检索结果-南通市图书馆

Management of Hypertension:JNC 8 and Beyond

Cardiovascular Innovations and Applications 2016年第B9期1卷 409-416页

作者： Ezra A.Amsterdam Sandhya Venugopal Jonathan Bui Balasingam Thevakumar Angela Thinda Sabrina Virk William J.Bommer Aman Khullar gagan Singh Division of Cardiovascular Medicine Department of Internal MedicineUniversity of CaliforniaDavisSchool of MedicineSacramentoCA 95817USA

Hypertension is a leading risk factor for cardiovascular disease,the leading cause of death and morbidity in our society and on a global *** components of cardiovascular disease include stroke,coronary artery disease,heart failure,and chronic kidney disease,in all of which hypertension plays a major *** risk of these complications increases directly and linearly with systolic blood pressure starting at 115 *** usually asymptomatic,hypertension is readily detectable on physical examination and is amenable to both lifestyle modifi cation and pharmacologic treatment in most ***,large proportions of the hypertensive population remain undetected and *** guidelines have been issued during the past few decades to promote detection and optimal *** the increase in risk with systolic blood pressure greater than 115 mmHg,the generally accepted threshold for diagnosis and treatment has been systolic blood pressure greater than 139 mmHg and diastolic blood pressure greater than 80 mmHg because until recently treatment to lower levels has been associated with an unfavorable relation between clinical benefi t and *** the past several years,new guidelines,advisories,commentaries,and clinical trials have provided evidence for a potential change in current recommendations for the management of *** this regard,the long-awaited eighth report of the Joint National Committee on the Prevention,Detection,Evaluation,and Treatment of High Blood Pressure recommended patients older than 60 years be treated to a systolic blood pressure of less than 150 mmHg,which has generated considerable controversy and *** striking fi ndings of the Systolic Blood Pressure Intervention Trial(SPRINT)have received considerable attention because of the demonstration that intensive therapy to a target systolic blood pressure below 120 mmHg decreases cardiovascular mortality and morbidity more than less intensive treatment to

关键词： hypertension JNC 7 JNC 8 cardiovascular risk factors SPRINT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial

引用

Stroke & Vascular Neurology 2022年第2期7卷 158-165页

作者： Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis Department of Medicine and Neurology Melbourne Brain Centre at The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Population Health and Immunity Division Walter and Eliza Hall Institute of Medical ResearchParkvilleVictoriaAustralia Ambulance Victoria MelbourneVictoriaAustralia Melbourne Medical School The University of MelbourneMelbourneVictoriaAustralia Stroke Division The Florey Institute of Neuroscience and Mental HealthParkvilleVictoriaAustralia Department of Neurology Christchurch HospitalChristchurchNew Zealand Department of Neurology Monash Medical CentreMonash UniversityClaytonVictoriaAustralia Department of Interventional Neuroradiology Liverpool HospitalLiverpoolNew South WalesAustralia Department of Neurology Royal Adelaide HospitalAdelaideSouth AustraliaAustralia Department of Neurology Princess Alexandra HospitalWoolloongabbaQueenslandAustralia Department of Neurology Box Hill HospitalEastern HealthBox HillVictoriaAustralia Stroke Centre and Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Medicine Dunedin School of MedicineUniversity of OtagoWellingtonNew Zealand Department of Neurosurgery E-Da HospitalYanchaoKaohsiungTaiwan Department of Neurology Alfred HospitalMelbourneVictoriaAustralia Department of Clinical Neuroscience Monash University Central Clinical SchoolMelbourneVictoriaAustralia Department of Medicine Sunshine Coast University HospitalNambourQueenslandAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia Department of Neurology John Hunter HospitalThe University of NewcastleNewcastleNew South WalesAustralia Department of Neurosurgery China Medical University HospitalTaichungTaiwan Department of Internal Medicine Palmerston North HospitalPalmerston NorthNew Zealand Department of Neurology St Vincent's HospitalFitzroyVictoriaAustralia Department of Neurology Royal Prince Alfred HospitalCamperdownNew South WalesAustra

Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of *** acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma *** and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical *** In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with *** size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of *** adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 *** Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching *** efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT *** We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.

关键词： placebo centre absolute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SMARCA4在鼻腔鼻窦畸胎癌肉瘤中高频性丢失

引用

临床与实验病理学杂志 2022年第4期38卷 512-512页

作者：王婷(摘译) 余英豪(审校) Rooper L M Uddin N gagan J 福建省泉州市中医院病理科泉州362000 中国人民解放军联勤保障部队第九〇〇医院病理科福州350001

分子分析通过定义新肿瘤实体和在已分类肿瘤类型中的确认复发性基因突变,从而重塑高级别鼻窦肿瘤的格局。鼻窦畸胎癌肉瘤(TCS)是一种罕见的高侵袭性肿瘤,混有畸胎瘤、癌和肉瘤成分,目前仍对该病知之甚少。因TCS的多表型分化引发对其组... 详细信息

分子分析通过定义新肿瘤实体和在已分类肿瘤类型中的确认复发性基因突变,从而重塑高级别鼻窦肿瘤的格局。鼻窦畸胎癌肉瘤(TCS)是一种罕见的高侵袭性肿瘤,混有畸胎瘤、癌和肉瘤成分,目前仍对该病知之甚少。因TCS的多表型分化引发对其组织起源的持续争议,并导致与其他几种恶性肿瘤在诊断上有重叠。

关键词：鼻窦肿瘤肿瘤类型组织起源基因突变鼻腔鼻窦畸胎瘤恶性肿瘤 TCS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Novel Approach for the Synthesis of (R) and (S )-Nicotine

引用

International Journal of Organic Chemistry（有机化学国际期刊） 2022年第4期

作者： Rohith Kumar Agarthimoole Sahir gagan Sudesna Parida Tarur Konikkaledom Dinesh Maheswaran S. Karatholuvhu Namasivayam Palani Soumitra Mukherjee

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Longevity of animals under reactive oxygen species stress and disease susceptibility due to global warming

引用

World Journal of Biological Chemistry 2016年第1期7卷 110-127页

作者： Biswaranjan Paital Sumana Kumari Panda Akshaya Kumar Hati Bobllina Mohanty Manoj Kumar Mohapatra Shyama Kanungo gagan Bihari Nityananda Chainy Department of Zoology College of Basic Science and HumanitiesOrissa University of Agriculture and Technology Department of Materia Medica Dr.Abhin Chandra Homoeopathic Medical College and HospitalUnit-III Sri Aurobindo Institute of Integral Science and Research Rural Health Centre Department of Zoology N.C.(Autonomous) College Department of Gynecology SCB Medical College and Hospital Department of Biotechnology Utkal University

The world is projected to experience an approximate doubling of atmospheric CO_2 concentration in the next decades. Rise in atmospheric CO_2 level as one of the most important reasons is expected to contribute to raise the mean global temperature 1.4 ℃-5.8 ℃ by that time. A survey from 128 countries speculates that global warming is primarily due to increase in atmospheric CO_2 level that is produced mainly by anthropogenic activities. Exposure of animals to high environmental temperatures is mostly accompanied by unwanted acceleration of certain biochemical pathways in their cells. One of such examples is augmentation in generation of reactive oxygen species(ROS) and subsequent increase in oxidation of lipids, proteins and nucleic acids by ROS. Increase in oxidation of biomolecules leads to a state called as oxidative stress(OS). Finally, the increase in OS condition induces abnormality in physiology of animals under elevated temperature. Exposure of animals to rise in habitat temperature is found to boost the metabolism of animals and a very strong and positive correlation exists between metabolism and levels of ROS and OS. Continuous induction of OS is negatively correlated with survivability and longevity and positively correlated with ageing in animals. Thus, it can be predicted that continuous exposure of animals to acute or gradual rise in habitat temperature due to global warming may induce OS, reduced survivability and longevity in animals in general and poikilotherms in particular. A positive correlation between metabolism and temperature in general and altered O_2 consumption at elevated temperature in particular could also increase the risk of experiencing OS in homeotherms. Effects of global warming on longevity of animals through increased risk of protein misfolding and disease susceptibility due to OS as the cause or effects or both also cannot be ignored. Therefore, understanding the physiological impacts of global warming in relation to longevity of

关键词： Reactive oxygen species Redox regulation Oxidative stress Survivability Climate change Disease susceptibility Global warming Longevity Thermal stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light treatment for seasonal Winter depression in African-American vs Caucasian outpatients

引用

World Journal of Psychiatry 2015年第1期5卷 138-146页

作者： Hyacinth N Uzoma Gloria M Reeves Patricia Langenberg Baharak Khabazghazvini Theodora G Balis Mary A Johnson Aamar Sleemi Debra A Scrandis Sarah A Zimmerman Dipika Vaswani gagan Virk Nijjar Johanna Cabassa Manana Lapidus Kelly J Rohan Teodor T Postolache Department of Psychiatry University of Maryland School of MedicineBaltimoreMD 21201-1549United States Psychiatry Residency Training Program St.Elizabeth’s HospitalWashingtonDC 20032United States Department of Epidemiology and Preventive Medicine University of Maryland School of MedicineBaltimoreMD 21201-1549United States Department of Ophthalmology and Visual Science University of Maryland School of MedicineBaltimoreMD 21201-1549United States Family and Community Health University of Maryland School of NursingBaltimoreMD 21201-1549United States Department of Psychological Science University of VermontBurlingtonVT 05405-0134United States VISN 5 Capitol Health Care Network Mental Illness Research Education and Clinical Center BaltimoreMD 21201United States VISN 19 Rocky Mountain Mental Illness Research Education and Clinical Center DenverCO 80220United States 不详

AIM: To compare adherence, response, and remission with light treatment in African-American and Caucasian patients with Seasonal Affective ***: Seventy-eight study participants, agerange 18-64(51 African-Americans and 27 Caucasians)recruited from the Greater Baltimore Metropolitan area, with diagnoses of recurrent mood disorder with seasonal pattern, and confirmed by a Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-Ⅳ, were enrolled in an open label study of daily bright light treatment. The trial lasted6 wk with flexible dosing of light starting with 10000 lux bright light for 60 min daily in the morning. At the end of six weeks there were 65 completers. Three patients had Bipolar Ⅱ disorder and the remainder had Major depressive disorder. Outcome measures were remission(score ≤ 8) and response(50% reduction)in symptoms on the Structured Interview Guide for the Hamilton Rating Scale for Depression(SIGH-SAD)as well as symptomatic improvement on SIGH-SAD and Beck Depression Inventory-Ⅱ. Adherence was measured using participant daily log. Participant groups were compared using t-tests, chi square, linear and logistic regressions. RESULTS: The study did not find any significant group difference between African-Americans and their Caucasian counterparts in adherence with light treatment as well as in symptomatic *** symptomatic improvement and rate of treatment response were not different between the two groups,African-Americans, after adjustment for age, gender and adherence, achieved a significantly lower remission rate(African-Americans 46.3%; Caucasians 75%; P =0.02).CONCLUSION: This is the first study of light treatment in African-Americans, continuing our previous work reporting a similar frequency but a lower awareness of SAD and its treatment in African-Americans. Similar rates of adherence, symptomatic improvement and treatment response suggest that light treatment is a feasible, acceptable,

关键词： Seasonal affective disorder Depression Light treatment African-American Black Remission gap Ethnicity Race

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：