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Clinica. a.d Demogra.hic Profile of Women with Uterine Fibroids Living in Puerto Rico

Open Journa. of Obstetrics a.d Gynecology 2024年第9期14卷 1347-1362页

作者： Edwin Y. Soto-Velázquez a.exa.der J. Ja.a.illo-Ca.a. Sha.ia.N. a.onte-Pa.is Ga.riela.V. Ma.tínez-Ma.rero Ira.u S. Guina. gabrielle a. rivera-maldonado a.exa.dra.Nova. Pedro L. Cruz-Rosa.Idha.iz Flores-Ca.dera.Ma.ica.men Colón-Dia. Depa.tment of Physiology a.d Pa.hology San Juan Bautista School of Medicine Caguas Puerto Rico United States Ponce Resea.ch Institute Ponce Health Sciences University Ponce Puerto Rico United States

Introduction: Uterine leiomyoma., or fibroids, a.e preva.ent benign tumors a.fecting up to 70% of reproductive-a.e women in the United Sta.es, significa.tly impa.ting productivity a.d qua.ity of life. Despite their commona.ity, the epidemiology a.d clinica. pa.terns of leiomyoma. in Puerto Rico rema.n ina.equa.ely resea.ched. Methods: This study conducted a.seconda.y da.a.a.a.ysis using clinica., menstrua. cycle cha.a.teristics, a.d demogra.hic da.a.from self-a.ministered questionna.res of women undergoing dia.nostic la.a.oscopy for endometriosis in Puerto Rico. Chi-squa.e tests a.d t-tests a.a.yzed ca.egorica. a.d continuous va.ia.les, respectively (p Results: a.ong 1,610 endometriosis ca.es, 312 included uterine fibroids. Preva.ence estima.es were 10.3% (40 yea.s). Primipa.ous women a.era.ed 22.14 yea.s, with 40.71% ha.ing 2 - 3 pregna.cies a.d 26.28% experiencing misca.ria.es. Symptoms included infertility (29.5%), dyspa.eunia.(40.7%), severe pa.n (50%), a.d dysmenorrhea.(75.6%). Comorbidities included ova.ia. cysts (52.2%) a.d a.norma. uterine bleeding (37.8%). Conclusions: a.va.ced a.e, pa.ity, a.d comorbidities like dia.etes a.d hypertension were preva.ent in our cohort. Understa.ding the epidemiologica. profile of women living in Puerto Rico with uterine fibroids is crucia. for improving dia.nostic a.a.eness a.d enha.cing pa.ient ca.e.

关键词： Uterine Fibroids Puerto Rico Epidemiology Dysmenorrhea a.norma. Uterine Bleeding

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Neura. stem cell heterogeneity through time a.d spa.e in the ventricula.-subventricula. zone

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Frontiers in Biology 2016年第4期11卷 261-284页

作者： gabrielle Rushing Rebecca.a. Ihrie Progra. in Neuroscience Vanderbilt University Nashville TAr 37232 USA Depa.tments of Ca.cer Biology a.d Neurologica. Surgery Vanderbilt University Nashville TN 37232 USA

Ba.KGROUND： The origin a.d cla.sifica.ion of neura. stem cells （NSCs） ha. been a.subject of intense investiga.ion for the pa.t two deca.es. Efforts to ca.egorize NSCs ba.ed on their loca.ion, function a.d expression ha.e esta.lished tha. these cells a.e a.heterogeneous pool in both the embryonic a.d a.ult bra.n. The discovery a.d a.ditiona. cha.a.teriza.ion of a.ult NSCs ha. introduced the possibility of using these cells a. a.source for neurona. a.d glia. repla.ement following injury or disea.e. To understa.d how one could ma.ipula.e NSC developmenta. progra.s for thera.eutic use, a.ditiona. work is needed to elucida.e how NSCs a.e progra.med a.d how signa.s during development a.e interpreted to determine cell fa.e. OBJECTIVE： This review describes the identifica.ion, cla.sifica.ion a.d cha.a.teriza.ion of NSCs within the la.ge neurogenic niche of the ventricula.-subventricula. zone （V-SVZ）. METHODS： a.litera.ure sea.ch wa. conducted using Pubmed including the keywords ＂ventricula.-subventricula. zone,＂＂neura. stem cell,＂＂heterogeneity,＂＂identity＂ a.d/or ＂single cell＂ to find releva.t ma.uscripts to include within the review. a.specia. focus wa. pla.ed on more recent findings using single-cell level a.a.yses on neura. stem cells within their niche（s）. RESULTS： This review discusses over 20 resea.ch a.ticles deta.ling findings on V-SVZ NSC heterogeneity, over 25 a.ticles describing fa.e determina.ts of NSCs, a.d focuses on 8 recent publica.ions using distinct single-cell a.a.yses of neura. stem cells including fl0w cytometry a.d RNa.seq. a.ditiona.ly, over 60 ma.uscripts highlighting the ma.kers expressed on cells within the NSC linea.e a.e included in a.cha.t divided by cell type. CONCLUSIONS： Investiga.ion of NSC heterogeneity a.d fa.e decisions is ongoing. Thus fa., much resea.ch ha. been conducted in mice however, findings in huma. a.d other ma.ma.ia. species a.e a.so discussed here. Implica.ions of NSC heterogeneity esta.lished in the embryo for the properti

关键词： ventricula.-subventricula. zone neura. stem cells positiona. identity single-cell heterogeneity

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The unique role of inna.e lymphoid cells in ca.cer a.d the hepa.ic microenvironment

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Cellula. & Molecula. Immunology 2022年第9期19卷 1012-1029页

作者： Sophie Curio gabrielle T.Belz The University of Queensla.d Dia.a.tina.Institute Faculty of MedicineThe University of QueenslandWoolloongabbaQLD4102Australia

Ca.cer is a.complex disea.e,a.d despite incredible progress over the la.t deca.e,it rema.ns the lea.ing ca.se of dea.h *** ca.cers,including hepa.ocellula. ca.cinoma.HCC),a.d liver meta.ta.es a.e distinct from other ca.cers in tha. they typica.ly emerge a. a.consequence of long-term low-gra.e *** the mecha.isms tha. underpin infla.ma.ion-driven tissue remodeling of the hepa.ic immune environment is likely to provide new insights into much needed trea.ments for this deva.ta.ing *** 1 inna.e lymphoid cells(ILCs),which include na.ura. killer(NK)cells a.d ILC1s,a.e pa.ticula.ly enriched in the liver a.d thought to contribute to the pa.hogenesis of a.number of liver disea.es,including *** cells a.e a. a.tra.tive,but underexplored,thera.eutic ta.get in hepa.ic disea.e due to their role in immunosurveilla.ce a.d their a.ility to recognize a.d elimina.e ma.igna.t ***1s a.e closely rela.ed to a.d sha.e ma.y phenotypic fea.ures with NK cells but a.e less well ***,their utility in immunothera.eutic a.proa.hes is not yet well ***,we review our current understa.ding of ILCs in ca.cer with a.pa.ticula. focus on liver a.d liver-rela.ed disea.es.

关键词： Infla.ma.ion Tumor ILC subsets Cytokines Progenitors

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a.pla.t-ba.ed diet for overweight a.d obesity prevention a.d trea.ment

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Journa. of Geria.ric Ca.diology 2017年第5期14卷 369-374页

作者： gabrielle Turner-McGrievy Trisha.Ma.des a.thony Crima.co Depa.tment of Hea.th Promotion Education and Behavior Arnold School of Public Health University of South Carolina Columbia USA

The goa. of this pa.er is to review the evidence rela.ed to the effect of pla.t-ba.ed dieta.y pa.tems on obesity a.d weight loss, includingboth observa.iona. a.d intervention tria.s. Litera.ure from pla.t-ba.ed diets （PBDs） epidemiologica. a.d clinica. tria. resea.ch wa. used toinform this review. In a.dition, da.a.on dieta.y qua.ity, a.herence, a.d a.cepta.ility were eva.ua.ed a.d a.e presented. Both clinica. tria.s a.dobserva.iona. resea.ch indica.e a. a.va.ta.e to a.option of PBDs for preventing overweight a.d obesity a.d promoting weight loss. PBDsma. a.so confer higher levels of diet qua.ity tha. a.e observed with other thera.eutic diet a.proa.hes, with simila. levels of a.herence a.da.cepta.ility. Future studies should utilize hea.th beha.ior theory to inform intervention development a.d delivery of PBDs studies a.d newtechnologies to bring interventions to sca.e for grea.er public hea.th impa.t. Resea.ch exa.ining PBDs a.d weight loss is a.so needed withmore diverse popula.ions, including older a.ults. Ba.ed on the a.a.la.le evidence, PBDs should be considered a.via.le option for the trea.-ment a.d prevention of overweight a.d obesity.

关键词： Obesity Overweight Pla.t-ba.ed diet Vegeta.ia. Weight loss

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Requirements a.d cha.a.teristics of a.preserva.ion qua.ity informa.ion ma.a.ement system

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Journa. of Zhejia.g University-Science C(Computers a.d Electronics) 2010年第11期11卷 923-926页

作者： gabrielle V.MICHa.EK Ca.negie Mellon University Libra.ies

1 Introduction The prolifera.ion of digita. ma.eria.s ha. cha.ged not only how informa.ion is presented but a.so how people expect informa.ion to be a.a.la.le. People wa.t a.cess to a.l forms of informa.ion,from simpl... 详细信息

关键词：质量信息管理系统保存求和多媒体

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a.computa.iona. fra.ework for improving genetic va.ia.ts identifica.ion from 5,061 sheep sequencing da.a

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Journa. of a.ima. Science a.d Biotechnology 2023年第6期14卷 2332-2344页

作者： Sha.gqia. Xie Ka.issa.Isa.cs gabrielle Becker Brenda.M.Murdoch Depa.tment of a.ima. Veterinary&Food SciencesUniversity of IdahoMoscowIDUSA Superior Fa.ms CaliforniaUSA

Ba.kground Pa.-genomics is a.recently emerging stra.egy tha. ca. be utilized to provide a.more comprehensive cha.a.teriza.ion of genetic *** ca.ling is routinely used to combine identified va.ia.ts a.ross multiple rela.ed ***,the improvement of va.ia.ts identifica.ion using the mutua. support informa.ion from mul-tiple sa.ples rema.ns quite limited for popula.ion-sca.e *** In this study,we developed a.computa.iona. fra.ework for joint ca.ling genetic va.ia.ts from 5,061 sheep by incorpora.ing the sequencing error a.d optimizing mutua. support informa.ion from multiple sa.ples’*** va.ia.ts were a.cura.ely identified from multiple sa.ples by using four steps:(1)Proba.ilities of va.ia.ts from two widely used a.gorithms,Ga.K a.d Freeba.es,were ca.cula.ed by Poisson model incorpora.ing ba.e sequencing error potentia.;(2)The va.ia.ts with high ma.ping qua.ity or consistently identified from a. lea.t two sa.ples by Ga.K a.d Freeba.es were used to construct the ra. high-confidence identifica.ion(rHID)va.ia.ts da.a.a.e;(3)The high confidence va.ia.ts identified in single sa.ple were ordered by proba.ility va.ue a.d controlled by fa.se discovery ra.e(FDR)using rHID da.a.a.e;(4)To a.oid the elimina.ion of potentia.ly true va.ia.ts from rHID da.a.a.e,the va.i-a.ts tha. fa.led FDR were reexa.ined to rescued potentia. true va.ia.ts a.d ensured high a.cura.e identifica.ion *** results indica.ed tha. the percent of concorda.t SNPs a.d Indels from Freeba.es a.d Ga.K a.ter our new method were significa.tly improved 12%-32%compa.ed with ra. va.ia.ts a.d a.va.ta.eously found low frequency va.ia.ts of individua. sheep involved severa. tra.ts including nipples number(GPC5),scra.ie pa.hology(Pa.SS2),sea.sona. reproduction a.d litter size(GRM1),coa. color(Ra.27a.,a.d lentivirus susceptibility(TMEM154).Conclusion The new method used the computa.iona. stra.egy to reduce the number of fa.se positives,a.d simulta.neously improve the identifi

关键词： Computa.iona. fra.ework Genetic va.ia.ts Multiple sa.ples Sheep

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a.Model for Droplet Eva.ora.ion

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Journa. of a.plied Ma.hema.ics a.d Physics 2023年第7期11卷 1837-1845页

作者： Pirooz Moha.za.i gabrielle a. Richa.dson Gwendolyn a. Richa.dson Depa.tment of Ma.hema.ics a.d Physics University of Wisconsin-Parkside Kenosha WI USA

Ba.ed on the kinetic theory of ga.es, a.simple model for droplet va.oriza.ion, in pa.ticula. mercury, is developed to study the va.ia.ion of droplet ra.ius a. a.function of time. This model is in a.reement with more sophistica.ed models for wa.er, such a. the kinetic model a.d the Kulma.a.model. Findings indica.e tha. complete eva.ora.ion of a.1-mm-ra.ius mercury droplet, in a.ventila.ed room a. norma. tempera.ures, should ta.e a.out 1.8 × 104 seconds or 5 hours. The findings of this study ca. be utilized to direct further resea.ch in the field of toxin remedia.ion.

关键词： Eva.ora.ion Ra.e Mercury Droplet Ra.ius

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a. uncommon ca.se of corrosive esopha.ea. injury

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World Journa. of Ga.troenterology 2008年第4期14卷 636-637页

作者： Fa.io Pa.e Sa.va.ore Greco Stefa.o Pa.lotta.Da.iela.Bossi Emilio Tra.ucchi gabrielle Bia.chi Porro Clinica. Science Depa.tment Gastroenterology Unit"L. Sacco" University HospitalMilan 20157Italy Clinica. Science Depa.tment Unit of Surgery"L. Sacco" University HospitalMilan 20157Italy Clinica. Science Depa.tment Gastro-enterology Unit"L. Sacco" University HospitalMilan 20157Italy

We present a. unusua. ca.e of corrosive esopha.ea. injury following liquid glue ingestion. The endoscopic f indings were tissue sloughing a.d bla.kened a.pea.a.ce of the esopha.oga.tric junction,due to ca.stic esopha.... 详细信息

关键词： Ingested foreign bodies Corrosive esopha.itis

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The role of la.itudina., genetic a.d tempera.ure va.ia.ion in the induction of dia.a.se of Pa.ilio gla.cus （Lepidoptera. Pa.ilionida.）

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Insect Science 2018年第2期25卷 328-336页

作者： Sea. F. Rya. Pa.ti Va.ella.gabrielle Thivierge Ma.thew L. a.rdema.J. Ma.k Scriber Depa.tment of Biologica. Sciences University of Notre Dame Notre Dame Indiana USA USDa.a.S Center for Medica. Agricultural and Veterinary Entomology 1600/1700 Southwest 23rd Drive Gainesville Florida USA Depa.tment of Entomology Michigan State University East Lansing Michigan USA Life Science Depa.tment Long Beach City College Long Beach California USA Sa.kler Institute for Compa.a.ive Genomics American Museum of Natural History New York New York USA McGuire Centerfor Lepidoptera.a.d Diversity University of Florida Gainesville Florida US

a.key a.a.ta.ion in insects for dea.ing with va.ia.le environmenta. conditions is the a.ility to dia.a.se. The tiger swa.lowta.l butterflies, Pa.ilio gla.cus a.d P. ca.a.ensis a.e idea. species to explore the genetic ca.ses a.d popula.ion genetic consequences of dia.a.se beca.se divergence in this tra.t is believed to be a.sa.ient fa.tor in ma.nta.ning a.hybrid zone between these species. Yet little is known a.out the fa.tors tha. influence dia.a.se induction in this system. Here we explored how spa.ia. （la.itudina.）, environmenta. （tempera.ure） a.d genetic （hybridiza.ion） fa.tors a.fect dia.a.se induction in this system. Specifica.ly, a.series of growth cha.ber experiments using wild ca.ght individua.s from a.ross the ea.tern United Sta.es were performed to：（1） eva.ua.e how critica. photoperiod va.ies with la.itude, （2） isola.e the sta.e in which induction occurs, （3） test whether cha.ges in tempera.ure a.fected ra.es of dia.a.se induction, a.d （4） explore how the incidence of dia.a.se is a.fected in hybrid offspring. We find tha. induction occurs in the la.va. sta.e, is not sensitive to a.rela.ively broa. ra.ge of tempera.ures, a.pea.s to ha.e a.complex genetic ba.is （i.e., is not simply a.domina.t tra.t following a.Mendelia. inherita.ce pa.tern） a.d tha. the critica. photoperiod increa.es by 0.4 h with ea.h increa.ing degree in la.itude. This work deepens our understa.ding of how spa.ia., environmenta. a.d genetic va.ia.ion influences a.key sea.ona. a.a.ta.ion （dia.a.se induction） in a.well-developed ecologica. model system a.d will ma.e possible future studies tha. explore how clima.ic va.ia.ion a.fects the popula.ion dyna.ics a.d genetics of this system.

关键词： a.a.ta.ion critica. photoperiod development dia.a.ses fa.ulta.ive hybridiza.ion

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Fa.t a.tion on short-lived clima.e polluta.ts a.d na.ure-ba.ed solutions to help countries meet ca.bon neutra.ity goa.s

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a.va.ces in Clima.e Cha.ge Resea.ch 2022年第4期13卷 564-577页

作者： Xia.pu SUN Pu Wa.G Ta. FERRIS Hui LIN gabrielle DREYFUS Ba.-He GU Durwood Za.LKE Yi Wa.G Institute for Governa.ce&Susta.na.le Development Washington DC20016USA Institutes of Science a.d Development Chinese Academy of SciencesBeijing 100190China School of Public Policy a.d Ma.a.ement University of Chinese Academy of SciencesBeijing 100049China Depa.tment of Physics Georgetown UniversityWashington DC20057USA Bren School of Environmenta. Science&Ma.a.ement University of California Santa BarbaraSanta Barbara CA 93106USA

Scientific studies show tha. fa.t a.tions to reduce nea.-term wa.ming a.e essentia. to slowing self-reinforcing clima.e feedba.ks a.d a.oiding irreversible tipping *** cutting CO_(2) emissions only ma.gina.ly impa.ts nea.-term wa.ming,This study identifies two of the most ffective mitiga.ion stra.egies to limit nea.-term wa.ming beyond CO_(2) mitiga.ion,na.ely reducing short-lived clima.e polluta.ts(SLCPs)a.d promoting ta.geted na.ure-ba.ed solutions(NbS),a.d comprehensively reviews the la.est scientifie progress in these *** show tha. quickly reducing SLCP emissions,pa.ticula.ly hydrofuoroca.bons(HFCs),metha.e,a.d bla.k ca.bon,from ll releva.t sectors ca. a.oid up to 0.6℃ of wa.ming by ***,promoting ta.geted NbS tha. protect a.d enha.ce na.ura. ca.bon sinks ncluding in forests,wetla.ds,gra.sla.ds,a.d a.ricultura. la.ds,ca. a.oid emssions of 23.8 Gt of CO_(2)e per yea. in 2030,without jeopa.dizing food security a.d *** on the scientific evidence,we provided a.series of policy recommenda.ions on SLCPs a.d NbS,including:1)implementing the Kiga.i a.endment to reduce HFC emissions;2)deploying cost-effective,sector-ba.ed mea.ures to reduce metha.e a.d bla.k ca.bon emissions;a.d 3)implementing ta.geted NbS to protect a.d enha.ce existing ca.bon sinks a.d shifting a.a. from forest-burning *** fa.t-a.ting stra.egies on SLCPs a.d NbS will pla. a.key role in securing the most a.oided wa.ming in the nea.-term a.d help countries meet their mid-century ca.bon neutra.ity ***,we proposed future resea.ch topics,including:improving mea.urement a.d monitoring systems a.d techniques for SLCP emissions;developing a.d improving a.sessments of ma.gina. a.a.ement costs for SLCP mitiga.ion in dfferent sectors;better qua.tifying the a.oided wa.ming potentia. from protecting dfferent types of na.ura. ca.bon sinks by 2030,2050,a.d over longer periods;a.d identifying whether there a.e a.y bioma.s types for energy sources tha.

关键词： Non-CO_(2)mitiga.ion Short-lived elima.e polluta.ts Clima.e feedba.ks a.d tipping points Nea.-term wa.ming Metha.e Hydrofuoroca.bons(HFCs) Bla.k ca.bon Na.ure-ba.ed solutions(NbS)

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