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国际GIC-EDP青宝成长课程分享会

中国宝玉石 2019年第2期 164-165页

作者： gachoucha kretz(戈秀沙·克雷兹) 欧莱雅集团

2019年2月21日在深圳IBC水贝珠宝总部大厦隆重举行由中国珠宝玉石首饰行业协会青年企业家委员会主办(以下简称青宝会)、中国地质大学(武汉)珠宝字院承办的“国际GIC-EDP青宝成长课程分享会”。会议邀请了珠宝行资深企业家、珠宝企业高... 详细信息

2019年2月21日在深圳IBC水贝珠宝总部大厦隆重举行由中国珠宝玉石首饰行业协会青年企业家委员会主办(以下简称青宝会)、中国地质大学(武汉)珠宝字院承办的“国际GIC-EDP青宝成长课程分享会”。会议邀请了珠宝行资深企业家、珠宝企业高管、珠宝青年企业家、青宝会和时尚买手协会的会长、秘书长以及会员等珠宝行业领军人才70余人参加了此次活动。

关键词：课程中国地质大学珠宝玉石企业家行业协会珠宝企业珠宝行业 IBC

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

DNA plasticity and damage in amyotrophic lateral sclerosis

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Neural Regeneration Research 2018年第2期13卷 173-180页

作者： Diane Penndorf Otto W.Witte Alexandra kretz Hans Berger Department of Neurology University Hospital Jena

The pathophysiology of amyotrophic lateral sclerosis （ALS） is particularly challenging due to the heteroge- neity of its clinical presentation and the diversity of cellular, molecular and genetic peculiarities involved. Molecular insights unveiled several novel genetic factors to be inherent in both familial and sporadic dis- ease entities, whose characterizations in terms of phenotype prediction, pathophysiological impact and putative prognostic value are a topic of current researches. However, apart from genetically well-defined high-confidence and other susceptibility loci, the role of DNA damage and repair strategies of the genome as a whole, either elicited as a direct consequence of the underlying genetic mutation or seen as an autono- mous parameter, in the initiation and progression of ALS, and the different cues involved in either process are still incompletely understood. This mini review summarizes current knowledge on DNA alterations and counteracting DNA repair strategies in ALS pathology and discusses the putative role of unconventional DNA entities including transposable elements and extrachromosomal circular DNA in the disease process. Focus is set on SODl-related pathophysiology, with extension to FUS, TDP-43 and C90RF72 mutations. Advancing our knowledge in the field will contribute to an improved understanding of this relentless dis- ease, for which therapeutic options others than symptomatic approaches are almost unavailable.

关键词： amyotrophic lateral sclerosis DNA damage and repair extrachromosomal circular DNA microDNA nuclear pore complex SOD1 mutations TDP-43 pathology transposable elements

High order aberration and straylight evaluation after cataract surgery with implantation of an aspheric,aberration correcting monofocal intraocular lens

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 736-741页

作者： Florian T A kretz Tamer Tandogan Ramin Khoramnia Gerd U Auffarth International Vision Correction Research Centre & David J Apple International Laboratory for Ocular Pathology of the Department of Ophthalmology University Hospital Heidelberg International Vision Correction Research Network (***) Augenklinik Ahaus-Raesfeld-Rheine Gerl Group

·AIM: To evaluate the quality of vision in respect to high order aberrations and straylight perception after implantation of an aspheric, aberration correcting,monofocal intraocular lens(IOL).·METHODS: Twenty-one patients(34 eyes) aged 50 to83 y underwent cataract surgery with implantation of an aspheric, aberration correcting IOL(Tecnis ZCB00,Abbott Medical Optics). Three months after surgery they were examined for uncorrected(UDVA) and corrected distance visual acuity(CDVA), contrast sensitivity(CS)under photopic and mesopic conditions with and without glare source, ocular high order aberrations(HOA, Zywave II) and retinal straylight(C-Quant).· RESULTS: Postoperatively, patients achieved a postoperative CDVA of 0.0 log MAR or better in 97.1% of eyes. Mean values of high order abberations were +0.02±0.27(primary coma components) and-0.04 ±0.16(spherical aberration term). Straylight values of the C-Quant were 1.35±0.44 log which is within normal range of age matched phakic patients. The CS measurements under mesopic and photopic conditions in combination with and without glare did not show any statistical significance in the patient group observed(P ≥0.28).· CONCLUSION: The implantation of an aspherical aberration correcting monofocal IOL after cataractsurgery resulted in very low residual higher order aberration(HOA) and normal straylight.

关键词： cataract aberrations intraocular lens

Identification of fungal fossils and novel azaphilone pigments in ancient carbonised specimens of Hypoxylon fragiforme from forest soils of Chatillon-sur-Seine(Burgundy)

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Fungal Diversity 2018年第5期92卷 345-356页

作者： Frank Surup Abolfazl Narmani Lucile Wendt Sebastian Pfutze Robin kretz Kevin Becker Cle ment Menbrives Alain Giosa Michelle Elliott Christophe Petit Manfred Rohde Marc Stadler Dept.Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany German Centre for Infection Research(DZIF) Partner Site Hannover-Braunschweig38124 BraunschweigGermany Department of Plant Protection Faculty of AgricultureUniversity of TabrizTabrizIran University of Paris 1 Panthéon-Sorbonne UMR 7041Archéologies EnvironnementalesParisFrance Helmholtz-Zentrum für Infektionsforschung GmbH Central Facility for MicroscopyInhoffenstrasse 738124 BraunschweigGermany

Fungal stromata were recently discovered in association with charcoal and burnt soil aggregates during an archaeological survey in the Chaˆtillon-sur-Seine forest *** wood and soil in the samples were dated to the medieval period(between 738 and 1411 AD).Light microscopy and scanning electron microscopy revealed that a few of the stromatal fragments still contained *** macromorphological characters were described and secondary metabolite profiles were generated using high performance liquid chromatography with diode array and mass spectrometric detection(HPLC–DAD/MS).The combination of these two data lines then allowed species *** of the fragments were assigned to Hypoxylon fragiforme,the type species of the Hypoxylaceae(Xylariales).Two further species whose stromata grew on the fossil charcoal could be tentatively identified as Jackrogersella cohaerens and(more tentatively)as Hypoxylon *** three species are still commonly encountered in the forests of Central Europe ***,the HPLC-HRMS data of *** suggested the presence of unknown azaphilone dimers and of further new *** archaeological compounds were compared to fresh stromata of *** collected in Germany and subjected to the same analytical *** the major components in both samples were identified as the known mitorubrin type azaphilones and orsellinic acid,the chemical structures of seven novel complex azaphilone pigments,for which we propose the trivial names rutilins C-D and fragirubrins A-E,were elucidated using spectral methods(NMR and CD spectroscopy,high resolution mass spectrometry).It appears that these pigments had indeed persisted for millennia in the fossil stromata.

关键词： Biodiversity Chemotaxonomy Phylogeny Sordariomycetes Xylariales Structure elucidation

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function

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Journal of Molecular Cell Biology 2015年第5期7卷 402-414页

作者： Gesa I.Albert Christoph Schell Karin M.Kirschner Sebastian Schafer Ronald Naumann Alexandra Muller Oliver kretz Benno Kuropka Mathias Girbig Norbert Hubner Eberhard Krause Holger Scholz Tobias B.Huber Klaus-Peter Knobeloch Christian Freund Institute for Chemistry and Biochemistry Freie Universitat Berlin14195 BerlinGermany Leibniz-Institut fuer Molekulare Pharmakologie 13125 BerlinGermany Renal Division University Hospital Freiburg79106 FreiburgGermany Speman Graduate School for Medicine and Biology University of Freiburg79106 FreiburgGermany Faculty of Biology University Freiburg79106 FreiburgGermany Institute fuer Vegetative Physiologie Charité-Universitatsmedizin Berlin10117 BerlinGermany Experimental Genetics and Cardiovascular Diseases MDC13125 BerlinGermany Transgenic Core Facility Max-Planck-Institute of Molecular Cell Biology and GeneticsDresdenGermany Institute of Neuropathology University of Freiburg79106 FreiburgGermany Institute of Cell Biology&Anatomy University of Freiburg79106 FreiburgGermany BIOSS Centre for Biological Signaling Studies Albert-Ludwigs-University79106 FreiburgGermany

Scaffolding proteins play pivotal roles in the assembly of macromolecular machines such as the *** adaptor protein CD2BP2,originally identified as a binding partner of the adhesion molecule CD2,is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine(GYF)domain to co-localize with spliceosomal *** far,its function in vertebrates is *** conditional gene targeting in mice,we show that CD2BP2 is crucial for embryogenesis,leading to growth retardation,defects in vascularization,and premature death at embryonic day 10.5 when *** of the protein in bone marrow-derived macrophages indicates that CD2BP2 is involved in the alternative splicing of mRNA transcripts from diverse *** the molecular level,we identified the phosphatase PP1 to be recruited to the spliceosome via the N-terminus of *** the strong expression of CD2BP2 in podocytes of the kidney,we use selective depletion of CD2BP2,in combination with next-generation sequencing,to monitor changes in exon usage of genes critical for podocyte functions,including VEGF and actin ***2BP2-depleted podocytes display foot process effacement,and cause proteinuria and ultimately lethal kidney failure in ***,our study defines CD2BP2 as a non-redundant splicing factor essential for embryonic development and podocyte integrity.

关键词： GYF domain CD2BP2 alternative splicing PP1 podocytes VEGF

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625行彩色电视信号分量的采样

电视技术 1980年第4期 38-52页

作者： J.Sabatier F.kretz 张风超

本文介绍CCETT(法国电视电信研究所)在625行彩色电视信号采样方面所做工作的概况。第一部分,强调在电视信号的国际交换中,采用固定采样结构这一原则的重要性,着重于介绍采样结构和采样时钟脉冲发生器的相对作用,并且叙述主观试看的结果... 详细信息

本文介绍CCETT(法国电视电信研究所)在625行彩色电视信号采样方面所做工作的概况。第一部分,强调在电视信号的国际交换中,采用固定采样结构这一原则的重要性,着重于介绍采样结构和采样时钟脉冲发生器的相对作用,并且叙述主观试看的结果。第二部分,从PAL制的限制开始,详细叙述提交给CCIR(国际无线电谘询委员会)的标准。确定了由要求的兼容性所提出的参数,强调了这个标准的演变过程及其对电视生产所要求的优良适应性。

关键词：图象 PAL 亮度信号视频信号分量 SECAM 分量信号色差信号

Development of Haloalkane Dehalogenases for Industrial Products

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Development of Haloalkane Dehalogenases for Industrial Produ...

幽门肌切开术后“无限制原则”进食法的经验:对97例病例进行的回顾

The Seventh China-Japan Joint Symposium on Enzyme Engineering

作者： Kai Li Mani Subramanian Paul Swanson Joeseph Krebs Kevin Gray Toby Richardson Keith kretz Dan Robertson The Dow Chemical Company

Commercial manufacture of propylene oxide and epichlorohydrin（epi） by chlorination and hydration of propylene,results in the production of 1,2,3-trichloropropane（TCP）,an undesirable side product,hi order to recover halohydrin from TCP and recycle into the epi process,a Rhodococcus rhodochrous slrain was isolated by cblorocarbon-enrichrnent technique.A haloalkane dehalogenase was purified from this bacteria which catalyzed the hydrolytic dehalogenation of TCP to dichlorohalohydrin（DCH）.However,the activity of mis enzyme was too low for recovery of DCH from TCP（turnover of 0.15/second）.In addition,the enzyme was competitively inhibited by *** different Directed Evolution methods were applied to the dehalogenase gene in order to improve the *** resulted in obtaining a thermostable enzyme as well as a 15-fold improvement of catalytic ***,biopanning of DNA-libraries from 576 different environmental samples（from tropical jungles,arid deserts,agricultural fields,contaminated waste sites,sediments from lakes,rivers,streams and marine environments） yielded25-full length and 27 partial *** analysis of the sequences revealed relationship spread across all seven known *** of the newly discovered genes were shown to have different properties such as:（a） Improved catalytic activity *** relative to the wild type enzyme（b）Activity against different analogs of TCP（c） Much reduced feedback inhibition by DCH and（d） Different *** of biopanning and Directed Evolution is a powerful tool for rapid discovery new genes and improvement of enzyme functions for production of industrial products from various starting materials.

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世界核心医学期刊文摘（儿科学分册） 2005年第7期1卷 8-9页

作者： kretz B. Watfa J. Sapin E. 朱新菊 Serv.de Chir.Pédiatrique Hpital d'Enfants CHU de Dijon 10 blvd.du M.de L.-de-Tassigny 21079 Dijon Cedex France

A recent alternative feeding regimen at the progressive feeding (PF) after a pyloromyotomy for hypertrophic pyloric stenosis (HPS) is the so-called ad libitum feeding (AL).The aim of this study was to determine if this new feeding regimen has modified the follow-up of postoperative course in *** and methods.-From January 1998 to December 2003, 97 consecutive neonates have been operated on for HPS in our *** retrospective study was based on the comparison between two groups of patients with different postoperative feeding regimens: group one of 30 neonates with PF regimen and group two of 60 neonates with AL *** remaining neonates had had a mucosal perforation and were not included in this comparative study but in a separate group (MP).The clinical, ultrasonographic, operative and postoperative data were ***.-There was no difference between the PF and AL groups for sex ratio M/F = 4/1, preoperative weight loss ratio, ultrasonographic data and intra-operative difficulties rate.A small difference was found -which was not significative -between the PF and the AL groups for median age at diagnosis (44,6 ν36,7 days, respectively).A statistically significative difference between the PF and the AL groups was observed for time to establish feeding (69 vs 35.6 hours, respectively) (P < 0,001), postoperative stay (4.16 vs 2.98 days, respectively) (P < 0,001) and total hospital *** didn’t found any difference in the incidence and severity of postoperative emesis whether slow (PF) or rapid (AL) feeding regimens were ***, intra-operative mucosal tear didn’t influence postoperative course and the duration of hospital ***.-We recommend AL regimen for routine feeding in simple cases after pyloromyotomy for *** has a positive impact on length of hospital stay, and decreases hospital *** neonates with MP can be managed with a rapid feeding regimen.

关键词：幽门肌切开术肥厚性幽门狭窄超声检查严重度术中并发症降低率无显著性差异性别比法能