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International Journal of Ophthalmology(English edition) 2019年第4期12卷 675-680页

作者： Mu li Xiao-Qin Yan gai-yun li Hong Zhang Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Retinal Department Shanxi Eye Hospital

To evaluate post-miosis changes in the anterior chamber structures in various angle-closure glaucomas(ACG). Totally 14 eyes of primary chronic angle-closure glaucoma(PCACG), 12 eyes of lens-induced secondary chronic angleclosure glaucoma(LSACG) and 14 healthy eyes were recruited. After miosis, for PCACG group, intraocular pressure(IOP) and anterior chamber depth(ACD) changed not significantly, while anterior chamber angle widened significantly. LSACG group showed a significant increase in IOP, decrease in ACD, and narrowing in anterior chamber angle. Healthy eyes showed significant decreases in IOP and anterior chamber parameters. Thus, miosis could widen the anterior chamber angle of patients with PCACG, while increase the narrowing of anterior chamber angle and IOP of patients with LSACG. We should pay attention to the distinction between PCACG and LSACG patients and the proper administration of pilocarpine in the treatment of patients with chronic ACG.

关键词： miosis chronic angle-closure glaucoma anterior chamber structure intraocular pressure optical coherence tomography

牛小脑肌醇磷脂激酶PI(4)K高产率纯化与特征

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生物化学与生物物理进展 1999年第5期26卷 473-477页

作者：乐加昌盖丽云中国科学院生物物理研究所生物大分子国家实验室北京100101

对牛小脑膜区肌醇磷脂激酶进行了１１５００倍纯化，过程包括：ＴｒｉｔｏｎＸ１００抽提，硫酸铵沉淀，阳离子交换层析（ｐｈｏｓｐｈｏｃｅｌｌｕｌｏｓｅ），亲和层析（ＨｅｐａｒｉｎＳｅｐｈａｒｏｓｅＣＬ６Ｂ） ... 详细信息

对牛小脑膜区肌醇磷脂激酶进行了１１５００倍纯化，过程包括：ＴｒｉｔｏｎＸ１００抽提，硫酸铵沉淀，阳离子交换层析（ｐｈｏｓｐｈｏｃｅｌｌｕｌｏｓｅ），亲和层析（ＨｅｐａｒｉｎＳｅｐｈａｒｏｓｅＣＬ６Ｂ）和阴离子交换层析（ＤＥＡＥ１０，ＦＰＬＣ）等．纯化程度可达９５％以上，对ＳＤＳＰＡＧＥ电泳结果进行扫描分析测其分子质量为５６ｋｕ．纯化的肌醇磷脂激酶的特异活性为４５０ｎｍｏｌ／ｍｇ·ｍｉｎ，动力学性质表现为ＡＴＰ的表观Ｋｍ值为７９ ×１０－７ｍｏｌ／Ｌ，ＰＩ的表观Ｋｍ值为６６ ×１０－７ｍｏｌ／Ｌ．腺嘌呤核苷是该酶的有效抑制剂，３５ ×１０－７ｍｏｌ／Ｌ腺嘌呤核苷可使该酶活力降低约５０％，而ＴｒｉｔｏｎＸ１００对该酶活力具有刺激作用，０５％ＴｒｉｔｏｎＸ１００可使该酶表现为最高活力．

关键词：信号传导牛小脑肌醇磷脂激酶纯化

One Novel Tetranuclear Mn（Ⅱ） Cluster Bridged by Carboxyl Substituted Nitronyl Nitroxide Radical:Crystal Structure and Magnetic Properties

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One Novel Tetranuclear Mn（Ⅱ） Cluster Bridged by Carboxyl ...

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

中国化学会第六届全国结构化学学术会议

作者： yun-gai li,Peng Hu,li-Cun li~* Department of Chemistry,Nankai University,Tianjin,300071

＜正＞The coordination complexes of paramagnetic metal ions with nitronyl nitroxides have recently attracted considerable interest for the purpose of exploiting new molecular-based magnetic *** various nitronyl nitrox...

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来源： cnki会议评论

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

A deeper and hotter Martian core-mantle differentiation inferred from FeO partitioning

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Science Bulletin 2025年第3期70卷 429-436页

作者： yunguo li Chunhui li You Zhou yun liu Huaiwei Ni State Key Laboratory of lithospheric and Environmental Coevolution University of Science and Technology of ChinaHefei 230026China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Research Centre for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Chinese Academy of SciencesGuiyang 550081China

The core-mantle differentiation process plays a pivotal role in redistributing material on a massive scale,shaping the long-term evolution of rocky *** this process is crucial for gaining insights into the accretion and evolution of planets like ***,the details of Mars’s core-mantle differentiation remain poorly understood due to limited compositional data for its core and *** this study,we aim to constrain the Martian core-mantle differentiation by examining FeO partitioning between core and mantle materials,incorporating improved Martian compositional data from the InSight *** ab initio thermodynamic techniques,we calculated the FeO partition coefficient between liquid iron and silicate *** results align with previous studies while also clarifying the factors affecting partitioning *** on these findings and estimates of oxygen concentration in the core,we infer that Mars’s core and mantle likely differentiated at temperatures above 2440 K and pressures ranging from 14 to 22 *** these estimates are higher than previously reported,they are consistent with observed abundances of moderately siderophile elements and Mars’s accretion models.

关键词： Mars Core-mantle differentiation Volatile Partitioning

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li Chengcheng gai Danqing Xin Yijing Zhao Yan Song Yahong Cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

IoT Empowered Early Warning of Transmission line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data

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Computers, Materials & Continua 2025年第1期82卷 1171-1192页

作者： Zhe li yun liang Jinyu Wang Yang Gao State Grid Henan Electric Power Company Electric Power Scientific Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China

Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power *** early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false *** address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather ***,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused ***,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network ***,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this ***,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.

关键词： Optical fiber sensing multi-source data fusion early warning of galloping time series data IoT adaptive weighted learning irregular time series perception closed-loop attention mechanism

The genetic basis and improvement of photosynthesis in tomato

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Horticultural Plant Journal 2025年第1期11卷 69-84页

作者： Haiqiang Dong Fangman li Xiaoxiao Xuan John Kojo Ahiakpa Jinbao Tao Xingyu Zhang Pingfei Ge Yaru Wang Wenxian gai Yuyang Zhang National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops Huazhong Agricultural UniversityWuhan 430070 China Hubei Hongshan Laboratory Wuhan 430070China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityWuhan 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministryof AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China

Photosynthesis is one the most important chemical reaction in plants,and it is the ultimate energy source of any living *** light and dark reactions are two essential phases of *** reaction harvests light energy to synthesize ATP and NADPH through an electron transport chain,and as well as giving out O_(2);dark reaction fixes CO_(2) into six carbon sugars by utilizing NADPH and energy from ***,plants convert optical energy into chemical energy for maintaining growth and development through absorbing light ***,firstly,we highlighted the biological importance of photosynthesis,and hormones and metabolites,photosynthetic and regulating enzymes,and signaling components that collectively regulate photosynthesis in ***,we reviewed the advances in tomato photosynthesis,including two aspects of genetic basis and genetic *** genes regulating tomato photosynthesis are gradually uncovered,and the interaction network among those genes remains to be ***,the photosynthesis occurring in fruit of tomato and the relationship between photosynthesis in leaf and fruit were *** and fruits are photosynthate sources and sinks of tomato respectively,and interaction between photosynthesis in leaf and fruit ***,future perspectives that needs to be addressed on tomato photosynthesis were proposed.

关键词： Photosynthesis Tomato Genetics Improvement Leaf Fruit

Electrochemical removal of nitrate in high-salt wastewater with low-cost iron electrode modified by phosphate

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Journal of Environmental Sciences 2025年第2期148卷 38-45页

作者： Fengjiao Quan Guangming Zhan Pengfei Xu Xiaolan Chen Wenjuan Shen Falong Jia yun He Jianfen li College of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China College of Chemistry Central China Normal UniversityWuhan 430079China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Nitrate(NO3-)is a widespread pollutant in high-salt wastewater and causes serious harm to human *** electrochemical removal of nitrate has been demonstrated to be a promising treatment method,the development of low-cost electro-catalysts is still *** this work,a phosphate modified iron(P-Fe)cathode was prepared for electrochemical removal of nitrate in high-salt *** phosphate modification greatly improved the activity of iron,and the removal rate of nitrate on P-Fe was three times higher than that on Fe *** experiments and density functional theory(DFT)calculations demonstrated that the modification of phosphoric acid improved the stability and the activity of the zero-valent iron electrode effectively for *** nitrate was firstly electrochemically reduced to ammonium,and then reacted with the anodic generated hypochlorite to *** this study,a strategy was developed to improve the activity and stability of metal electrode for NO_(3)^(-)removal,which opened up a new field for the efficient reduction of NO3-removal by metal electrode materials.

关键词： Nitrate removal High-salt wastewater Electrocatalysis Phosphate modified Iron

Different Acupuncture Therapies for Postherpetic Neuralgia:An Overview of Systematic Reviews and Meta-analysis

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Chinese Journal of Integrative Medicine 2025年第1期31卷 55-67页

作者： XIA yun-fan SUN Ruo-han li Shi-min WANG Yi-yi li Rong-rong FANG Jian-qiao The Third Clinical Medical College of Zhejiang Chinese Medical University Hangzhou310000China Department of Rehabilitation Medicine Hangzhou Third People’s Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou310000China Department of Acupuncture the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310000China

Background: Postherpetic neuralgia(PHN) is the most common complication of herpes zoster infection and affects patients' quality of life. Acupuncture therapy is regarded as a competitive method of treatment for analgesia. Objective: To summarize evidence from systematic reviews(SRs) and evaluate the effectiveness and safety of different acupuncture therapies for treating PHN. Methods: Eight electronic databases were searched from their inception to August 5, 2022, including 4 international electronic databases(PubMed, EMBASE, the Cochrane library, and Web of Science) and 4 Chinese databases(Chinese Biomedical Database, China National Knowledge Infrastructure, VIP Database and Wanfang Database).Methodological quality was assessed by A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2).The Risk of Bias in Systematic Review(ROBIS) tool was used to assess the risk of bias in SRs. Evidence level was assessed by the Grading of Recommendations Assessment, Development, and Evaluation(GRADE)approach. Results: Totally, 7 SRs were included, including 128 studies and 9,792 patients. In AMSTAR 2, most of the SRs were of low or critically low levels since they had more than 1 critical deficiency. In ROBIS, 1 SR(14.29%)was rated as high risk, and the other 6(85.71%) were rated as low risk. In the GRADE system, 9 outcomes(28.13%)were valued as high level, 5(15.63%) as moderate level, 1(3.13%) as low, and 17(53.13%) as very low. In the effectiveness of acupuncture therapy, the group "moxibustion vs. original medical treatment" [mean difference(MD)=–1.44, 95% confidence interval(CI): –1.80 to –1.08, I2=99%, P<0.00001] was of the highest heterogeneity and the group "bloodletting vs. original medical treatment"(MD=–2.80, 95% CI: –3.14 to –2.46, I2=0, P<0.00001)was of the lowest heterogeneity. Six SRs have reported the safety of their studies and no serious events were shown in the treatment and control groups. Conclusions: Acupuncture therapy seems to be effective in treating PH

关键词： acupuncture postherpetic neuralgia systematic review Chinese medicine