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Pulsed lavage in joint arthroplasty: A systematic review and metaanalysis

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World Journal of Orthopedics 2024年第3期15卷 293-301页

作者： Mohammad Daher gaby Haykal Marven Aoun Marc Moussallem Ali Ghoul Jean Tarchichi Amer Sebaaly Department of Orthopedics Saint Joseph UniversityBeirut 1001Lebanon

BACKGROUND Knee and hip osteoarthritis affects millions of people around the world and is expected to rise even more in frequency as the population *** arthroplasty is the surgical management of choice in these *** ossi-fication and radiolucent lines formation are two frequent problems faced in hip and knee replacements *** studies show that the usage of pulsed lavage may prevent their *** To compare pulsed lavage to standard lavage in joint *** PubMed,Cochrane,and Google Scholar(page 1-20)were searched till December *** comparative studies were *** clinical outcomes evaluated were the heterotopic ossification formation in hip replacements,radiolucent lines formation,and functional knee scores in knee *** Four studies met the inclusion criteria and were included in this *** lavage was shown to reduce the formation of radiolucent lines(P=0.001).However,no difference was seen in the remaining outcomes CONCLUSION Pulsed lavage reduced the formation of radiolucent lines in knee *** difference was seen in the remaining ***,the clinical significance of these radiolucent lines is poorly *** conducted randomized controlled studies and cost-effectivity studies are needed to reinforce these findings.

关键词： Knee arthroplasty Hip arthroplasty Pulsed lavage Syringe lavage Heterotopic ossification Radiolucent lines

Janus:Toward preventing counterfeits in supply chains utilizing a multi-quorum blockchain

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Blockchain(Research and Applications) 2023年第4期4卷 75-85页

作者： Vika Crossland Connor Dellwo Golam Bashar gaby G.Dagher Computer Science Central Washington UniversityWA 98926United States Computer Science Washington State UniversityWA 99163United States Computer Science Boise State UniversityID 83725United States

The modern pharmaceutical supply chain lacks transparency and traceability,resulting in alarming rates of counterfeit products entering the *** illegitimate products cause harm to end users and wreak havoc on the supply chain itself,costing billions of dollars in profit *** this paper,in response to the Drug Supply Chain Security Act(DSCSA),we introduce Janus,a novel pharmaceutical track-and-trace system that utilizes blockchain and cloning-resistant hologram tags to prevent counterfeits from entering the pharmaceutical supply *** design a multi-quorum consensus protocol that achieves load balancing across the *** perform a security analysis to show robustness against various threats and *** implementation of Janus proves that the system is fair,scalable,and resilient.

关键词： Blockchain Pharmaceutical supply chain Consensus protocol

Synthesis of Water-soluble, Polyester-based Dendrimer Prodrugs for Exploiting Therapeutic Properties of Two Triterpenoid Acids

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Chinese Journal of Polymer Science 2018年第9期36卷 999-999,1000-1010页

作者： Silvana Alfei gaby Brice Taptue Silvia Catena Angela Bisio Dipartimento di Farmacia Sezione di Chimica e Tecnologie Farmaceutiche e Alimentari Università di Genova

Dendrimers are macromolecules characterized by high controlled size, shape and architecture, presence of inner cavities able to accommodate small molecules and many peripheral functional groups to bind target entities. They are of eminent interest for biomedical applications, including gene transfection, tissue engineering, imaging, and drug delivery. The well-known pharmacological activities of ursolic and oleanolic acids are limited by their small water solubility, non-specific cell distribution, low bioavailability, poor pharmacokinetics, and their direct administration could result in the release of thrombi. To overcome such problems, in this paper we described their physical incorporation inside amino acids-modified polyester-based dendrimers which made them highly water-soluble. IR, NMR, zeta potential, mean size of particles, buffer capacity and drug release profiles of prepared materials were reported. The achieved water-soluble complexes harmonize a polycationic character and a buffer capacity which presuppose efficient cell penetration and increased residence time with a biodegradable cell respectful scaffold, thus appearing as a promising team of not toxic prodrugs for safe administration of ursolic and oleanolic acids.

关键词： Polyester-based amino acids-modified dendrimers Physical encapsulation Water-soluble dendriplexes Buffer capacity NMR investigations

Bioavailability and Solubility of Different Calcium-Salts as a Basis for Calcium Enrichment of Beverages

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Food and Nutrition Sciences 2010年第2期1卷 53-58页

作者： gaby Kressel 不详

Background: When usual calcium consumption patterns were analysed most people in the U.S. and Europe consume less than the recommended daily allowance. Supplements and fortified foods offer alternative and additional sources of calcium to traditional food. Calcium carbonate is the most common supplement but it is less soluble in water and, therefore, not suitable for enrichment of beverages. New organic calcium salts have a better solubility but less is known about their bioavailability. In the present study, we assessed the solubility and bioavailability of the new organic calcium salts, calcium lactate citrate and calcium lactate malate, in comparison to the traditional supplements, calcium carbonate and calcium gluconate. Design: Randomized, single-blind, four way cross-over study comparing single doses of 500 mg calcium in the form of four different calcium-salts. Subjects were advised to consume 25 μg vitamin D3 daily two weeks prior to the start of the study and during the whole study period. Subjects: 20 healthy young men, Methods: Blood samples were drawn immediately before and 2, 4, 6, 8, 12 and 24 h after ingestion of the calcium preparation. Concentration of total calcium and intact parathyroid hormone were measured in the serum. Urine was collected at baseline and during the intervals 0-3, 3-6, 9-15 and 15-24 h and excretion of calcium, sodium and creatinine was examined. Results: The tested new salts were easily water soluble, significantly better than calcium gluconate. Calcium carbonate is almost insoluble. The bioavailability of the four different calcium salts was found to be almost identical. The maximum total serum calcium increased by 7.6 % two hours after ingestion calcium lactate citrate, by 7.4 % after calcium lactate malate, by 5.5 % after calcium carbonate, and by 5.8 % after calcium gluconate. Intact parathyroid hormone concentration showed the expected depression for calcium lactate citrate, calcium lactate malate and calcium carbonate, wh

关键词： Calcium Salt Bioavailability Solubility Enrichment of Beverages

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以色列理工学院研究生村——以色列海法

世界建筑导报 2023年第3期38卷 110-113页

作者： Gidi Bar Orian gaby Schwartz Bar Orian建筑师事务所 Schwartz Besnosoff建筑师事务所

以色列理工学院研究生村位于以色列理工学院的正门附近,面积为22德南(22,000平方米),包括215套住宅单元,从2室到4室不等。该村还将设置一个带有学前课堂的社区中心和一个多功能厅,作为村中居民和非住校研究生的社交中心。项目设计依据... 详细信息

以色列理工学院研究生村位于以色列理工学院的正门附近,面积为22德南(22,000平方米),包括215套住宅单元,从2室到4室不等。该村还将设置一个带有学前课堂的社区中心和一个多功能厅,作为村中居民和非住校研究生的社交中心。项目设计依据的是景观敏感和生态规划的原则。具体表现为:对景观的破坏最小、尽可能少的开发作业、保护现有的自然环境,以及创造一个能融入自然环境的轮廓。

关键词：研究生住宅单元自然环境生态规划多功能厅住校设计依据以色列

Synthesis and spectroscopic characterization of novel 2-amino-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidine and pyrimido[1,2-α]pyrimidine derivatives

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Chinese Chemical Letters 2015年第6期26卷 690-694页

作者： Mohamed S.A.El-gaby Jehan A.Micky Nadia M.Saleh Yousry A.Ammar Heba S.A.Mohamed Chemistry Department Faculty of ScienceAl-Azhar University at Assiut Chemistry Department Faculty of Science (Girl’s)Al-Azhar University Chemistry Department Faculty of ScienceAl-Azhar University Photochemistry Department National Research CenterEl-DokkiGizaEgypt

2-Aminocyclopenta[d]pyrimidines 3a-c were achieved via a one-pot, three-component reactions of cyclopentanone 1, aromatic aldehyde and guanidine hydrochloride （1：2：1 molar ratio）. Also, cyclization of 2,5-bis-（arylmethylidene）cyclopentanones 2 with guanidine hydrochloride （1：1 molar ratio） in methanol in the presence of sodium methoxide afforded cyclopenta-[d]pyrimidines 3. Compound 3c has been shown to be a useful building block for the synthesis of some novel pyrimido[ 1,2-a]pyrimidines 5, 7 and 12. The structures of the newly synthesized compounds were confirmed on the basis of analytical and spectral data,

关键词： Multicomponent reaction Cyclopenta[d]pyrimidine Pyrimido[1 2-a]pyrimidine Cyclopentanone

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MISTY LIGHT美发沙龙

现代装饰 2022年第2期 164-167页

作者： gaby Teng 杨文彩无不详 DPD递加设计

空间的灵感来源于雾光,朦胧又神秘。艺术装置与空间氛围戏剧性地碰撞在一起,独特的艺术装置、色彩和光线共同创造了微妙的效果,塑造出空间的精神与内核。迷雾若隐若现游离于空间之中,在结构与光影之间产生美与吸引力,使人前往与探索。... 详细信息

空间的灵感来源于雾光,朦胧又神秘。艺术装置与空间氛围戏剧性地碰撞在一起,独特的艺术装置、色彩和光线共同创造了微妙的效果,塑造出空间的精神与内核。迷雾若隐若现游离于空间之中,在结构与光影之间产生美与吸引力,使人前往与探索。项目地址位于深圳皇庭广场,皇庭广场是深圳CBD的钻石之心,为高端及中端国际品牌的旗舰店,店铺门面开阔,采光充足,周边人流量高。设计师在满足美业常规需求之后,试图打破传统发廊的固有模式,在空间中注入新的艺术手法。以装置性的弧形构造,消解了原有空间的规则感,虚虚实实中改变了视觉焦点,同时构成了人与空间交流的新介质。

关键词：视觉焦点空间氛围国际品牌弧形构造项目地址旗舰店人流量

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月光的独白——蔚蓝卡地亚别墅

现代装饰 2023年第3期 54-63页

作者：林镇 gaby Teng 陈雪仪奉玉盈叶松杨之 DPD递加设计不详瀚默视觉

项目位于天府之都——成都,拥有最先锋的文化艺术底蕴,不断生长、融合、突破,在生活中寻找平衡。自由且浪漫的城市文化让成都生活美学充满松弛和想象力。作为中国十大超级豪宅——牧马山蔚蓝卡地亚,是顶级圈层品质生活的风向标。漫步湖... 详细信息

项目位于天府之都——成都,拥有最先锋的文化艺术底蕴,不断生长、融合、突破,在生活中寻找平衡。自由且浪漫的城市文化让成都生活美学充满松弛和想象力。作为中国十大超级豪宅——牧马山蔚蓝卡地亚,是顶级圈层品质生活的风向标。漫步湖畔,感受欧式皇家园林的审美情趣,呈现原生、自然、闲适的场所感。设计团队深耕“当代新贵族生活”研究,在远离城市喧器的第二居所建立生活延伸,提供更多的生活形态和居住体验的可能性。

关键词：卡地亚品质生活皇家园林生活美学场所感牧马山独白想象力

Dystocia in Cattle: Prospective Analysis in Daily Veterinary Practice (N = 573 Parturitions)

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Open Journal of Veterinary Medicine 2018年第12期8卷 241-249页

作者： Chantal Bühler Jürg Hüsler gaby Hirsbrunner Tierarztpraxis Unternä hrer Langenthal Switzerland Institute of Mathematical Statistics and Actuarial Science University of Bern Bern Switzerland Clinic for Ruminants Vetsuisse Faculty University of Bern Bern Switzerland

Purpose: The aim of this prospective study was to collect cases of dystocia in 4 rural veterinary practices in Switzerland over 12 months, focusing on calf vitality. Methods: During 12 months, data of 573 assisted parturitions were collected. The age of the cows involved ranged from 2 to 17 years (median 5.2 yr) with a median gestation length of 288 days. Results: Overall, 651 calves were born (61.2% male). 481 were single and 85 were twin births. For 7 calves, no data were available. As to calf vitality: 66.1% of the calves were alive, 25.4% dead, 5.1% weak and 3.4% died during the assisted parturition process. The percentage of dead calves was higher in twins (43.5%) than in singletons (18.9%). The vitality was influenced by gestation length, parity and the time elapsed since the rupture of the amniotic sac. In this study, calf vitality was neither influenced by sex of the calf nor breed of the parents. A uterine torsion was found in 31.8% of the cases with the direction of the rotation anti-clockwise in 94%. Twins were twice as often in posterior presentation as single-born calves (31.4% versus 15.6%). Conclusion: Calf vitality was influenced by parity, gestation length and time from amniotic sac rupture to veterinary intervention.

关键词： Cattle Dystocia Veterinary Practice Obstetrics Calf Vitality