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从宫颈癌治疗患者中收集RAN进行微矩阵基因表达分析的可行性:RTOGC-0128相关的科学性研究

世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 25-26页

作者： gaffney d.k. Winter k. Fuhrman C. 侯巍 department of Radiatio n Oncology Huntsman Cancer Hospital University of Utah Medical Center 1950 Ci rcle of Hope Salt Lake City UT 84112-5560 United States

Purpose. To determine the feasibility of RNA collection in a multi-institutio nal cooperative group setting to be utilized for micro-array gene expression an alysis, and to describe the methodology. Methods. RTOG C0128, a phase I-II, pro tocol was designed to look at the safety and efficacy of external beam radiation therapy to 45 Gy with concomitant 5-FU and cisplatin chemotherapy, brachythera py to deliver 85 Gy to point A, and Celecoxib at 400 mg twice daily for 1 year. Patients had the option of participating in a tissue collection portion of the p rotocol to be utilized for micro-array gene expression analysis before treatmen t and at the time of the first implant. RNA quality was determined by two parame ters: the absorbance ratio at 260 nm/280 nm, and by the ratio of the integrated peak of 28S RNA to 18S RNA after gel electrophoresis. Results. From August 2001 to March 2004, 84 patients were accrued to the trial, and tissue was obtained pr ior to initiation of therapy on 34 patients (40%). FIGO stages for the patients who provided tissue were IB (23%), II (57%), and IIIA-IVA (20%). Additional ly, biopsies were obtained at the time of the first implant from 22 of the accru ed patients making paired samples available on 26%for RNA extraction and micro -array gene expression analysis. The mean ±SEM amount of tissue obtained pretr eatment was 97±13 mg compared with 51±8 mg for tissue obtained at the time of the first implant (P = 0.009). The mean total RNA extracted from the samples pri or to treatment was 119 ±19 μg versus 35 ±6 μg at the time of the first proc edure (P = 0.001). The RNA quality was assessed via the absorbance ratio at 260 nm divided by 280 nm. The mean values pretreatment and at first implant were 1.8 7 ±0.07 versus 1.66 ±0.11, respectively (P = 0.002); however, the integrated p eak of 28S RNA to 18S RNA after gel electrophoresis was not significantly differ ent (P = 0.26). Conclusions. RNA extraction for gene expression analysis can be success

关键词：宫颈癌治疗 RAN RTOGC-0128 基因表达分析体外放疗活检组织吸光度比值顺铂化疗尿嘧啶塞来昔布

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Early Hearing detection and Intervention in the United States: Achievements and Challenges in the 21^(st) Century

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China CdC weekly 2020年第21期2卷 378-382页

作者： Xidong deng Marcus gaffney Scott d.Grosse National Center on Birth defects and developmental disabilities Centers for Disease Control and PreventionAtlantaGAUnited States

INTROdUCTION Congenital hearing loss affects approximately two infants per 1,000 live births in the United States(USA),making it one of the nation’s most common developmental disabilities(1).When left undetected,permanent congenital hearing loss can negatively impact children through delays in their speech,language,social,and emotional development(2).Children who are identified as deaf or hard of hearing(d/HH)should begin receiving intervention services as early as possible to help mitigate the potential adverse effects(3).

关键词： Achievements Challenges emotional

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肿瘤专科化是否影响早期阶段子宫内膜腺癌术后结局

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世界核心医学期刊文摘（妇产科学分册） 2006年第4期2卷 45-46页

作者： Macdonald O.k. Sause W.T. Lee R.J. d.k. gaffney 朱晓明 department of Radiation Oncology Huntsman Cancer Hospital University of Utah 1950 Circle of Hope Salt Lake City UT 84112-5560 United States

Objective. To evaluate treatment outcomes in women with early-stage endometrial cancer (FIGO IA, IB, IC, or IIA)-surgically managed by a general gynecologist (GYN) or a gynecologic oncologist (GYO). Methods and results. 349 women treated from 1990-2003 were studied. Median follow-up was 3.7 years. Ninety-five were classified as highintermediate risk (HIR: stages IB grade III, IC grade II or III, any stage IIA). 110 women received adjuvant radiotherapy. The GYO group had more unfavorable tumor characteristics based on stage and grade (P dian 3.1 vs. 5.1 years, P = 0.0002), and an absolute 12%less likelihood of receiving adjuvant radiotherapy (P = 0.04). Local and distant failures were not significantly different. Overall survival favored GYN patients (P = 0.02) with no difference in disease-specific survival (P = 0.38). Multivariate analysis for disease-free survival revealed HIR disease (P = 0.04) and GYO treatment (P = 0.049) to be significant, with a trend for age ≤64 (P = 0.05). Multivariate analysis for overall survival found age ≤64 (P = 0.0001), HIR disease (P = 0.01), and adjuvant radiotherapy (P = 0.0055) to be significant. Conclusions. Women primarily managed by a GYO for early-stage disease were significantly less likely to receive adjuvant radiotherapy. despite significantly more unfavorable disease characteristics among GYO-managed women,disease-free and cause-specific survival were equivalent between the two groups. Favorable disease characteristics and adjuvant radiotherapy correlated with improved survival on multivariate analysis.

关键词：子宫内膜腺癌专科化妇科肿瘤学妇科医师早期病变放射治疗恶性程度疾病特异性疾病特征无瘤

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高中甜心(英文)

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疯狂英语（初中天地） 2006年第12期 56-57页

作者： Jennifer gaffney

Phil was so cute that he made my most boring classes during senior year seem fun. At the end of senior year, I was sure he'd ask me to prom[毕业舞会]. But weeks went by and he never did. I figured, sadly,

关键词：甜心英文

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塔斯马尼亚州澳大利亚电锌公司里斯登厂的镉生产

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中国有色冶金 1984年第10期 19-20+22页

作者： d.J.gaffney ,路景春

前言自从上次霍普金和尼克松(1965年)介绍了澳大利亚电锌公司里斯登锌厂的镉回收实践之后,由于锌厂的扩大以及渣处理工作使得有必要在改变某些操作实践的同时把镉工厂的某些部分扩大。现在镉工厂正在处理锌厂两段锌粉净化阶段产出的镍... 详细信息

前言自从上次霍普金和尼克松(1965年)介绍了澳大利亚电锌公司里斯登锌厂的镉回收实践之后,由于锌厂的扩大以及渣处理工作使得有必要在改变某些操作实践的同时把镉工厂的某些部分扩大。现在镉工厂正在处理锌厂两段锌粉净化阶段产出的镍铜镉渣和铜镉渣。

关键词：电锌沉淀物渣处理浸出渣锌粉金属粉末里斯澳大利亚大洋洲

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宫颈癌放疗后人类表皮生长因子受体家族(EGFR,HER2,HER3,HER4)、磷酸化Akt(P-Akt)与临床预后的相关性

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世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 52-52页

作者： Lee C.M. Shrieve d.C. Zempolichk.A. d.k. gaffney 张丽娟 department of Radiation Oncology Huntsman Cancer Hospital University of Utah Medical Center 1950 Circle of Hope Salt Lake City UT 84112 United State

Objective. To investigate prognostic significance of and correlations between HER1 (EGFR), HER2 (c-erb-B2), HER3 (c-erb-B3), HER4 (c-erb-B4), and phosphorylated Akt (P-Akt) in patients treated with radiation for cervical carcinoma. Methods. Fifty-five patients with stages I-IVA cervical carcinoma were treated with definitive radiotherapy. Tumor expression of each biomarker was quantitatively scored by an automated immunohistochemical imaging system. Parametric correlations were performed between biomarkers. Univariate and multivariate analysis was performed with disease-free survival (dFS) and overall survival (OS) as primary endpoints. Results. Correlations were observed between expression of HER2 and HER4 (P = 0.003), and HER3 and HER4 (P = 0.004). decreased HER2, HER4, and P-Akt expressions were significant for diminished dFS on univariate analysis (P = 0.04, P = 0.008, and P = 0.02, respectively). Increased EGFR, and diminished HER2, HER4, and P-Akt expression were significant or showed trends toward significance for diminished OS on univariate analysis (P = 0.07, P = 0.008, P = 0.09, and P = 0.08, respectively). After controlling for pretreatment factors, multivariate analysis revealed HER2 associated with improved OS (P = 0.05). Thesedata emphasize that significant correlations exist between the differential expression of various HER family receptors. Multivariate analysis revealed only increased HER2 expression associated with improved OS after controlling for pretreatment clinical factors. Conclusions. These data emphasize the importance of continued basic and translational research on the HER family of receptors in cervical carcinoma.

关键词： P-Akt 预后意义无瘤生存率临床因素转化性研究局部放射治疗单变量分析生物标记物原发病

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二维数字化乳腺摄影与数字乳腺断层摄影在乳腺癌筛查率和间歇乳腺癌特征中的对比研究

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国际医学放射学杂志 2018年第3期 351-351页

作者： M.Bahl S.gaffney A.M.Mc Carthy k.P.Lowry P.A.dang C.d.Lehman 魏铃 division of Breast Imaging Department of MedicineMassachusetts General Hospital

摘要目的确定二维数字化乳腺摄影(dM)与数字乳腺断层摄影(dBT)在筛查率和间歇癌的特征中是否存在差异。材料与方法回顾分析2009年1月—2011年2月(dM

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HPS 70W桥梁大梁的结构性能和设计评估

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建筑钢结构进展 2008年第5期10卷 63-64页

作者： J.P. Felkel d.C. Rizos P. H. Ziehl 美国

该文进行了包含HPS 70W高性能钢的桥梁大梁的性能评估。该研究的背景是在美国南卡罗莱纳州的gaffney的一座三跨的桥梁，该桥梁在负弯矩区采用了HPS 70W高性能钢。该文的研究包括了现场实测（该项工作目前仍在进行）、试验以及理论分析... 详细信息

该文进行了包含HPS 70W高性能钢的桥梁大梁的性能评估。该研究的背景是在美国南卡罗莱纳州的gaffney的一座三跨的桥梁，该桥梁在负弯矩区采用了HPS 70W高性能钢。该文的研究包括了现场实测（该项工作目前仍在进行）、试验以及理论分析工作。在南卡罗莱纳大学的结构实验室进行了3个1：2比例的试件在单调及循环加载下的试验，其中，每个试件都有不同的支撑和加劲肋形式。

关键词：结构性能 HPS 桥梁设计评估大梁高性能钢性能评估负弯矩区

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