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Anti eotaxin-2 antibodies attenuate the initiation and progression of experimental atherosclerosis

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World Journal of Cardiovascular Diseases 2013年第4期3卷 339-346页

作者： Adi Mor Arnon Afek Michal Entin-Meer gad keren Jacob George ChemomAb Ltd. Tel Aviv Israel The Department of Cardiology Tel Aviv Sourasky Medical Center Tel Aviv Israel

Background: The chemokine eotaxin-2 is a potent chemoattractant for inflammatory cells, the predominants of which are eosinophils. Human and murine atherosclerotic plaques are known to exhibit inflammatory phenotypes where a complex interaction of cytokine and chemokines plays a role. We tested the hypothesis that eotaxin-2 (eo-2) plays a causative role in the initiation and progression of experimental atherosclerosis. Methods and Results: Sera collected from atherosclerotic ApoE knockout (KO) mice, exhibited significantly higher levels of eo-2 compared to sera collected from their background age matched C57BL/6 litters by ELISA. Moreover, levels of eo-2 were higher in old atherosclerotic ApoE KO mice than in young animals. Similarly, the expression level of the eo-2 receptor, CCR3, was increased in splenocytes of old ApoE compared to the young littermates. Administration of polyclonal blocking antibodies to eotaxin-2 resulted in a significant reduction of early atherosclerotic plaques in ApoE KO mice whereas prolonged treatment of mice with advanced plaques led to atheroma stabilization. A monoclonal antibody (D8) prepared against eo-2 attenuated adhesion of lymphocytes to fibronectin and potently inhibited their migration towards VEGF. Monoclonal blocking antibodies to eo-2 also significantly reduced atherosclerotic plaques in ApoE KO mice. Conclusion: Eo-2 serum levels are elevated in sera of ApoE KO mice with experimental atherosclerosis and its blockade is associated with reduced fatty streak accumulation and increased plaque stabilization.

关键词： Atherosclerosis Vulnerable Plaque Inflammation Eotaxin-2 Chemokines

以色列研究生教育的基本特征、内容体系与实践路径

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研究生教育研究 2024年第2期 111-117页

作者：王晨霏 gad Yair 东北师范大学思想政治教育研究中心长春130024 耶路撒冷希伯来大学创新教育研究中心耶路撒冷91905以色列

以色列以教育立国,其研究生教育为人才培养、科技创新、农业振兴、经济增长、民族复兴、国防安全作出了重大贡献。以色列研究生教育的形成和发展受意识形态、社会文化、道德习俗等多方面综合影响,经历了精英教育到大众教育的转变,形成... 详细信息

以色列以教育立国,其研究生教育为人才培养、科技创新、农业振兴、经济增长、民族复兴、国防安全作出了重大贡献。以色列研究生教育的形成和发展受意识形态、社会文化、道德习俗等多方面综合影响,经历了精英教育到大众教育的转变,形成了科研方向以国家意志为导向、教育体系以追求卓越与普及大众相结合、教育对象多元化的现实样态。以色列研究生教育以培养人才和学术卓越为根本目标,其内容体系涵盖坚定理想信念、坚守卓越学术、坚持自我完善三个维度,其实践进路包括专业课程培养、隐性思政培育、职业技能培训等主要途径。

关键词：以色列研究生研究生教育大学学术学院

Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome

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World Journal of Cardiology 2010年第9期2卷 299-304页

作者： Shmuel Schwartzenberg Arnon Afek Gideon Charach Ardon Rubinstein Yossi Ben-Shoshan Sarina Kissil Sofia Maisel-Auslender gad keren Jacob George Department of Cardiology Kaplan Medical Center affiliated to the Hebrew University Rehovot 76100 Israel Department of Cardiology Tel Aviv Sourasky Medical Center Affiliated to the Tel Aviv University Sackler School of Medicine Tel Aviv 64239 Israel

AIM: To compare the predictive power of different endothelial progenitor cell (EPC) phenotypic markers for future cardiovascular events. METHODS: Peripheral blood was collected from 76 consecutive patients with acute coronary syndromes (ACS) who underwent percutaneous coronary intervention in our institute. The various EPC phenotypes of peripheral blood mononuclear cells were CD34+CD133+, CD34+KDR+, and CD 133+KDR+. The outcome endpoint included cardiovascular mortality, recurrent ACS, and hospitalization for decompensated heart failure during a 24-mo follow-up ***: CD34+CD133+ cells (P = 0.034), but not CD34+KDR+ (P = 0.35) or CD 133+KDR+ cells (P = 0.19), were found to predict recurrent ACS. We found no correlation between EPCs measured by any of the three phenotypic combinations of accepted CD markers and the total combination of these separate outcomes. CONCLUSION: The EPC CD34+CD133+ phenotype, but not the CD34+KDR+ or the CD 133+KDR+ phenotypes, is predictive of future adverse cardiovascular outcomes.

关键词： Stem cells Endothelial progenitor cells Acute coronary syndrome Biomarkers

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礼贤未来社区安置房,衢州,浙江,中国

世界建筑 2024年第4期 90-93页

作者： gad 杰地设计集团有限公司

每个社区都是城市的片段,社区生活氛围也需要通过一定的城市性获得,孤岛式的住宅虽能居住但往往无法被认为真正的宜居。作为浙江省未来社区首批试点项目,政策上的支持为设计变革和居住本源上的创新带来机会。我们在设计中摒弃一切让社... 详细信息

每个社区都是城市的片段,社区生活氛围也需要通过一定的城市性获得,孤岛式的住宅虽能居住但往往无法被认为真正的宜居。作为浙江省未来社区首批试点项目,政策上的支持为设计变革和居住本源上的创新带来机会。我们在设计中摒弃一切让社区孤立的手段,安置房分为南北两个组团,组团之间的景观通廊向城市开放,联通了东侧的双水公园及西侧的景观步行轴;基于48m限高条件下2.33的超高容积率要求,安置房采用半围合的布局形成安定、内向的院落空间,沿西侧景观轴及东侧双水公园设置若干具有标识性的门洞,采用开放式社区的方式与周边进行衔接,东侧双水公园的自然景观渗透到庭院内部,整体营造出“居住在公园中”的独特体验。

关键词：高容积率安置房院落空间设计变革整体营造独特体验标识性生活氛围

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郡安里一期A,德清,浙江,中国

世界建筑 2024年第4期 102-103页

作者： gad 杰地设计集团有限公司

郡安里一期A住区规划项目选址于莫干山长林坞湖畔,此地山林茂密、水草丰美。当人类大规模开发不可避免地浸入到自然环境时,我们总是希望尽可能地保护这片青山绿水。本项目采用了三个层面的策略:在规划层面,采用点状用地群簇状布局将组... 详细信息

郡安里一期A住区规划项目选址于莫干山长林坞湖畔,此地山林茂密、水草丰美。当人类大规模开发不可避免地浸入到自然环境时,我们总是希望尽可能地保护这片青山绿水。本项目采用了三个层面的策略:在规划层面,采用点状用地群簇状布局将组团依山就势地嵌入茂密植被,避免过高密度对环境的破坏;在建筑层面,采用钢结构吊脚楼原型,减少落地截面,保留原生场地和植被;在营造方面,采用装配式、人工挖孔桩等措施,减少现场湿作业、减少机械操作和堆料场地,并且对重要树木进行原址保护或移植,以期减少环境扰动,实现水土保持和植被保护。

关键词：机械操作环境扰动植被保护莫干山原址保护依山就势人工挖孔桩水土保持

Effects of Moringa oleifera aqueous extract on the growth performance,blood characteristics,and histological features of gills and livers in Nile tilapia

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Aquaculture and Fisheries 2024年第1期9卷 85-92页

作者： Mahamoud A.Emam Ramy M.Shourbela Waleed N.El-Hawarry Seham Y.Abo-Kora Fatma Abdel-Monem gad Ashraf M.Abd El-latif Mahmoud A.O.Dawood Histology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Animal Husbandry and Animal Wealth Development Faculty of Veterinary MedicineAlexandria UniversityAlexandria22758Egypt Pharmacology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Clinical Pathology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Aquatic Animal Diseases and Management Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Animal Production Department Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33511Egypt The Center for Applied Research on the Environment and Sustainability The American University in CairoCairo11835Egypt

Moringa oleifera is well known as a highly nutritious plant and a water purifier in fish *** fish has many impressive qualities making them very suitable for ***,this study aimed to evaluate the effect of supplementation of Moringa oleifera aqueous extract(MOAE)at varying concentrations(0,100,200,and 400 mg/kg diet for 90 days)on growth performance,hematological,and some biochemical parameters of Nile ***,histological changes and immunohistochemical expression of caspase 3 in gills and livers were *** enhancements(P<0.05)in the final weight,weight gain,specific growth rate,red blood cells,hemoglobin,packed cell volume,white blood cells,and total serum protein were observed in fish fed 200 mg MOAE/kg diet compared with other ***,a significant reduction(P<0.05)of liver and kidney function tests and non-significant changes in lipid profile were *** the other hand,fish fed 400 mg MOAE/kg diet revealed disturbance in the corresponding *** histological degenerative changes were detected in the gills and liver of fish fed 400 mg MOAE/kg *** comparison,fish fed 200 mg MOAE/kg diet showed the best histo-architectures of these organs compared with other *** immune expressions of caspase 3 were determined where gills and liver of fish fed 400 mg MOAE/kg diet revealed extensive number of positive caspase 3 cells indicating severe apoptotic ***,a dietary MOAE at 200 mg/kg diet is recommended to improve the growth performance,hematological parameters,liver and kidney functions in Nile ***,caution must be considered when using MOAE at a concentration over 200 mg/kg diet.

关键词： Growth performance Liver Gills Moringa oleifera Nile tilapia

DLBT:Deep Learning-Based Transformer to Generate Pseudo-Code from Source Code

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Computers, Materials & Continua 2022年第2期70卷 3117-3132页

作者： Walaa gad Anas Alokla Waleed Nazih Mustafa Aref Abdel-badeeh Salem Faculty of Computers and Information Sciences Ain Shams UniversityAbassiaCairo11566Egypt College of Computer Engineering and Sciences Prince Sattam Bin Abdulaziz UniversityAl Kharj11942Saudi Arabia

Understanding the content of the source code and its regular expression is very difficult when they are written in an unfamiliar ***-code explains and describes the content of the code without using syntax or programming language ***,writing Pseudo-code to each code instruction is ***,neural machine translation is used to generate textual descriptions for the source *** this paper,a novel deep learning-based transformer(DLBT)model is proposed for automatic Pseudo-code generation from the source *** proposed model uses deep learning which is based on Neural Machine Translation(NMT)to work as a language *** DLBT is based on the transformer which is an encoder-decoder *** are three major components:tokenizer and embeddings,transformer,and *** code line is tokenized to dense *** transformer captures the relatedness between the source code and the matching Pseudo-code without the need of Recurrent Neural Network(RNN).At the post-processing step,the generated Pseudo-code is *** proposed model is assessed using a real Python dataset,which contains more than 18,800 lines of a source code written in *** experiments show promising performance results compared with other machine translation methods such as Recurrent Neural Network(RNN).The proposed DLBT records 47.32,68.49 accuracy and BLEU performance measures,respectively.

关键词： Natural language processing long short-term memory neural machine translation pseudo-code generation deep learning-based transformer

Small-extracellular vesicles and their microRNA cargo from porcine follicular fluids:the potential association with oocyte quality

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1727-1742页

作者： Ahmed gad Matej Murin Alexandra Bartkova Veronika Kinterova Katerina Marcollova Jozef Laurincik Radek Prochazka Institute of Animal Physiology and Genetics Czech Academy of Sciences27721 LiběchovCzech Republic Department of Animal Production Faculty of AgricultureCairo UniversityGiza 12613Egypt Department of Botany and Genetics Faculty of Natural SciencesConstantine the Philosopher University in Nitra94901 NitraSlovakia.

Background: Ovarian follicular fluids(FFs) contain several kinds of regulatory factors that maintain a suitable micro-environment for oocyte development. Extracellular vesicles(EVs) are among the factors that play essential roles in regulating follicle and oocyte development through their cargo molecules that include microRNAs(miRNAs). This study aimed to investigate small-EV(s-EV) miRNAs in porcine FFs and their potential association with oocyte ***: Individual aspirated oocytes were stained with lissamine green B stain(LB), a vital stain for oocyte quality, and each oocyte was classified as high-quality(unstained;HQ) or low-quality(stained;LQ). FFs corresponding to oocytes were pooled together into HQ and LQ groups. Small-EVs were isolated from FFs, characterized, and their miRNA cargo was identified using the Illumina Nova Seq sequencing platform. Additionally, s-EVs from the HQ and LQ groups were utilized to investigate their effect on oocyte development after co-incubation during in vitro ***: A total of 19 miRNAs(including miR-125b, miR-193a-5p, and miR-320) were significantly upregulated, while 23(including miR-9, miR-206, and miR-6516) were downregulated in the HQ compared to the LQ group. Apoptosis, p53 signaling, and cAMP signaling were among the top pathways targeted by the elevated miRNAs in the HQ group while oocyte meiosis, gap junction, and TGF-beta signaling were among the top pathways targeted by the elevated miRNAs in the LQ group. The supplementation of small-EVs during maturation does not affect the oocyte developmental rates. However, LQ s-EVs increase the proportion of oocytes with homogeneous mitochondrial distribution and decrease the proportion of heterogeneous ***: Our findings indicated that FF-EVs contain different miRNA cargos associated with oocyte quality and could affect the mitochondrial distribution patterns during oocyte maturation.

关键词： Extracellular vesicles Follicular fuids MiRNA Oocyte quality Porcine

Impact of different nano additives on performance, combustion, emissions and exergetic analysis of a diesel engine using waste cooking oil biodiesel

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Propulsion and Power Research 2022年第2期11卷 209-223页

作者： M.S.gad Mostafa M.Abdel Aziz Hatem Kayed Mechanical Engineering Department Faculty of EngineeringFayoum UniversityEgypt Mechanical Engineering Department Institute of Aviation Engineering and TechnologyGizaEgypt Mechanical Power Engineering Department Faculty of EngineeringCairo University12613Egypt

Biodiesel is derived from waste cooking oil (WCO) by transesterification. Methylester was prepared by mixing diesel and biodiesel oils as 20% by volume. Nano particles asTiO2, Al2O3 and CNTs were blended with biodiesel blend at different concentrations of 25,50, and 100 mg/l to enhance the physicochemical fuel characteristics to obtain clean and effi-cient combustion performance. An experimental setup was incorporated into a diesel engine toinvestigate the influence of these nano-materials on engine performance, exergy analysis, combustion characteristics and emissions using WCO biodiesel-diesel mixture. Enriching methylester mixture with 100 ppm titanium, alumina and CNTs (B20T100, B20A100 andB20C100) increased the thermal efficiency by 4%, 6% and 11.5%, respectively compared toB20. Biodiesel blending with nano additives B20T100, B20A100 and B20C100 decreasedthe emissions of CO (11%, 24% and 30%, respectively), HC (8%, 17% and 25%, respectively)and smoke (10%, 13% and 19%, respectively) compared to B20. However, the noticeable increase of NOx was estimated by 5%, 12% and 27% for B20T100, B20A100 and B20C100,respectively. Finally, the results showed the rise in peak cylinder pressure by 5%, 9% and 11% and increase in heat release rate by 4%, 8% and 13% for B20T100, B20A100 andB20C100, respectively. The fuel exergy of B20T100, B20A100 and B20C100 are lower thanbiodiesel blend B20 by 6.5%, 16% and 23% but the exergetic efficiency are increased by 7%,19% and 30% at full load about B20.

关键词： Waste cooking oil(WCO) Nano additives Engine performance Exergy Combustion characteristics Emissions