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急性毒性研究的新实验设计和方法

国外医学.药学分册 1986年第1期 48-49页

作者： gad SC

标准急性毒性实验设计需用大量动物,但并不能得到有价值的全身毒性资料。作者介绍的急性毒性实验设计方法,可以用少量的动物得到更多的有用资料,最大地发挥人员和设备的效率,此外还对许多毒性试验理论的基本概念进行了评价,设计方法为... 详细信息

标准急性毒性实验设计需用大量动物,但并不能得到有价值的全身毒性资料。作者介绍的急性毒性实验设计方法,可以用少量的动物得到更多的有用资料,最大地发挥人员和设备的效率,此外还对许多毒性试验理论的基本概念进行了评价,设计方法为单只动物试探（Singleanimal probe）:作者认为,LD50不应仅作为毒性的一个数据,它是对群体动物毒性估计的一个指标,只有在和

关键词：急性毒性常规方法动物低剂量实验设计试验设计给药毒性试验形态变化神经行为

Locally Isolated Bacterial Strains with Multiple Degradation Potential Capabilities on Petroleum Hydrocarbon Pollutants

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Advances in Microbiology 2016年第11期6卷 852-866页

作者： A. Bahobail S. M. F. gad El-Rab G. A. Amin Department of Biology Faculty of Science Taif University Taif KSA Department of Biotechnology Faculty of Science Taif University Taif KSA Department of Botany and Microbiology Faculty of Science Assuit University Assuit Egypt Department of Microbiology Faculty of Agriculture Cairo University Cairo Egypt

In the present study, 23 isolates, dominated by bacterial genera (74%) were isolated from petroleum sludge at refinery wastewater plant, Jeddah, KSA, by means of selective enrichment in nutritionally optimized refinery wastewater (NORWW) and over twelve successive transfers. Efficiency of biodegradation on complex mixture of hydrocarbons present in refinery wastewater was evidenced by changes in both total viable counts (TVC) and COD content of cultivation broth. Out of the 23 isolates three most potent isolates named BDCC-TUSA-8, BDCC-TUSA-12 and BDCC-TUSA-18 were selected for their efficient COD removal and active growth. The three isolates were tested separately in Bushnell-Haas (BH) media for their capabilities to degrade n-Hexadecane, phenol and phenanthrene, representing the major types of hydrocarbon pollutants. The results strongly indicated that all three isolates showed multiple degradation potentials with remarkably fast reaction rates. Before being recommended for future work, the three isolates were fully characterized and identified employing culture-dependent techniques such as API 20E, API 20NE and API 50CHB, and further confirmed by partial 16S rRNA gene sequencing and phylogenetic analysis as Pantoea agglomerans, Acinetobacter lwoffii and Bacillus thuringiensis respectively. The obtained potent strains provide valuable candidates if assemblages of mixed fewer strains with overall broad and complementary enzymatic capacities are to be considered in order to bring the rate and extent of petroleum biodegradation further as a cost-effective process.

关键词： Biodegradation Consortium Multiple Degradation Potentials Acinetobacter Bacillus Pantoea

Missing Data Imputation: A Comprehensive Review

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Journal of Computer and Communications 2024年第11期12卷 53-75页

作者： Majed Alwateer El-Sayed Atlam Mahmoud Mohammed Abd El-Raouf Osama A. Ghoneim Ibrahim gad Department of Computer Science College of Computer Science and Engineering Taibah University Yanbu Saudi Arabia Computer Science Department Faculty of Science Tanta University Tanta Egypt Basic and Applied Science Institute College of Engineering and Technology Arab Academy for Science and Technology (AAST) Alexandria Egypt Department of Computer Science Faculty of Computers and informatics Tanta University Tanta Egypt

Missing data presents a significant challenge in statistical analysis and machine learning, often resulting in biased outcomes and diminished efficiency. This comprehensive review investigates various imputation techniques, categorizing them into three primary approaches: deterministic methods, probabilistic models, and machine learning algorithms. Traditional techniques, including mean or mode imputation, regression imputation, and last observation carried forward, are evaluated alongside more contemporary methods such as multiple imputation, expectation-maximization, and deep learning strategies. The strengths and limitations of each approach are outlined. Key considerations for selecting appropriate methods, based on data characteristics and research objectives, are discussed. The importance of evaluating imputation’s impact on subsequent analyses is emphasized. This synthesis of recent advancements and best practices provides researchers with a robust framework for effectively handling missing data, thereby improving the reliability of empirical findings across diverse disciplines.

关键词： Missing Data Machine Learning Prediction Deep Learning Imputation

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One＆Ortakoy屋顶平台

景观设计 2011年第6期 34-39页

作者： gad Architecture 吴迪（翻译）

One＆Ortakoy屋顶平台对于整幢建筑而言具有举足轻重的地位。该项目临近博斯普斯大桥．远远望去可以看到醒目的One＆OrtaKoy屋顶平台。因而，屋顶平台的重要性不言而喻。设计师们在进行设计时，也始终没有忘记这一点。

关键词：屋顶平台设计师建筑

Formulation and evaluation of anti-asthmatic drug montelukast in mucoadhesive buccal patches

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Journal of Coastal Life Medicine 2014年第11期 907-914页

作者： Magdy Ibrahim Mohamed Enas Abd El-Moneim Mohamed Radwan Afify Mary Kamal gad Mekhael Department of Pharmaceutics Faculty of PharmacyCairo UniversityCairoEgypt National Organization for Drug Control and Research DokyGizaEgypt

Objective: To formulate and evaluate anti-asthmatic drug montelukast in mucoadhesive buccal patches. Methods:Buccal patches were formulated by using different hydrophilic polymers by solvent casting technique. Buccal patches were evaluated by seven physical appearances, in addition toin vitro drug release study. Results: All patches were uniform and translucent, and had smooth surface. In vitro release studies were conducted for montelukast buccal patches proved that release in the range of 75.26%-92.30% in 8 h. Emission of montelukast from all patches simulated zero order and diffusion mechanism. Finally it can be concluded that F3, F15 and F16 are the best formulation. Conclusions: The investigation concluded that patch of 5 mg of montelukast sodium were formulated by using sodium alginate with sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose K100M with sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose K100M with sodium alginate (F3, F15 and F16 formulations) were the best formulations.

关键词： Montelukast sodium Gelatin Hydroxy propyl methyl cellulose Poly vinyl pyrrolidone Buccal film In-vitro release

Effects of Moringa oleifera aqueous extract on the growth performance,blood characteristics,and histological features of gills and livers in Nile tilapia

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Aquaculture and Fisheries 2024年第1期9卷 85-92页

作者： Mahamoud A.Emam Ramy M.Shourbela Waleed N.El-Hawarry Seham Y.Abo-Kora Fatma Abdel-Monem gad Ashraf M.Abd El-latif Mahmoud A.O.Dawood Histology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Animal Husbandry and Animal Wealth Development Faculty of Veterinary MedicineAlexandria UniversityAlexandria22758Egypt Pharmacology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Clinical Pathology Department Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Department of Aquatic Animal Diseases and Management Faculty of Veterinary MedicineBenha UniversityBenha13511Egypt Animal Production Department Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33511Egypt The Center for Applied Research on the Environment and Sustainability The American University in CairoCairo11835Egypt

Moringa oleifera is well known as a highly nutritious plant and a water purifier in fish *** fish has many impressive qualities making them very suitable for ***,this study aimed to evaluate the effect of supplementation of Moringa oleifera aqueous extract(MOAE)at varying concentrations(0,100,200,and 400 mg/kg diet for 90 days)on growth performance,hematological,and some biochemical parameters of Nile ***,histological changes and immunohistochemical expression of caspase 3 in gills and livers were *** enhancements(P<0.05)in the final weight,weight gain,specific growth rate,red blood cells,hemoglobin,packed cell volume,white blood cells,and total serum protein were observed in fish fed 200 mg MOAE/kg diet compared with other ***,a significant reduction(P<0.05)of liver and kidney function tests and non-significant changes in lipid profile were *** the other hand,fish fed 400 mg MOAE/kg diet revealed disturbance in the corresponding *** histological degenerative changes were detected in the gills and liver of fish fed 400 mg MOAE/kg *** comparison,fish fed 200 mg MOAE/kg diet showed the best histo-architectures of these organs compared with other *** immune expressions of caspase 3 were determined where gills and liver of fish fed 400 mg MOAE/kg diet revealed extensive number of positive caspase 3 cells indicating severe apoptotic ***,a dietary MOAE at 200 mg/kg diet is recommended to improve the growth performance,hematological parameters,liver and kidney functions in Nile ***,caution must be considered when using MOAE at a concentration over 200 mg/kg diet.

关键词： Growth performance Liver Gills Moringa oleifera Nile tilapia

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当代乡村聚落——杭州富阳东梓关回迁农居

建筑技艺 2017年第8期23卷 80-85页

作者： gad建筑设计 gad建筑设计

中国高速的城市化进程使得城乡差距非常大，呈现出乡村空心化、人员外流、居住环境恶劣等现状。本案面对的就是一个非常典型的江南村落，为了改善居民的居住与生活条件，当地政府决定一期先外迁50户，遵循宅基地一户一宅的分配方式，在... 详细信息

中国高速的城市化进程使得城乡差距非常大，呈现出乡村空心化、人员外流、居住环境恶劣等现状。本案面对的就是一个非常典型的江南村落，为了改善居民的居住与生活条件，当地政府决定一期先外迁50户，遵循宅基地一户一宅的分配方式，在老村落的南侧进行回迁安置。

关键词：乡村聚落农居杭州居住环境城市化进程城乡差距空心化宅基地

Outcome of Management of Pseudomyxoma Peritonei: National Cancer Institute Experience

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Journal of Cancer Therapy 2018年第4期9卷 323-337页

作者： Z. gad O. Nassar H. Soliman S. Mohamed M. Mohamed Surgical Oncology Department National Cancer Institute Cairo University Giza Egypt Medical Oncology Department National Cancer Institute Cairo University Giza Egypt Ain Shams University Cairo Egypt

Background: The current treatment for pseudomyxoma peritonei (PMP) consists of radical cytoreductive surgery (CRS) followed by hyperthermic intra-peritoneal chemotherapy (HIPEC). Aim: To assess PMP patients regarding the clinical and pathological characteristics, the treatment including surgery (CRS) and chemotherapy either HIPEC type or post-operative systemic chemotherapy aiming to evaluate end results regarding recurrence and survival. Patients and Methods: This retrospective study included 39 patients with PMP who were diagnosed, treated and followed-up from 2009-2014 at National Cancer Institute, Cairo, Egypt. Results: High grade mucinous adenocarcinoma was found in 23.1% of patients. Patients with low grade tumor showed higher survival rate compared with patients with high grade disease. The mean operative PCI score (peritoneal cancer index) that was done to all patients who were explored was 15.81. Our study reported success to achieve complete cytoreduction that was combined with HIPEC in 44% of patients who were planned for this modality. Treatment related postoperative grade (3 - 5) complications mainly surgery related developed in 17.3 of patients. Operative mortality was 22.2%. The follow up period in our study was quite short (mean 22.9). However the overall survival at the end of the follow up in our study was 48.7%, 1 year survival was 82%, and 2 year survival was 41%. The overall survival in patients treated with CRS and HIPEC was 66.6%, with 1 year and 2 year survival of 91% and 66.6% respectively. Only 2 patients developed recurrent disease during the follow up period. Conclusions: The outcome of PMP treatment process is extremely variable. Combined CRS and HIPEC is considered the best therapeutic approach for patients with PMP. Surgical experience combined with proper patient selection have to be built up together to improve the outcome. That could only be achieved through more centralization of patients’ treatment in specialized units or center.

关键词： HIPEC NCI Experience Pseudomyxoma Peritonii

Physicians’ Instructions to Patients Regarding Medications in a Saudi University Hospital

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Health 2015年第11期7卷 1441-1447页

作者： Ashry gad Saud Almousa Mohanned Sharefi Ali Alshaqrawi Azzam Alqashami Meshari Al-Salloom Abdulaziz Binsaid Department of Family and Community Medicine College of Medicine King Saud University Riyadh Saudi Arabia College of Medicine King Saud University Riyadh Saudi Arabia

Objectives: To estimate the proportion of patients who received instructions regarding their medications’ functions, methods of administration, dosages, adverse effects, drug-drug interactions, as well as to identify the sources of knowledge concerning medications’ instructions. Methods: A cross-sectional study was carried out in King Khalid University Hospital (KKUH) in the out-patient pharmacy in 2013. The data collection method includes personal interview with patients who are randomly selected from adults above 18 years of age. The interview was conducted among patients and any person who attends the consultation. Results: The sample was 274 patients. Patients who received instructions for drugs’ functions 208 (75.9%), method of administration 229 (83.6%), doses of drugs 220 (80.3%), drugs’ adverse effects 47 (17.1%), and drug-drug interactions 41 (15%). Sources of medications’ instructions were physicians (73.6%), pharmacists (42.3%), patient information leaflets (PILs) (40.5%) and family or friends (12.8%). Conclusion: The provided instructions about prescribed medications to patients in KKUH were incomplete that may lead to therapeutic failure.

关键词： Physicians’ Instructions Prescriptions Communication Patients Knowledge