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Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

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Chinese Journal of Polymer Science 2018年第9期36卷 999-999,1000-1010页

作者： Silvana Alfei gaby Brice Taptue Silvia Catena Angela Bisio Dipartimento di Farmacia Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari Università di Genova

Dendrimers are macromolecules characterized by high controlled size, shape and architecture, presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications, including gene transfection, tissue engineering, imaging, and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility, non-specific cell distribution, low bioavailability, poor pharmacokinetics, and their direct administration could result in the release of thrombi. To overcome such problems, in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR, NMR, zeta potential, mean size of particles, buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold, thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.

关键词： Polyester-based amino acids-modified dendrimers Physical encapsulation Water-soluble dendriplexes Buffer capacity NMR investigations

Janus:Toward preventing counterfeits in supply chains utilizing a multi-quorum blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 75-85页

作者： Vika Crossland Connor Dellwo Golam Bashar gaby G.Dagher Computer Science Central Washington UniversityWA 98926United States Computer Science Washington State UniversityWA 99163United States Computer Science Boise State UniversityID 83725United States

The modern pharmaceutical supply chain lacks transparency and traceability,resulting in alarming rates of counterfeit products entering the *** illegitimate products cause harm to end users and wreak havoc on the supply chain itself,costing billions of dollars in profit *** this paper,in response to the Drug Supply Chain Security Act(DSCSA),we introduce Janus,a novel pharmaceutical track-and-trace system that utilizes blockchain and cloning-resistant hologram tags to prevent counterfeits from entering the pharmaceutical supply *** design a multi-quorum consensus protocol that achieves load balancing across the *** perform a security analysis to show robustness against various threats and *** implementation of Janus proves that the system is fair,scalable,and resilient.

关键词： Blockchain Pharmaceutical supply chain Consensus protocol

Bioavailability and Solubility of Different Calcium-Salts as a Basis for Calcium Enrichment of Beverages

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Food and Nutrition Sciences 2010年第2期1卷 53-58页

作者： gaby Kressel 不详

Background: When usual calcium consumption patterns were analysed most people in the U.S. and Europe consume less than the recommended daily allowance. Supplements and fortified foods offer alternative and additional sources of calcium to traditional food. Calcium carbonate is the most common supplement but it is less soluble in water and, therefore, not suitable for enrichment of beverages. New organic calcium salts have a better solubility but less is known about their bioavailability. In the present study, we assessed the solubility and bioavailability of the new organic calcium salts, calcium lactate citrate and calcium lactate malate, in comparison to the traditional supplements, calcium carbonate and calcium gluconate. Design: Randomized, single-blind, four way cross-over study comparing single doses of 500 mg calcium in the form of four different calcium-salts. Subjects were advised to consume 25 μg vitamin D3 daily two weeks prior to the start of the study and during the whole study period. Subjects: 20 healthy young men, Methods: Blood samples were drawn immediately before and 2, 4, 6, 8, 12 and 24 h after ingestion of the calcium preparation. Concentration of total calcium and intact parathyroid hormone were measured in the serum. Urine was collected at baseline and during the intervals 0-3, 3-6, 9-15 and 15-24 h and excretion of calcium, sodium and creatinine was examined. Results: The tested new salts were easily water soluble, significantly better than calcium gluconate. Calcium carbonate is almost insoluble. The bioavailability of the four different calcium salts was found to be almost identical. The maximum total serum calcium increased by 7.6 % two hours after ingestion calcium lactate citrate, by 7.4 % after calcium lactate malate, by 5.5 % after calcium carbonate, and by 5.8 % after calcium gluconate. Intact parathyroid hormone concentration showed the expected depression for calcium lactate citrate, calcium lactate malate and calcium carbonate, wh

关键词： Calcium Salt Bioavailability Solubility Enrichment of Beverages

Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-α]pyrimidine derivatives

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Chinese Chemical Letters 2015年第6期26卷 690-694页

作者： Mohamed S.A.El-gaby Jehan A.Micky Nadia M.Saleh Yousry A.Ammar Heba S.A.Mohamed Chemistry Department Faculty of ScienceAl-Azhar University at Assiut Chemistry Department Faculty of Science (Girl’s)Al-Azhar University Chemistry Department Faculty of ScienceAl-Azhar University Photochemistry Department National Research CenterEl-DokkiGizaEgypt

2-Aminocyclopenta[d]pyrimidines 3a-c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride （1：2：1 molar ratio）. Also, cyclization of 2,5-bis-（arylmethylidene）cyclopentanones 2 with guanidine hydrochloride （1：1 molar ratio） in methanol in the presence of sodium methoxide afforded cyclopenta-[d]pyrimidines 3. Compound 3c has been shown to be a useful building block for the synthesis of some novel pyrimido[ 1,2-a]pyrimidines 5, 7 and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data,

关键词： Multicomponent reaction Cyclopenta[d]pyrimidine Pyrimido[1 2-a]pyrimidine Cyclopentanone

Pulsed lavage in joint arthroplasty: A systematic review and metaanalysis

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World Journal of Orthopedics 2024年第3期15卷 293-301页

作者： Mohammad Daher gaby Haykal Marven Aoun Marc Moussallem Ali Ghoul Jean Tarchichi Amer Sebaaly Department of Orthopedics Saint Joseph UniversityBeirut 1001Lebanon

BACKGROUND Knee and hip osteoarthritis affects millions of people around the world and is expected to rise even more in frequency as the population *** arthroplasty is the surgical management of choice in these *** ossi-fication and radiolucent lines formation are two frequent problems faced in hip and knee replacements *** studies show that the usage of pulsed lavage may prevent their *** To compare pulsed lavage to standard lavage in joint *** PubMed,Cochrane,and Google Scholar(page 1-20)were searched till December *** comparative studies were *** clinical outcomes evaluated were the heterotopic ossification formation in hip replacements,radiolucent lines formation,and functional knee scores in knee *** Four studies met the inclusion criteria and were included in this *** lavage was shown to reduce the formation of radiolucent lines(P=0.001).However,no difference was seen in the remaining outcomes CONCLUSION Pulsed lavage reduced the formation of radiolucent lines in knee *** difference was seen in the remaining ***,the clinical significance of these radiolucent lines is poorly *** conducted randomized controlled studies and cost-effectivity studies are needed to reinforce these findings.

关键词： Knee arthroplasty Hip arthroplasty Pulsed lavage Syringe lavage Heterotopic ossification Radiolucent lines

Dystocia in Cattle: Prospective Analysis in Daily Veterinary Practice (N = 573 Parturitions)

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Open Journal of Veterinary Medicine 2018年第12期8卷 241-249页

作者： Chantal Bühler Jürg Hüsler gaby Hirsbrunner Tierarztpraxis Unternä hrer Langenthal Switzerland Institute of Mathematical Statistics and Actuarial Science University of Bern Bern Switzerland Clinic for Ruminants Vetsuisse Faculty University of Bern Bern Switzerland

Purpose: The aim of this prospective study was to collect cases of dystocia in 4 rural veterinary practices in Switzerland over 12 months, focusing on calf vitality. Methods: During 12 months, data of 573 assisted parturitions were collected. The age of the cows involved ranged from 2 to 17 years (median 5.2 yr) with a median gestation length of 288 days. Results: Overall, 651 calves were born (61.2% male). 481 were single and 85 were twin births. For 7 calves, no data were available. As to calf vitality: 66.1% of the calves were alive, 25.4% dead, 5.1% weak and 3.4% died during the assisted parturition process. The percentage of dead calves was higher in twins (43.5%) than in singletons (18.9%). The vitality was influenced by gestation length, parity and the time elapsed since the rupture of the amniotic sac. In this study, calf vitality was neither influenced by sex of the calf nor breed of the parents. A uterine torsion was found in 31.8% of the cases with the direction of the rotation anti-clockwise in 94%. Twins were twice as often in posterior presentation as single-born calves (31.4% versus 15.6%). Conclusion: Calf vitality was influenced by parity, gestation length and time from amniotic sac rupture to veterinary intervention.

关键词： Cattle Dystocia Veterinary Practice Obstetrics Calf Vitality

Retrospective Surveillance over 11 Years for Intussusception in Children Younger than 14 Years in the State of Qatar

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Open Journal of Pediatrics 2014年第1期4卷 1-11页

作者： Tariq O. Abbas Noora AlShahwani gaby Jabbour Mansour Ali Department of Pediatric Surgery Hamad General Hospital Doha Qatar

Background: Accurate estimates of the baseline incidence of childhood intussusception could help safety monitoring after introduction of rotavirus vaccines. Therefore, we studied the incidence of intussusception in the state ofQatar. Methods: We retrospectively reviewed cases of intussusception in children younger than 14 years. Children were treated between 2002 and 2012 at a single hospital inQatar. We analyzed information according to age, sex, clinical signs, diagnostic- and treatment-related characteristics, and length of stay. We calculated the national incidence of intussusception using census data. Results: A total of 106 children were diagnosed and treated for intussusception over 11 years. The male to female ratio of intussusception was 1.4:1. The most common symptom was bleeding per rectum (37%). One hundred andfour children with intussusception underwent diagnostic and therapeutic contrast enema, and 31.7% of patients underwent operative management. The length of stay was longer in patients who underwent operative reduction thanthat in those who did not. Conclusions: This is the first study to estimate the incidence of childhood intussusception prior to introduction of rotavirus vaccination in Qatar. A prospective surveillance system using a standardized case definition would be useful for examining the occurrence of intussusception in theArabicGulfarea and developing countries.

关键词： Children Intussusception Surgical Reduction Therapeutic Contrast Enema

Factors influencing the yield of mesenteric angiography in lower gastrointestinal bleed

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World Journal of Radiology 2014年第5期6卷 218-222页

作者： Pasteur Rasuli Joseph Doumit Majdi Boulos Caroline Rizk gaby Doumit Department of Diagnostic Imaging The Ottawa Hospital University of Ottawa Ottawa Ontario K1H 8L6Canada Dermatology and Plastic Surgery Institute Cleveland Clinic Cleveland OH 44195 United States Department of Internal Medicine University of Ottawa Ottawa Ontario K1H 8L6 Canada

AIM: To assess if certain triaging rules could be established to optimize the yield of mesenteric angiography. METHODS: Medical records of 101 patients were retrospectively reviewed and parameters relating to age, gender, pulse rate, blood pressure, serum hemoglobin, intensive care unit(ICU) admission, and the number of packed red blood cells(PRBC) transfused in the 12 and 24 h prior to the angiography were tabulated in two groups with positive and negative angiography results. RESULTS: We found no correlation between gender, pulse rate, blood pressure or serum hemoglobin and positivity of the mesenteric angiogram. But patients with positive angiogram were found to be on average 7 years older(73.2 years vs 65.9 years old)(P = 0.02). Angiogram was positive in 39.3 %(11/28) of patientsadmitted in ICU vs 23.2%(17/73) who were admitted elsewhere in the hospital(P = 0.03). In the 12 and 24 h prior to angiography, patients with a positive angiogram received a mean of 2.7 ± 2.3 and 3.3 ± 2.6 units of PRBC s respectively, while patients with a negative angiogram had a mean of 1.6 ± 1.9(P = 0.02) and 2.1 ± 2.6 units(P = 0.04) received respectively in the same period. CONCLUSION: Older age, ICU admission, having received at least 4 units PRBC over 12 h or 5 units over 24 h prior to angiogram are leading indicators for a positive study.

关键词： Angiography Diagnostic use Colon Blood supply Radiograph Gastrointestinal hemorrhage Emergencies Mesenteric arteries

Population Structure and Sexual Maturity of the Pufferfish Lagocephalus sceleratus （Osteichthyes, Tetraodontidae） in the Lebanese and Syrian Marine Waters （Eastern Mediterranean）

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Journal of Earth Science and Engineering 2014年第4期4卷 236-244页

作者： gaby Khalaf Adib Saad Sherif Jemaa Waad Sabour Myriam Lteif Stefano Lelli National Centre for Marine Sciences CNRS (National Council for Scientific Research) Batroun 534 Lebanon Faculty of Agricultural Engineering Tishreen University Lattakieh 1408 Syria

The pufferfish Lagocephalus sceleratus is an invasive Lessepsian species of Indo-Pacific origin that has established an increasing population over the past decade in the Levantine basin of the Mediterranean. Besides its toxicity due to the accumulation of tetrodotoxin in its body, it is causing damage to fishing gears and fishermen＇s catches. This study aims to provide data on the population structure and sexual maturity of this species in the eastern basin of the Mediterranean. A total of 214 individuals were collected in the coastal marine waters of Lebanon and Syria, between January 2012 and June 2013 by means of different types of nets and lines, on soft bottoms, at depths ranging from 10 m to 170 m. The TL （total length） of the samples varies between 10.8 cm and 71 cm. The most common size classes, represented by 125 individuals, are the ones between 30 cm and 50 cm TL, with a bulge at 40 cm, represented by 44 individuals. The average TL is 43.99 cm （standard deviation： SD = 17.65） for both males and females. The TW （total weight） of the specimens ranges between 14 g and 4,603 g with an average value of 1,458.52 g （SD = 1,329.49）. The sex ratio （M/F） is 1：1.35 with a total number of 87 males, 118 females and nine unidentified individuals. The weight-length relationship （TW = aTLb） shows a negative allometric growth with b = 2.9481 and R2 = 0.9806. The condition factor （K） is close to one for all samples. The average value of the GSI （gonadosomatic index） shows a substantial increase from winter to spring. The spawning takes place between April and June.

关键词： Lagocephalus sceleratus Lessepsian species population structure eastern Mediterranean.