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Potential of triptolide in reproductive management of the house rat,Rattus rattus

Integrative Zoology 2013年第3期8卷 260-276页

作者： Neena SINGLA gaganpreet kaur Bhupinder kaur BABBAR Bhupinder Singh SANDHU Department of Zoology Punjab Agricultural UniversityLudhianaIndia Department of Veterinary Pathology Guru Angad Dev Veterinary and Animal Science UniversityLudhianaIndia

Mature and healthy male house rats,Rattus rattus(n=160)were fed on bait(cracked wheat:powdered sugar,98:2)containing different concentrations of triptolide(0.1,0.05,0.025 and 0%)for 7 and 14 days in no-choice and bi-choice feeding tests in the *** objective of the study was to record the antifertility affects of triptolide after 30 and 60 days of termination of *** revealed no significant effect of triptolide treatment on weights of testis,epididymis,seminal vesicles and prostate gland of ***,sperm motility,live sperm count,sperm density and sperm morphology in the cauda epididymal fluid were found to differ significantly(P≤0.05)between untreated and treated groups of *** major effect of triptolide on sperm morphology was in the form of sperm head tail separation,which was up to 56.0%in rats treated for 14 days in no-choice and autopsied after 30 days.A significant effect(P≤0.05)of triptolide treatment was observed on the histomorphology of the testis,which included a dose-dependent decrease in diameter of seminiferous tubules,thickness of germinal epithelium and numbers of various spermatogenic *** associations in the seminiferous epithelial cycle were poorly developed in rats ingesting medium(4.7-5.1 mg/100 g bw)and high doses(6.9-7.2 mg/100 g bw)of triptolide than rats ingesting low doses(1.8-2.3 mg/100 g bw)and untreated *** cell stages affected had not recovered fully within the 60 day period following triptolide *** present study suggests the potential of triptolide in reproductive management of Rattus rattus.

关键词： Rattus rattus reproductive organs seminiferous tubules sperm parameters triptolide

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