.

关键词： Ruptured Appendicitis Failure Non-Operative Management Appendicolith

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Book Recommendation: Advances in Water Quality Control

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Journal of Water Resource and Protection 2010年第12期2卷 995-996页

作者： gail Krantzberg Aysegul Tanik 不详

Book Recommendation: Advances in Water Quality Control gail Krantzberg, Aysegul Tanik et al. Scientific Research Publishing, 2010 316 pages ISBN: 978-1-935068-08-2 Paperback (US$89.00) e-book (US$89.00) Order online: ... 详细信息

关键词： Book Recommendation Advances in Water Quality Control

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Polynomial Lag-effect Modelling for Relationship between Particulate Matter and Respiratory Hospital Admissions,Brisbane,Australia

Polynomial Lag-effect Modelling for Relationship between Par...

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第三届环境与职业医学国际学术研讨会

作者： gail Williams School of Population Health University of QueenslandHerstonQLD4006Australia

＜正＞ Although it has been highlighted recently that air pollutants usually have continuous impacts on health （i.e. lag-effects） , most of the studies were based on the assumption that relationship between environmental exposure and health outcomes is linear. However, the assumption may be invalid because the biological dose-response relationship is often curvilinear. This study aimed to develop a polynomial lag-effect model parametrically to estimate the association between particulate matter less than 10μmin diameter （PM10） and respiratory hospital admissions（RHA） .Two-stage generalized additive Poisson regression models were used. In stage I, nonparametric estimation was performed to discover an appropriate form of the dependence of RHA on

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<i>Stachybotrys chartarum</i>(<i>atra</i>) spore extract alters surfactant protein expression and surfactant function in isolated fetal rat lung epithelial cells, fibroblasts and human A549 cells

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Open Journal of Pediatrics 2013年第3期3卷 243-256页

作者： gail F. Pollard Anthony Shaw Michael Sowa Thomas Rand James A. Thliveris James e. Scott Department of Biology St. Mary’s University Halifax Nova Scotia Department of Human Anatomy and Cell Science University of Manitoba Winnipeg Canada Department of Oral Biology University of Manitoba Winnipeg Canada National Research Council Biodiagnostics Institute Winnipeg Canada

Moulds, notably Stachybotrys chartarum (atra), are constant contributors to air pollution particularly to air quality in buildings. The spores themselves or their volatile organic products are present in variable amounts in almost all environments, particularly in buildings affected by flooding. These moulds and products can account for the sick building syndrome and have been tied to such occurrences as the outbreak of pulmonary hemosiderosis and hemorrhage in infants in Cleveland, Ohio. The present study was designed to investigate the effects of S. chartarum extracts on surfactant protein expression, surfactant quality and cell survival in the developing lung. S. chartarum extracts were incubated with cultures of several cell types;isolated fetal lung type II cells and fetal lung fibroblasts, and human lung A549 cells, a continuously growing cell line derived from surfactant producing type II alveolar cells. MTT formazan assays were employed to test cell viability. The synthesis and release of the predominant surfactant protein A (SP-A), which is involved in the regulation of surfactant turnover and metabolism, and surfactant protein B (SP-B) involved in shuttling phospholipids between surfactant subcompartments was also assessed. Antibodies to these proteins and western blotting results were used to assess the quantity of protein produced by the various cell types. A novel approach utilizing captive bubble surfactometry was employed to investigate the quality of surfactant in terms of surface tension and bubble volume measurements. electron microscopy was used to examine changes in cellular structure of control and S. chartarum-treated cells. Results of the study showed that exposure to the S. chartarum extracts had deleterious effects on fetal lung epithelial cell viability and their ability to produce pulmonary surfactant. S. chartarum extracts also induced deleterious changes to the developing fetal lung cells in terms of expression of SP-A and SP-B as well a

关键词： Fetal Lung Surfactant Surface Tension Black Mould Captive Bubble Surfactometer Surfactant Proteins

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Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

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Protein & Cell 2018年第1期9卷 121-129页

作者： Philip D. Bardwelll Matthew M. Staron Junjian Liu Qingfeng Tao Susanne scesney gail Bukofzer Luis e. Rodriguez Chee-Ho Choi Jennifer Wang Qing Chang Feng Dong Cherrie Donawho Jieyi Wang Christine M. Grinnell edit Tarcsa Charles Hutchins Tariq Ghayur Jijie Gu Foundational Immunology AbbVie Bioresearch Center Worcester MA 01605 USA Global Preclinical Safety AbbVie Bioresearch Center Worcester MA 01605 USA Oncology Discovery AbbVie Inc. North Chicago IL 60064 USA DMPK-BA AbbVie Bioresearch Center Worcester MA 01605 USA Research and Development AbbVie Inc. North Chicago IL 60064 USA Torque Therapeutics Inc. Cambridge MA 02142 USA Innovent Bioloqics Inc. Suzhou China Lyvgen Biopharma Shanghai 201203 China

Novel biologics that redirect cytotoxic T lymphocytes （CTLs） to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens （TAA） expressed on tumor cells remains a challenge of both technology and biol- ogy. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each speci- ficity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.

关键词： DVD-Ig Half DVD-Ig Halt'body epidermal growth factor receptor redirected T-cell cytotoxicity rCTL

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穆鲁罗瓦和方阿陶法环礁放射学状况的国际研究——穆鲁罗瓦研究

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国际原子能机构通报 1998年第4期40卷 21-23页

作者： e.gail De PLANQUe 美国核管理委员会

规模最大的国际环境评估之一——过去3年中由IAeA组织的旨在评估南太平洋穆鲁罗瓦和方阿陶法环礁放射学状况的研究——终于有了结果。法国政府曾在1966—1996年间在这两个环礁上进行过核试验。我作为领导这项研究的国际咨询委员会(IAC)... 详细信息

规模最大的国际环境评估之一——过去3年中由IAeA组织的旨在评估南太平洋穆鲁罗瓦和方阿陶法环礁放射学状况的研究——终于有了结果。法国政府曾在1966—1996年间在这两个环礁上进行过核试验。我作为领导这项研究的国际咨询委员会(IAC)的主席,获得了一些领导这一国际项目的专门经验。

关键词：放射学环礁国际咨询委员会辐射防护法国政府核试验南太平洋研究所状况澳大利亚

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Monitoring the autoproteolysis of hiv-1 protease by site-directed spin-labeling and electron paramagnetic resonance spectroscopy

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Journal of Biophysical Chemistry 2011年第2期2卷 137-146页

作者： Jamie L. Kear Luis Galiano Angelo M. Veloro Laura S. Busenlehner gail e. Fanucci Department of Chemistry University of Florida Gainesville Florida USA

Site-directed spin-labeling with continuous wave electron paramagnetic resonance spectroscopy was used to monitor autoproteolysis of HIV-1 protease, an enzyme essential for viral maturation. Two protein constructs were examined, namely subtype F and the circulating recombinant form CRF01_A/e. As the protease undergoes self-cleavage, protein unfolds and small peptide fragments containing the spin label are generated, which collectively give rise to a sharp spectral component that is easily discernable in the high-field resonance line in the ePR spectrum. By monitoring the intensity of this spectral component over time, the autoproteolytic stability of each construct was characterized under various conditions. Data were collected for samples stored at 4 °C, 25 °C, and 37 °C, and on a subtype F HIV-1 protease sample stored at 25 °C and containing the FDA-approved protease inhibitor Tipranavir. As expected, the rate of autoproteolysis decreased as the storage temperature was lowered. Minimal autoproteolysis was seen for the sample that contained Tipranavir, providing direction for future spectroscopic studies of active protease samples. When compared to standard methods of monitoring protein degradation such as gel electrophoresis or chromatographic analyses, spin-labeling with CW ePR offers a facile, real-time, non-consuming way to monitor autoproteolysis or protein degradation. Additionally, mass spectrometry studies revealed that the N-termini of both constructs are sensitive to degradation and that the sites of specific autoproteolysis vary.

关键词： HIV-1 Protease Autoproteolysis Self-Proteolytic Activity Site-Directed Spin-Labeling electron Paramagnetic Resonance (ePR) Spectroscopy

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